Imagine someone as abrasive and inappropriate as House, and you've got Tim Roth as Dr. Cal Lightman.
Dr. Lightman's company specializes in discerning whether or not people are telling the truth. They work with all areas of law enforcement, including the FBI, corporations, and different government departments. Their work is based on the research of Dr. Paul Ekman, who served as an adviser on the series.
The work of the Lightman Group revolves around reading people's facial expressions, voices, eye pupils, and gestures to tell if someone is being truthful.
Cal's business partner Gillian is played by the beautiful Kelli Williams, and her cool, calm demeanor is wonderful juxtaposition to Lightman's often flamboyant behavior. Tim Roth, sporting his Cockney accent, is quirky Lightman to a T- he stands in people's personal space, looks them straight in the eye, and tells them they're lying. The rest of the cast - Brendan Hines, Monica Raymond, Hayley McFarland, and Mekhi Phifer provide excellent support.
Original and offbeat, "Lie to Me" is an excellent series that unfortunately only ran three years. It's well worth seeing.