WO2024038402A1 - Packaging for pharmaceutical products - Google Patents

Abstract

The invention relates to a packaging for pharmaceutical products, comprising a primary packaging (5) for receiving one dose or a plurality of doses of a pharmaceutical product and at least two cooling elements, which together completely enclose the primary packaging (5) and which each contain a latent heat storage material (4) in a plastic casing (1, 2), wherein the plastic casing (1, 2) is adapted in shape to the primary packaging (5) and preferably lies flat, in particular flat on all sides, against it, and a thermal insulation layer (3) is further provided, which is arranged on the side of the latent heat storage material (4) facing away from the primary packaging (5) and surrounds the primary packaging (5), preferably completely.

Description

eracun rarmazeuscerzeunsse rezeurnnssuen,umearssen eenneeerrmacrvun rarmazeusce eneross oer me eracun zuruname rzeunsses un wenrerserensoszewneeneesramrmravzeuscen together vosn umsceene eemeenrea.cun esecrearcweun vonarmazeus rsaecuunr cen rzeunssen ero eunrve c. enermrveracun un ene remravmeerna.cuenensesnenenescamennreemona m em ser,ascen, en were z..ecer, oer muen oeruoneoren ausunsso seravservearcweunneen.eca.eenrmeneamenen sn eeunamrevneruancuwnerenensn nccerwenseareseamroonnscaacmenem aus nwerurn.enweescz..zemnecaensrcmerveracun vorueren onnenensraun.u neasunen oer eaczee m aeeremeen seazr enen m zurermarun nonweennneonrmanoornmeanuonnennenvon auen were, we z..nwese zurn neruc aare ereame wenun oernaen zur cerwese nc vornane.en.nermscercuzs ze.m.rmanssoorevnonmsesmerauremnceneamenen we emeraurer enurcn vorescreene sn , umecee euanea uennunr nsaacmeeweseernweereanm.enees sener-°n,nam-e z°uoarearn-ere°n..nuereeermzeeraurecreence oreeunensrwveerseacweurneennenernzeerneencaarconescn,acen onaner verac, weceeeunr oxen oer vosn umeen un er en avevser oacunen ssem veren.e nacnza er zerassves aron scacen unerscee u versenen ene.ne ce seceeenraeee renew nernaonaenuransor m enerroen ecn enenansvereunneneren czaen za, "ezeee",eer enzeneeame un ene so. aenen oer to verarecenenrzneeeerre wezrumen. eemmenmeanceenrereeeamennneenzwscenen enzenen meunsemeraur a cen aureen,nenene emeraurere uera es vorescreenen eunrveraccuensee.aearonscacen e sn,ann enserze cerwese nc enzen wrenesma vorommen,ass sc eeamene emera cens auera er vorescreenen wr ure rece auwarmen oer a en.nesema ees m naesenm aa mneesene,swa aeen menaneear raunnee sorn, weewe rccezme w.eams eee arraenuraeurec ann, oneass es senersame v er wer reseoreenswes erer.oraussezun emeraurenereaemense aerns,asse auezecne were. Wreneresamen ee nranenransorneneren czaen, z..eer vesrvearceunuenn,vewrewrenene,erwzeecemceernweerseuenen aauroensacucsn,.eneersssoaonsscc un enem meum , z..,n , escre oer erza von asen en. s meum would be en oer ene ese verac wecsemaeraen verwene.a esamen eeruunen ee amene nc would he macsc n umeen nnen, sn en or merere enzener e nowen .ac errou on must e cernweeunrveracunen ascacen z.. ernervesreenun noxernanveernacuserweurn en.oeenaecnmsscenza e amene s ern enere,e eransoroxen e uvmereaarcecweenreenn.rzroeenrraansenorenvonenzenenosen to the nocmas umeac were. must ee amene so vonemeraura esemacscr e er enas e amene. ees wecunen an anuaonener mesens nweveraccruneeenneunn werveernancacunenresrnerauerem ensor. n weererace s ereeruweenun veracunen.uszc zursoaonsscc ren meumn e neer oxen enerac wmeurssas it r to enerroenansreer veracuen. un am enemroener ns zwscenemeuae nen oumen un emoumenerransoreren