Jane McNeill nació el 10 de febrero de 1966 en Carolina del Norte, EE.UU.. Es una actriz y escritora, conocida por Ozark (2017), The Walking Dead (2010) y Mi tío Frank (2020). Está casada con Yoel Balter. Tienen dos niños.
McNeill was diagnosed with breast cancer shortly after returning to Wilmington in 2007. Her treatment and recovery put her acting career briefly on hold. After a year of recovery, acting was at the top of her 'bucket list' and she started taking classes with casting director Tracy Kilpatrick. As of 2010 she is a cancer-free.