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Jocelyn, Rainier, and Bingbong are film-school graduates dead-set on making an Oscar-worthy film. They set out to do a quick pre-production as a courtesy call to their lead actress (Eugene Domingo), and a thorough inspection of their film's major location, the Payatas dumpsite. They believe they have a winning script and the energy and drive to make their dreams come true, no matter what the cost.

Eugene prepares for her comeback vehicle after a long sabbatical from movie making. Rainier proposes "The Itinerary," a heartbreaking anatomy of a crumbling marriage as told through a couple's trip to Baguio, their former honeymoon location. Eugene Domingo is excited by the project but she has other ideas in mind. In the film within the film, we see Eugene's absurd suggestions and recommendations changing Rainier's script by employing the poetic of the Pinoy romantic comedy genre into what is supposedly a realistic portrayal of love and marriage.

100 chronicles the last three months of a cancer-stricken woman who has a list of things to do before she dies. Her list of tasks, mostly closures and practical undertakings, expands to the worldly and the spiritual as people close to her share her last days. The film examines the betrayal of the body, celebrates the senses, and contemplates the end of life and how to live it.