First thing first- this game chugs on most machines like you wouldn't believe. We're talking Rambo pulling an army helicopter on a chain- it would obviously still go (hey it's Rambo) but it would really slow...
That being said; the story, the art, the style, the fighting and the gameplay are all superb. The game has multiple endings and several different ways to complete the game.
You start off choosing a race, much like an MMORPG. Race affects your starting abilities, as well as how you play the game. Some races are good with firearms and fist fighting, some are stealthy, some wield magic very well, and others have a silver tongue for smooth diplomacy. And, I don't mean the boring diplomacy where you roll a dice and hope your saving throw works- I mean a choose what to say in a dialogue based on your playing style and charisma and affect how the NPCs respond.
Because there are different playing styles and a horde of abilities, one can redo missions over and over with different results each time. However, that isn't so far as to say that each outcome is different. Let's face it, there are a hundred ways to skin a cat, but each time you are left with a sticky pile of fur.
The game is dark and yet romantic, stylized at it's very core. Sometimes it feels more like a Detective NOIR or a mob story then a typical Vampire.
Vampire: The Masquerade II: Bloodlines is really 50% First Person Shooter, 50% RPG, and 10% Adventure. Yes, the developer's gave this game 110% of effort. XD