GEP20012388B
(en)
*
|
1995-12-08 |
2001-03-25 |
Agouron Pharma |
Metalloproteinase Inhibitors, Pharmaceutical Compositions on Their Base, Use and Methods for Obtaining and Intermediates
|
US6500948B1
(en)
|
1995-12-08 |
2002-12-31 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
|
US6174915B1
(en)
|
1997-03-25 |
2001-01-16 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
|
US6008243A
(en)
*
|
1996-10-24 |
1999-12-28 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
|
US5985900A
(en)
*
|
1997-04-01 |
1999-11-16 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
|
AU7294098A
(en)
*
|
1997-05-09 |
1998-11-27 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
|
AUPO721997A0
(en)
*
|
1997-06-06 |
1997-07-03 |
Queensland Institute Of Medical Research, The |
Anticancer compounds
|
ES2176913T3
(en)
*
|
1997-08-08 |
2002-12-01 |
Pfizer Prod Inc |
DERIVATIVES OF ARILSULFONYLAMINOHYDROXAMIC ACIDS.
|
GT199900044A
(en)
*
|
1998-04-10 |
2000-09-14 |
|
PROCEDURES FOR PREPARING PHENOXYPHENYL SULFONYL HALIDES.
|
PA8469301A1
(en)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
PROCEDURES FOR THE PREPARATION OF HYDROXAMIC ACIDS.
|
DE69917124T2
(en)
*
|
1998-04-10 |
2005-05-12 |
Pfizer Products Inc., Groton |
Cyclobutyl Aryloxysulfonylamin-hydroxamic acid
|
PA8469601A1
(en)
*
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
PROCEDURE FOR RENTING STERICALLY IMPAIRED SULFONAMIDES
|
US6326516B1
(en)
|
1999-01-27 |
2001-12-04 |
American Cyanamid Company |
Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
|
US6200996B1
(en)
|
1999-01-27 |
2001-03-13 |
American Cyanamid Company |
Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors
|
US6225311B1
(en)
|
1999-01-27 |
2001-05-01 |
American Cyanamid Company |
Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors
|
US6762178B2
(en)
|
1999-01-27 |
2004-07-13 |
Wyeth Holdings Corporation |
Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
|
US6946473B2
(en)
|
1999-01-27 |
2005-09-20 |
Wyeth Holdings Corporation |
Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
|
BR0007784A
(en)
|
1999-01-27 |
2002-02-05 |
American Cyanamid Co |
Compound, method for inhibiting pathological changes mediated by the enzyme that converts tnf-alpha (tace) into a mammal, pharmaceutical composition, and, process for preparing a compound
|
US6340691B1
(en)
|
1999-01-27 |
2002-01-22 |
American Cyanamid Company |
Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors
|
US6277885B1
(en)
|
1999-01-27 |
2001-08-21 |
American Cyanamid Company |
Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
|
US6313123B1
(en)
|
1999-01-27 |
2001-11-06 |
American Cyanamid Company |
Acetylenic sulfonamide thiol tace inhibitors
|
US6753337B2
(en)
|
1999-01-27 |
2004-06-22 |
Wyeth Holdings Corporation |
Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
|
ATE245152T1
(en)
*
|
1999-03-31 |
2003-08-15 |
Pfizer Prod Inc |
DIOXOCYCLOPENTYLHYDROXAMIC ACID
|
DE19920907A1
(en)
*
|
1999-05-06 |
2000-11-09 |
Basf Ag |
Preparation of cyclohexylglycine ester derivatives comprises reacting cyclohexylglycine derivatives with methanesulfonic acid and benzyl alcohol derivative in organic solvent
|
UA74803C2
(en)
|
1999-11-11 |
2006-02-15 |
Осі Фармасьютікалз, Інк. |
A stable polymorph of n-(3-ethynylphenyl)-6,7-bis(2-methoxyetoxy)-4-quinazolinamine hydrochloride, a method for producing thereof (variants) and pharmaceutical use
|
SE0000382D0
(en)
|
2000-02-07 |
2000-02-07 |
Astrazeneca Ab |
New process
|
US7141607B1
(en)
|
2000-03-10 |
2006-11-28 |
Insite Vision Incorporated |
Methods and compositions for treating and inhibiting retinal neovascularization
|
US6458822B2
(en)
|
2000-03-13 |
2002-10-01 |
Pfizer Inc. |
2-oxo-imidazolidine-4-carboxylic acid hydroxamide compounds that inhibit matrix metalloproteinases
|
MA26040A1
(en)
|
2001-01-05 |
2004-04-01 |
Pfizer |
ANTIBODIES FOR INSULIN GROWTH FACTOR RECEPTOR I
|
US6995171B2
(en)
|
2001-06-21 |
2006-02-07 |
Agouron Pharmaceuticals, Inc. |
Bicyclic pyrimidine and pyrimidine derivatives useful as anticancer agents
|
EP1440057A1
(en)
|
2001-11-01 |
2004-07-28 |
Wyeth Holdings Corporation |
Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and tace inhibitors
|
AR039067A1
(en)
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
ANTIBODIES FOR CD40
|
EP1466899A4
(en)
*
|
2001-12-27 |
2010-01-06 |
Dainippon Sumitomo Pharma Co |
Hydroxamic acid derivative and mmp inhibitor containing the same as active ingredient
|
JP2005527511A
(en)
|
2002-03-01 |
2005-09-15 |
ファイザー インコーポレイテッド |
Indolyl-urea derivatives of thienopyridine useful as anti-angiogenic agents and methods of use thereof
|
US20050232915A1
(en)
*
|
2002-03-08 |
2005-10-20 |
Motowo Nakajima |
Matrix metalloproteinase inhibitors in combination with hypothermia and/or radiotherapy for the treatment of cancer
|
PT3000810T
(en)
|
2002-03-13 |
2017-10-25 |
Array Biopharma Inc |
N3 alkylated benzimidazole derivative as mek inhibitor
|
UA77303C2
(en)
|
2002-06-14 |
2006-11-15 |
Pfizer |
Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
|
OA12977A
(en)
|
2002-12-19 |
2006-10-13 |
Pfizer |
2-(1H-indazol-6-ylamino)-benzamide compounds as protein kinases inhibitors useful for the treatment of ophthamic diseases.
