Charles Krauthammer nació el 13 de marzo de 1950 en Nueva York, Nueva York, EE.UU.. Estuvo casado con Robyn Trethewey. Murió el 21 de junio de 2018 en Atlanta, Georgia, Estados Unidos.
When he was a medical student, had a diving accident, in Massachusetts in July 1972, which injured his spinal cord and left him paralyzed. Later regained the use of the upper part of his body.