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Social worker Plaifon meets Mawin, a boy fleeing abusive father whose mother dies. As Mawin's sole support, Plaifon fears getting too attached and leaves, with regretting. Will their paths cross again as they move on from the past?

Paeng had tragic life of losing her parent, which made her live at Artit's house. Her crazy approach had nearly cost Artit which made him hate her. She had to leave home for 6 years until they met again. Will Artit forgive or hate her?

Bua, a medical student from today's 5G era, is mysteriously swept back to King Rama III's reign - the golden era of Thai traditional medicine. Immediately thrown into an unknown world where she finds allies and rivals, her modern ways inevitably clash with old traditions.

Thong In, an experienced doctor, isolates himself after a patient dies. His grandson Thong Ake wants to become a traditional doctor despite Thong In's wish. Thong Ake studies ancient Thai medicine and is determined to prove himself.

Tharatorn is a hot tempered businessman who has a telekinetic ability which manifests itself every time he gets angry. Unknown to him, he also has another problem - sometimes another personality of his emerges which makes him behave in ways very different to his main self, and it doesn't help that he can't remember anything. He has also been dreaming of a girl when he sleeps and he has no idea who she is. That is, until he meets Kewalin and recognises her as the woman in his dreams. Kewalin's presence starts to unravel the mystery behind Tharatorn's dual personality and it appears that there is another soul from an ancient time also inhabiting his body. What happens when these two souls/ spirits start falling for Kewalin? Thus begins the 'two spirits' love.'