|
AU2003294917A1
(en)
*
|
2002-12-20 |
2004-07-14 |
Novartis Ag |
Device and method for delivering mmp inhibitors
|
WO2005021489A2
(en)
|
2002-12-23 |
2005-03-10 |
Wyeth Holdings Corporation |
Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors
|
DK1603570T5
(en)
|
2003-02-26 |
2013-12-09 |
Sugen Inc |
AMINOHETEROARYL COMPOUNDS AS PROTEINKINASE INHIBITORS
|
DK1606288T3
(en)
*
|
2003-03-25 |
2009-10-05 |
Fournier Lab Sa |
Benzenesulfonamide derivatives, their method of preparation and their use in the treatment of pain
|
BRPI0413466A
(en)
|
2003-08-13 |
2006-10-17 |
Pfizer Prod Inc |
modified human igf-1r antibodies
|
ATE412655T1
(en)
|
2003-08-29 |
2008-11-15 |
Pfizer |
THIENOPYRIDINPHENYLACETAMIDE AND DERIVATIVES THEREOF SUITABLE AS NEW ANTIANGIOGENIC AGENTS
|
US7144907B2
(en)
|
2003-09-03 |
2006-12-05 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
AR045563A1
(en)
|
2003-09-10 |
2005-11-02 |
Warner Lambert Co |
ANTIBODIES DIRECTED TO M-CSF
|
SI1682138T1
(en)
|
2003-11-19 |
2011-04-29 |
Array Biopharma Inc |
Heterocyclic inhibitors of mek
|
DK1786785T3
(en)
|
2004-08-26 |
2010-05-31 |
Pfizer |
Enantiomerically pure amino heteroaryl compounds as protein kinase inhibitors
|
MY146381A
(en)
|
2004-12-22 |
2012-08-15 |
Amgen Inc |
Compositions and methods relating relating to anti-igf-1 receptor antibodies
|
US7429667B2
(en)
|
2005-01-20 |
2008-09-30 |
Ardea Biosciences, Inc. |
Phenylamino isothiazole carboxamidines as MEK inhibitors
|
ES2333182T3
(en)
|
2005-05-18 |
2010-02-17 |
Array Biopharma, Inc. |
DERIVATIVES OF 4- (PHENYLAMINE) -6-OXO-1,6-DIHIDROPIRIDAZINA-3-CARBOXAMIDE AS MEK INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES.
|
US8101799B2
(en)
|
2005-07-21 |
2012-01-24 |
Ardea Biosciences |
Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
|
AU2006292278B2
(en)
|
2005-09-20 |
2012-03-08 |
Osi Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
TWI405756B
(en)
|
2005-12-21 |
2013-08-21 |
Array Biopharma Inc |
Novel hydrogen sulfate salt
|
WO2007121269A2
(en)
|
2006-04-11 |
2007-10-25 |
Ardea Biosciences, Inc. |
N-aryl-n'alkyl sulfamides as mek inhibitors
|
ES2354182T3
(en)
|
2006-04-18 |
2011-03-10 |
Ardea Biosciences, Inc. |
PIRIDONA SULFONAMIDS AND PIRIDONA SULFAMIDS AS MEK INHIBITORS.
|
US20100029615A1
(en)
|
2006-12-15 |
2010-02-04 |
Michael John Munchhof |
Benzimidazole derivatives
|
MX2009007661A
(en)
|
2007-01-19 |
2009-12-14 |
Ardea Biosciences Inc |
Inhibitors of mek.
