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Young Kitty runs away from home to avoid marrying a man she doesn't love. Her car breaks down on a country road and she meets Robert, a young artist who has just been turned down by a woman he loved madly and is about to commit suicide by lying on the railroad tracks. He sees Kitty in trouble and decides to help her. They get the car running, but it runs out of gas in front of a farmhouse. The farmer, mistakenly believing that the two are married, has them share a bedroom for the night. The next morning Kitty's father shows up looking for her and discovers that she has "spent the night" with a stranger. Complications ensue.

Mind, in the form of a college student, becomes infatuated with Body, a local barmaid, and neglects his studies, despite the warnings of his brother, Soul. Finally, however, he heeds Soul's advice and graduates to become a noted writer. Meanwhile, Soul becomes a minister and Body an adventuress. Body acquires four more lovers: a Champion Pugilist, a Musician, an Actor and a Banker, ruining and then discarding each one in turn. Eventually she enters Soul's church, where she realizes that her sinful mode of living can only lead to unhappiness. In trying to rescue Frail Sister, a white slave in the power of Slimy Thing, Body is shot and killed.