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Two close friends are employed as guinea pigs for a pharmaceutical company. Each episode deals with the different "Research Products" given to the "Test Subjects". There are other stories playing throughout the seasons.

After testing a radical new pill for Testico, the boys discover there is a miracle growing inside Peter.

After suffering an unexpected loss in the pants department, Ron and Peter see if they have what it takes to be women.

A brainwashing experiment goes horribly wrong for Ron and Peter, but horribly right for Nugget.

When super slob Peter earns the boys a chance to test a million dollar vacuum, they discover having a hyper intelligent, military grade home appliance really sucks.

Ron and Peter test the world's strongest glue and they become closer than they ever thought possible.

Ron and Peter test chastity belts and have to go without sex for a week.

Peter and Ron are given a cologne that is supposed to attract women through pheromones. However, it turns out to only work on old, fat, unattractive ones, who are turned into zombie rapists.

It isn't until Ron and Peter face their deaths that they realize they've never really lived.

Peter takes a potent new muscle relaxant and is left totally paralyzed. Now he must try and survive Ron's special care.

Ron and Peter lose the ability to feel pain and the doctors warn them to be careful.

A new shampoo leaves Ron and Peter blind, and Nugget sees the perfect opportunity to live rent free.

Testico won't tell Ron and Pete what they are testing and they start to imagine symptoms everywhere; they're not eating, sleeping or leaving the apartment as they quickly descend into madness.

Ron and Peter are subjected to their most dangerous test yet: Truth Serum. Can their friendship survive this much honesty, or will they be torn apart by the secret of Peter's mysterious past?