ZA864602B - 2-arylimidazoles and pharmaceutical compositions containing these compounds - Google Patents
2-arylimidazoles and pharmaceutical compositions containing these compoundsInfo
- Publication number
- ZA864602B ZA864602B ZA864602A ZA864602A ZA864602B ZA 864602 B ZA864602 B ZA 864602B ZA 864602 A ZA864602 A ZA 864602A ZA 864602 A ZA864602 A ZA 864602A ZA 864602 B ZA864602 B ZA 864602B
- Authority
- ZA
- South Africa
- Prior art keywords
- arylimidazoles
- compounds
- pharmaceutical compositions
- compositions containing
- pharmaceutical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853522230 DE3522230A1 (en) | 1985-06-21 | 1985-06-21 | NEW 2-ARYLIMIDAZOLES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS, AND METHOD FOR THE PRODUCTION THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA864602B true ZA864602B (en) | 1988-02-24 |
Family
ID=6273829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA864602A ZA864602B (en) | 1985-06-21 | 1986-06-20 | 2-arylimidazoles and pharmaceutical compositions containing these compounds |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0209707A3 (en) |
| JP (1) | JPS62471A (en) |
| AU (1) | AU5893286A (en) |
| DE (1) | DE3522230A1 (en) |
| DK (1) | DK290986A (en) |
| ES (3) | ES8800907A1 (en) |
| FI (1) | FI862623A (en) |
| GR (1) | GR861583B (en) |
| HU (1) | HUT42452A (en) |
| NO (1) | NO862477L (en) |
| PT (1) | PT82789B (en) |
| ZA (1) | ZA864602B (en) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU85544A1 (en) * | 1984-09-19 | 1986-04-03 | Cird | AROMATIC HETEROCYCLIC DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THE THERAPEUTIC AND COSMETIC FIELDS |
| GB8510758D0 (en) * | 1985-04-27 | 1985-06-05 | Wellcome Found | Compounds |
| DE3634066A1 (en) * | 1986-10-07 | 1988-04-21 | Boehringer Mannheim Gmbh | NEW 5-ALKYLBENZIMIDAZOLES, PROCESS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS |
| ZA889365B (en) * | 1987-12-22 | 1990-08-29 | Lilly Co Eli | Hydrates of andinotropic agent |
| GB8804016D0 (en) * | 1988-02-22 | 1988-03-23 | Boots Co Plc | Therapeutic agents |
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | Di-substituted imidazo fused 6-membered nitrogen-containing heterocycles and pharmaceutical compositions containing them |
| US5064825A (en) * | 1989-06-01 | 1991-11-12 | Merck & Co., Inc. | Angiotensin ii antagonists |
| JPH06759B2 (en) * | 1989-09-22 | 1994-01-05 | ファイザー製薬株式会社 | Novel benzimidazole compound |
| US5208240A (en) * | 1991-03-12 | 1993-05-04 | Merrell Dow Pharmaceuticals Inc. | 8-substituted purines as selective adenosine receptor agents |
| JPH05112533A (en) * | 1991-05-08 | 1993-05-07 | Upjohn Co:The | Imidazobenzoquinoline and agent for preventing and treating hypertension and conjestive heart failure containing same as effective component |
| US5506361A (en) * | 1991-05-08 | 1996-04-09 | Theupjohn Company | Imidazobenzoquinones and composition for preventing or treating hypertension or congestive heart failure containing the same |
| US5821258A (en) * | 1994-12-27 | 1998-10-13 | Mitsui Chemicals, Inc. | Phenylbenzimidazole derivatives |
| CZ30398A3 (en) | 1995-08-02 | 1998-06-17 | Newcastle University Ventures Limited | Benzimidazole compounds, pharmaceutical preparation in which the compounds are comprised and use of the compounds as chemotherapeutic agents |
| IL142917A0 (en) | 1998-11-03 | 2002-04-21 | Basf Ag | Substituted 2-phenylbenzimidazoles, the production thereof and their use |
