Nothing Special   »   [go: up one dir, main page]

ZW290A1 - 2-aminopyrimidinone derivatives - Google Patents

2-aminopyrimidinone derivatives

Info

Publication number
ZW290A1
ZW290A1 ZW2/90A ZW290A ZW290A1 ZW 290 A1 ZW290 A1 ZW 290A1 ZW 2/90 A ZW2/90 A ZW 2/90A ZW 290 A ZW290 A ZW 290A ZW 290 A1 ZW290 A1 ZW 290A1
Authority
ZW
Zimbabwe
Prior art keywords
6alkyl
hydrogen
chem
compounds
pharmaceutical compositions
Prior art date
Application number
ZW2/90A
Inventor
Edmond Josephine Kennis Ludo
Vandenberk Jan
Martin Boey Jozef
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZW290A1 publication Critical patent/ZW290A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel 2-aminopyrimidinone derivatives of formula <CHEM> wherein R<1> is <CHEM> R<3> is hydrogen or C1-6alkyl; R<4> is hydrogen, C1-6alkyl or substituted C1-6alkyl; R<5> is hydrogen, C1-6alkyl, C1-6alkylaminocarbonyl, Ar-aminocarbonyl, C1-6alkylcarbonyl or Ar-carbonyl; R<6> is hydrogen, C1-6alkyl or Ar-C1-6alkyl; or R<5> and R<6> taken together is -CH2-CH2-, -CH2-CH2-CH2-, -CH=CH-, -CH=N-, -N=CH- or -N=CH-CH2-; the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.
ZW2/90A 1989-01-09 1990-01-08 2-aminopyrimidinone derivatives ZW290A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898900382A GB8900382D0 (en) 1989-01-09 1989-01-09 2-aminopyrimidinone derivatives

Publications (1)

Publication Number Publication Date
ZW290A1 true ZW290A1 (en) 1991-09-11

Family

ID=10649779

Family Applications (1)

Application Number Title Priority Date Filing Date
ZW2/90A ZW290A1 (en) 1989-01-09 1990-01-08 2-aminopyrimidinone derivatives

Country Status (25)

Country Link
EP (1) EP0378255B1 (en)
JP (1) JP2938492B2 (en)
KR (1) KR0159099B1 (en)
CN (1) CN1034865C (en)
AT (1) ATE104971T1 (en)
AU (1) AU617918B2 (en)
CA (1) CA2007200C (en)
DE (1) DE69008366T2 (en)
DK (1) DK0378255T3 (en)
ES (1) ES2055860T3 (en)
FI (1) FI94525C (en)
GB (1) GB8900382D0 (en)
HU (1) HU203747B (en)
IE (1) IE62874B1 (en)
IL (1) IL92730A (en)
JO (1) JO1605B1 (en)
MA (1) MA21722A1 (en)
MY (1) MY106259A (en)
NO (1) NO173139C (en)
NZ (1) NZ231788A (en)
PT (1) PT92806B (en)
RU (1) RU2028297C1 (en)
TN (1) TNSN90003A1 (en)
ZA (1) ZA90123B (en)
ZW (1) ZW290A1 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0347146B1 (en) * 1988-06-16 1993-09-01 Smith Kline & French Laboratories Limited Fused pyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
GB9008850D0 (en) * 1990-04-19 1990-06-13 Janssen Pharmaceutica Nv Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones
US5075315A (en) * 1990-05-17 1991-12-24 Mcneilab, Inc. Antipsychotic hexahydro-2H-indeno[1,2-c]pyridine derivatives
US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
JPH07508741A (en) * 1992-07-13 1995-09-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Novel 4-(3-benzofuranyl)piperidinyl and 4-(3-benzothienyl)piperidinyl derivatives and pharmaceutical compositions containing them
US5599815A (en) * 1993-02-04 1997-02-04 Meiji Seika Kabushiki Kaisha Antipsychotic benzoisothiazolyl piperazine derivatives
GB9305623D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
HUP9800417A3 (en) * 1995-03-20 2001-04-28 Lilly Co Eli 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)-indoles and 5-substituted-3-(piperidin-4-yl)-1h-indoles, their use as new 5-ht agonists, pharmaceutical compositions containing these compounds
IL122072A (en) * 1996-11-14 2001-03-19 Akzo Nobel Nv Piperidine derivatives their preparation and pharmaceutical compositions containing them
ES2165274B1 (en) * 1999-06-04 2003-04-01 Almirall Prodesfarma Sa NEW DERIVATIVES OF INDOLILPIPERIDINE AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
US6995144B2 (en) * 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
ES2201907B1 (en) 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. NEW DERIVATIVES OF INDOLILPIPERIDINE AS POWERFUL ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
US20040242566A1 (en) 2003-03-25 2004-12-02 Syrrx, Inc. Dipeptidyl peptidase inhibitors
ZA200602051B (en) * 2003-08-13 2007-10-31 Takeda Pharmaceutical 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors
EP1911754B1 (en) * 2003-08-13 2013-10-09 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7790734B2 (en) 2003-09-08 2010-09-07 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
CN102134231B (en) 2004-03-15 2020-08-04 武田药品工业株式会社 Dipeptidyl peptidase inhibitors
TW200626575A (en) * 2004-12-07 2006-08-01 Solvay Pharm Bv Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US7371769B2 (en) 2004-12-07 2008-05-13 Solvay Pharmaceuticals B.V. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US20060122247A1 (en) 2004-12-08 2006-06-08 Solvay Pharmaceuticals B.V. Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
US7872124B2 (en) 2004-12-21 2011-01-18 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
EA015169B1 (en) 2005-09-14 2011-06-30 Такеда Фармасьютикал Компани Лимитед Use of dipeptidyl peptidase inhibitors
WO2007035629A2 (en) 2005-09-16 2007-03-29 Takeda Pharmaceutical Company Limited Process for the preparation of pyrimidinedione derivatives
TW200813015A (en) 2006-03-15 2008-03-16 Mitsubishi Pharma Corp 2-(cyclic amino)-pyrimidone derivatives
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
PE20091236A1 (en) * 2007-11-22 2009-09-16 Astrazeneca Ab PYRIMIDINE DERIVATIVES AS IMMUNOMODULATORS OF TLR7
BR102012024778A2 (en) * 2012-09-28 2014-08-19 Cristalia Prod Quimicos Farm Heteroaromatic compounds; PROCESS FOR PREPARING COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, USES AND TREATMENT METHOD FOR ACUTE AND CHRONIC PAIN
WO2015064714A1 (en) * 2013-10-31 2015-05-07 国立大学法人東京大学 1-substituted imidazopyrimidinone derivative having autotaxin-inhibiting activity
SI3448859T1 (en) 2017-03-20 2020-02-28 Forma Therapeutics, Inc. Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators
WO2018188590A1 (en) * 2017-04-11 2018-10-18 Sunshine Lake Pharma Co., Ltd. Fluorine-substituted indazole compounds and uses thereof
EP3853206B1 (en) 2018-09-19 2024-04-10 Novo Nordisk Health Care AG Treating sickle cell disease with a pyruvate kinase r activating compound
US11001588B2 (en) 2018-09-19 2021-05-11 Forma Therapeutics, Inc. Activating pyruvate kinase R and mutants thereof
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443451A (en) * 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
FR2537764A1 (en) * 1982-12-08 1984-06-15 Framatome Sa DEVICE FOR CONTROLLING TWO CLUSTERS OF CONTROL PADS VERTICALLY MOVABLE IN THE SAME COMBUSTIBLE ASSEMBLY OF THE HEART OF A NUCLEAR REACTOR
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
GB8900380D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives

Also Published As

Publication number Publication date
IL92730A (en) 1993-06-10
ATE104971T1 (en) 1994-05-15
EP0378255B1 (en) 1994-04-27
AU4777990A (en) 1990-07-12
KR0159099B1 (en) 1998-12-01
FI900085A0 (en) 1990-01-08
GB8900382D0 (en) 1989-03-08
MY106259A (en) 1995-04-29
PT92806A (en) 1990-07-31
IE62874B1 (en) 1995-03-08
CN1034865C (en) 1997-05-14
ES2055860T3 (en) 1994-09-01
MA21722A1 (en) 1990-10-01
NO900071L (en) 1990-07-10
CA2007200A1 (en) 1990-07-09
JO1605B1 (en) 1990-07-01
HU203747B (en) 1991-09-30
FI900085A (en) 1990-07-10
CN1044094A (en) 1990-07-25
DE69008366T2 (en) 1994-08-25
NO173139C (en) 1993-11-03
JPH02225482A (en) 1990-09-07
FI94525B (en) 1995-06-15
NO900071D0 (en) 1990-01-08
HUT52770A (en) 1990-08-28
IL92730A0 (en) 1990-09-17
NZ231788A (en) 1990-12-21
AU617918B2 (en) 1991-12-05
ZA90123B (en) 1991-09-25
IE900069L (en) 1990-07-09
RU2028297C1 (en) 1995-02-09
PT92806B (en) 1995-11-30
EP0378255A2 (en) 1990-07-18
JP2938492B2 (en) 1999-08-23
KR900011755A (en) 1990-08-02
NO173139B (en) 1993-07-26
EP0378255A3 (en) 1991-01-09
CA2007200C (en) 1999-07-20
DE69008366D1 (en) 1994-06-01
DK0378255T3 (en) 1994-05-24
TNSN90003A1 (en) 1991-03-05
HU900064D0 (en) 1990-03-28
FI94525C (en) 1995-09-25

Similar Documents

Publication Publication Date Title
AU617918B2 (en) 2-aminopyrimidinone derivatives
GR3004114T3 (en)
IL91194A0 (en) 3-piperazinylbenzazole derivatives,their preparation and pharmaceutical compositions containing them
IL90879A0 (en) 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them