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YU50293A - HETEROCYCLIC UNITS - Google Patents

HETEROCYCLIC UNITS

Info

Publication number
YU50293A
YU50293A YU50293A YU50293A YU50293A YU 50293 A YU50293 A YU 50293A YU 50293 A YU50293 A YU 50293A YU 50293 A YU50293 A YU 50293A YU 50293 A YU50293 A YU 50293A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
aryl
substituted
aralkyl
cho
Prior art date
Application number
YU50293A
Other languages
Serbo-Croatian (sh)
Inventor
K.W. Franzmann
J.N. Stables
P.V.R. Shannon
N.K.R. Rao
L. Chunchatprasert
Original Assignee
The Wellcome Foundation Limited
University College Cardiff Consultants Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Limited, University College Cardiff Consultants Limited filed Critical The Wellcome Foundation Limited
Publication of YU50293A publication Critical patent/YU50293A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Prikazani pronalazak se odnosi na jedinjenja kao što su pirolo-/3,2-b/-karbazoli, 1H-benzofuro-/3,2-f/-indoli i lH-/l/-benzotieno/2,3-f/-indoli, opšte formule III u kojoj je A, X je = , S, SO, SO2, CH2, CO ili NR7 gde R7 je H, alkil, aralkil, alkenil, acil, alkinil ili sulfoil; Y je O, S, SO, SO2. CO ili N7; R'je COR8, COOR8, CHO, CH2OH, CH2OR9, CONH2, CON-HNR,0Rn, CONHR10, CONR,0Rn, gde je R8 H, alkil, aril, supstituisani aril ili aralkil, R9 je acil ili supstituisani acil, R10 i R su nezavisno vodonik, alkil ili aril, a n je 1 do 4 atoma ugljenika; R je H, COOR8, alkil, aril, supstituisani aril ili CH2CH2C02R12 gde je R12 alkil ili aril; R3 i R4 su nezavisno H, hidroksi, alkil, haloalkil, alkoksi, halo, cijano, nitro, amino, alkilamino, dialkilamino, supstituisani alkil, karboksil ili CO2R12; R5 je H, alkil, supstituisani alkil, aralkil, nitro, amino, halo, cijano, CHO, COOR8; R6 je H, aril, alkil, aralkil, nitro, halogen, CHO ili COR13, gde je R13 alkil ili aril.The present invention relates to compounds such as pyrrolo- (3,2-b) -carbazoles, 1H-benzofuro- (3,2-f) -indoles and 1H- (1H-benzothieno) 2,3-f / - indoles, of general formula III wherein A, X is =, S, SO, SO2, CH2, CO or NR7 wherein R7 is H, alkyl, aralkyl, alkenyl, acyl, alkynyl or sulfoyl; Y is O, S, SO, SO2. CO or N7; R 1 is COR 8, COOR 8, CHO, CH 2 OH, CH 2 OR 9, CONH 2, CON-HNR, OR 11, CONHR 10, CONR, O R 11, wherein R 8 is H, alkyl, aryl, substituted aryl or aralkyl, R 9 is acyl or substituted acyl, R 10 and R is independently hydrogen, alkyl or aryl, and is 1 to 4 carbon atoms; R is H, COOR8, alkyl, aryl, substituted aryl or CH2CH2CO2R12 wherein R12 is alkyl or aryl; R 3 and R 4 are independently H, hydroxy, alkyl, haloalkyl, alkoxy, halo, cyano, nitro, amino, alkylamino, dialkylamino, substituted alkyl, carboxyl or CO2R 12; R 5 is H, alkyl, substituted alkyl, aralkyl, nitro, amino, halo, cyano, CHO, COOR 8; R 6 is H, aryl, alkyl, aralkyl, nitro, halogen, CHO or COR 13, wherein R 13 is alkyl or aryl.