mreenne. nrseerereenerun vconzaenzaeunenero "ermererene amenen erze auc veracunen v ezenee" were escreen m eneru erwene, wece we oen soaonsscc un enerenaronscc, ener uerem wereracuem meum aueau sn. verwene, if NEN m unsor ons ssemen escreen. ernss err eenas en weerer m eermacersac .urraeweno escw cue rnn een, enuenwec naner veua ras acouns neno ene vroneamene ersnweveracunen un we sn auerem ensor.n wee ren after rererwenun veracunen.rerace s ereerueren meumn uszc zursoaonsscc mussas it r to eeneer oxen enerac were. and he asneerrronesn zwanscsenreemeruerenveroaucmeunnuenn emoumenerransorereneamene. uesreerseneeracun urnaerrmaz s eanneworen,ee euscerzeunsse aenwarmes rermrveracunn en an ecermaera auwesenensoaons e emeoerraneurs.eseru aueree,e eunrvesraacunse arneznuoernnene,mesnoeassmnenelaufener vorescreenenemeraurens aune s vorereenensor- ers nc voner enerme. aen oerracveracun, we z.. oe nr.acconaner, a ransorwaen eermesrcveonrceuenzenrrennzeunns es, a vereseren emeraurem e oer merereosen von e nceneamenenerezuseen, wecer rourmornversaczuurnnwwenreunn veorsesanmenumeer uee voner aecenner ee nam czer sce.uem so anuaaonnsssarenzereeree un en were.eercsu soz auenozneavmernaacounnseeseneeerammenscm raemenswormeens,ewceezr.ma.earusar,eveenremner were. uerrasun eseruaenese ernun e ener r cun r armazeuscerzeunsse, ene enmesrveraramcazuenu zsucrenunrazmeenerossoer merererosen eracun wensens twoeunessresm urmvearssac,unarznu,samamses e vosn umsc eene eemene umass, een enaen heat secermaera n ener was enaen, woe eunsso e an uensrsmo e ormaneass s un evorzu c , rveracun ase c , an eser ane, unnsaesonere weers ene rmemmunsscc ss eeracun rmrveracun aewa umass, e otherer aenwarmesecermaenraens aeneees rmrveracun,evorzu vosornne,s um un.e ausnsosrsoeeneeneerraanu eenrmrveracun ormaneassen aenwrm esecermae e scereunamees erseunsosen.nsrase ecze ernen asn r enaeneaesonere sc e eunsso ea un vern enwarmeseermaera vosn aenwarmeseerceraurc enusreenes nurc uneremnaeuras auser oeras he ernunsemenrecr eunsso e. ess e ore, we acun esween vonesonerem e amens ernverrauceremusacenes er.unaruesnrem uennesen esanene vewe rrm rme aen use cen ercn s,ersmo oan nearao nmmc, wnoureene e amens cause. also it uacnau.n auerreeernaecsunoneunrscaoennswanssveerrrsauce er nsc c esrscenuns sereracuer sowo errouscere sren. ernun sne asa also ass ene rmemmunsscc anere erere, aewaneneesaenwarme rrmrveracun s un ermrver secermaeras aneorne e rmemmunss acun,evorzu vosn , in order to . esus ececr eree zum enen e ermsce erneremewc un vernmeenee ecem oer onensaonswas r zum aneren e un von nnera ereseurn aneruen eer eemene if war rveracun.onensaonr au, a muenunauerucceu ner e eneraenan weceann a wenereuc e aunemenann, ur ner of asonic water. ec e rmemmun er eemene wr eemeraur orneunseanwonnsewaesrserweuneaemn verennesre.un from nenensremeemmunsscc ann ere aneruen- oer aneorne erunsso e un an eser aneen nnense sen.enn e rmemmunsscc aner ass see anererunesrsromrverea a cnuenoraneewasn,eneeeueeeses, aaeenwarmesecermaeras zwscenem anenowrmesecermaera un erunsso e uenrsne s.enn e rmemmunsscc aner asseeerunsso e aneorne s,eeue es, he see anemeenreevrerrumr.vereacurnmeammeuwnansscencuenseee soamenewnremermemmun zwscenem eracun.secermaera un eruenseeer evromrezue wesee vonrm<e,mmunsmscauc. ene wee z.rm.emmuonesrscc ma ennnearusermnemanarmmmaera, m, auseroe ee e <, un m enerrmee e <, m rmoeeeraus eneer <au,umsomaoenseen. m ener aeuuamusuomasooansonaaennnzauussamemennereerza von eauumsoao sez sen. Preferably, there were ttzrerrasnsm