ZW385A1 - Chemical compounds - Google Patents
Chemical compoundsInfo
- Publication number
- ZW385A1 ZW385A1 ZW3/85A ZW385A ZW385A1 ZW 385 A1 ZW385 A1 ZW 385A1 ZW 3/85 A ZW3/85 A ZW 3/85A ZW 385 A ZW385 A ZW 385A ZW 385 A1 ZW385 A1 ZW 385A1
- Authority
- ZW
- Zimbabwe
- Prior art keywords
- compounds
- chemical compounds
- formula
- hydrogon
- bronchodilating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Compounds of the formula (I):
<CHEM>
and pharmaceutically acceptable salts are described, wherein R<1> is hydrogon or methyl and R<2> is hydrogen or C1-4alkyl. These compounds have inotropic, vasodilator, bronchodilating and platelet aggregation inhibiting properties. Pharmaceutical compositions are described as are methods of use. Intermediates and processes for the preparation of the compounds of the formula (I) are described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848400863A GB8400863D0 (en) | 1984-01-13 | 1984-01-13 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZW385A1 true ZW385A1 (en) | 1985-08-07 |
Family
ID=10554924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZW3/85A ZW385A1 (en) | 1984-01-13 | 1985-01-07 | Chemical compounds |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US4654342A (en) |
| EP (1) | EP0150937B1 (en) |
| JP (3) | JPS60158181A (en) |
| KR (1) | KR920006781B1 (en) |
| CN (1) | CN85101722A (en) |
| AT (1) | ATE37179T1 (en) |
| AU (1) | AU572252B2 (en) |
| CA (2) | CA1251209A (en) |
| CS (1) | CS248731B2 (en) |
| DD (1) | DD231350A5 (en) |
| DE (1) | DE3564941D1 (en) |
| DK (1) | DK162519C (en) |
| ES (3) | ES8607949A1 (en) |
| FI (1) | FI850140L (en) |
| GB (1) | GB8400863D0 (en) |
| GR (1) | GR850068B (en) |
| HU (1) | HU193591B (en) |
| IE (1) | IE57969B1 (en) |
| IL (1) | IL74031A (en) |
| JO (1) | JO1351B1 (en) |
| MY (1) | MY100124A (en) |
| NO (1) | NO850129L (en) |
| NZ (1) | NZ210816A (en) |
| PH (1) | PH22136A (en) |
| PL (1) | PL147123B1 (en) |
| PT (1) | PT79819B (en) |
| RO (1) | RO92607A (en) |
| SU (1) | SU1396963A3 (en) |
| WO (1) | WO1985003076A1 (en) |
| ZA (1) | ZA85251B (en) |
| ZW (1) | ZW385A1 (en) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1251448A (en) * | 1985-03-27 | 1989-03-21 | William J. Coates | Pyridazinone derivatives |
| US4946842A (en) * | 1985-07-05 | 1990-08-07 | Smith Kline & French Laboratories Limited | Novel guanidino pyridazinones as cardiac stimulants |
| GB8603780D0 (en) * | 1986-02-15 | 1986-03-19 | Smith Kline French Lab | Chemical compounds |
| GB8722776D0 (en) * | 1987-09-28 | 1987-11-04 | Smith Kline French Lab | Chemical compounds |
| US5011837A (en) * | 1988-08-09 | 1991-04-30 | E. R. Squibb & Sons, Inc. | Aryl cyanoguanidines: potassium channel activators and method of making same |
| NZ229828A (en) * | 1988-08-09 | 1992-03-26 | Squibb & Sons Inc | Aryl cyanoguanidine derivatives and pharmaceutical compositions |
| EP1377282B1 (en) | 2001-02-27 | 2006-08-16 | MIGENIX Corp. | Aryl-n-cyanoguanidines and methods related thereto |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| DE102004011512B4 (en) * | 2004-03-08 | 2022-01-13 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical preparation containing pimobendan |
| EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
| US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| CN101355876B (en) | 2005-11-09 | 2012-09-05 | 康宾纳特克斯公司 | Compositions for the eye adminstration |
| DK1951227T3 (en) * | 2005-11-14 | 2017-07-10 | Boehringer Ingelheim Vetmedica Gmbh | APPLICATION OF PIMOBENDAN TO TREAT ASYMPTOMATIC (OCCULT) HEART FAILURE |
| EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| CA2688161C (en) | 2007-06-04 | 2020-10-20 | Kunwar Shailubhai | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| JP2011522828A (en) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders |
| JP2011528375A (en) | 2008-07-16 | 2011-11-17 | シナジー ファーマシューティカルズ インコーポレイテッド | Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders |
| WO2010060874A1 (en) | 2008-11-25 | 2010-06-03 | Boehringer Ingelheim Vetmedica Gmbh | Phosphodiesterase type iii (pde iii) inhibitors or ca2+-sensitizing agents for the treatment of hypertrophic cardiomyopathy |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| MX357121B (en) | 2011-03-01 | 2018-06-27 | Synergy Pharmaceuticals Inc Star | Process of preparing guanylate cyclase c agonists. |
| US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| EP3167876B1 (en) | 2012-03-15 | 2021-09-08 | Boehringer Ingelheim Vetmedica GmbH | Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof |
| EP2958577A2 (en) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Guanylate cyclase receptor agonists for use in colonic cleansing |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| JP2016514670A (en) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | Guanylate cyclase receptor agonists in combination with other drugs |
| CA2913737A1 (en) | 2013-06-05 | 2014-12-11 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| CN113197846A (en) | 2013-07-19 | 2021-08-03 | 勃林格殷格翰动物保健有限公司 | Liquid aqueous pharmaceutical composition containing preserved etherified cyclodextrin derivatives |
| US20160184387A1 (en) | 2013-08-09 | 2016-06-30 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
| CA2930033C (en) | 2013-12-04 | 2022-12-13 | Boehringer Ingelheim Vetmedica Gmbh | Improved pharmaceutical compositions of pimobendan |
| CN104987310A (en) * | 2015-06-03 | 2015-10-21 | 青岛农业大学 | Synthesis process of levosimendan |
| US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
| CN110117257B (en) * | 2018-02-05 | 2022-12-06 | 安徽省新星药物开发有限责任公司 | P2Y12 receptor antagonist containing guanidyl as well as preparation method and application thereof |
| US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3822260A (en) * | 1970-10-09 | 1974-07-02 | American Cyanamid Co | 6-(cyanophenyl)-4,5-dihydro-3(2h)-pyridazinones |
| BE791539A (en) * | 1971-11-19 | 1973-05-17 | Basf Ag | DIHYDROPYRIDAZONES, THEIR PREPARATION AND THEIR THERAPEUTIC USES |
| DE3063196D1 (en) * | 1979-12-05 | 1983-06-16 | Morishita Pharma | Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them |
| EP0059688B1 (en) * | 1981-03-04 | 1985-05-15 | Ciba-Geigy Ag | Pyridazinones, method for their preparation, pharmaceutical compositions containing these compounds and their use |
| JPS58113180A (en) * | 1981-12-28 | 1983-07-05 | Mitsui Toatsu Chem Inc | Pyridazinone derivative |
| DE3204375C2 (en) * | 1982-02-09 | 1983-12-01 | J. Rettenmaier & Söhne GmbH + Co, 7091 Holzmühle | Process for reducing the absorbency of wood |
| JPS58140076A (en) * | 1982-02-09 | 1983-08-19 | Mitsubishi Chem Ind Ltd | Pyridazinone derivative or its salt |
| DE3302021A1 (en) * | 1983-01-22 | 1984-07-26 | Basf Ag, 6700 Ludwigshafen | 6-ARYL-4,5-DIHYDRO-3 (2H) -PYRIDAZINONE, THEIR PRODUCTION AND USE |
| US4946842A (en) * | 1985-07-05 | 1990-08-07 | Smith Kline & French Laboratories Limited | Novel guanidino pyridazinones as cardiac stimulants |
-
1984
- 1984-01-13 GB GB848400863A patent/GB8400863D0/en active Pending
-
1985
- 1985-01-02 JO JO19851351A patent/JO1351B1/en active
- 1985-01-07 CA CA000471594A patent/CA1251209A/en not_active Expired
- 1985-01-07 ZW ZW3/85A patent/ZW385A1/en unknown
- 1985-01-08 DK DK009185A patent/DK162519C/en not_active IP Right Cessation
- 1985-01-09 PH PH31697A patent/PH22136A/en unknown
- 1985-01-10 DD DD85272500A patent/DD231350A5/en not_active IP Right Cessation
- 1985-01-10 ES ES539446A patent/ES8607949A1/en not_active Expired
- 1985-01-10 CS CS85202A patent/CS248731B2/en unknown
- 1985-01-10 GR GR850068A patent/GR850068B/el unknown
- 1985-01-10 IL IL74031A patent/IL74031A/en unknown
- 1985-01-10 PT PT79819A patent/PT79819B/en not_active IP Right Cessation
- 1985-01-11 EP EP85300196A patent/EP0150937B1/en not_active Expired
- 1985-01-11 AT AT85300196T patent/ATE37179T1/en active
- 1985-01-11 DE DE8585300196T patent/DE3564941D1/en not_active Expired
- 1985-01-11 FI FI850140A patent/FI850140L/en not_active Application Discontinuation
- 1985-01-11 NO NO850129A patent/NO850129L/en unknown
- 1985-01-11 IE IE69/85A patent/IE57969B1/en not_active IP Right Cessation
- 1985-01-11 NZ NZ210816A patent/NZ210816A/en unknown
- 1985-01-11 WO PCT/GB1985/000014 patent/WO1985003076A1/en unknown
- 1985-01-11 PL PL1985251516A patent/PL147123B1/en unknown
- 1985-01-11 JP JP60003912A patent/JPS60158181A/en active Pending
- 1985-01-11 AU AU37611/85A patent/AU572252B2/en not_active Ceased
- 1985-01-11 ZA ZA85251A patent/ZA85251B/en unknown
- 1985-01-11 HU HU85109A patent/HU193591B/en not_active IP Right Cessation
- 1985-01-12 KR KR1019850000179A patent/KR920006781B1/en not_active IP Right Cessation
- 1985-01-14 US US06/690,911 patent/US4654342A/en not_active Expired - Fee Related
- 1985-04-01 CN CN198585101722A patent/CN85101722A/en active Pending
- 1985-09-12 RO RO85120090A patent/RO92607A/en unknown
- 1985-09-12 SU SU853958649A patent/SU1396963A3/en active
- 1985-12-05 ES ES549629A patent/ES8703846A1/en not_active Expired
-
1986
- 1986-05-14 ES ES554965A patent/ES8706645A1/en not_active Expired
-
1987
- 1987-06-02 MY MYPI87000758A patent/MY100124A/en unknown
-
1988
- 1988-05-09 JP JP63113410A patent/JPS63313775A/en active Pending
- 1988-05-09 JP JP63113411A patent/JPS63313776A/en active Pending
- 1988-10-21 CA CA000581012A patent/CA1260471A/en not_active Expired
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