ZA200810484B - Imidazol-pyrimidine derivatives for treatment of diseases related to glycogen synthase kinase (GSK3) - Google Patents

Imidazol-pyrimidine derivatives for treatment of diseases related to glycogen synthase kinase (GSK3)

Info

Publication number: ZA200810484B
Authority: ZA; South Africa
Prior art keywords: gsk3; imidazol; treatment; diseases related; pyrimidine derivatives
Prior art date: 2006-06-27

Application number

ZA200810484A

Other languages

English (en)

Inventor

Burrows Jeremy

Huerta Fernando

Lake Fredrik

Torben Pedersen

Rein Tobias

Rotticci Didier

Staff Karin

Yngve Ulrika

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-27

Filing date

2008-12-10

Publication date

2009-08-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38846127&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200810484(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-12-10 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2009-08-26 Publication of ZA200810484B publication Critical patent/ZA200810484B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Dermatology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)

ZA200810484A 2006-06-27 2008-12-10 Imidazol-pyrimidine derivatives for treatment of diseases related to glycogen synthase kinase (GSK3) ZA200810484B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US81675606P	2006-06-27	2006-06-27

Publications (1)

Publication Number	Publication Date
ZA200810484B true ZA200810484B (en)	2009-08-26

Family

ID=38846127

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200810484A ZA200810484B (en)	2006-06-27	2008-12-10	Imidazol-pyrimidine derivatives for treatment of diseases related to glycogen synthase kinase (GSK3)

Country Status (20)

Country	Link
US (1)	US20080188502A1 (pt)
EP (1)	EP2046782A4 (pt)
JP (1)	JP2009542638A (pt)
KR (1)	KR20090024817A (pt)
CN (1)	CN101511825A (pt)
AR (1)	AR061652A1 (pt)
AU (1)	AU2007265731A1 (pt)
BR (1)	BRPI0713576A2 (pt)
CA (1)	CA2655441A1 (pt)
CL (1)	CL2007001881A1 (pt)
CO (1)	CO6140059A2 (pt)
EC (1)	ECSP088973A (pt)
IL (1)	IL195666A0 (pt)
MX (1)	MX2008015720A (pt)
NO (1)	NO20090327L (pt)
RU (1)	RU2008148902A (pt)
TW (1)	TW200815418A (pt)
UY (1)	UY30440A1 (pt)
WO (1)	WO2008002244A2 (pt)
ZA (1)	ZA200810484B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1934213A1 (en)	2005-09-30	2008-06-25	Astra Zeneca AB	Imidazo [1,2-a] pyridine having anti-cell-proliferation activity
UY29827A1 (es) *	2005-10-03	2007-05-31	Astrazeneca Ab	2-amina-pirimidina-4-(2-metil-1-(tetrahidro-2h-piran-4-il)-1-imidazol-5-y1) sustituidas y sus derivados, composiciones farmacéuticas que las contienen, procesos para su preparación y aplicaciones
TW200811169A (en) *	2006-05-26	2008-03-01	Astrazeneca Ab	Chemical compounds
TW200815417A (en) *	2006-06-27	2008-04-01	Astrazeneca Ab	New compounds II
ES2450081T3 (es) *	2006-06-27	2014-03-21	Takeda Pharmaceutical Company Limited	Compuestos cíclicos condensados como moduladores del receptor GPR40
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP2406230A1 (en)	2009-03-11	2012-01-18	Pfizer Inc.	Substituted indazole amides and their use as glucokinase activators
BRPI1015014A2 (pt)	2009-04-15	2017-06-27	Astrazeneca Ab	composto, composição farmacêutica , e, método de tratamento de distúrbio(s) cognitivo(s) ou indicações com déficit(s) em cognição
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en)	2011-09-27	2015-10-21	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN103724207B (zh) *	2013-12-20	2016-07-06	北京智博高科生物技术有限公司	苯基苄基醚类衍生物及其制备方法和应用
JP2017524739A (ja)	2014-07-17	2017-08-31	アンセルムＩｎｓｅｒｍ	神経筋接合部関連疾患の処置方法
UY36547A (es)	2015-02-05	2016-06-01	Bayer Cropscience Ag	Derivados heterocíclicos condensados bicíclicos sustituidos por 2-(het)arilo como pesticidas
WO2016207366A1 (en)	2015-06-26	2016-12-29	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of viral infections
WO2017025419A2 (de)	2015-08-07	2017-02-16	Bayer Cropscience Aktiengesellschaft	2-(het)aryl-substituierte kondensierte heterocyclen-derivate als schädlingsbekämpfungsmittel
GB201519573D0 (en)	2015-11-05	2015-12-23	King S College London	Combination

