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Naturalistic Language Input is Associated with Resting-State Functional Connectivity in Infancy

J Neurosci. 2021 Jan 20;41(3):424-434. doi: 10.1523/JNEUROSCI.0779-20.2020. Epub 2020 Nov 30.

Abstract

The quantity and quality of the language input that infants receive from their caregivers affects their future language abilities; however, it is unclear how variation in this input relates to preverbal brain circuitry. The current study investigated the relation between naturalistic language input and the functional connectivity (FC) of language networks in human infancy using resting-state functional magnetic resonance imaging (rsfMRI). We recorded the naturalistic language environments of five- to eight-month-old male and female infants using the Linguistic ENvironment Analysis (LENA) system and measured the quantity and consistency of their exposure to adult words (AWs) and adult-infant conversational turns (CTs). Infants completed an rsfMRI scan during natural sleep, and we examined FC among regions of interest (ROIs) previously implicated in language comprehension, including the auditory cortex, the left inferior frontal gyrus (IFG), and the bilateral superior temporal gyrus (STG). Consistent with theory of the ontogeny of the cortical language network (Skeide and Friederici, 2016), we identified two subnetworks posited to have distinct developmental trajectories: a posterior temporal network involving connections of the auditory cortex and bilateral STG and a frontotemporal network involving connections of the left IFG. Independent of socioeconomic status (SES), the quantity of CTs was uniquely associated with FC of these networks. Infants who engaged in a larger number of CTs in daily life had lower connectivity in the posterior temporal language network. These results provide evidence for the role of vocal interactions with caregivers, compared with overheard adult speech, in the function of language networks in infancy.

Keywords: caregiving; environment; fMRI; infancy; language; resting-state.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Auditory Cortex / physiology
  • Brain Mapping
  • Caregivers / psychology
  • Comprehension / physiology
  • Family Characteristics
  • Female
  • Frontal Lobe / physiology
  • Humans
  • Infant
  • Language Development
  • Language*
  • Magnetic Resonance Imaging
  • Male
  • Nerve Net / physiology*
  • Neural Pathways / physiology*
  • Social Class
  • Temporal Lobe / physiology
  • Young Adult