YU37153B - Process for obtaining new 2,4-diaminobenzyl-pyrimidines - Google Patents

Process for obtaining new 2,4-diaminobenzyl-pyrimidines

Info

Publication number: YU37153B
Authority: YU; Yugoslavia
Prior art keywords: diaminobenzyl; pyrimidines; obtaining new; obtaining; new
Prior art date: 1973-09-12

Application number

YU3015/80A

Other versions

YU301580A (en

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-09-12

Filing date

1980-11-27

Publication date

1984-08-31

1980-11-27 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1983-04-27 Publication of YU301580A publication Critical patent/YU301580A/en

1984-08-31 Publication of YU37153B publication Critical patent/YU37153B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

YU3015/80A 1973-09-12 1980-11-27 Process for obtaining new 2,4-diaminobenzyl-pyrimidines YU37153B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH1305773A CH591456A5 (en)	1973-09-12	1973-09-12

Publications (2)

Publication Number	Publication Date
YU301580A YU301580A (en)	1983-04-27
YU37153B true YU37153B (en)	1984-08-31

Family

ID=4388903

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
YU02178/74A YU217874A (en)	1973-09-12	1974-08-06	Process for obtaining new 2,4-diaminobenzyl-pyrimidines
YU3016/80A YU37154B (en)	1973-09-12	1980-11-27	Process for obtaining new 2,4-diaminobenzyl-pyrimidines
YU3015/80A YU37153B (en)	1973-09-12	1980-11-27	Process for obtaining new 2,4-diaminobenzyl-pyrimidines

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
YU02178/74A YU217874A (en)	1973-09-12	1974-08-06	Process for obtaining new 2,4-diaminobenzyl-pyrimidines
YU3016/80A YU37154B (en)	1973-09-12	1980-11-27	Process for obtaining new 2,4-diaminobenzyl-pyrimidines

Country Status (28)

Country	Link
JP (1)	JPS6042238B2 (en)
AR (2)	AR207764A1 (en)
AT (1)	AT338797B (en)
BE (1)	BE819773A (en)
BR (1)	BR7407614D0 (en)
CA (1)	CA1037476A (en)
CH (1)	CH591456A5 (en)
CU (1)	CU34115A (en)
DD (2)	DD122785A5 (en)
DE (1)	DE2443682C2 (en)
DK (1)	DK135683B (en)
ES (7)	ES429949A1 (en)
FI (1)	FI58638C (en)
FR (1)	FR2242984B1 (en)
GB (3)	GB1484482A (en)
HK (1)	HK181A (en)
HU (1)	HU170427B (en)
IE (1)	IE40523B1 (en)
IL (1)	IL45510A (en)
LU (1)	LU70878A1 (en)
NL (1)	NL155827B (en)
NO (1)	NO140858C (en)
PH (1)	PH10643A (en)
PL (2)	PL99159B1 (en)
SE (1)	SE419443B (en)
SU (3)	SU577987A3 (en)
YU (3)	YU217874A (en)
ZA (1)	ZA745317B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4515948A (en) *	1973-09-12	1985-05-07	Hoffmann-La Roche Inc.	2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
EP0001633A1 (en) *	1977-10-18	1979-05-02	The Wellcome Foundation Limited	Processes for preparing tri-heterocyclic substituted methanes and their conversion into further intermediates useful in the preparation of pharmacologically active compounds
CH639273A5 (en) *	1978-09-12	1983-11-15	Hoffmann La Roche	DIURETIC MEANS.
FR2516081B1 (en) *	1981-11-09	1987-05-29	Wellcome Found	SYNTHESIS OF BENZYLPYRIMIDINES AND INTERMEDIATES FOR THE SYNTHESIS
DE3250132C2 (en) *	1981-11-09	1997-01-16	Mallinckrodt Veterinary Inc	2,4-Di:amino-5-benzyl-pyrimidine derivs. prepn.
GB2180836A (en) *	1985-09-27	1987-04-08	William James Stephen Barker	Sunscreen
JPH0431685Y2 (en) *	1987-06-01	1992-07-30
US4900859A (en) *	1987-12-03	1990-02-13	Hoffman-La Roche Inc.	Process for 4-dimethylamino-3,5-dimethoxybenzaldehyde
CA1300166C (en) *	1987-12-03	1992-05-05	Alfredo Guerrato	Process for the preparation of a benzoic acid ester

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1103931B (en) *	1957-02-21	1961-04-06	Wellcome Found	Process for the preparation of 2,4-diamino-5-benzylpyrimidine derivatives
US3485840A (en) *	1964-11-12	1969-12-23	Hoffmann La Roche	2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes

1973
- 1973-09-12 CH CH1305773A patent/CH591456A5/xx not_active IP Right Cessation
1974
- 1974-01-01 AR AR255569A patent/AR207764A1/en active
- 1974-08-06 YU YU02178/74A patent/YU217874A/en unknown
- 1974-08-19 ZA ZA00745317A patent/ZA745317B/en unknown
- 1974-08-21 CA CA207,509A patent/CA1037476A/en not_active Expired
- 1974-08-21 IL IL45510A patent/IL45510A/en unknown
- 1974-09-02 FI FI2561/74A patent/FI58638C/en active
- 1974-09-03 NL NL7411685.A patent/NL155827B/en not_active IP Right Cessation
- 1974-09-04 DK DK468374AA patent/DK135683B/en unknown
- 1974-09-06 PL PL1974195308A patent/PL99159B1/en unknown
- 1974-09-06 PL PL1974173909A patent/PL97757B1/en unknown
- 1974-09-09 IE IE1870/74A patent/IE40523B1/en unknown
- 1974-09-09 SE SE7411382A patent/SE419443B/en unknown
- 1974-09-09 PH PH16253A patent/PH10643A/en unknown
- 1974-09-10 DD DD190238A patent/DD122785A5/xx unknown
- 1974-09-10 DD DD181015A patent/DD116824A5/xx unknown
- 1974-09-10 LU LU70878A patent/LU70878A1/xx unknown
- 1974-09-10 JP JP49103536A patent/JPS6042238B2/en not_active Expired
- 1974-09-10 FR FR7430568A patent/FR2242984B1/fr not_active Expired
- 1974-09-11 SU SU7402058406A patent/SU577987A3/en active
- 1974-09-11 GB GB47893/76A patent/GB1484482A/en not_active Expired
- 1974-09-11 AT AT735174A patent/AT338797B/en not_active IP Right Cessation
- 1974-09-11 GB GB39617/74A patent/GB1484481A/en not_active Expired
- 1974-09-11 ES ES429949A patent/ES429949A1/en not_active Expired
- 1974-09-11 HU HUHO1718A patent/HU170427B/hu not_active IP Right Cessation
- 1974-09-11 NO NO743271A patent/NO140858C/en unknown
- 1974-09-11 GB GB47894/76A patent/GB1484483A/en not_active Expired
- 1974-09-11 CU CU34115A patent/CU34115A/en unknown
- 1974-09-11 BE BE148396A patent/BE819773A/en not_active IP Right Cessation
- 1974-09-12 BR BR7614/74A patent/BR7407614D0/en unknown
- 1974-09-12 DE DE2443682A patent/DE2443682C2/en not_active Expired
1975
- 1975-04-25 ES ES437008A patent/ES437008A1/en not_active Expired
- 1975-04-25 ES ES437009A patent/ES437009A1/en not_active Expired
- 1975-04-25 ES ES437012A patent/ES437012A1/en not_active Expired
- 1975-04-25 ES ES437007A patent/ES437007A1/en not_active Expired
- 1975-04-25 ES ES437011A patent/ES437011A1/en not_active Expired
- 1975-04-25 ES ES437013A patent/ES437013A1/en not_active Expired
- 1975-06-20 SU SU752145937A patent/SU609465A3/en active
- 1975-06-20 SU SU7502145932A patent/SU571189A3/en active
- 1975-06-30 AR AR259408A patent/AR211387Q/en unknown
1980
- 1980-11-27 YU YU3016/80A patent/YU37154B/en unknown
- 1980-11-27 YU YU3015/80A patent/YU37153B/en unknown
1981
- 1981-01-08 HK HK1/81A patent/HK181A/en unknown