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0021726D0 (en) *	2000-09-05	2000-10-18	Astrazeneca Ab	Chemical compounds
WO2004005283A1 (en) *	2002-07-09	2004-01-15	Vertex Pharmaceuticals Incorporated	Imidazoles, oxazoles and thiazoles with protein kinase inhibiting activities
JP2007500178A (ja) *	2003-07-30	2007-01-11	サイクラセル・リミテッド	プロテインキナーゼ阻害剤としてのピリジニルアミノ−ピリミジン誘導体
CA2542880A1 (en) *	2003-10-21	2005-05-12	Cyclacel Limited	Pyrimidin-4-yl-3, 4-thione compounds and their use in therapy
GB0402653D0 (en) *	2004-02-06	2004-03-10	Cyclacel Ltd	Compounds
MX2007007272A (es) *	2004-12-17	2007-07-11	Astrazeneca Ab	4-(4-imidazol-4-il)pirimidin-2-ilamino)benzamidas como inhibidores de cdk.
GB0504753D0 (en) *	2005-03-08	2005-04-13	Astrazeneca Ab	Chemical compounds
UY29827A1 (es) *	2005-10-03	2007-05-31	Astrazeneca Ab	2-amina-pirimidina-4-(2-metil-1-(tetrahidro-2h-piran-4-il)-1-imidazol-5-y1) sustituidas y sus derivados, composiciones farmacéuticas que las contienen, procesos para su preparación y aplicaciones
TW200815417A (en) *	2006-06-27	2008-04-01	Astrazeneca Ab	New compounds II

2007
- 2007-06-21 TW TW096122338A patent/TW200815418A/zh unknown
- 2007-06-26 CL CL200701881A patent/CL2007001881A1/es unknown
- 2007-06-26 EP EP07748281A patent/EP2046782A4/en not_active Withdrawn
- 2007-06-26 AR ARP070102831A patent/AR061652A1/es not_active Application Discontinuation
- 2007-06-26 CA CA002655441A patent/CA2655441A1/en not_active Abandoned
- 2007-06-26 BR BRPI0713576-9A patent/BRPI0713576A2/pt not_active IP Right Cessation
- 2007-06-26 AU AU2007265731A patent/AU2007265731A1/en not_active Abandoned
- 2007-06-26 JP JP2009518044A patent/JP2009542638A/ja active Pending
- 2007-06-26 CN CNA2007800322107A patent/CN101511825A/zh active Pending
- 2007-06-26 RU RU2008148902/04A patent/RU2008148902A/ru not_active Application Discontinuation
- 2007-06-26 MX MX2008015720A patent/MX2008015720A/es not_active Application Discontinuation
- 2007-06-26 KR KR1020097001642A patent/KR20090024817A/ko not_active Application Discontinuation
- 2007-06-26 UY UY30440A patent/UY30440A1/es unknown
- 2007-06-26 WO PCT/SE2007/000620 patent/WO2008002244A2/en active Application Filing
- 2007-06-27 US US11/769,102 patent/US20080188502A1/en not_active Abandoned
2008
- 2008-12-02 IL IL195666A patent/IL195666A0/en unknown
- 2008-12-10 ZA ZA200810484A patent/ZA200810484B/xx unknown
- 2008-12-12 EC EC2008008973A patent/ECSP088973A/es unknown
- 2008-12-17 CO CO08134161A patent/CO6140059A2/es unknown
2009
- 2009-01-21 NO NO20090327A patent/NO20090327L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
IL195666A0 (en)	2009-09-01
ECSP088973A (es)	2009-01-30
CN101511825A (zh)	2009-08-19
TW200815418A (en)	2008-04-01
WO2008002244A8 (en)	2008-10-09
WO2008002244A2 (en)	2008-01-03
EP2046782A2 (en)	2009-04-15
RU2008148902A (ru)	2010-08-10
BRPI0713576A2 (pt)	2012-10-23
NO20090327L (no)	2009-02-09
AU2007265731A1 (en)	2008-01-03
JP2009542638A (ja)	2009-12-03
CL2007001881A1 (es)	2008-02-08
UY30440A1 (es)	2008-01-31
MX2008015720A (es)	2008-12-19
CO6140059A2 (es)	2010-03-19
KR20090024817A (ko)	2009-03-09
WO2008002244A3 (en)	2008-02-14
AR061652A1 (es)	2008-09-10
US20080188502A1 (en)	2008-08-07
CA2655441A1 (en)	2008-01-03
EP2046782A4 (en)	2010-10-13

