ZA92990B - Calcium channel antagonists and methodology for their identification - Google Patents

Calcium channel antagonists and methodology for their identification

Info

Publication number: ZA92990B
Authority: ZA; South Africa
Prior art keywords: methodology; identification; calcium channel; channel antagonists; antagonists
Prior art date: 1991-02-11

Application number

ZA92990A

Other languages

English (en)

Inventor

Stanley M Goldin

M Goldin Stanley

Kazumi Kobayashi

Kobayashi Kazumi

Andrew G Knapp

G Knapp Andrew

Subbarao Katragadda

Katragadda Subbarao

Deborah Daly

Daly Deborah

Lain-Yen Hu

Hu Lain-Yen

N Laxma Reddy

Laxma Reddy N

Lee Margolin

Margolin Lee

Original Assignee

Cambridge Neuroscience Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-11

Filing date

1992-02-11

Publication date

1992-11-25

1992-02-11 Application filed by Cambridge Neuroscience Inc filed Critical Cambridge Neuroscience Inc

1992-11-25 Publication of ZA92990B publication Critical patent/ZA92990B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ZA92990A 1991-02-11 1992-02-11 Calcium channel antagonists and methodology for their identification ZA92990B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/654,104 US5312928A (en)	1991-02-11	1991-02-11	Calcium channel antagonists and methodology for their identification

Publications (1)

Publication Number	Publication Date
ZA92990B true ZA92990B (en)	1992-11-25

Family

ID=24623446

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA92990A ZA92990B (en)	1991-02-11	1992-02-11	Calcium channel antagonists and methodology for their identification

Country Status (6)

Country	Link
US (1)	US5312928A (xx)
AU (1)	AU1530692A (xx)
IE (1)	IE920327A1 (xx)
PT (1)	PT100117A (xx)
WO (1)	WO1992014709A2 (xx)
ZA (1)	ZA92990B (xx)