|
CN103951658B
(en)
|
2007-04-18 |
2017-10-13 |
辉瑞产品公司 |
Sulfamide derivative for treating abnormal cell growth
|
US8530463B2
(en)
|
2007-05-07 |
2013-09-10 |
Hale Biopharma Ventures Llc |
Multimodal particulate formulations
|
CA2924418A1
(en)
|
2007-07-30 |
2009-02-05 |
Jean-Michel Vernier |
Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same
|
TWI441820B
(en)
|
2007-12-19 |
2014-06-21 |
Genentech Inc |
5-anilinoimidazopyridines and methods of use
|
KR20100099185A
(en)
|
2007-12-21 |
2010-09-10 |
제넨테크, 인크. |
Azaindolizines and methods of use
|
MY159955A
(en)
|
2008-01-04 |
2017-02-15 |
Intellikine Inc |
Certain chemical entities, compositions and methods
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
JP5547099B2
(en)
|
2008-03-14 |
2014-07-09 |
インテリカイン, エルエルシー |
Kinase inhibitors and methods of use
|
JP5613657B2
(en)
|
2008-03-28 |
2014-10-29 |
ヘイル バイオファーマ ベンチャーズ,エルエルシー |
Administration of benzodiazepine composition
|
MX2011000216A
(en)
|
2008-07-08 |
2011-03-29 |
Intellikine Inc |
Kinase inhibitors and methods of use.
|
JP5836125B2
(en)
|
2008-10-16 |
2015-12-24 |
ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション |
Fully human antibodies against high molecular weight melanoma-related antigens and uses thereof
|
US8476282B2
(en)
|
2008-11-03 |
2013-07-02 |
Intellikine Llc |
Benzoxazole kinase inhibitors and methods of use
|
NZ594177A
(en)
|
2009-02-05 |
2014-02-28 |
Immunogen Inc |
Novel benzodiazepine derivatives
|
US20100204221A1
(en)
|
2009-02-09 |
2010-08-12 |
Hariprasad Vankayalapati |
Pyrrolopyrimidinyl axl kinase inhibitors
|
EP2400985A2
(en)
|
2009-02-25 |
2012-01-04 |
OSI Pharmaceuticals, LLC |
Combination of an either an anti-igf-1r antibody or an igf binding protein and a small molecule igf-1r kinase inhibitor
|
WO2010099137A2
(en)
|
2009-02-26 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
In situ methods for monitoring the emt status of tumor cells in vivo
|
WO2010099364A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
JP2012519281A
(en)
|
2009-02-27 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
Methods for identifying mesenchymal tumor cells or agents that inhibit their production
|
TW201035088A
(en)
|
2009-02-27 |
2010-10-01 |
Supergen Inc |
Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
|
CN102448938A
(en)
|
2009-03-27 |
2012-05-09 |
阿迪生物科学公司 |
Dihydropyridin sulfonamides and dihydropyridin sulfamides as mek inhibitors
|
JP5789252B2
(en)
|
2009-05-07 |
2015-10-07 |
インテリカイン, エルエルシー |
Heterocyclic compounds and uses thereof
|
WO2011014726A1
(en)
|
2009-07-31 |
2011-02-03 |
Osi Pharmaceuticals, Inc. |
Mtor inhibitor and angiogenesis inhibitor combination therapy
|
JP5819831B2
(en)
|
2009-08-17 |
2015-11-24 |
インテリカイン, エルエルシー |
Heterocyclic compounds and their use
|
CA2772194A1
(en)
|
2009-09-01 |
2011-03-10 |
Pfizer Inc. |
Benzimidazole derivatives
|
EP2488507B1
(en)
|
2009-10-13 |
2014-12-17 |
Allostem Therapeutics LLC |
Novel mek inhibitors, useful in the treatment of diseases
|
WO2011049625A1
(en)
|
2009-10-20 |
2011-04-28 |
Mansour Samadpour |
Method for aflatoxin screening of products
|
AU2010316780B2
(en)
|
2009-11-05 |
2015-07-16 |
Rhizen Pharmaceuticals Sa |
Novel benzopyran kinase modulators
|
WO2011100403A1
(en)
|
2010-02-10 |
2011-08-18 |
Immunogen, Inc |
Cd20 antibodies and uses thereof
|
ES2753748T3
(en)
|
2010-02-12 |
2020-04-14 |
Pfizer |
Salts and polymorphs of 8-fluoro-2- {4 - [(methylamino} methyl] phenyl} -1,3,4,5-tetrahydro-6H-azepine [5,4,3-cd] indole-6-one
|
CA2783665A1
(en)
|
2010-03-03 |
2011-09-09 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
AU2011223643A1
(en)
|
2010-03-03 |
2012-06-28 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
DK2571878T3
(en)
|
2010-05-17 |
2019-02-11 |
Indian Incozen Therapeutics Pvt Ltd |
Hitherto unknown 3,5-DISUBSTITUTED-3H-IMIDAZO [4,5-B] PYRIDINE AND 3,5- DISUBSTITUTED -3H- [1,2,3] TRIAZOL [4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN CHINES
|
US8604032B2
(en)
|
2010-05-21 |
2013-12-10 |
Infinity Pharmaceuticals, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
AU2011268356B2
(en)
|
2010-06-16 |
2013-09-19 |
University Of Pittsburgh-Of The Commonwealth System Of Higher Education |
Antibodies to endoplasmin and their use
|
EP2630134B9
(en)
|