| KR20010080474A (en) * | 1998-11-17 | 2001-08-22 | 스타르크, 카르크 | 2-Phenylbenzimidazoles and 2-Phenylindoles, and Production and Use Thereof |
| DE19918211A1 (en) * | 1999-04-22 | 2000-10-26 | Basf Ag | New 2-carbocyclyl-benzimidazole-carboxamide derivatives, are PARP inhibitors useful e.g. for treating neurodegenerative disease, epilepsy, ischemia, tumors, inflammation or diabetes |
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| DE60221866T2 (en) | 2001-10-19 | 2008-05-29 | Ortho-Mcneil Pharmaceutical, Inc. | 2-PHENYL BENZIMIDAZOLE AND IMIDAZO-i4,5ö-PYRIDINE AS CDS1 / CHK2 INHIBITORS AND ADJUVANTIES IN CHEMOTHERAPY OR RADIATION THERAPY FOR THE TREATMENT OF CANCER |
| ES2321502T3 (en) * | 2002-04-05 | 2009-06-08 | Cadila Healthcare Limited | COMPOUNDS OF 4- (HETEROCICLIL) -BENZENOSULFOXIMINE FOR THE TREATMENT OF INFLAMMATION. |
| WO2004010996A1 (en) * | 2002-07-29 | 2004-02-05 | Shizuoka Coffein Co., Ltd. | 1,3-azole derivative and medicinal composition containing the derivative for treatment for thombosis |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7132440B2 (en) | 2003-04-17 | 2006-11-07 | Janssen Pharmaceutica, N.V. | Substituted benzimidazoles and imidazo-[4,5]-pyridines |
| RS52931B (en) | 2004-02-20 | 2014-02-28 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7250427B2 (en) | 2004-06-30 | 2007-07-31 | Janssen Pharmaceutica, N.V. | Aryl-substituted benzimidazole and imidazopyridine ethers |
| WO2006110683A1 (en) | 2005-04-11 | 2006-10-19 | Abbott Laboratories | 2-substituted-1h-benzimidazole-4-carboxamides are parp inhibitors |
| TWI375673B (en) | 2005-04-11 | 2012-11-01 | Abbott Lab | 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors |
| US8076365B2 (en) | 2005-08-12 | 2011-12-13 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| EP1966157B1 (en) | 2005-11-15 | 2010-03-24 | Abbott Laboratories | Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors |
| JP5228237B2 (en) | 2006-05-02 | 2013-07-03 | アボット・ラボラトリーズ | Substituted 1H-benzimidazole-4-carboxamide is a potent PARP inhibitor |
| US8067613B2 (en) | 2007-07-16 | 2011-11-29 | Abbott Laboratories | Benzimidazole poly(ADP ribose)polymerase inhibitors |
| WO2010083199A1 (en) | 2009-01-19 | 2010-07-22 | Abbott Laboratories | Benzthiazole inhibitors of poly(adp-ribose)polymerase |
| MX2013006847A (en) * | 2010-12-24 | 2013-07-29 | Sumitomo Chemical Co | Fused heterocyclic compound and use for pest control thereof. |
| CN105246876B (en) * | 2013-02-28 | 2017-06-16 | 住友化学株式会社 | Condensed heterocyclic compouds and its Pesticidal purposes |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1089853A (en) * | 1965-02-25 | 1967-11-08 | Merck & Co Inc | Substituted benzimidazoles and compositions containing them |
| US3669979A (en) * | 1967-12-14 | 1972-06-13 | Gaf Corp | Novel process for the production of 2-benzothiazolyl-phenol and derivatives thereof employing phosphorus trichloride as a catalyst |
| DE2305339C3 (en) * | 1973-02-03 | 1980-05-08 | Dr. Karl Thomae Gmbh, 7950 Biberach | Imidazo [4,5-b] pyridines, their preparation and their use as cardiotonica |
| DE2927987A1 (en) * | 1979-07-11 | 1981-02-05 | Thomae Gmbh Dr K | NEW 2-ALKOXYPHENYL-IMIDAZO ANGLE CLAMP ON 4.5-B ANGLE CLAMP ON PYRIDINE, THEIR PRODUCTION AND THE USE THEREOF AS MEDICINAL PRODUCTS |
| DE2927988A1 (en) * | 1979-07-11 | 1981-02-05 | Thomae Gmbh Dr K | NEW 8-PHENYL PURINS, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS |
| DD147317A1 (en) * | 1979-11-23 | 1981-04-01 | Gerald Igel | DEVICE FOR ELECTRIC STIMULATION OF THE HEART |
| DE3037464A1 (en) * | 1980-10-03 | 1982-05-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | 6-HYDROXY-2-PHENYL-IMIDAZO 4,5-B TO PYRIDINE, THEIR PRODUCTION AND THIS MEDICINAL PRODUCT CONTAINING IT |
| DE3044497A1 (en) * | 1980-11-26 | 1982-06-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW METHOD FOR PRODUCING IMIDAZO (4,5-B) PYRIDINES AND PYRIMIDINES |
| ES8401486A1 (en) * | 1981-11-10 | 1983-12-01 | Wellcome Found | New imidazo[4,5-c]pyridine derivatives, processes for their preparation and pharmaceutical formulations containing such compounds. |
| IL68495A0 (en) * | 1982-05-03 | 1983-07-31 | Lilly Co Eli | 2-phenylimidazo(4,5-c)pyridines |
| DE3224512A1 (en) * | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW IMIDAZOLE DERIVATIVES, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DE3324115A1 (en) * | 1983-07-05 | 1985-01-17 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW IMIDAZOLES, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| US4515796A (en) * | 1983-09-08 | 1985-05-07 | Eli Lilly And Company | Certain naphthalenyl imidazo compounds and their pharmaceutical use |
| DE3340076A1 (en) * | 1983-11-05 | 1985-05-15 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW PURINE DERIVATIVES, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DE3346575A1 (en) * | 1983-12-23 | 1985-07-04 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW BENZIMIDAZOLES, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| ZA851236B (en) * | 1984-02-24 | 1986-09-24 | Lilly Co Eli | 2-arylimidazo 4,5-cpyridines |
-
1985
- 1985-06-21 DE DE19853522230 patent/DE3522230A1/en not_active Withdrawn
-
1986
- 1986-06-11 EP EP86107969A patent/EP0209707A3/en not_active Withdrawn
- 1986-06-18 GR GR861583A patent/GR861583B/en unknown
- 1986-06-19 FI FI862623A patent/FI862623A/en not_active IP Right Cessation
- 1986-06-19 PT PT82789A patent/PT82789B/en unknown
- 1986-06-20 HU HU862615A patent/HUT42452A/en unknown
- 1986-06-20 DK DK290986A patent/DK290986A/en not_active Application Discontinuation
- 1986-06-20 ES ES556338A patent/ES8800907A1/en not_active Expired
- 1986-06-20 ZA ZA864602A patent/ZA864602B/en unknown
- 1986-06-20 NO NO862477A patent/NO862477L/en unknown
- 1986-06-20 AU AU58932/86A patent/AU5893286A/en not_active Abandoned
- 1986-06-20 JP JP61144658A patent/JPS62471A/en active Pending
- 1986-12-04 ES ES557241A patent/ES8705864A1/en not_active Expired
- 1986-12-04 ES ES557240A patent/ES8705863A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES556338A0 (en) | 1987-12-01 |
| PT82789A (en) | 1986-07-01 |
| FI862623A (en) | 1986-12-22 |
| ES8705863A1 (en) | 1987-05-16 |
| PT82789B (en) | 1988-05-17 |
| EP0209707A3 (en) | 1989-02-01 |
| EP0209707A2 (en) | 1987-01-28 |
| JPS62471A (en) | 1987-01-06 |
| ES8800907A1 (en) | 1987-12-01 |
| DK290986D0 (en) | 1986-06-20 |
| NO862477D0 (en) | 1986-06-20 |
| DK290986A (en) | 1986-12-22 |
| GR861583B (en) | 1986-10-21 |
| HUT42452A (en) | 1987-07-28 |
| ES557241A0 (en) | 1987-05-16 |
| ES557240A0 (en) | 1987-05-16 |
| ES8705864A1 (en) | 1987-05-16 |
| FI862623A0 (en) | 1986-06-19 |
| DE3522230A1 (en) | 1987-01-02 |
| NO862477L (en) | 1986-12-22 |
| AU5893286A (en) | 1986-12-24 |
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