OR51E2
| Olfaktorni receptor, familija 51, potfamilija E, član 2 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | OR51E2; OR51E3P; OR52A2; PSGR | ||||||||||
| Vanjski ID | OMIM: 611268 MGI: 2157548 HomoloGene: 23713 GeneCards: OR51E2 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 81285 | 170639 | |||||||||
| Ensembl | ENSG00000167332 | ENSMUSG00000043366 | |||||||||
| UniProt | Q9H255 | Q8VBV9 | |||||||||
| RefSeq (mRNA) | NM_030774.3 | NM_001168503.1 | |||||||||
| RefSeq (protein) | NP_110401.1 | NP_001161975.1 | |||||||||
| Lokacija (UCSC) |
Chr 11: 4.7 - 4.72 Mb |
Chr 7: 102.74 - 102.76 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Olfaktorni receptor 51E2 je protein koji je kod ljudi kodiran OR51E2 genom.[1][2]
Olfaktorni receptori formiraju interakcije sa molekulima mirisa u nosu, čime se inicira neuronski respons koji izaziva percepciju mirisa. Oni su odgovorni za prepoznavanje i G proteinima posredovanu transdukciju mirisnih signala. Proteini olfaktornih receptora su članovi velike familije G protein spregnutih receptora (GPCR). Poput mnogih receptora za neurotransmitere i hormone, olfaktorni receptori imaju strukturu 7-transmembranskog domena. Oni su kodirani genima sa jednim eksonom. Geni olfaktornih receptora su najveća familija genoma. Nomenklatura gena i proteina olfaktornih receptora je nezavisna od drugih organizama.[2]
Reference
[уреди | уреди извор]- ^ Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, Zou Z, Srikantan V, Augustus M, Roschke V, Carter K, McLeod DG, Moul JW, Soppett D, Srivastava S (2000). „PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer”. Cancer Res. 60 (23): 6568—72. PMID 11118034.
- ^ а б „Entrez Gene: OR51E2 olfactory receptor, family 51, subfamily E, member 2”.
Literatura
[уреди | уреди извор]- Adams MD; Kerlavage AR; Fleischmann RD; et al. (1995). „Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence” (PDF). Nature. 377 (6547 Suppl): 3—174. PMID 7566098.
- Xia C; Ma W; Wang F; et al. (2001). „Identification of a prostate-specific G-protein coupled receptor in prostate cancer”. Oncogene. 20 (41): 5903—7. PMID 11593396. doi:10.1038/sj.onc.1204803.
- Yuan TT; Toy P; McClary JA; et al. (2002). „Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species”. Gene. 278 (1–2): 41—51. PMID 11707321. doi:10.1016/S0378-1119(01)00709-0.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899.
- Malnic B, Godfrey PA, Buck LB (2004). „The human olfactory receptor gene family”. Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584—9. PMC 356993
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928
- Weng J; Wang J; Cai Y; et al. (2005). „Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers”. Int. J. Cancer. 113 (5): 811—8. PMID 15499628. doi:10.1002/ijc.20635.
- Weng J; Ma W; Mitchell D; et al. (2006). „Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors”. J. Cell. Biochem. 96 (5): 1034—48. PMID 16149059. doi:10.1002/jcb.20600.
- Xu LL; Sun C; Petrovics G; et al. (2006). „Quantitative expression profile of PSGR in prostate cancer”. Prostate Cancer Prostatic Dis. 9 (1): 56—61. PMID 16231015. doi:10.1038/sj.pcan.4500836.
- Wang J; Weng J; Cai Y; et al. (2006). „The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase”. Prostate. 66 (8): 847—57. PMID 16491480. doi:10.1002/pros.20389.
Vidi još
[уреди | уреди извор]Spoljašnje veze
[уреди | уреди извор]- OR51E2+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)