2010-10-20 |
2018-04-18 |
Pfizer Inc |
Pyridine-2- derivatives as smoothened receptor modulators
|
JP2013545749A
(en)
|
2010-11-10 |
2013-12-26 |
インフィニティー ファーマシューティカルズ, インコーポレイテッド |
Heterocyclic compounds and uses thereof
|
EP3581574A1
(en)
|
2011-01-10 |
2019-12-18 |
Infinity Pharmaceuticals, Inc. |
A composition for oral administration for use in the treatment of cancer, an inflammatory disease or an auto-immune disease
|
AU2012212075A1
(en)
|
2011-02-02 |
2013-07-18 |
Amgen Inc. |
Methods and compositons relating to inhibition of IGF-1R
|
KR20190089048A
(en)
|
2011-02-15 |
2019-07-29 |
이뮤노젠 아이엔씨 |
Methods of preparation of conjugates
|
WO2012116040A1
(en)
|
2011-02-22 |
2012-08-30 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
|
WO2012116237A2
(en)
|
2011-02-23 |
2012-08-30 |
Intellikine, Llc |
Heterocyclic compounds and uses thereof
|
US9150644B2
(en)
|
2011-04-12 |
2015-10-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
|
EP3536708A1
(en)
|
2011-04-19 |
2019-09-11 |
Pfizer Inc |
Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer
|
EP2702173A1
(en)
|
2011-04-25 |
2014-03-05 |
OSI Pharmaceuticals, LLC |
Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
|
SI2705029T1
(en)
|
2011-05-04 |
2019-03-29 |
Rhizen Pharmaceuticals S.A. |
Novel compounds as modulators of protein kinases
|
CN107737100A
(en)
|
2011-06-14 |
2018-02-27 |
哈尔生物药投资有限责任公司 |
The administration of Benzodiazepine composition
|
MX2014000648A
(en)
|
2011-07-19 |
2014-09-25 |
Infinity Pharmaceuticals Inc |
Heterocyclic compounds and uses thereof.
|
CN103930422A
(en)
|
2011-07-19 |
2014-07-16 |
无限药品股份有限公司 |
Heterocyclic compounds and uses thereof
|
DK3409278T3
(en)
|
2011-07-21 |
2020-11-09 |
Sumitomo Dainippon Pharma Oncology Inc |
Heterocyclic protein kinase inhibitors
|
CN103998442B
(en)
|
2011-08-29 |
2016-09-14 |
无限药品股份有限公司 |
Heterocyclic compound and application thereof
|
CN102408411B
(en)
|
2011-09-19 |
2014-10-22 |
北京康辰药业股份有限公司 |
Hydroximic acid compound containing quinolyl and preparation method thereof, and drug composition containing the compound and use thereof
|
MX2014003501A
(en)
|
2011-09-22 |
2014-07-22 |
Pfizer |
Pyrrolopyrimidine and purine derivatives.
|
WO2013049332A1
(en)
|
2011-09-29 |
2013-04-04 |
Infinity Pharmaceuticals, Inc. |
Inhibitors of monoacylglycerol lipase and methods of their use
|
WO2013050725A1
(en)
|
2011-10-04 |
2013-04-11 |
King's College London |
Ige anti -hmw-maa antibody
|
MX2014005570A
(en)
|
2011-11-08 |
2014-05-30 |
Pfizer |
Methods of treating inflammatory disorders using anti-m-csf antibodies.
|
US9452215B2
(en)
|
2012-02-22 |
2016-09-27 |
The Regents Of The University Of Colorado |
Bourvadin derivatives and therapeutic uses thereof
|
EP2817004B1
(en)
|
2012-02-22 |
2018-04-11 |
The Regents of The University of Colorado, A Body Corporate |
Bouvardin derivatives and therapeutic uses thereof
|
NZ629499A
(en)
|
2012-03-30 |
2016-05-27 |
Rhizen Pharmaceuticals Sa |
Novel 3,5-disubstituted-3h-imidazo[4,5-b]pyridine and 3,5- disubstituted -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of c-met protein kinases
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
PL2859017T3
(en)
|
2012-06-08 |
2019-07-31 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
WO2014004639A1
(en)
|
2012-06-26 |
2014-01-03 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
EP2887965A1
(en)
|
2012-08-22 |
2015-07-01 |
ImmunoGen, Inc. |
Cytotoxic benzodiazepine derivatives
|
KR102182800B1
(en)
|
2012-08-31 |
2020-11-25 |
서트로 바이오파마, 인크. |
Modified amino acids comprising an azido group
|
JP6243918B2
(en)
|
2012-10-16 |
2017-12-06 |
トレロ ファーマシューティカルズ, インコーポレイテッド |
PKM2 modulators and methods for their use
|
NZ744567A
(en)
|
2012-11-01 |
2020-03-27 |
Infinity Pharmaceuticals Inc |
Treatment of cancers using pi3 kinase isoform modulators
|
JP6494533B2
(en)
|
2013-02-28 |
2019-04-03 |
イミュノジェン・インコーポレーテッド |
Complexes comprising maytansinoids as cell binding agents and cytotoxic agents
|
EP2961435B1
(en)
|
2013-02-28 |
2019-05-01 |
ImmunoGen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
CN105308033B
(en)
|
2013-03-14 |
2018-08-24 |
特雷罗药物股份有限公司 |
JAK2 and ALK2 inhibitor and its application method
|
UY35464A
(en)
|
2013-03-15 |
2014-10-31 |
Araxes Pharma Llc |
KRAS G12C COVALENT INHIBITORS.
