I actually watched this before I watched Run Lola Run (the German film that this is sort of based on), so my initial opinion was unbiased. Very rarely do I turn a film off but this was one of the few- I think I only made it about half an hour in.
Lola's girlfriend has a job interview, she forgets her documents (or something to that effect) and Lola has to run through San Francisco to get them to her. As she is running she encounters various scenarios that get in her way- the scenarios I actually managed to sit through were ridiculous. I am trying to refrain from comparing it to Run Lola Run which I have now watched but it is hard not to. And Then Came Lola completely lacks the urgency of Run Lola Run (in which her boyfriend gets tangled up in a drug deal and loses the money he needs to pay up).
This film seems to try too hard to say Look! We made a movie with lesbians in it! That also seems to be the main pro in the positive reviews of the film I've read. Although its great to see people trying to make this more the norm in movies, it would have been far better to have made an original film with a decent plot.