ZA9811339B - Benzamidine derivatives. - Google Patents
Benzamidine derivatives.Info
- Publication number
- ZA9811339B ZA9811339B ZA9811339A ZA9811339A ZA9811339B ZA 9811339 B ZA9811339 B ZA 9811339B ZA 9811339 A ZA9811339 A ZA 9811339A ZA 9811339 A ZA9811339 A ZA 9811339A ZA 9811339 B ZA9811339 B ZA 9811339B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzamidine derivatives
- benzamidine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19755268A DE19755268A1 (en) | 1997-12-12 | 1997-12-12 | Benzamidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA9811339B true ZA9811339B (en) | 1999-07-08 |
Family
ID=7851688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9811339A ZA9811339B (en) | 1997-12-12 | 1998-12-10 | Benzamidine derivatives. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1056743A1 (en) |
JP (1) | JP2002508370A (en) |
KR (1) | KR20010032963A (en) |
CN (1) | CN1281451A (en) |
AR (1) | AR017844A1 (en) |
AU (1) | AU744002B2 (en) |
BR (1) | BR9813477A (en) |
CA (1) | CA2313651A1 (en) |
DE (1) | DE19755268A1 (en) |
HU (1) | HUP0004353A3 (en) |
NO (1) | NO20002958L (en) |
PL (1) | PL341008A1 (en) |
RU (1) | RU2203897C2 (en) |
SK (1) | SK8572000A3 (en) |
WO (1) | WO1999031092A1 (en) |
ZA (1) | ZA9811339B (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6747023B1 (en) * | 1998-08-11 | 2004-06-08 | Daiichi Pharmaceutical Co., Ltd. | Sulfonyl derivatives |
SE9902987D0 (en) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
DE19962924A1 (en) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituted oxazolidinones and their use |
AU2004202422B2 (en) * | 1999-12-24 | 2007-11-22 | Bayer Intellectual Property Gmbh | Substituted oxazolidinones and their use in the field of blood coagulation |
CO5300399A1 (en) | 2000-02-25 | 2003-07-31 | Astrazeneca Ab | HETEROCICLIOCS CONTAINING NITROGEN, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
DE10027024A1 (en) * | 2000-05-31 | 2001-12-06 | Merck Patent Gmbh | Carbamic acid ester |
US7005439B2 (en) | 2000-06-20 | 2006-02-28 | Astrazeneca Ab | Compounds |
AR028948A1 (en) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | NEW COMPOUNDS |
DE10105989A1 (en) * | 2001-02-09 | 2002-08-14 | Bayer Ag | Substituted oxazolidinones and their use |
GB0104050D0 (en) | 2001-02-19 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
AR035230A1 (en) | 2001-03-19 | 2004-05-05 | Astrazeneca Ab | BENCIMIDAZOL COMPOUNDS, PROCESS FOR PREPARATION, PHARMACEUTICAL COMPOSITION, PROCESS FOR THE PREPARATION OF SUCH PHARMACEUTICAL COMPOSITION, AND USES OF THESE COMPOUNDS FOR THE PREPARATION OF MEDICINES |
GB0107228D0 (en) | 2001-03-22 | 2001-05-16 | Astrazeneca Ab | Chemical compounds |
SE0101038D0 (en) | 2001-03-23 | 2001-03-23 | Astrazeneca Ab | Novel compounds |
DE10129725A1 (en) * | 2001-06-20 | 2003-01-02 | Bayer Ag | Combination therapy of substituted oxazolidinones |
SE0103818D0 (en) | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
DE10159453A1 (en) * | 2001-12-04 | 2003-06-18 | Merck Patent Gmbh | Use of 1-phenyl-oxazolidin-2-one compounds as a protease |
AU2003302238A1 (en) | 2002-12-03 | 2004-06-23 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
DE10300111A1 (en) | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Process for the preparation of 5-chloro-N - ({(5S) -2-oxo-3- [4- (3-oxo-4-morpholinyl) phenyl] -1,3-oxazolidin-5-yl} methyl ) -2-thiophenecarboxamide |
SE0301369D0 (en) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
DE10322469A1 (en) * | 2003-05-19 | 2004-12-16 | Bayer Healthcare Ag | Heterocyclic compounds |
US7208496B2 (en) | 2003-06-23 | 2007-04-24 | Cv Therapeutics, Inc. | Substituted heterocyclic compounds |
DE10355461A1 (en) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Solid, high bioavailabilty oral formulations of N-substituted 5-chloro-2-thiophene-carboxamide derivative in hydrophilized form, useful for combating thrombo-embolic diseases |
EP1685841A1 (en) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
TW200738634A (en) | 2005-08-02 | 2007-10-16 | Astrazeneca Ab | New salt |
DE102005045518A1 (en) | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | New 5-thienylaminocarbonylmethyl-oxazolidin-2-one derivatives, useful for treating and preventing thromboembolic disease, are selective inhibitors of coagulation factor Xa |
DE102005047561A1 (en) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Drug delivery system, useful to treat and/or prevent e.g. thromboembolic disease, comprises 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxo-4-morpholinyl)-phenyl)-1,3-oxazolidine-5-yl)-methyl)-2-thiophene carboxamide with fast release active substance |