|
US20160024051A1
(en)
|
2013-03-15 |
2016-01-28 |
Infinity Pharmaceuticals, Inc. |
Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
|
CN105189456B
(en)
|
2013-03-15 |
2017-12-19 |
亚瑞克西斯制药公司 |
KRAS G12C covalency inhibitor
|
JP2016512835A
(en)
|
2013-03-15 |
2016-05-09 |
インテリカイン, エルエルシー |
Combinations of kinase inhibitors and their use
|
US9745319B2
(en)
|
2013-03-15 |
2017-08-29 |
Araxes Pharma Llc |
Irreversible covalent inhibitors of the GTPase K-Ras G12C
|
RU2705204C2
(en)
|
2013-05-30 |
2019-11-06 |
Инфинити Фармасьютикалз, Инк. |
Treating malignant tumors using piz-kinase isoform modulators
|
WO2014194030A2
(en)
|
2013-05-31 |
2014-12-04 |
Immunogen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
ES2865473T3
(en)
|
2013-07-10 |
2021-10-15 |
Sutro Biopharma Inc |
Antibodies Comprising Multiple Site-Specific Unnatural Amino Acid Residues, Methods for Their Preparation, and Methods of Use
|
ME02991B
(en)
|
2013-10-03 |
2018-10-20 |
Kura Oncology Inc |
Inhibitors of erk and methods of use
|
UA121104C2
(en)
|
2013-10-04 |
2020-04-10 |
Інфініті Фармасьютикалз, Інк. |
HETEROCYCLIC COMPOUNDS AND THEIR APPLICATIONS
|
WO2015051241A1
(en)
|
2013-10-04 |
2015-04-09 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
TWI659021B
(en)
|
2013-10-10 |
2019-05-11 |
亞瑞克西斯製藥公司 |
Inhibitors of kras g12c
|
JP6559123B2
(en)
|
2013-10-10 |
2019-08-14 |
アラクセス ファーマ エルエルシー |
Inhibitor of KRASG12C
|
US9840493B2
(en)
|
2013-10-11 |
2017-12-12 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
WO2015061204A1
(en)
|
2013-10-21 |
2015-04-30 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
UA115388C2
(en)
|
2013-11-21 |
2017-10-25 |
Пфайзер Інк. |
2,6-substituted purine derivatives and their use in the treatment of proliferative disorders
|
WO2015155624A1
(en)
|
2014-04-10 |
2015-10-15 |
Pfizer Inc. |
Dihydropyrrolopyrimidine derivatives
|
WO2015168079A1
(en)
|
2014-04-29 |
2015-11-05 |
Infinity Pharmaceuticals, Inc. |
Pyrimidine or pyridine derivatives useful as pi3k inhibitors
|
MD20160111A2
(en)
|
2014-04-30 |
2017-06-30 |
Pfizer Inc. |
Cycloalkyl-linked diheterocycle derivatives
|
PH12016502453B1
(en)
|
2014-06-19 |
2022-11-23 |
Takeda Pharmaceuticals Co |
Heteroaryl compounds for kinase inhibition
|
WO2016001789A1
(en)
|
2014-06-30 |
2016-01-07 |
Pfizer Inc. |
Pyrimidine derivatives as pi3k inhibitors for use in the treatment of cancer
|
EP3473271B1
(en)
|
2014-07-31 |
2022-07-20 |
The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services |
Human monoclonal antibodies against epha4 and their use
|
JO3556B1
(en)
|
2014-09-18 |
2020-07-05 |
Araxes Pharma Llc |
Combination therapies for treatment of cancer
|
WO2016049568A1
(en)
|
2014-09-25 |
2016-03-31 |
Araxes Pharma Llc |
Methods and compositions for inhibition of ras
|
EP3197870B1
(en)
|
2014-09-25 |
2020-08-19 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
JP6621477B2
(en)
|
2014-12-18 |
2019-12-18 |
ファイザー・インク |
Pyrimidine and triazine derivatives and their use as AXL inhibitors
|
US10246424B2
(en)
|
2015-04-10 |
2019-04-02 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use thereof
|
WO2016168540A1
(en)
|
2015-04-15 |
2016-10-20 |
Araxes Pharma Llc |
Fused-tricyclic inhibitors of kras and methods of use thereof
|
WO2016172214A1
(en)
|
2015-04-20 |
2016-10-27 |
Tolero Pharmaceuticals, Inc. |
Predicting response to alvocidib by mitochondrial profiling
|
CA2984421C
(en)
|
2015-05-01 |
2024-04-09 |
Cocrystal Pharma, Inc. |
Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer
|
ES2739749T3
(en)
|
2015-05-18 |
2020-02-03 |
Tolero Pharmaceuticals Inc |
Alvocidib prodrugs that have increased bioavailability
|
TWI703150B
(en)
|
2015-06-04 |
2020-09-01 |
美商庫拉腫瘤技術股份有限公司 |
Methods and compositions for inhibiting the interaction of menin and mll proteins
|
WO2017009751A1
(en)
|
2015-07-15 |
2017-01-19 |
Pfizer Inc. |
Pyrimidine derivatives
|
US10144724B2
(en)
|
2015-07-22 |
2018-12-04 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use thereof
|
BR112018002427A8
(en)
|
2015-08-03 |
2022-10-18 |
Tolero Pharmaceuticals Inc |