YU50293A 1992-07-20 1993-07-20 HETEROCYCLIC UNITS YU50293A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929215361A GB9215361D0 (en) 1992-07-20 1992-07-20 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
YU50293A true YU50293A (en) 1997-01-08

Family

ID=10718981

Family Applications (1)

Application Number Title Priority Date Filing Date
YU50293A YU50293A (en) 1992-07-20 1993-07-20 HETEROCYCLIC UNITS

Country Status (23)

Country Link
EP (1) EP0651750A1 (en)
JP (1) JPH08502037A (en)
KR (1) KR950702563A (en)
CN (1) CN1088209A (en)
AU (1) AU4579593A (en)
BG (1) BG99359A (en)
CA (1) CA2140662A1 (en)
CZ (1) CZ14995A3 (en)
FI (1) FI950229A (en)
GB (1) GB9215361D0 (en)
HR (1) HRP931066A2 (en)
HU (1) HUT76787A (en)
IL (1) IL106385A0 (en)
MX (1) MX9304355A (en)
NO (1) NO950202L (en)
NZ (1) NZ254207A (en)
PL (1) PL307169A1 (en)
RU (1) RU95104939A (en)
SI (1) SI9300390A (en)
SK (1) SK7595A3 (en)
WO (1) WO1994002483A1 (en)
YU (1) YU50293A (en)
ZA (1) ZA935213B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9401921D0 (en) * 1994-02-01 1994-03-30 Wellcome Found Heterocyclic compounds
GB9413758D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Heterocyclic compounds
GB9804343D0 (en) * 1998-02-27 1998-04-22 Univ Cardiff Chemical compounds
BR0207689A (en) * 2001-02-14 2004-03-09 Wisconsin Alumni Res Found Preparation, and, method of preparing endogenous ah receptor ligand
US7419992B2 (en) 2001-02-14 2008-09-02 Wisconsin Alumni Research Foundation Use of aryl hydrocarbon receptor ligand as a therapeutic intervention in angiogenesis-implicated disorders
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
US20100130579A1 (en) * 2006-10-23 2010-05-27 Georgetown University Cancer therapy
BRPI0917411A2 (en) 2008-08-15 2015-12-01 Univ Georgetown dansyl carbazole compound, method for treating cancer in a subject, method for reducing dna menthyltransferase activity in a cell, method for increasing expression of family domain 1a (rassf1a) association in a cell, cell identification methods Method of determining whether one or more cells of a subject are cancer cells, pharmaceutical composition and kit.
JP2012051804A (en) * 2008-12-26 2012-03-15 Kyoto Univ Eg5 INHIBITOR
KR20160066490A (en) 2014-12-02 2016-06-10 주식회사 씨앤드씨신약연구소 Heterocyclic derivatives and use thereof
US11053255B2 (en) 2015-06-22 2021-07-06 Georgetown University Synthesis of mahanine and related compounds
CN109776550B (en) * 2019-01-17 2021-08-10 广东轻工职业技术学院 Alkaloid compound derived from marine fungi and application thereof in preparation of food preservative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300688A1 (en) * 1987-07-21 1989-01-25 FISONS plc Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them
GB2239013B (en) * 1989-11-01 1993-06-02 Toyama Chemical Co Ltd Novel isoindole derivatives and salts thereof,processes for producing the same and antitumor agent comprising the same
MC2251A1 (en) * 1990-03-20 1993-03-25 Wellcome Found BIOCIDAL HETEROCYCLIC COMPOUNDS, THEIR SYNTHESIS AND THEIR INTERIORS, COMPOSITIONS CONTAINING THEM AND THEIR USE IN MEDICINE

Also Published As

Publication number Publication date
HU9500171D0 (en) 1995-03-28
JPH08502037A (en) 1996-03-05
HRP931066A2 (en) 1995-12-31
NO950202D0 (en) 1995-01-19
WO1994002483A1 (en) 1994-02-03
ZA935213B (en) 1995-01-19
AU4579593A (en) 1994-02-14
KR950702563A (en) 1995-07-29
PL307169A1 (en) 1995-05-15
HUT76787A (en) 1997-11-28
RU95104939A (en) 1996-10-27
MX9304355A (en) 1994-04-29
CN1088209A (en) 1994-06-22
NO950202L (en) 1995-01-19
CZ14995A3 (en) 1995-10-18
IL106385A0 (en) 1993-11-15
NZ254207A (en) 1997-03-24
GB9215361D0 (en) 1992-09-02
FI950229A0 (en) 1995-01-19
EP0651750A1 (en) 1995-05-10
CA2140662A1 (en) 1994-02-03
FI950229A (en) 1995-03-10
BG99359A (en) 1995-11-30
SI9300390A (en) 1994-03-31
SK7595A3 (en) 1995-07-11

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