Genetic polymorphisms in immune- and inflammation-associated genes and their association with bovine mastitis resistance/susceptibility

Front Immunol. 2023 Feb 23:14:1082144. doi: 10.3389/fimmu.2023.1082144. eCollection 2023.

Authors

Muhammad Zahoor Khan^{1

2}, Jingjun Wang¹, Yulin Ma¹, Tianyu Chen¹, Mei Ma¹, Qudrat Ullah², Ibrar Muhammad Khan³, Adnan Khan⁴, Zhijun Cao¹, Shuai Liu¹

Affiliations

¹ State Key Laboratory of Animal Nutrition, Beijing Engineering Technology Research Center of Raw Milk Quality and Safety Control, College of Animal Science and Technology, China Agricultural University, Beijing, China.
² Faculty of Veterinary and Animal Sciences, The University of Agriculture, Dera Ismail Khan, Pakistan.
³ Anhui Province Key Laboratory of Embryo Development and Reproduction Regulation, Anhui Province Key Laboratory of Environmental Hormone and Reproduction, School of Biological and Food Engineering, Fuyang Normal University, Fuyang, China.
⁴ Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.

Abstract

Bovine mastitis, the inflammation of the mammary gland, is a contagious disease characterized by chemical and physical changes in milk and pathological changes in udder tissues. Depressed immunity and higher expression of inflammatory cytokines with an elevated milk somatic cell count can be observed during mastitis in dairy cattle. The use of somatic cell count (SCC) and somatic cell score (SCS) as correlated traits in the indirect selection of animals against mastitis resistance is in progress globally. Traditional breeding for mastitis resistance seems difficult because of the low heritability (0.10-0.16) of SCC/SCS and clinical mastitis. Thus, genetic-marker-selective breeding to improve host genetics has attracted considerable attention worldwide. Moreover, genomic selection has been found to be an effective and fast method of screening for dairy cattle that are genetically resistant and susceptible to mastitis at a very early age. The current review discusses and summarizes the candidate gene approach using polymorphisms in immune- and inflammation-linked genes (CD4, CD14, CD46, TRAPPC9, JAK2, Tf, Lf, TLRs, CXCL8, CXCR1, CXCR2, C4A, C5, MASP2, MBL1, MBL2, LBP, NCF1, NCF4, MASP2, A2M, and CLU, etc.) and their related signaling pathways (Staphylococcus aureus infection signaling, Toll-like receptor signaling, NF-kappa B signaling pathway, Cytokine-cytokine receptor, and Complement and coagulation cascades, etc.) associated with mastitis resistance and susceptibility phenotypic traits (IL-6, interferon-gamma (IFN-γ), IL17, IL8, SCS, and SCC) in dairy cattle.

Keywords: SCC; SCS; bovine mastitis; genetic markers; immunity and inflammation; inflammatory cytokines; polymorphisms.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cattle
Female
Humans
Inflammation
Mannose-Binding Lectin* / genetics
Mastitis, Bovine*
Milk / chemistry
Polymorphism, Genetic

Substances

MBL2 protein, human
Mannose-Binding Lectin

Grants and funding

This work was supported by the grants from National Key Research and Development Program of China (2021YFF1000703-03), the 2115 Talent Development Program of China Agricultural University (2115) and the Key Research and Development Program of Ningxia Hui Autonomous Region (2022BBF02018-01). The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.