Izoniazid

Izoniazid
(IUPAC) ime
	izonikotinohidrazid
Klinički podaci
AHFS/Drugs.com	Monografija
MedlinePlus	a682401
Identifikatori
CAS broj	54-85-3
ATC kod	J04AC01
PubChem	3767
DrugBank	DB00951
ChemSpider	3635
UNII	V83O1VOZ8L
KEGG	D00346
ChEBI	CHEBI:6030
ChEMBL	CHEMBL64
Hemijski podaci
Formula	C6H7N3O
Mol. masa	137,139 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10) ; Key: QRXWMOHMRWLFEY-UHFFFAOYSA-N
Farmakokinetički podaci
Vezivanje za proteine plazme	Veoma sporo (0-10%)
Metabolizam	jetra; CYP450: 2C19, 3A4 inhibitor
Poluvreme eliminacije	0,5-1,6 h (brz acetilatori), 2-5 h (spori acetilatori)
Izlučivanje	urine (primarily), feces
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	samo na recepat (US)
Način primene	oralno, intramuskularno, intravenozno

Isoniazid (Laniazid, Nidrazid, izonikotinilhidrazin, INH) organsko jedinjenje je primarni lek za prevenciju i tretman tuberkuloze. Ovo jedinjenje je prvi put sintetisano početkom 20. veka,^[6] ali je njegovo antituberkolozno dejstvo otkriveno 1950-tih, i tri farmaceuticska preduzeća su istovremeno neuspešno pokušala da patentiraju lek.^[7] Lek je initicijalno testiran u Arizoni na Navaho zajednici, koja ima veoma veliki problem sa tuberkulozom i koja nije bila izložena streptomicinu, glavnom tuberkuloznom tretmanu tog vremena.^[8]

Isoniazid je dostupan u obliku tablete, sirupa, i injekcija (za intramuskularnu ili intravenoznu upotrebu). On je dostupan širom sveta. Ovaj lek ima nisku cenu i generalno je dobro tolerisan. On se proizvodi iz izonikotinske kiseline, koja se formira iz 4-metilpiridina.^[9]

Povezano

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Meyer H, Mally J (1912). „On hydrazine derivatives of pyridine carbonic acids” (German). Monatshefte Chemie verwandte Teile anderer Wissenschaften 33: 393–414. DOI:10.1007/BF01517946. PDF fulltext
↑ Hans L Riede (2009). „Fourth-generation fluoroquinolones in tuberculosis”. Lancet 373 (9670): 1148–1149. DOI:10.1016/S0140-6736(09)60559-6. PMID 19345815.
↑ Jones, David (2002). „The Health Care Experiments at Many Farms: The Navajo, Tuberculosis, and the Limits of Modern Medicine, 1952-1962”. Bulletin of the History of Medicine 76 (4): 749–790.
↑ Shinkichi Shimizu, Nanao Watanabe, Toshiaki Kataoka, Takayuki Shoji, Nobuyuki Abe, Sinji Morishita, Hisao Ichimura (2007). „Pyridine and Pyridine Derivatives”. Ullmann's Encyclopedia of Industrial Chemistry. New York: John Wiley & Sons. DOI:10.1002/14356007.a22_399.

Literatura

Spoljašnje veze

	Portal Medicina
	Portal Hemija

Core Curriculum on Tuberculosis (2000) Division of Tuberculosis Elimination, Centers for Disease Control and Prevention
Isoniazid Overdose: Recognition and Management Arhivirano 2011-11-01 na Wayback Machine-u American Family Physician 1998 Feb 15

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Meyer H, Mally J (1912). „On hydrazine derivatives of pyridine carbonic acids” (German). Monatshefte Chemie verwandte Teile anderer Wissenschaften 33: 393–414. DOI:10.1007/BF01517946. PDF fulltext

[7] Hans L Riede (2009). „Fourth-generation fluoroquinolones in tuberculosis”. Lancet 373 (9670): 1148–1149. DOI:10.1016/S0140-6736(09)60559-6. PMID 19345815.

[8] Jones, David (2002). „The Health Care Experiments at Many Farms: The Navajo, Tuberculosis, and the Limits of Modern Medicine, 1952-1962”. Bulletin of the History of Medicine 76 (4): 749–790.

[9] Shinkichi Shimizu, Nanao Watanabe, Toshiaki Kataoka, Takayuki Shoji, Nobuyuki Abe, Sinji Morishita, Hisao Ichimura (2007). „Pyridine and Pyridine Derivatives”. Ullmann's Encyclopedia of Industrial Chemistry. New York: John Wiley & Sons. DOI:10.1002/14356007.a22_399.

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