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US5688938A (en) *	1991-08-23	1997-11-18	The Brigham & Women's Hospital, Inc.	Calcium receptor-active molecules
US6031003A (en) *	1991-08-23	2000-02-29	Nps Pharmaceuticals, Inc.	Calcium receptor-active molecules
US5858684A (en) *	1991-08-23	1999-01-12	The Brigham And Women's Hospital, Inc.	Method of screening calcium receptor-active molecules
US6001884A (en) *	1991-08-23	1999-12-14	Nps Pharmaceuticals, Inc.	Calcium receptor-active molecules
US6017965A (en) *	1993-02-08	2000-01-25	Nps Pharmaceuticals, Inc.	Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US7087765B2 (en)	1995-06-07	2006-08-08	Nps Pharmaceuticals, Inc.	Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6750244B2 (en)	1993-02-08	2004-06-15	Nps Pharmaceuticals, Inc.	Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6211245B1 (en)	1993-02-08	2001-04-03	Nps Pharmaceuticals, Inc.	Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6071970A (en) *	1993-02-08	2000-06-06	Nps Pharmaceuticals, Inc.	Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US5962314A (en) *	1993-02-23	1999-10-05	Nps Pharmaceuticals, Inc.	Calcium receptor-active molecules
ATE267009T1 (de) *	1993-02-23	2004-06-15	Brigham & Womens Hospital	Calciumrezeptoraktive moleküle
JPH09505058A (ja) *	1993-11-15	1997-05-20	ベイカー・メディカル・リサーチ・インスティテュート	心機能不全の治療方法およびそのために有用な医薬組成物
JPH09509484A (ja)	1994-02-08	1997-09-22	エヌピーエス・ファルマシューティカルズ，インコーポレイテッド	神経障害および神経病の治療に有用な受容体作動性カルシウムチャネル上の新規部位で活性な化合物
EP0746544B1 (en) *	1994-02-22	1998-09-09	Merrell Pharmaceuticals Inc.	Novel indole derivatives useful to treat estrogen-related neoplasms and disorders
PL183499B1 (pl)	1994-10-21	2002-06-28	Nps Pharma Inc	Związki do modulowania receptorów wapniowych i kompozycje farmaceutyczne
TR199700625T1 (xx) *	1995-01-10	1998-02-21	Smithkline Beecham S.P.A.	Osteoporoz (kemik erimesi) tedavisinde yararl� olan indol t�revleri.
EP0907631B1 (en) *	1996-05-01	2003-06-18	Nps Pharmaceuticals, Inc.	Inorganic ion receptor-active compounds
GB9614366D0 (en) *	1996-07-09	1996-09-04	Smithkline Beecham Spa	Novel compounds
GB9614347D0 (en) *	1996-07-09	1996-09-04	Smithkline Beecham Spa	Novel compounds
US6458806B1 (en)	1996-08-15	2002-10-01	Millennium Pharmaceuticals, Inc.	Aryl alkenamides derivatives as MCP-1 antagonists
US7208528B1 (en)	1997-07-15	2007-04-24	Mediquest Therapeutics, Inc.	Polyamine analogues as therapeutic and diagnostic agents
CA2297413A1 (en)	1997-07-15	1999-01-28	Oridigm Corporation	Novel polyamine analogues as therapeutic and diagnostic agents
US6646149B1 (en)	1997-07-15	2003-11-11	Nicolaas M. J. Vermeulin	Polyamine analogues as therapeutic and diagnostic agents
CA2338855A1 (en)	1998-08-03	2000-02-17	Eli Lilly And Company	Indole spla2 inhibitors
JP2002531498A (ja) *	1998-12-04	2002-09-24	ニューロサーチ、アクティーゼルスカブ	イオンチャネル活性剤としてのイサチン誘導体の使用方法
US6441156B1 (en)	1998-12-30	2002-08-27	The United States Of America As Represented By The Department Of Health And Human Services	Calcium channel compositions and methods of use thereof
USRE43327E1 (en)	2001-01-08	2012-04-24	Aminex Therapeutics, Inc.	Hydrophobic polyamine analogs and methods for their use
FR2820136A1 (fr) *	2001-01-26	2002-08-02	Aventis Pharma Sa	Nouveaux derives de l'uree, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
US7166463B2 (en) *	2001-11-16	2007-01-23	The Regents Of The University Of Colorado	Nucleic acids encoding modified olfactory cyclic nucleotide gated ion channels
JP2007505095A (ja) *	2003-09-12	2007-03-08	ワーナー−ランバートカンパニーリミティドライアビリティーカンパニー	うつ病及び不安障害の治療のためのアルファ−２−デルタリガンド及びｓｓｒｉ及び／又はｓｎｒｉを含む組み合わせ
EP1673436A4 (en) *	2003-10-02	2009-11-11	Merck & Co Inc	CALCIUM CHANNEL PROTEINS ACTIVATED BY LOW VOLTAGE FOR NUCLEIC MANAGEMENT, INCLUDING ALPHA 1I-1 AND ALPHA 1I-2 CODING NUCLEIC ACID MOLECULES, CODED PROTEINS AND USE THEREOF
US20070178462A1 (en) *	2004-02-18	2007-08-02	Uebele Victor N	Nucleic acid molecules encoding novel murine low-voltage activated calcium channel proteins, designated-alpha1h, encoded proteins and methods of use thereof
FR2885129B1 (fr) *	2005-04-29	2007-06-15	Proskelia Sas	Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation.
WO2007060026A1 (en) *	2005-11-25	2007-05-31	Galapagos Sas	Urea derivatives useful as calcium receptor modulators
GB0613674D0 (en) *	2006-07-10	2006-08-16	Proskelia Sas	Derivatives of urea and related diamines, methods for their manufacture, and uses therefor
KR102454783B1 (ko)	2016-03-25	2022-10-13	아미넥스 테라퓨틱스, 인크.	생체이용가능한 폴리아민
US20230220306A1 (en)	2020-05-29	2023-07-13	Basf Se	Amphoterically-Modified Oligopropyleneimine Ethoxylates for Improved Stain Removal of Laundry Detergents
CN115698244A (zh)	2020-05-29	2023-02-03	联合利华知识产权控股有限公司	液体洗衣组合物
US11865095B2 (en)	2020-09-30	2024-01-09	Aminex Therapeutics, Inc.	Combination drug substance of polyamine transport inhibitor and DFMO
EP4441188A1 (en)	2021-11-29	2024-10-09	Basf Se	Amphoterically-modified trialkylene tetramine ethoxylates for improved stain removal of laundry detergents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4925664A (en) *	1986-10-20	1990-05-15	University Of Utah	Spider toxins and methods for their use as blockers of calcium channels and amino acid receptor function
US4950739A (en) *	1988-02-10	1990-08-21	New York University	Membrane calcium channels and factors and methods for blocking, isolating and purifying calcium channels
DD298412A5 (de) *	1989-04-28	1992-02-20	��@��Kk��	Verfahren zur herstellung von polypeptiden, die geeignet sind als antagonisten exzitatorischer aminosaeure-neurotransmitter und/oder blocker der calciumkanaele
US5037846A (en) *	1990-01-02	1991-08-06	Pfizer Inc.	Indolyl-3 polyamines and their use as antagonists of excitatory amino acid neurotransmitters

1991
- 1991-02-11 US US07/654,104 patent/US5312928A/en not_active Expired - Fee Related
1992
- 1992-02-11 IE IE032792A patent/IE920327A1/en unknown
- 1992-02-11 PT PT100117A patent/PT100117A/pt not_active Application Discontinuation
- 1992-02-11 ZA ZA92990A patent/ZA92990B/xx unknown
- 1992-02-11 WO PCT/US1992/001091 patent/WO1992014709A2/en active Application Filing
- 1992-02-11 AU AU15306/92A patent/AU1530692A/en not_active Abandoned

Also Published As

Publication number	Publication date
WO1992014709A2 (en)	1992-09-03
US5312928A (en)	1994-05-17
WO1992014709A3 (en)	1992-12-10
IE920327A1 (en)	1992-08-12
PT100117A (pt)	1993-08-31
AU1530692A (en)	1992-09-15

Publication	Publication Date	Title
ZA92990B (en)	1992-11-25	Calcium channel antagonists and methodology for their identification
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GB9112349D0 (en)	1991-07-31	Tamper evident device
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