LPHN1
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| Latrofilin 1 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | LPHN1; CIRL1; CL1; LEC2 | ||||||||||
| Vanjski ID | MGI: 1929461 HomoloGene: 8951 IUPHAR: LPHN1 GeneCards: LPHN1 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 22859 | 330814 | |||||||||
| Ensembl | ENSG00000072071 | ENSMUSG00000013033 | |||||||||
| UniProt | O94910 | Q80TR1 | |||||||||
| RefSeq (mRNA) | NM_001008701.2 | NM_181039.2 | |||||||||
| RefSeq (protein) | NP_001008701.1 | NP_851382.2 | |||||||||
| Lokacija (UCSC) | Chr 19: 14.26 - 14.32 Mb | Chr 8: 86.42 - 86.47 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Latrofilin-1 je protein koji je kod ljudi kodiran LPHN1 genom.[1][2]
Ovaj protein je član latrofilinske familije G protein spregnutih receptora (GPCR). Latrofilini mogu da učestvuju u ćelijskoj adheziji i u prenosu signala. Endogeno proteolitičko razlaganje unutar cisteinom bogatog GPS (GPCR proteolizno mesto) domena proizvodi dve podjedinice (veliku ekstracelularnu N-terminalnu adhezionu jedinicu i podjedinicu koja je u znatno meri slična sa sekretinskom/kalcitoninskom familijom). Ovi domeni su nekovalentno vezani na ćelijskoj membrani. Latrofilin-1 vezuje neurotoksin iz venuma pauka crna udovica, alfa-latrotoksin.[2]
- ↑ Hayflick JS (Jan 2001). „A family of heptahelical receptors with adhesion-like domains: a marriage between two super families”. J Recept Signal Transduct Res 20 (2–3): 119–31. DOI:10.3109/10799890009150640. PMID 10994649.
- ↑ 2,0 2,1 „Entrez Gene: LPHN1 latrophilin 1”.
- Südhof TC (2001). „alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins”. Annu. Rev. Neurosci. 24: 933–62. DOI:10.1146/annurev.neuro.24.1.933. PMID 11520923.
- Ushkaryov YA, Volynski KE, Ashton AC (2004). „The multiple actions of black widow spider toxins and their selective use in neurosecretion studies”. Toxicon 43 (5): 527–42. DOI:10.1016/j.toxicon.2004.02.008. PMID 15066411.
- Nagase T, Ishikawa K, Suyama M i dr.. (1999). „Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Res. 5 (6): 355–64. DOI:10.1093/dnares/5.6.355. PMID 10048485.
- Kreienkamp HJ, Zitzer H, Gundelfinger ED i dr.. (2000). „The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins”. J. Biol. Chem. 275 (42): 32387–90. DOI:10.1074/jbc.C000490200. PMID 10964907.
- Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Brill LM, Salomon AR, Ficarro SB i dr.. (2004). „Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry”. Anal. Chem. 76 (10): 2763–72. DOI:10.1021/ac035352d. PMID 15144186.
- Bjarnadóttir TK, Fredriksson R, Höglund PJ i dr.. (2005). „The human and mouse repertoire of the adhesion family of G-protein-coupled receptors”. Genomics 84 (1): 23–33. DOI:10.1016/j.ygeno.2003.12.004. PMID 15203201.
- Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.