MTV teamed up with Nelvana to produce it, so the production values and writing were a couple of notches above their usual fare. It was created by the same people who created "Scrubs" for NBC and used a lot of the same actors to voice the characters.
A secret government agency has cloned a bunch of historical figures so that they can raise their own clone army. The clones, who are all in the teenage angst-y phase are all in High School together dealing with love, sex, drugs and social inadequacy while being watched by a maniacal Principal with plans of his own.
It simultaneously lampoons the current WB-style "tween" shows and after-school specials. The shows comedic style is fast paced, almost vaudevillian and it becomes even more bizarre and disconnected as it moves along.
Too bad MTV dropped it after only airing like, six episodes. I hear it still plays in Canada, though...