IanneernenevonroeresneseKVearnumuamteurnaeanes core material umeeneascte He au, what was presented from en oeas core material oenorem Posoecma Aneurroate,esoteetn.oDrereVmorPtoeuretanoer core materialaeneenerermmcerr esetnererneren Dc oener Kesesure e enerermmcen Vauumte,atwtoenurecrreecnetweewrcentsearnsarns Dcte vonAeroe et egm Berec ³ n. De aursoweenset.KDeseesseurencceerweseeneDc-1t4evonm1,-wo4em ³ mWm.K. n Wrmeeteenscatenm Berec- caevoerzunesmeusanauummes eonaeoneoc asurceene, umar nunereracun rmssenermemmunsscc auser, soass aueumrscoen anenossseen enzener auumsoaaoonnsananener veermeeneenAuweernweann,ennneen.avone aeuassetaneetteeIVnaneunuw manammun enezwscenAuen-un Innenwan urceene,e Keerem aeuntweeusnen,weoPermreveVraaucumunammmertas AVuasnuaummeamemenrerausenunsestetset.erVeracun aset umeene DuenrBeerrAu “Vauum”eeuet,aser space between the interior ene warmthmwmaunn zeureVrareuucmesoatonevauertst,umaurc WBermeetunerasmoeen r,eunzeemrtuorceruansteVrauunumenwer. ,v1ormzuart.etrter Lutrucner Vauumsoaton,1- emmarume.mmunsscc wesevorzu enece von- eereemrevrervoarcuenenernernancunersromuesoennncen,ass ernunsemsseneracun azer wr u er nwenun vere.aurc wr erm nor s zur wrenesesamenransors rveracun ee werenes cosse escz un cenner ransors,he so. no. acun azer lakes,rzm.r.veracunannrunszcee ause e sccen, asuonseervoerr,acuuen,,osme,uee,en uenons.amuee, rrmerveermacununsenearuracrreeceunnnzseocrmne,ass se ene aus e. scearrecuns eneseamens umassensunen ormen eneseamens ranuae,rue,,mausseonn,en,arusaesnesno,nene,cuavesre,n, anuesoenns,zuereceunn,enn.eonszuereunen un remurnvsersaocuneormearneasese,mewnaes ane errmrveracun z seeue,ass se aner aneeneneeeueewacneeneo umneransceeseorrmvoaruzuweswseswe ermrveracun.eec vorzu e eunsso e aer anerrmrveracun an.eunsso en umsc ermrveracun together from sn aseeenenc aenemeernermerveenraecsounnerasn.evorzu errena,ass eneeunrveracun voreseens,n aueneom ee aneeunrveracun saonwo anermr-ur acs auecoarnmaneasseununerrvereracacununoer anenreeurmveorenaneeneeraacumuneenwez..eneersanscace, ene run sser ausenuz were.r z.. rans eascen eneruaerrmenascace to ecor aenr,enenesweeeneanucreunnuesruomrem.eurrans from run ormaneassen eemene wr It is used, in order to warm up the heat, send it out, eamene ^the aeusweesu.n vorzuswese eneansre von,-mm eenesunseszoeverearaennnsvoerrzuessweeseenzumerneecsaeunweensme es aera r eunsso e oer zumnes r n. s eezoenenerec erunsso eomm en eesre -osw ,eese cee:noe en o , ,e cn n msere aa ,osro 3 -eso,nerecmo ³ enreane .oer ce unesrnsaovanne eunsso e oer enerec er sen. urc en rzussverarenerese unnessevoorzueeeusneruensezoormenseecavoer,auawss e uenseeevorzu m it was, a another oe missed nsens ener ae oer vorzuwese auns. e ae oeroeann erunmaeras, ewneemz..ecneernaumernaum,nsesonere enem eseen un ene ce von,- verunoe, verner enusauen mm auwesen. es aenwrmesec oer nurc unerenes e ermaeras.asersc eenercae m errnaunes oveerraoreneoerero raesvcorazuscmwessveerrmascreenn. two eemene voesnennen ummesccanossscene.nunewenermsens cuzerrmrveracun. e wens scen nnenae eseswese ens two eemene ewes ene an euenor zmweerarsmcraveernaacusun aenn,easese eernereurnennaeuewneesaenne,nwaoneereeenascaen enan meerravserzwe aueen.snnen aer also eemeenemee.nevoreseen sen, we z..re mremnrevnermacucnszucenosenermscencuzer asses wensens zewwereseeenm,enseanevorrzeunmvoereseen, were together ennern to naner ormscssenernunrneuns un ener auwesen.urc anerreeneanroe renneenean eerauneranroener verwrc wnereenr.e enerarn cun erernnaunvsenenmeenneez..eeemeensereaucenumrceuere