USE OF ALVOCIDIB AND AZACITIDINE OR DECITABINE TO TREAT CANCER AND PHARMACEUTICAL KIT AND COMPOSITION CONTAINING SUCH SUBSTANCES
|
WO2017058728A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
US10875842B2
(en)
|
2015-09-28 |
2020-12-29 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
EP3356351A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
EP3356349A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
WO2017058805A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
WO2017058902A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
US10882847B2
(en)
|
2015-09-28 |
2021-01-05 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
WO2017070256A2
(en)
|
2015-10-19 |
2017-04-27 |
Araxes Pharma Llc |
Method for screening inhibitors of ras
|
MX2018005967A
(en)
|
2015-11-16 |
2018-08-29 |
Araxes Pharma Llc |
2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof.
|
EA201891304A1
(en)
|
2015-12-03 |
2019-01-31 |
Агиос Фармасьютикалс, Инк. |
MAT2A INHIBITORS FOR THE TREATMENT OF MTAP-null MALIGNANT TUMORS
|
US9988357B2
(en)
|
2015-12-09 |
2018-06-05 |
Araxes Pharma Llc |
Methods for preparation of quinazoline derivatives
|
CN109069664B
(en)
|
2016-01-27 |
2022-05-13 |
苏特罗生物制药公司 |
anti-CD 74 antibody conjugates, compositions comprising anti-CD 74 antibody conjugates, and methods of use of anti-CD 74 antibody conjugates
|
HRP20230537T1
(en)
|
2016-03-16 |
2023-08-04 |
Kura Oncology, Inc. |
Substituted thieno[2,3-d]pyrimidine derivatives as inhibitors of menin-mll and methods of use
|
EP3429585B1
(en)
|
2016-03-16 |
2021-11-24 |
Kura Oncology, Inc. |
Bridged bicyclic inhibitors of menin-mll and methods of use
|
US10822312B2
(en)
|
2016-03-30 |
2020-11-03 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use
|
WO2017197240A1
(en)
|
2016-05-12 |
2017-11-16 |
The Regents Of The University Of Michigan |
Ash1l inhibitors and methods of treatment therewith
|
WO2017201302A1
(en)
|
2016-05-18 |
2017-11-23 |
The University Of Chicago |
Btk mutation and ibrutinib resistance
|
WO2017214269A1
(en)
|
2016-06-08 |
2017-12-14 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
US10646488B2
(en)
|
2016-07-13 |
2020-05-12 |
Araxes Pharma Llc |
Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
|
US10870694B2
(en)
|
2016-09-02 |
2020-12-22 |
Dana Farber Cancer Institute, Inc. |
Composition and methods of treating B cell disorders
|
US10280172B2
(en)
|
2016-09-29 |
2019-05-07 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
JP2019534260A
(en)
|
2016-10-07 |
2019-11-28 |
アラクセス ファーマ エルエルシー |
Heterocyclic compounds as inhibitors of RAS and methods of use thereof
|
WO2018094275A1
(en)
|
2016-11-18 |
2018-05-24 |
Tolero Pharmaceuticals, Inc. |
Alvocidib prodrugs and their use as protein kinase inhibitors
|
WO2018098352A2
(en)
|
2016-11-22 |
2018-05-31 |
Jun Oishi |
Targeting kras induced immune checkpoint expression
|
EP3362471B1
(en)
|
2016-12-19 |
2021-11-17 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Profiling peptides and methods for sensitivity profiling
|
CA3048217A1
(en)
|
2016-12-22 |
2018-06-28 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
WO2018140514A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
|
EP3573966A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
Fused n-heterocyclic compounds and methods of use thereof
|
WO2018140599A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
Benzothiophene and benzothiazole compounds and methods of use thereof
|
CN110382482A
(en)
|
2017-01-26 |
2019-10-25 |
亚瑞克西斯制药公司 |
Condensed miscellaneous-Heterobicyclic compounds and its application method
|
US11274093B2
(en)
|
2017-01-26 |
2022-03-15 |
Araxes Pharma Llc |
Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
|
WO2018137705A1
(en)
|
2017-01-26 |
2018-08-02 |
Zai Lab (Shanghai) Co., Ltd. |
Cd47 antigen binding unit and uses thereof
|
US11279689B2
(en)
|
2017-01-26 |
2022-03-22 |
Araxes Pharma Llc |
1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
|
WO2018175746A1
(en)
|
2017-03-24 |
2018-09-27 |
Kura Oncology, Inc. |
