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A young mother, Dr. Marie Sol passed away soon after discovering that the fossil fuel company she worked for had been falsifying her research. Years later, her colleague turned world renowned climate scientist and author, Dr. Phyllis Lambert, has retired into isolation. A journalist, Claire Dimas, now seeks to expose their employer's greenwashing campaigns and fraudulent reports. Dr. Lambert refuses to cooperate as she battles haunting visions of her past decisions, forcing Claire to involve Dr. Sol's daughter, Isabel. By placing her at the center of this investigation, Isabel is now determined to find the truth and confront her grief.

Recent studies show that insects are in decline across the globe and there may be a direct connection between the current climate crisis and these declining populations. DESYNCHRONIZED focuses on Pope Canyon Queens, a beekeeping and queen breeding company in Northern California. Pope Canyon Queens is currently trying to rebuild after the 2020 LNU Lightning Complex fires destroyed their farm, shop, and half of their hives. Their crucial work to breed honey bee queens with stronger genes fortifies beekeepers' hives across the country while they face the effects of climate change and unregulated industries. Dr. Nicholas Teets, PhD Entomology, explains how shifts in phenology are predicted to cause bigger issues. Howard Goldstein, Senior Forest Ecologist at the Prospect Park Alliance explores how community gardens and green spaces in large metropolitan areas may help insect populations recover from loss of habitat and food scarcity.

Sophie and Denise can hardly stand to be in the same room together, but they continue to try as long as their mother is there. A regular Sunday gathering turns into a confrontation as the two sisters learn of their mother's decision to die with dignity.