verunen were, umreeavo naner xeren. son zuenaner zu eceerrseanne ernunsemeeracunurc en e wensssenesezweversceosesmeennseemn.eenseeswesennen zersrarenceresse mrreverse ersceener e verunen sen.urcas ecrerne ernunsemeneracun m enem vers.see werenanuaonenereamene mueermereerrmecamenee e zurrmrveracun enzener oer esmmu asnrnen vonsensoren zur em n vonemeraur unr.aurcanner aueerzaeucrvneerauunerreenuzaenenuenamrenseemransor were.ersesmmunssensoren ananmeern anuacereewmeseenn zwesscaeneenrweensameennzew.eeeresemann anerrenneene anuaonsscuzsensor an enen en outeren eorne sen,he enen nc eranuaounsrscu azusensoerranmnrveersaceusnweseeea er. csensor or asemeraursensor ause e sesn. eermneumnesraemureererreancuransor ener eza z.. ene nenn enerransorene, we ore,masosnaenneru oeerresenermeersuamnoscerace,ese he ssem nowen sn.s wr e ce enna ves soaonen .asaenwarmesece your er ernunsemen nz rmaera nnera rmrverac everacunen, wecesee enereuenree.se amens um , se ene neerecevnersceeuneraunsneorraerunereerrseans e ecm e em enerevorzuenee scace. It was errec,ass eer r un errnun aurc ase umeen acun ene ermrveracun aer enerevereunsscc from enem ccae meneeaner rmee e from > m ner ere e uwes. enerevereunsscc e ru ne ermrveracun cenos umeene umanusrm aus,vweerceeauunenaerurceer eennaene rmeenere errauc esaenwarmesec en ecm en erm c ene nmerun ermaera sor. es esun erorerceneos r eneesmme aenwrmesecermaeras.umenses nenerneareveesrecucnsasucacusearnneranneuneuneree aneorne sen, soane s eneracun around . eermrveracun ase eeneermeneveereunsscc annmnnerener rm aneorne sen, and indeed another aaeenrv wawer nrma eec nsuen ec z eeurme eawa senraaen enswoe remre esanesererrmrveracun ezerena s esevo ecermaeras.m between rzu, Wennermmmunsscc aenwrmeersenecreremvaerereaunanssecorcne uns.em eeneerevereunsscc ann auc auera er rmervm eee mrn enaeca eunneo n earn neee rwanse euen nn, re.. vere an acerere u eremene.enne annenerevere n auenommen sn, anunseneseeeoenereanunerun rveus res anc csec une aneers e zr.e ac.sawe ssse ena an .scearce eemneeersneerweeerremnrvues unann voreseen sen ,ass nerevereunssccracmun umeene ene two inner ones eemene un nerevereunmrveracun umeene aneornes.sscc auera er eemene amnaeeer eenrersecuaseruaremrseeneeracunanneseswese nerevereunseemen ann en eenes aenrmennerevereeournnseee smeenn,eweoneeuaeesrecrsme sru.ur ereen,n wecer ermrveracun aneorne eumnnerumsecverce,uwnesszc.au.cse anneseswese as umnumesccun, eneeum sennu.moe oer ene aeuvsorezxuanumerasesmraenerevereunsscc enecc ra zecne oerese araus.xanerer oe rmee sceur c enernesewc un ene erccev aourszuexa nercceene from. e ce smm, n,memr,emerraaen. annvorzuswese,mm en. cerw un e anewanexaonsm e sn aeersurese aumcora, romsure,aumermana e, senzuaerneernun na un erecen. onzenrerecweesure was eseswese ra -nerc used. e exaneraren a aaonsvernunen unereenemr zen euneernsearemeneraouurmeonzeura ersoenannennse-emeraur as , name m xansonsaoren von mer ccsrueaurc caused wr,ass en e nercaaonusrveesra s eneaeren eseem rnunenurc as scneer zen au wer, woeruarcuruneer ra usnccasenrmzeerarmoonea zaerrsez auesrencancereeerneeeexn,an.er oeerraauear ewerseenn.rec to rnwrerunvoesnesnrucexesanomerera unererceer cceenenesra a er, so ornen sc e nwrunsrcu sevorzu senrec to the reae unerennaneesr vreurcaesena.n,awourec scs eenzenen nerzusaz ene se sraen s sc one ra erseen. ecc from exanerem zeercexneansecreeraenereervornzeureenveruseununsscac aus,ass ecceenenes ex eraurc esen cenarae zuen anerenra sm vnoerevereunsscc vaenrearuuenn.arearuerczuerr enescern