Publication	Publication Date	Title
IL195665A0 (en)	2009-09-01	Imidazol-pyrimidine derivatives for treatment of diseases related to glycogen synthase kinase (gsk3)
ZA200810484B (en)	2009-08-26	Imidazol-pyrimidine derivatives for treatment of diseases related to glycogen synthase kinase (GSK3)
EP2237664A4 (en)	2013-05-22	(HET) ARYL-p-CHINONE DERIVATIVES FOR THE TREATMENT OF OCHONDRIAL DISEASES
PL2120932T3 (pl)	2015-02-27	Indazolowe pochodne jako inhibitory kinazy do leczenia raka
HK1160607A1 (zh)	2012-08-10	用於治療乾眼症和其它與眼相關疾病的激酶
ZA200810673B (en)	2009-11-25	1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof
IL199323A (en)	2015-08-31	Converted Pirazolo-Quinazoline History, Process for Preparation and Use as Kinase Inhibitors
EP2063897A4 (en)	2010-09-29	KINASEHEMMER FOR THE TREATMENT OF PROLIFERATIVE DISEASES
EP2063896A4 (en)	2010-09-29	KINASEHEMMER FOR THE TREATMENT OF PROLIFERATIVE DISEASES
IL195864A0 (en)	2009-09-01	2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase c-alpha
IL211835A0 (en)	2011-05-31	Therapeutic uses of inhibitors of rtp801
PL2097457T3 (pl)	2017-12-29	Pochodne kwasowych polisacharydów
PT1847524E (pt)	2009-12-18	Derivados de terfenilo para o tratamento da doença de alzheimer
IL196202A0 (en)	2009-09-22	Indazole derivatives for the treatment of hsp90-induced diseases
GB0624963D0 (en)	2007-01-24	Derivatives of 188-Glycyrrhetinic Acid
IL196228A0 (en)	2009-09-22	4-hydroxythiobenzamide derivatives of drugs
HK1129206A1 (en)	2009-11-20	New medical use of triazine derivatives
ZA200904912B (en)	2010-09-29	Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
ZA200900230B (en)	2010-03-31	4-hydroxythiobenzamide derivatives of drugs
ZA200901452B (en)	2010-04-28	Treatment of vertigo with acetyl-L-leucine
HK1155163A1 (zh)	2012-05-11	羥基烷基吡咯衍生物的阻轉異構體
GB0717955D0 (en)	2007-10-24	Preparation of modified nucleosides
EP2250178A4 (en)	2011-04-06	IMPROVED PROCESS FOR THE PREPARATION OF TRIAZOL-BENZODIAZEPINE DERIVATIVES
GB0715257D0 (en)	2007-09-12	Phenylthiazolylpiperazine derivatives for the treatment of nuero degenerative diseases
GB0816549D0 (en)	2008-10-15	Inhibitors of protein kinase Nek6