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ZA200809284B - Polymorph forms of (2S) - (4E) -N-Methyl-5- )3-Isopropoxypyridin) YL]-4-Penten-2-amine for the treatment of central nervous system disorders - Google Patents

Polymorph forms of (2S) - (4E) -N-Methyl-5- )3-Isopropoxypyridin) YL]-4-Penten-2-amine for the treatment of central nervous system disorders

Info

Publication number
ZA200809284B
ZA200809284B ZA200809284A ZA200809284A ZA200809284B ZA 200809284 B ZA200809284 B ZA 200809284B ZA 200809284 A ZA200809284 A ZA 200809284A ZA 200809284 A ZA200809284 A ZA 200809284A ZA 200809284 B ZA200809284 B ZA 200809284B
Authority
ZA
South Africa
Prior art keywords
isopropoxypyridin
penten
amine
methyl
treatment
Prior art date
Application number
ZA200809284A
Other languages
English (en)
Inventor
Dull Gary Maurice
Julio A Munoz
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of ZA200809284B publication Critical patent/ZA200809284B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
ZA200809284A 2006-05-09 2008-10-29 Polymorph forms of (2S) - (4E) -N-Methyl-5- )3-Isopropoxypyridin) YL]-4-Penten-2-amine for the treatment of central nervous system disorders ZA200809284B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74682106P 2006-05-09 2006-05-09

Publications (1)

Publication Number Publication Date
ZA200809284B true ZA200809284B (en) 2009-08-26

Family

ID=38441430

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200809284A ZA200809284B (en) 2006-05-09 2008-10-29 Polymorph forms of (2S) - (4E) -N-Methyl-5- )3-Isopropoxypyridin) YL]-4-Penten-2-amine for the treatment of central nervous system disorders

Country Status (29)

Country Link
US (3) US8461344B2 (es)
EP (2) EP2021326A1 (es)
JP (1) JP4477097B2 (es)
KR (1) KR20090005369A (es)
CN (1) CN101472893A (es)
AR (1) AR060786A1 (es)
AU (1) AU2007249485B2 (es)
BR (1) BRPI0709781A2 (es)
CA (1) CA2649961A1 (es)
DK (1) DK2418201T3 (es)
EC (1) ECSP088876A (es)
ES (1) ES2460919T3 (es)
HR (1) HRP20140385T1 (es)
IL (1) IL194833A0 (es)
MX (1) MX2008013982A (es)
MY (1) MY144132A (es)
NO (1) NO20084567L (es)
NZ (1) NZ597177A (es)
PL (1) PL2418201T3 (es)
PT (1) PT2418201E (es)
RS (1) RS53286B (es)
RU (1) RU2440984C2 (es)
SA (1) SA07280230B1 (es)
SI (1) SI2418201T1 (es)
TW (1) TWI389889B (es)
UA (1) UA96447C2 (es)
UY (1) UY30330A1 (es)
WO (1) WO2007134034A1 (es)
ZA (1) ZA200809284B (es)

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US7790757B2 (en) 1998-06-16 2010-09-07 Targacept, Inc. Compounds capable of activating cholinergic receptors
UA88792C2 (ru) * 2004-11-10 2009-11-25 Таргасепт, Інк. Гидроксибензоатные соли метаникотиновых соединений
US7459469B2 (en) * 2004-11-10 2008-12-02 Targacept, Inc. Hydroxybenzoate salts of metanicotine compounds
TWI389889B (zh) * 2006-05-09 2013-03-21 Targacept Inc （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型
JP2009536665A (ja) 2006-05-09 2009-10-15 アストラゼネカ・アクチエボラーグ （２ｓ）−（４ｅ）−ｎ−メチル−５−［３−（５−イソプロポキシピリジン）イル］−４−ペンテン−２−アミンの新規な塩形態
PE20081374A1 (es) * 2006-09-15 2008-10-30 Astrazeneca Ab Combinacion que comprende un agente antipsicotico y (2s)-(4e)-n-metil-5-[3-(5-isopropoxipiridin)il]-4-penten-2-amina
US20100028447A1 (en) * 2007-01-22 2010-02-04 Targacept, Inc. Intranasal, Buccal, And Sublingual Administration Of Metanicotine Analogs
RU2010107278A (ru) * 2007-07-31 2011-09-10 Таргасепт, Инк. (Us) Трансдермальное введение (2s)-(4е)-n-метил-5-(3-(5-изопропоксипиридин)ил)-4-пентен-2-амина
US20110130428A1 (en) * 2008-06-11 2011-06-02 Astrazeneca Ab Sublingual Compositions Comprising (2S) - (4E) -N-Methyl-5- (3- (5-Isopropoxypyridin) YL)-4-Penten-2-Amine
WO2010080757A2 (en) * 2009-01-07 2010-07-15 Astrazeneca Ab Combinations with an alpha-4beta-2 nicotinic agonist
FR2959107B1 (fr) 2010-04-23 2015-03-27 Oreal Unite d'application d'un produit cosmetique
AU2011256866B2 (en) * 2010-05-20 2014-05-22 Astrazeneca Ab New process for the preparation of aryl substituted olefinic amines
WO2013184732A1 (en) * 2012-06-06 2013-12-12 Targacept, Inc. Crystalline (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]4-penten-2-amine 1,5-naphthalenedisulfonate
KR101579904B1 (ko) 2014-09-05 2016-01-05 동신대학교산학협력단 마스카라

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Also Published As

Publication number Publication date
CA2649961A1 (en) 2007-11-22
UY30330A1 (es) 2008-10-31
US8461344B2 (en) 2013-06-11
PL2418201T3 (pl) 2014-07-31
NZ597177A (en) 2013-06-28
UA96447C2 (ru) 2011-11-10
TW200808726A (en) 2008-02-16
IL194833A0 (en) 2009-08-03
US20100048643A1 (en) 2010-02-25
PT2418201E (pt) 2014-04-14
AR060786A1 (es) 2008-07-10
JP2009531465A (ja) 2009-09-03
MY144132A (en) 2011-08-15
SA07280230B1 (ar) 2010-08-20
RU2440984C2 (ru) 2012-01-27
DK2418201T3 (da) 2014-05-12
MX2008013982A (es) 2009-03-13
BRPI0709781A2 (pt) 2011-07-26
ES2460919T3 (es) 2014-05-16
KR20090005369A (ko) 2009-01-13
EP2418201A1 (en) 2012-02-15
AU2007249485A1 (en) 2007-11-22
WO2007134034A1 (en) 2007-11-22
NO20084567L (no) 2008-12-04
ECSP088876A (es) 2009-02-27
EP2021326A1 (en) 2009-02-11
US20070265314A1 (en) 2007-11-15
SI2418201T1 (sl) 2014-06-30
RS53286B (en) 2014-08-29
US20130310425A1 (en) 2013-11-21
AU2007249485B2 (en) 2012-11-01
CN101472893A (zh) 2009-07-01
JP4477097B2 (ja) 2010-06-09
HRP20140385T1 (hr) 2014-06-06
EP2418201B1 (en) 2014-02-12
RU2008148325A (ru) 2010-06-20
TWI389889B (zh) 2013-03-21

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