Strihnin
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Identifikacija
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CAS registarski broj
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57-24-9 Y
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PubChem[1][2]
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441071
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ChemSpider[3]
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389877 Y
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UNII
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H9Y79VD43J Y
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KEGG[4]
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C06522
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ChEBI
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28973
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ChEMBL[5]
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CHEMBL227934 Y
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Jmol-3D slike
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Slika 1
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O=C1C[C@@H]2OCC=C3CN4CC[C@]56[C@@H]4C[C@@H]3[C@@H]2[C@@H]5N1c7ccccc67 |
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InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21-/m0/s1 Y Kod: QMGVPVSNSZLJIA-ZNOLUWNGSA-N Y
InChI=1/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 |
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Svojstva
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Molekulska formula
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C21H22N2O2
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Molarna masa
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334.41 g mol−1
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Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
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Infobox references
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Strihnin se dobija iz biljaka Strihinos vrste. On je veoma stabilan alkaloid, dobro se čuva i može se dokazati u leševima nakon trovanja. Veoma je jak otrov. Strihnin se teško rastvara u vodi i etru, lakše u alkoholu u benzenu, a lako u hloroformu. Karakteristična je reakcija za strihnin da se sumpornom kiselinom u prisustvu kalijumovog dihromata daje intezivno modro obojenje. Strihnin izaziva grčevito kočenje mišića. U veoma malim količinama upotrebljava se kao analeptik (sredstvo za jačanje i okrepljenje). Strihnin se najviše koristi za uništavanje pacova, [miš]eva i drugih štetočina. Jedan od najpoznatijih otrova. Često korišćen u kriminalističkim knjigama.
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o.
- ↑ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573.
- ↑ Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286.