ChemInform Abstract: Synthesis of Enantiomerically Pure (+)- and (-)-18-Methoxycoronaridine Hydrochloride and Their Preliminary Assessment as anti-Addictive Agents

2019

Aldose reductase is associated with diabetes. Many inhibitors are design that may be used as potential inhibitors for treatment of diabetes. Molecular docking is the most used tool in structure based drug-design. In the present study, we have tried to investigate novel Nitrophenyl derivative as aldose reductase inhibitor via in silico docking studies using AutoDock 4.2.6. In the docking studies three important parameters like Interaction Pattern, Binding Moeties and Binding Energy were determined. The results showed that the selected novel molecule shows binding energy i.e., (-1.90) kcal/mol and HIS110, TYR48, CYS80, LEU300, TRP111, CYS298, PHE1115, THR113, CYS303, TRP79 and PHE122 as binding moieties. Thus, Molecular docking study reveals that novel nitrophenyl derivative has good interaction pattern and exhibits aldose reductase inhibitory activity because of its structural properties. This molecular docking could lead to further development of potent aldose reductase inhibitor he...

Trends in Sciences

The current study aimed to screen, identify and evaluate the biological activity of fungi strains from the mangrove plant Acanthus ilicifolius L, which has proven to be a rich source of fungal species. Thirteen fungi were screened from the leaves, stem bark, and roots. Each fungal strain was cultivated in rice as media, and then the secondary metabolites of the fungus were extracted with ethyl acetate. The extracts were tested for antimicrobial and cytotoxic activities. Next, a phylogenetic tree was reconstructed based on the sequence similarities of each strain. The fungal extract AIA1 displayed excellent antimicrobial activity in a concentration of 5 % against some pathogenic bacterial strains with an inhibition zone in the range of 11.87 ± 0.87 to 15.42 ± 0.51 mm. The brine shrimp lethality test (BSLT) showed that strains AIA1 and AIKB3 were toxic against Artemisia salina L with an LC50 value of less than 80 ppm. The MTT assay determined the cytotoxicity against the human ductal ...

BMC …, 2004

© 2004 Martinelli et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. ... 2) Do these compounds ...

Fungal Biology and Biotechnology

Aspergillus terreus microorganism represents a promising prospective source for drug discovery since it is rich in diverse kinds of bioactive secondary metabolites. It contributed to many biotechnological applications and its metabolites are used in the synthesis of certain pharmaceuticals and food products, in addition to its useful uses in fermentation processes. There are about 346 compounds identified from marine and terrestrial-derived A. terreus from 1987 until 2022, 172 compounds of them proved a vast array of bioactivity. This review aimed to create an up-to-date comprehensive literature data of A. terreus’s secondary metabolites classes supported by its different bioactivity data to be a scientific record for the next work in drug discovery.

Medicinal Chemistry Research, 2013

2007

Synthesis, 2004

Tetrahedron Letters, 2005

N.B. Ces diagrammes et images préfigurent (a) certains aspects de ma contribution à un projet en cours d’élaboration avec Mahoro Murasawa sur le besoin actuel de nouveaux sensibles et intelligibles, et (b) l’idée principale que j’aimerais développer dans le cadre d’un projet futur avec Jérôme Rosanvallon auquel je contribuerai par une étude sur les seuils de la pensée pré-représentationnelle après Guattari et sur lequel j’espère commencer à travailler à l’automne 2024. N.B. The following diagrams and images foreshadow (a) certain aspects of my contribution to a project currently being developed with Mahoro Murasawa on the today's need for new sensitive and intelligibles, and (b) the main idea that I would like to develop in the framework of a future project with Jérôme Rosanvallon to which I intend to contribute with a study on the thresholds of pre-representational thought after Guattari and on which I hope to begin working in the fall of 2024. This work is still at the project stage; I would therefore be grateful if it is neither quoted nor distributed it without my authorization.

Evangelico Digital, 2024

Entre los griegos las mujeres eran consideradas como sensibles a lo divino y por eso los oráculos eran casi siempre trasmitidos por una doncella (la pitonisa en Delfos es el caso más célebre) inspiradas por la divinidad de turno. En la tradición judía existieron mujeres con dones proféticos alguna de las cuales encontramos en el Nuevo Testamento como Ana la viuda de ochenta y cuatro años que daba testimonio de Jesús en el Templo o las hijas de Felipe atestiguadas en el libro de Hechos (Lc.2:36-38, Hch. 21:9).