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The series focuses on a single Harley Quinn, who sets off to make it on her own in Gotham City.

Follow the staff of an insurance company, specialising in products to protect defenseless bystanders from the collateral damage of superheroes and supervillains.

Anxious for more publicity, Harley sets out to find a nemesis.

Harley looks to recruit her very own crew.

When Clayface loses his arm in a heist, it turns out to be not only evidence for Jim Gordon, but also a key witness against Harley and her crew.

Harley makes an effort to impress the Legion of Doom.

Harley has an identity crisis that sends her into a strange brain freeze. Dr. Psycho leads the team into Harley's mind to find the source of the problem.

Harley recruits her friend and mentor Queen of Fables to help her steal a force field from STAR Labs, to steal a weather-changing machine, so she can impress the Legion of Doom. Meanwhile, Poison Ivy dates Kite Man.

Harley gets an invite to the Legion of Doom's prospective members party, but Ivy discovers that it's her Lex Luthor is really after.

Harley discovers that she can go home again - but it's very dangerous. As Harley reconciles with her father, Ivy tries to escape from the factory and Frank drives to the rescue.

Harley reunites her crew and they set out to save Ivy, who has fallen into Scarecrow's hands and is a vital part of the villain's plan.

Harley and her crew attempt to rescue Gotham from the hands of Joker and Queen of Fables.

Ivy is dead, Harley's crew is captured, and Batman is his captive. Joker has everything he's ever wanted - but is it enough without Harley at his side?

Ivy and the crew find themselves abandoned when Harley pursues her dream after the Legion makes her a member - and Joker woos her. But when he uses her to escape Batman, Harley realizes that she's made a mistake...but it may be too late to fix things with her friends.

After Gotham is declared no longer part of the United States, the newly formed Injustice League tries to seize control of the city away from Harley.

Harley and Ivy go undercover as college students to take down Riddler, who's made himself dean of the local university with sinister plans for students.

Harley gets Catwoman to help her and Ivy steal a flamethrower they need to take on Mr. Freeze.

Harley goes after Freeze, while Ivy and Kite Man look for a wedding venue.

While Bruce is frustrated by his inability to fight crime because of his injuries, Bane insists that Two-Face make him a full partner now that Harley has killed the other members of the Injustice League. Batgirl emerges from the shadows to fight crime in Gotham, and carry on the Bat tradition - whether Batman wants her to or not.

When Harley and Ivy spot a seemingly sane Joker, they debate whether people can change at their core, revisiting a flashback about Harleen Quinzel's first day at Arkham Asylum.

Two-Face has Harley and Ivy sentenced to life in Bane's prison, which is a giant pit in the ground; Jim Gordon and Batgirl vow to take back the GCPD headquarters from Two-Face.

Harley covers up for the "kiss" by going to Apokolips to get an army to conquer Gotham.

Harley takes Ivy and her "friends" for a bachelorette party on Themyscira. Meanwhile, King Shark is summoned home.

Alone on Christmas Eve, Harley reconnects with a now-sane Joker and heads to Wayne Tower, where their dinner is interrupted by an escaped Riddler and ParaDemons.