Long non-coding RNAs in the development, diagnosis and prognosis of nasopharyngeal carcinoma

Int J Clin Exp Pathol. 2017 Aug 1;10(8):8098-8105. eCollection 2017.

Authors

Qing Dong^{1

2}, Liang Zhou^{1

3}, Fangteng Liu^{1

4}, Fan Ao², Xiaochang Gong², Chunling Jiang², Zheng Yuan^{1

5}, Jingao Li²

Affiliations

¹ Medical School of Nanchang University P. R. China.
² Department of Radiation Oncology, Jiangxi Cancer Hospital Nanchang, P. R. China.
³ Department of Ocular Oncology, The Eye Hospital of Nanchang University P. R. China.
⁴ Department of General Surgery, The Second Affiliated Hospital of Nanchang University P. R. China.
⁵ Department of Hematology, The Second Affiliated Hospital of Nanchang University P. R. China.

PMID: 31966662
PMCID: PMC6965397

Abstract

Long noncoding RNAs (lncRNAs), which transcripts longer than 200 nucleotides, are lack of protein coding potential. Emerging studies have shown that lncRNAs play critical roles in carcinogenesis and progression, including human nasopharyngeal carcinoma (NPC). In this article, we first provide an overview on the molecular mechanisms of lncRNAs in NPC, and then discuss the influence of lncRNAs on the diagnosis and treatment of patients with nasopharyngeal carcinoma.

Keywords: Nasopharyngeal carcinoma; diagnosis; long non-coding RNAs; mechanisms; prognosis.

Publication types

Review