COX-1

Ciclo-oxigenase-1 (COX-1) também conhecida como prostaglandin G/H synthase 1, prostaglandin-endoperoxide synthase 1 ou prostaglandin H2 synthase 1 é uma enzima que em humanos é codificada pelo gene PTGS1. É responsável pela catálise de prostaglandinas e tromboxano. Possui função fisiológica constitutiva e participa de uma série de processos de manutenção dos processos do organismo como a proteção da mucosa gástrica, hemostasia e regulação de perfusão renal.^[1]

Ver também

COX-2
COX-3

Notas e referências

↑ SCHELLACK, Gustav. Farmacologia na prática clínica da área de saúde. São Paulo: Fundamento Educacional, 2006

Leitura de apoio

Richards JA, Petrel TA, Brueggemeier RW (2002). «Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells.». J. Steroid Biochem. Mol. Biol. 80 (2): 203–12. PMID 11897504. doi:10.1016/S0960-0760(01)00187-X
Jain S, Khuri FR, Shin DM (2004). «Prevention of head and neck cancer: current status and future prospects.». Current problems in cancer. 28 (5): 265–86. PMID 15375804. doi:10.1016/j.currproblcancer.2004.05.003
Bingham S, Beswick PJ, Blum DE,; et al. (2007). «The role of the cylooxygenase pathway in nociception and pain.». Semin. Cell Dev. Biol. 17 (5): 544–54. PMID 17071117. doi:10.1016/j.semcdb.2006.09.001
Diaz A, Reginato AM, Jimenez SA (1992). «Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha.». J. Biol. Chem. 267 (15): 10816–22. PMID 1587858
Takahashi Y, Ueda N, Yoshimoto T,; et al. (1992). «Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase).». Biochem. Biophys. Res. Commun. 182 (2): 433–8. PMID 1734857. doi:10.1016/0006-291X(92)91750-K
Vane JR, Mitchell JA, Appleton I,; et al. (1994). «Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.». Proc. Natl. Acad. Sci. U.S.A. 91 (6): 2046–50. PMC 43306. PMID 7510883. doi:10.1073/pnas.91.6.2046
Mollace V, Colasanti M, Rodino P,; et al. (1994). «HIV coating gp 120 glycoprotein-dependent prostaglandin E2 release by human cultured astrocytoma cells is regulated by nitric oxide formation.». Biochem. Biophys. Res. Commun. 203 (1): 87–92. PMID 7521167. doi:10.1006/bbrc.1994.2152
Inoue H, Yokoyama C, Hara S,; et al. (1995). «Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element.». J. Biol. Chem. 270 (42): 24965–71. PMID 7559624. doi:10.1074/jbc.270.42.24965
Ren Y, Loose-Mitchell DS, Kulmacz RJ (1995). «Prostaglandin H synthase-1: evaluation of C-terminus function.». Arch. Biochem. Biophys. 316 (2): 751–7. PMID 7864630. doi:10.1006/abbi.1995.1100
Picot D, Loll PJ, Garavito RM (1994). «The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.». Nature. 367 (6460): 243–9. PMID 8121489. doi:10.1038/367243a0
Kosaka T, Miyata A, Ihara H,; et al. (1994). «Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2.». Eur. J. Biochem. 221 (3): 889–97. PMID 8181472. doi:10.1111/j.1432-1033.1994.tb18804.x
Otto JC, DeWitt DL, Smith WL (1993). «N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum.». J. Biol. Chem. 268 (24): 18234–42. PMID 8349699
O'Neill GP, Ford-Hutchinson AW (1993). «Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues.». FEBS Lett. 330 (2): 156–60. PMID 8365485
Corasaniti MT, Melino G, Navarra M,; et al. (1996). «Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.». Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. 4 (3): 315–21. PMID 8581564
Ballif BA, Mincek NV, Barratt JT,; et al. (1996). «Interaction of cyclooxygenases with an apoptosis- and autoimmunity-associated protein.». Proc. Natl. Acad. Sci. U.S.A. 93 (11): 5544–9. PMC 39283. PMID 8643612. doi:10.1073/pnas.93.11.5544
Hla T (1996). «Molecular characterization of the 5.2 KB isoform of the human cyclooxygenase-1 transcript.». Prostaglandins. 51 (1): 81–5. PMID 8900446. doi:10.1016/0090-6980(95)00158-1
Mahida YR, Beltinger J, Makh S,; et al. (1998). «Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2.». Am. J. Physiol. 273 (6 Pt 1): G1341–8. PMID 9435560
Tsujii M, Kawano S, Tsuji S,; et al. (1998). «Cyclooxygenase regulates angiogenesis induced by colon cancer cells.». Cell. 93 (5): 705–16. PMID 9630216. doi:10.1016/S0092-8674(00)81433-6

[1] SCHELLACK, Gustav. Farmacologia na prática clínica da área de saúde. São Paulo: Fundamento Educacional, 2006

[1]