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2010, ChemInform
2019 •
Aldose reductase is associated with diabetes. Many inhibitors are design that may be used as potential inhibitors for treatment of diabetes. Molecular docking is the most used tool in structure based drug-design. In the present study, we have tried to investigate novel Nitrophenyl derivative as aldose reductase inhibitor via in silico docking studies using AutoDock 4.2.6. In the docking studies three important parameters like Interaction Pattern, Binding Moeties and Binding Energy were determined. The results showed that the selected novel molecule shows binding energy i.e., (-1.90) kcal/mol and HIS110, TYR48, CYS80, LEU300, TRP111, CYS298, PHE1115, THR113, CYS303, TRP79 and PHE122 as binding moieties. Thus, Molecular docking study reveals that novel nitrophenyl derivative has good interaction pattern and exhibits aldose reductase inhibitory activity because of its structural properties. This molecular docking could lead to further development of potent aldose reductase inhibitor he...
Trends in Sciences
Endophytic Fungi from Mangrove Plant Acanthus ilicifolius L.: Antimicrobial, Anticancer, and Species DeterminationThe current study aimed to screen, identify and evaluate the biological activity of fungi strains from the mangrove plant Acanthus ilicifolius L, which has proven to be a rich source of fungal species. Thirteen fungi were screened from the leaves, stem bark, and roots. Each fungal strain was cultivated in rice as media, and then the secondary metabolites of the fungus were extracted with ethyl acetate. The extracts were tested for antimicrobial and cytotoxic activities. Next, a phylogenetic tree was reconstructed based on the sequence similarities of each strain. The fungal extract AIA1 displayed excellent antimicrobial activity in a concentration of 5 % against some pathogenic bacterial strains with an inhibition zone in the range of 11.87 ± 0.87 to 15.42 ± 0.51 mm. The brine shrimp lethality test (BSLT) showed that strains AIA1 and AIKB3 were toxic against Artemisia salina L with an LC50 value of less than 80 ppm. The MTT assay determined the cytotoxicity against the human ductal ...
2004 •
© 2004 Martinelli et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. ... 2) Do these compounds ...
Fungal Biology and Biotechnology
Unearthing the fungal endophyte Aspergillus terreus for chemodiversity and medicinal prospects: a comprehensive reviewAspergillus terreus microorganism represents a promising prospective source for drug discovery since it is rich in diverse kinds of bioactive secondary metabolites. It contributed to many biotechnological applications and its metabolites are used in the synthesis of certain pharmaceuticals and food products, in addition to its useful uses in fermentation processes. There are about 346 compounds identified from marine and terrestrial-derived A. terreus from 1987 until 2022, 172 compounds of them proved a vast array of bioactivity. This review aimed to create an up-to-date comprehensive literature data of A. terreus’s secondary metabolites classes supported by its different bioactivity data to be a scientific record for the next work in drug discovery.
Synthesis
Regioselectivity of the Intramolecular Photocycloaddition of α,β-Butenolides to a Terminal Alkene2004 •
Tetrahedron Letters
Regioselectivity of Dimerisation of Butenolides via Captodative Stabilised Radicaloid Intermediates2005 •
2023 •
Presentazione dei primi risultati degli scavi condotti nel Santuario di Giove Anxur e della forma del monastero altomedievale
Đã đăng ký bản quyền tác giả Đã đăng ký bản quyền tác giả
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