Methods for treating hematological malignancies and ewing's sarcoma
|
JOP20190272A1
(en)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
Kras g12c inhibitors and methods of using the same
|
JP2020521740A
(en)
|
2017-05-25 |
2020-07-27 |
アラクセス ファーマ エルエルシー |
Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS
|
TW201906832A
(en)
|
2017-05-25 |
2019-02-16 |
美商亞瑞克西斯製藥公司 |
Compounds for cancer treatment and methods of use thereof
|
EP3630745A2
(en)
|
2017-05-25 |
2020-04-08 |
Araxes Pharma LLC |
Covalent inhibitors of kras
|
WO2018226976A1
(en)
|
2017-06-08 |
2018-12-13 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with mll proteins
|
US20200207859A1
(en)
|
2017-07-26 |
2020-07-02 |
Sutro Biopharma, Inc. |
Methods of using anti-cd74 antibodies and antibody conjugates in treatment of t-cell lymphoma
|
CN111051306B
(en)
|
2017-09-08 |
2023-01-03 |
美国安进公司 |
Inhibitors of KRAS G12C and methods of use thereof
|
US11497756B2
(en)
|
2017-09-12 |
2022-11-15 |
Sumitomo Pharma Oncology, Inc. |
Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib
|
US10596270B2
(en)
|
2017-09-18 |
2020-03-24 |
Sutro Biopharma, Inc. |
Anti-folate receptor antibody conjugates, compositions comprising anti-folate receptor antibody conjugates, and methods of making and using anti-folate receptor antibody conjugates
|
EP3684361A4
(en)
|
2017-09-20 |
2021-09-08 |
Kura Oncology, Inc. |
Substituted inhibitors of menin-mll and methods of use
|
WO2019075367A1
(en)
|
2017-10-13 |
2019-04-18 |
Tolero Pharmaceuticals, Inc. |
Pkm2 activators in combination with reactive oxygen species for treatment of cancer
|
US11110177B2
(en)
|
2017-11-10 |
2021-09-07 |
The Regents Of The University Of Michigan |
ASH1L degraders and methods of treatment therewith
|
AU2018378935B2
(en)
|
2017-12-07 |
2024-10-31 |
The Regents Of The University Of Michigan |
NSD family inhibitors and methods of treatment therewith
|
EP3773591A4
(en)
|
2018-04-05 |
2021-12-22 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Axl kinase inhibitors and use of the same
|
MA52496A
(en)
|
2018-05-04 |
2021-03-10 |
Amgen Inc |
KRAS G12C INHIBITORS AND THEIR PROCEDURES FOR USE
|
MX2020010836A
(en)
|
2018-05-04 |
2021-01-08 |
Amgen Inc |
Kras g12c inhibitors and methods of using the same.
|
JP7361720B2
(en)
|
2018-05-10 |
2023-10-16 |
アムジエン・インコーポレーテツド |
KRAS G12C inhibitors for the treatment of cancer
|
AU2019278998B2
(en)
|
2018-06-01 |
2023-11-09 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
JP2021527064A
(en)
|
2018-06-07 |
2021-10-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
PRC1 inhibitor and treatment method using it
|
EP4268898A3
(en)
|
2018-06-11 |
2024-01-17 |
Amgen Inc. |
Kras g12c inhibitors for treating cancer
|
US11285156B2
(en)
|
2018-06-12 |
2022-03-29 |
Amgen Inc. |
Substituted piperazines as KRAS G12C inhibitors
|
JP2021530554A
(en)
|
2018-07-26 |
2021-11-11 |
スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド |
Methods and ACVR1 Inhibitors for Treatment of Diseases with Abnormal ACVR1 Expression
|
AU2019312670B2
(en)
|
2018-08-01 |
2025-01-02 |
Araxes Pharma Llc |
Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer
|
EP3852811A1
(en)
|
2018-09-17 |
2021-07-28 |
Sutro Biopharma, Inc. |
Combination therapies with anti-folate receptor antibody conjugates
|
AU2019364417A1
(en)
|
2018-10-24 |
2021-05-20 |
Araxes Pharma Llc |
2-(2-acryloyl-2,6-diazaspiro[3.4]octan-6-yl)-6-(1H-indazol-4-yl)-benzonitrile derivatives and related compounds as inhibitors of G12C mutant KRAS protein for inhibiting tumor metastasis
|
JP7516029B2
(en)
|
2018-11-16 |
2024-07-16 |
アムジエン・インコーポレーテツド |
Improved synthesis of key intermediates for KRAS G12C inhibitor compounds
|
JP7377679B2
(en)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
Combination therapy comprising a KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancer
|
AU2019384118A1
(en)
|
2018-11-19 |
2021-05-27 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
MX2021005924A
(en)
|
2018-11-29 |
2021-06-30 |
Araxes Pharma Llc |
Compounds and methods of use thereof for treatment of cancer.
