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VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint
/ Wanstall, Hannah C (Manchester U. ; Daresbury) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfred (CERN) ; Corsini, Roberto (CERN) ; Bateman, Joseph J (Oxford U., Theor. Phys.) ; Rieker, Vilde (CERN ; Oslo U.) ; Hemming, Abigail (U. Manchester (main)) ; Henthorn, Nicholas T (U. Manchester (main) ; Manchester U.) ; Merchant, Michael J (Manchester U.) ; Santina, Elham (Manchester U.) et al.
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical energy electrons, however, very little data is available for the effect of FLASH with Very High Energy Electrons (VHEE). [...]
2024 - 13 p.
- Published in : Sci. Rep. 14 (2024) 14803
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CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications
/ Whitmore, L (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech. ; Texas U., Houston) ; Mackay, R I (Manchester U.) ; van Herk, M (Manchester U.) ; Korysko, P (Oxford U. ; CERN) ; Farabolini, W (CERN) ; Malyzhenkov, A (CERN) ; Corsini, R (CERN) ; Jones, R M (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.)
Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability as a modality for FLASH (ultra-high dose-rate) radiotherapy. The dose distributions due to VHEE need to be optimised; one option is through the use of quadrupole magnets to focus the beam, reducing the dose to healthy tissue and allowing for targeted dose delivery at conventional or FLASH dose-rates. [...]
2024 - 15 p.
- Published in : Sci. Rep. 14 (2024) 11120
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Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage
/ Small, K L (Manchester U. ; Daresbury) ; Henthorn, N T (Manchester U. ; Unlisted, GB) ; Angal-Kalinin, D (Manchester U. ; Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Chadwick, A L (Manchester U. ; Unlisted, GB) ; Santina, E (Manchester U. ; Unlisted, GB) ; Aitkenhead, A (Manchester U. ; Unlisted, GB) ; Kirkby, K J (Manchester U. ; Unlisted, GB) ; Smith, R J (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Surman, M (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Jones, J (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) et al.
This paper presents the first plasmid DNA irradiations carried out with Very High Energy Electrons (VHEE) over 100–200 MeV at the CLEAR user facility at CERN to determine the Relative Biological Effectiveness (RBE) of VHEE. DNA damage yields were measured in dry and aqueous environments to determine that ~ 99% of total DNA breaks were caused by indirect effects, consistent with other published measurements for protons and photons. [...]
2021 - 12 p.
- Published in : Sci. Rep. 11 (2021) 3341
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Influence of heterogeneous media on Very High Energy Electron (VHEE) dose penetration and a Monte Carlo-based comparison with existing radiotherapy modalities
/ Lagzda, Agnese (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.) ; Angal-Kalinin, Deepa (Cockcroft Inst. Accel. Sci. Tech. ; Daresbury) ; Jones, James (Cockcroft Inst. Accel. Sci. Tech. ; Daresbury) ; Aitkenhead, Adam (Unlisted, UK ; Manchester U.) ; Kirkby, Karen J (Unlisted, UK ; Manchester U.) ; MacKay, Ranald (Unlisted, UK ; Manchester U.) ; Van Herk, Marcel (Unlisted, UK ; Manchester U.) ; Farabolini, Wilfrid (CERN) ; Zeeshan, Sumaira (CERN) ; Jones, Roger M (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.)
• First experimental demonstration of the relative insensitivity of VHEE beams to inhomogeneities. • Topas/GEANT4 simulations on experiments conducted at CERN’s CLEAR facility are in good agreement. [...]
2020 - 12 p.
- Published in : Nucl. Instrum. Methods Phys. Res., B 482 (2020) 70-81
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HOM characterization for beam diagnostics at the european XFEL injector
/ Baboi, Nicoletta (DESY) ; Hellert, Thorsten (DESY and University of Hamburg) ; Shi, Liangliang (DESY and Manchester University) ; Wamsat, Thomas, DESY ; Jones, Roger M (Cockcroft Institute and Manchester University) ; Joshi, Nirav (Cockcroft Institute and Manchester University)
Higher Order Modes (HOM) excited by bunched electron beams in accelerating cavities carry information about the beam position and phase. This principle is used at the FLASH facility, at DESY, for beam position monitoring in 1.3 and 3.9 GHz cavities. [...]
CERN-ACC-2017-0046.-
Geneva : CERN, 2017
- Published in :
Fulltext: PDF;
In : International Beam Instrumentation Conference, Barcelona, Spain, 11 - 15 Sep 2016, pp.WEPG03
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Measurement of beam phase at FLASH using HOMs in accelerating cavities
/ Shi, Lianliang (Manchester University and Cockcroft Institute and DESY) ; Baboi, Nicoletta (DESY) ; Jones, Roger M (Manchester University and Cockcroft Institute) ; Joshi, Nirav (Manchester University and Cockcroft Institute)
The beam phase relative to the accelerating field is of vital importance for the quality of photon beams produced in modern Free Electron Lasers based on superconducting cavities. Normally, the phase is determined by detecting the transient field induced by the beam. [...]
CERN-ACC-2017-0044.-
Geneva : CERN, 2017
- Published in : 10.18429/JACoW-IPAC2016-MOPOR039
Fulltext: CERN-ACC-2017-0044 - PDF; Fulltext - PDF;
In : 7th International Particle Accelerator Conference, Busan, Korea, 8 - 13 May 2016, pp.MOPOR039
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Eigenmode compendium of the third harmonic module of the European X-ray Free Electron Laser
/ Flisgen, Thomas (Rostock U.) ; Heller, Johann (Rostock Universitaet) ; Galek, Tomasz, Rostock Universitaet ; Shi, Liangliang (Cockcroft institute, Manchester University and DESY) ; Joshi, Nirav (Manchester University) ; Baboi, Nicoletta (DESY) ; Jones, Roger M (Cockcroft Institute and Manchester University) ; van Rienen, Ursula (Rockstock Universitaet)
Chains of superconducting radio-frequency resonators are key components of modern particle accelerators such as the European XFEL, which is currently under construction in the north of Germany. In addition to the accelerating mode of the resonators, their beam excited higher order modes are of special interest, because they can harm the beam quality. [...]
CERN-ACC-2017-0041.-
Geneva : CERN, 2017
- Published in : Phys. Rev. Accel. Beams 20 (2017) 042002
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