Also Published As

Publication number	Publication date
DK468374A (en)	1975-05-12
IE40523B1 (en)	1979-06-20
ES437012A1 (en)	1977-04-01
SE419443B (en)	1981-08-03
ES437008A1 (en)	1977-04-01
ES437009A1 (en)	1977-04-01
ES437007A1 (en)	1977-04-01
JPS6042238B2 (en)	1985-09-20
BE819773A (en)	1975-03-11
YU301580A (en)	1983-04-27
YU37154B (en)	1984-08-31
FR2242984B1 (en)	1977-11-04
YU301680A (en)	1983-04-27
AT338797B (en)	1977-09-12
IE40523L (en)	1975-03-12
AU7263174A (en)	1976-02-26
ZA745317B (en)	1975-11-26
ES429949A1 (en)	1976-10-01
FI256174A (en)	1975-03-13
NL155827B (en)	1978-02-15
ES437013A1 (en)	1977-04-01
AR207764A1 (en)	1976-10-29
HU170427B (en)	1977-06-28
DK135683C (en)	1977-11-14
SU609465A3 (en)	1978-05-30
CU34115A (en)	1983-10-04
IL45510A (en)	1978-08-31
DD116824A5 (en)	1975-12-12
NO140858C (en)	1979-11-28
PL97757B1 (en)	1978-03-30
YU217874A (en)	1982-06-18
PL99159B1 (en)	1978-06-30
DE2443682A1 (en)	1975-03-20
PH10643A (en)	1977-07-22
DE2443682C2 (en)	1983-11-10
DD122785A5 (en)	1976-11-05
DK135683B (en)	1977-06-06
CU21022L (en)	1981-09-09
FR2242984A1 (en)	1975-04-04
GB1484483A (en)	1977-09-01
ES437011A1 (en)	1977-04-01
SU577987A3 (en)	1977-10-25
FI58638C (en)	1981-03-10
JPS5053385A (en)	1975-05-12
IL45510A0 (en)	1974-11-29
NO743271L (en)	1975-04-07
LU70878A1 (en)	1976-08-19
NO140858B (en)	1979-08-20
GB1484481A (en)	1977-09-01
FI58638B (en)	1980-11-28
CH591456A5 (en)	1977-09-15
SU571189A3 (en)	1977-08-30
CA1037476A (en)	1978-08-29
AR211387Q (en)	1977-12-15
HK181A (en)	1981-01-16
NL7411685A (en)	1975-03-14
SE7411382L (en)	1975-03-13
ATA735174A (en)	1977-01-15
GB1484482A (en)	1977-09-01
BR7407614D0 (en)	1975-07-08

Publication	Publication Date	Title
YU36946B (en)	1984-08-31	Process for obtaining hexahydro-dibenzo(b,d)-pyrane-9-one compounds
YU254979A (en)	1982-10-31	Process for preparing new 3,4-dihydrocarbostyryl-derivatives
YU282474A (en)	1982-02-28	Process for obtaining 1,2-benzisooxazole derivatives
YU39604B (en)	1985-03-20	Process for obtaining new 3-phenyl-6-halopyridazine
YU36745B (en)	1984-08-31	Process for obtaining new d-homosteroids
YU324080A (en)	1983-04-27	Process for obtaining 14 beta-alkyloxamorphinane
CS182300B2 (en)	1978-04-28	Process for preparing 1,3-oxidated 8alfa-estratrienes
YU180474A (en)	1982-06-30	Process for obtaining 0,0-diethyldithiophosphoryl-methyl-3-chloro-6-benzoxazolone
YU37154B (en)	1984-08-31	Process for obtaining new 2,4-diaminobenzyl-pyrimidines
YU256374A (en)	1982-02-28	New process for obtaining 2,5-disubstituted benzamides
YU157180A (en)	1982-02-25	Process for preparing new substituted 2-phenyl-aminoimidazolines-(2)
YU36922B (en)	1984-08-31	Process for obtaining new m-diurethanes
YU226674A (en)	1982-02-28	Process for obtaining 2-amino-5-alkyl-1,3,4-thiadiazole
HU171222B (en)	1977-12-28	Process for preparing substituted 2,1,3-benzothiadiazin-4-on-2,2-dioxides
YU39526B (en)	1984-12-31	Process for obtaining 3,4-diamino-benzophenones
YU36941B (en)	1984-08-31	Process for obtaining new thiadizolyl-carbamides
YU36520B (en)	1984-02-29	Process for obtaining new thiadiazolylimidazolidinones
HU171824B (en)	1978-03-28	Process for producing new 2,3-methylene-prostaglandine derivatives
HU172290B (en)	1978-07-28	Process for preparing substituted 7h-indolizino/5,6,7-ij/-isoquinoline
YU39721B (en)	1985-04-30	Process for obtaining 2,6-dinitroanilines
YU35750B (en)	1981-06-30	Process for obtaining racemic 13beta-ethyl-3methoxy-8,14-seco-gona-1,3-5(10)8-tetraene-17-01-14-one
GB1407381A (en)	1975-09-24	Process for the manufacture of 2,2-anhydro-1beta-d-arabino furanosyl-5-fluoroctosine
HU171180B (en)	1977-11-28	Process for preparing 4,5-seco-steroids
YU40071B (en)	1985-06-30	Process for obtaining substituted 2-chloro-4-alkylamino-6-cyanoalky-amino-1,2,3-triazines
KR780000654B1 (en)	1978-12-18	Process for preparing 11,12-secoprostaglandins