|
EP3890749A4
(en)
|
2018-12-04 |
2022-08-03 |
Sumitomo Dainippon Pharma Oncology, Inc. |
CDK9 INHIBITORS AND POLYMORPHS THEREOF FOR USE AS CANCER TREATMENT AGENT
|
MA54546A
(en)
|
2018-12-20 |
2022-03-30 |
Amgen Inc |
HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS
|
CA3123042A1
(en)
|
2018-12-20 |
2020-06-25 |
Amgen Inc. |
Kif18a inhibitors
|
AU2019401495A1
(en)
|
2018-12-20 |
2021-06-24 |
Amgen Inc. |
Heteroaryl amides useful as KIF18A inhibitors
|
MX2021007156A
(en)
|
2018-12-20 |
2021-08-16 |
Amgen Inc |
KIF18A INHIBITORS.
|
EP3924351A4
(en)
|
2019-02-12 |
2022-12-21 |
Sumitomo Pharma Oncology, Inc. |
FORMULATIONS COMPRISING HETEROCYCLIC PROTEIN KINASE INHIBITORS
|
AU2020232242A1
(en)
|
2019-03-01 |
2021-09-09 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
US20230096028A1
(en)
|
2019-03-01 |
2023-03-30 |
Revolution Medicines, Inc. |
Bicyclic heterocyclyl compounds and uses thereof
|
US11793802B2
(en)
|
2019-03-20 |
2023-10-24 |
Sumitomo Pharma Oncology, Inc. |
Treatment of acute myeloid leukemia (AML) with venetoclax failure
|
US11712433B2
(en)
|
2019-03-22 |
2023-08-01 |
Sumitomo Pharma Oncology, Inc. |
Compositions comprising PKM2 modulators and methods of treatment using the same
|
EP3962951A1
(en)
|
2019-05-03 |
2022-03-09 |
Sutro Biopharma, Inc. |
Anti-bcma antibody conjugates
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
JOP20210310A1
(en)
|
2019-05-21 |
2023-01-30 |
Amgen Inc |
Solid state forms
|
EP3994132A1
(en)
|
2019-07-03 |
2022-05-11 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof
|
WO2021026100A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Pyridine derivatives as kif18a inhibitors
|
MX2022001295A
(en)
|
2019-08-02 |
2022-02-22 |
Amgen Inc |
Kif18a inhibitors.
|
EP4007753A1
(en)
|
2019-08-02 |
2022-06-08 |
Amgen Inc. |
Kif18a inhibitors
|
EP4007756A1
(en)
|
2019-08-02 |
2022-06-08 |
Amgen Inc. |
Kif18a inhibitors
|
WO2021055728A1
(en)
|
2019-09-18 |
2021-03-25 |
Merck Sharp & Dohme Corp. |
Small molecule inhibitors of kras g12c mutant
|
TW202126636A
(en)
|
2019-09-30 |
2021-07-16 |
美商阿吉歐斯製藥公司 |
Piperidine compounds as menin inhibitors
|
CA3155857A1
(en)
|
2019-10-24 |
2021-04-29 |
Amgen Inc. |
Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer
|
JOP20220101A1
(en)
|
2019-10-28 |
2023-01-30 |
Merck Sharp & Dohme |
Small-molecule inhibitors of the G12C mutant Kirsten's rat sarcoma protein (KRAS)
|
JP2023515235A
(en)
|
2019-10-31 |
2023-04-12 |
大鵬薬品工業株式会社 |
4-aminobut-2-enamide derivatives and salts thereof
|
CR20220243A
(en)
|
2019-11-04 |
2022-08-04 |
Revolution Medicines Inc |
Ras inhibitors
|
KR20220109406A
(en)
|
2019-11-04 |
2022-08-04 |
레볼루션 메디슨즈, 인크. |
RAS inhibitors
|
WO2021091982A1
(en)
|
2019-11-04 |
2021-05-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
BR112022008858A2
(en)
|
2019-11-08 |
2022-09-06 |
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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Nuvalent Inc |
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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2022-11-10 |
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Ras inhibitors
|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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Revolution Medicines, Inc. |
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|
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(en)
|
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Sutro Biopharma, Inc. |
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|
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(en)
|
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Nested Therapeutics, Inc. |
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|
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(en)
|
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Black Diamond Therapeutics, Inc. |
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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Revolution Medicines, Inc. |
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|