Scaling catalytic contributions of small self‐cleaving ribozymes

M Egger, R Bereiter, S Mair, R Micura - Angewandte Chemie, 2022 - Wiley Online Library
Nucleolytic ribozymes utilize general acid‐base catalysis to perform phosphodiester
cleavage. In most ribozyme classes, a conserved active site guanosine is positioned to act …

Chemical Synthesis of Modified RNA

L Flemmich, R Bereiter, R Micura - Angewandte Chemie, 2024 - Wiley Online Library
Ribonucleic acids (RNAs) play a vital role in living organisms. Many of their cellular
functions depend critically on chemical modification. Methods to modify RNA in a controlled …

Calculated pKa Values for a Series of Aza- and Deaza-Modified Nucleobases

AJ Mlotkowski, HB Schlegel… - The Journal of Physical …, 2023 - ACS Publications
A variety of synthetic modified nucleobases have been used to investigate the structure and
function of RNA and DNA or act as enzyme inhibitors. A set of these modifications involves …

Atomic Mutagenesis of N6-Methyladenosine Reveals Distinct Recognition Modes by Human m6A Reader and Eraser Proteins

F Seitz, T Jungnickel, N Kleiber… - Journal of the …, 2024 - ACS Publications
N 6-methyladenosine (m6A) is an important modified nucleoside in cellular RNA associated
with multiple cellular processes and is implicated in diseases. The enzymes associated with …

Ketone-based conjugated microporous poly (aniline) s for the ultradeep separation of heavy metal ions

X Lou, D Tang, X Chen, L Mo, Y Li, C Ye, J Chen… - Chemical Engineering …, 2025 - Elsevier
The heavy-metal contamination of aquatic environments presents imminent threat. Herein,
we report a class of dual-heteroatomic conjugated microporous poly (aniline) s showing …

A new route for the synthesis of 1-deazaguanine and 1-deazahypoxanthine

R Bereiter, M Oberlechner… - Beilstein Journal of …, 2022 - beilstein-journals.org
Imidazopyridines and pyrrolopyrimidines are an important class of compounds in medicinal
chemistry. They can also be considered as deaza-modified purine nucleobases, and as …

Impact of Single Acyclic Phosphonate Nucleotide (ZNA) Modifications on DNA Duplex Stability

X Li, E Groaz, P Herdewijn… - Chemistry–A European …, 2024 - Wiley Online Library
An acyclic phosphonate‐linked nucleic acid backbone (ZNA) demonstrated the capability to
support duplex formation and propagate genetic information in vivo, unveiling its potential …

Trendbericht Organische Chemie 2023

M Breugst, JN Andexer, SB Beil… - Nachrichten aus der …, 2023 - Wiley Online Library
Polystyrolproben werden mit Eisen (III) chlorid und weißen LEDs zu Oligomeren und
Benzoylprodukten; ein Wolframatkatalysator invertiert die Absolutkonfiguration an sp3 …

A New Tool for RNA Atomic Mutagenesis

D Trauner, KP Ruehmann - Synfacts, 2022 - thieme-connect.com
Significance: RNA structure, function, and catalysis rely on hydrogen-bonding networks of
distinct base pairing patterns. Atomic mutagenesis, in which a hydrogen-bond donor or …