PEPA (lek)

PEPA (lek)
(IUPAC) ime
	2-[2,6-difluoro-4-({2-[(fenilsulfonil)amino]etil}tio)fenoksi]acetamid
Klinički podaci
Identifikatori
CAS broj	141286-78-4
ATC kod	nije dodeljen
PubChem	6603828
Hemijski podaci
Formula	C16H16F2N2O4S2
Mol. masa	402.436 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C16H16F2N2O4S2/c17-13-8-11(9-14(18)16(13)24-10-15(19)21)25-7-6-20-26(22,23)12-4-2-1-3-5-12/h1-5,8-9,20H,6-7,10H2,(H2,19,21) ; Key: GTACSIONMHMRPD-UHFFFAOYSA-N
Sinonimi	PEPA
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Lek u razvoju

PEPA je ampakinski lek koji deluje kao alosterni potencijator desenzitizacije AMPA receptora.^[3]^[4] On je oko 100 puta potentniji od aniracetama in vitro.^[5] It produces memory-enhancing effects in rats when administered intravenously.^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Sekiguchi M, Takeo J, Harada T, Morimoto T, Kudo Y, Yamashita S, Kohsaka S, Wada K (1998). „Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures”. British Journal of Pharmacology 123 (7): 1294–303. DOI:10.1038/sj.bjp.0701707. PMC 1565288. PMID 9579722.
↑ Sekiguchi (2002). „A desensitization-selective potentiator of AMPA-type glutamate receptors”. British Journal of Pharmacology 136 (7): 1033–41. DOI:10.1038/sj.bjp.0704804. PMC 1573432. PMID 12145103.
↑ Sekiguchi, M; Fleck, MW; Mayer, ML; Takeo, J; Chiba, Y; Yamashita, S; Wada, K (1997). „A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide”. Journal of Neuroscience 17 (15): 5760–71. PMID 9221774.
↑ Sekiguchi, M; Yamada, K; Jin, J; Hachitanda, M; Murata, Y; Namura, S; Kamichi, S; Kimura, I et al (2001). „The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment”. NeuroReport 12 (13): 2947–50. DOI:10.1097/00001756-200109170-00038. PMID 11588608.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Sekiguchi M, Takeo J, Harada T, Morimoto T, Kudo Y, Yamashita S, Kohsaka S, Wada K (1998). „Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures”. British Journal of Pharmacology 123 (7): 1294–303. DOI:10.1038/sj.bjp.0701707. PMC 1565288. PMID 9579722.

[4] Sekiguchi (2002). „A desensitization-selective potentiator of AMPA-type glutamate receptors”. British Journal of Pharmacology 136 (7): 1033–41. DOI:10.1038/sj.bjp.0704804. PMC 1573432. PMID 12145103.

[5] Sekiguchi, M; Fleck, MW; Mayer, ML; Takeo, J; Chiba, Y; Yamashita, S; Wada, K (1997). „A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide”. Journal of Neuroscience 17 (15): 5760–71. PMID 9221774.

[6] Sekiguchi, M; Yamada, K; Jin, J; Hachitanda, M; Murata, Y; Namura, S; Kamichi, S; Kimura, I et al (2001). „The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment”. NeuroReport 12 (13): 2947–50. DOI:10.1097/00001756-200109170-00038. PMID 11588608.

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