RU2429236C2 (en) | 2005-10-04 | 2011-09-20 | Байер Шеринг Фарма Акциенгезельшафт | Novel polymorphous form and amorphous form of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophene carboxamide |
EP1979334B1 (en) | 2006-01-31 | 2011-06-22 | Dong Wha Pharmaceutical Co., Ltd. | Novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same |
DE102007018662A1 (en) | 2007-04-20 | 2008-10-23 | Bayer Healthcare Ag | Oxazolidinone for the treatment and prophylaxis of pulmonary hypertension |
KR101009594B1 (en) | 2007-05-09 | 2011-01-20 | 주식회사 레고켐 바이오사이언스 | FXa inhibitors with cyclic amidines as P4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof |
WO2008140220A1 (en) * | 2007-05-09 | 2008-11-20 | Legochem Bioscience Ltd. | Fxa inhibitors with cyclic amidines as p4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof |
DE102007028318A1 (en) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Oxazolidinone for the treatment and prophylaxis of sepsis |
US20100249402A1 (en) * | 2007-07-27 | 2010-09-30 | Dong Wha Pharmaceutical Co. Ltd. | Novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition for preventing or treating osteporosis comprising the same |
EP2138178A1 (en) | 2008-06-28 | 2009-12-30 | Bayer Schering Pharma Aktiengesellschaft | Oxazolidninones for the treatment fo chronic obstructive pulmonary disease (COPD) and/or asthma |
EP2140866A1 (en) | 2008-07-04 | 2010-01-06 | Bayer Schering Pharma Aktiengesellschaft | Oxazolidinones for the treatment of inflammatory conditions of the gastrointestinal tract |
CN102822167A (en) * | 2010-01-04 | 2012-12-12 | 埃南蒂亚有限公司 | Process for the preparation of rivaroxaban and intermediates thereof |
AU2011245441B2 (en) * | 2010-04-29 | 2014-12-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Activators of human pyruvate kinase |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4166132A (en) * | 1977-08-18 | 1979-08-28 | Pfizer Inc. | Antiviral amine derivatives of glycerol and propanediols |
DE4203201A1 (en) * | 1992-02-05 | 1993-08-12 | Boehringer Ingelheim Kg | New amidine derivatives are LTB antagonists - useful for treating allergic disorders e.g. asthma, colitis ulcerosa or psoriasis |
DK0623615T3 (en) * | 1993-05-01 | 1999-12-13 | Merck Patent Gmbh | Adhesion receptor antagonists |
EP0710657B1 (en) * | 1994-11-02 | 1998-08-26 | MERCK PATENT GmbH | Antagonists of adhesion receptors |
DE19504954A1 (en) * | 1995-02-15 | 1996-08-22 | Merck Patent Gmbh | Adhesion receptor antagonists |
DE19516483A1 (en) * | 1995-05-05 | 1996-11-07 | Merck Patent Gmbh | Adhesion receptor antagonists |
WO1997023212A1 (en) * | 1995-12-21 | 1997-07-03 | The Du Pont Merck Pharmaceutical Company | ISOXAZOLINE, ISOTHIAZOLINE AND PYRAZOLINE FACTOR Xa INHIBITORS |
AU729745B2 (en) * | 1997-07-11 | 2001-02-08 | Pharmacia & Upjohn Company | Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents |
-
1997
- 1997-12-12 DE DE19755268A patent/DE19755268A1/en not_active Withdrawn
-
1998
- 1998-11-27 PL PL98341008A patent/PL341008A1/en unknown
- 1998-11-27 HU HU0004353A patent/HUP0004353A3/en unknown
- 1998-11-27 BR BR9813477-9A patent/BR9813477A/en not_active IP Right Cessation
- 1998-11-27 EP EP98964455A patent/EP1056743A1/en not_active Withdrawn
- 1998-11-27 CA CA002313651A patent/CA2313651A1/en not_active Abandoned
- 1998-11-27 SK SK857-2000A patent/SK8572000A3/en unknown
- 1998-11-27 KR KR1020007006310A patent/KR20010032963A/en not_active Application Discontinuation
- 1998-11-27 WO PCT/EP1998/007673 patent/WO1999031092A1/en not_active Application Discontinuation
- 1998-11-27 CN CN98812087A patent/CN1281451A/en active Pending
- 1998-11-27 AU AU19647/99A patent/AU744002B2/en not_active Ceased
- 1998-11-27 RU RU2000118792/04A patent/RU2203897C2/en not_active IP Right Cessation
- 1998-11-27 JP JP2000539016A patent/JP2002508370A/en active Pending
- 1998-12-10 ZA ZA9811339A patent/ZA9811339B/en unknown
- 1998-12-11 AR ARP980106293A patent/AR017844A1/en not_active Application Discontinuation
-
2000
- 2000-06-09 NO NO20002958A patent/NO20002958L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2002508370A (en) | 2002-03-19 |
BR9813477A (en) | 2000-10-24 |
RU2203897C2 (en) | 2003-05-10 |
NO20002958L (en) | 2000-08-11 |
DE19755268A1 (en) | 1999-06-17 |
WO1999031092A1 (en) | 1999-06-24 |
PL341008A1 (en) | 2001-03-12 |
HUP0004353A3 (en) | 2002-04-29 |
CN1281451A (en) | 2001-01-24 |
AU1964799A (en) | 1999-07-05 |
AU744002B2 (en) | 2002-02-14 |
NO20002958D0 (en) | 2000-06-09 |
KR20010032963A (en) | 2001-04-25 |
AR017844A1 (en) | 2001-10-24 |
SK8572000A3 (en) | 2001-07-10 |
EP1056743A1 (en) | 2000-12-06 |
CA2313651A1 (en) | 1999-06-24 |
HUP0004353A2 (en) | 2002-03-28 |
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