On a desert planet in a far future lives a guns man named Vash the Stampede. He's feared and seen as a murder by all individuals alike. He gain the nickname "Humanoid Typhoon" because he brings disaster to wherever he goes. After demolishing a city, a bounty was placed on his head $$60 billion. Two insurance girls(Meryl and Milly) were hired to locate and keep an eye on Vash to insure the damages that occur around him. At first they don't know what Vash is really like. But eventually they'll learn that he's the one guy you'd least suspect to be a wanted criminal.
Throughout the whole series, you'll learn about the past, personality, and tragedy of Vash. As well seeing many interesting minor, secondary, and vile characters that surround him. Not to mention the dozens of "Wild West" themed towns on the desert plant they all live on.
Trigun is one of the common 26 episode TV anime. But it's indeed one of the best ones out there. The animation is well done, for it being made back when Anime is still done with original cell animation. The western/punk look makes it stand out more than the other series. The story is really unique. It's also well balances in drama, comedy, action, and sci-fi.
Those who like Lupin III and Cowboy Bebop will indeed admire Trigun as well.