nrereevaereeruenssescencea.nsoesroeeeureme,ee er urmeene ceocese,s eexmanurecreannra a urcsss enean sener eoc ern. eseoeeun ona asarera zuerewnscen rmevere enerses nerevereunsscc u un ner eneer es rme n anererses to enereu on nereveerneraunsssncacs.ransoru uer zur eneer nesresoaneerewes ecc from exaneremra nm oneerene-evorzum eaune. rmee e from - smzeen un.nesreanaencacare auszeuxvaneremra to voreseen,ass enerevereunerssecssecrn, wesnseveonrszu eexneanrereresmcrca auawneesor,naeu wsecunermeweccc from verunens.nsesonereann he se . cc from exaner voreseen sen,asse rersccen aneoremra between two rerscc annernees.e wensens ene unsso ese. vorea ausaron oer eexraarera -erunaen,.. enecc from nnnenernevmersrcaeensnenomeonmaeronenmereenserrerscc, z.. asace oerermmea e were, we ormerrmrveracu en, un nnenaere eunrveracunormnan oeearssanseen.ormer vneresraenneenm,aasenwrmesecermaera wr enaera ermscenner eneenroe erm zueren ann.aenwrmesenceorrmma veornaaeennweerrenrmaeucseacern asenwecsemaeraenezecne,he s cmezwarme, sunswarm oers enaene rers aserme, oronswarme wesenc sezscenrm e se aurun rer normaen asenwecsemaeaaz secernnnen. ase eraen vererenaerrerun, soa urcsameaeraenasenwecse vosn asenawuena.urcusreneseenuen aueaecense wesreann.neraenwrmesecereoc weer eenneamcemreraesurearremaczeuvonscensrze°unessaesemnuswsereensesn n enememeraurerec from s° o , z.. em eraurerec von° s°.asern enem voarseenswcecrseeemnaenereameraaureerreeceaneeau en aseneransemeraur. smme assw.as-enewercaseecamnaoereran-eesxaeecevorzu ausara n, ser, nearen ooen an,ser, sw.e waaszserraaseenr,enassesru-naenz, , oeme ersrc,eo snr c,an uaszc-ensunnenr uneno,er wereaz rae nen ervon.evorzu e as asenwecsemaera verwene,a rsmeesaurun reroen ce eneoe aseneecrearnavaoznesr zouousmsenenee veevrorzuen.mer e°m.eraurerec -° s +°,evorzu merec - voerzursmweesseecmereareazc es asenwecsemaeras e > . s ,evorzu masennuusrcauenuneereesnc unenerunsso e oer urc eu esaenwarmesecermaeras e eraunssesmoeraureo zrumsvearmeesen,raenrnm esesn ener cmewac zrumnesse aera aen een sc en nenomere o aen. s z... veesronerasreeaumernvnoerraeenenscrernuenuwc ,aer sarerenzs unur nrveracunen ec uner ceomereerne von run zu aenwrmessceecercmaeersasn zeuresrmrveracun aureen. sceemranscuna wrresneaceoneuns anruannsveonsnerecnun eruer. een ner urn eeser zeen usrun nenuerscn urc ene erse ,urso ermneennernesrscnnunsemeneracun, . urc eeracunem usruunrso ermneenneureresrcnnunsurecm eenneezrweae ra scceen u cun m usruunrso ermneenn neureresrcnn urc enere nsaz vonemeraur-,rusn-s unemaennueraaconusnsenmsoren. r.nu unn. zeeerenneunneseresmeeuserarunsvaraneer eemene, weceer cun umass two umeen un anese mrveracun vosn eeneneenusncrvzeursaamcmeunor n mman auseenaesms ene sn enac. azee sce e acenem een .neer uenssoeemenee,es weeceneenwerse from enerormsaen rmrveracun se un aneemona m er unsso e wrev seormaneasss.e erse us un morzu mezeveraren oe anereener eeneenrenaceenevuenrsscsoossena.easoer ersrcasceaenscerweossverevaorrzu m ermscen oer nne en anenerscussanen. asrenaw er eemeneene sc en rmeemcmusnesmsacerca uenneenescrmemmunsscc . e rmrveracun aew anenuenwnen voner sn s. e eemene voson um uemscrmerveenr.aceun aneorne,ass se ese ormscuss mena eemene sn er arn cu ner verunen, woe ene rmrveracunn sorr. enenu cen scusser uensusnsos,owe ze ese from enem ezearen eneer . , oer - un what evorzu errecenn,e wereunrcansssreen vaoun.,m-emmneverowremnsea. to eeroscwe oe oerunsso ae zumersc een ecremnsaaerenau wnsesoeunsesoesee enweer ausem cenerunmaera or aus enem umnumveruno ,evorzu ener au. e un wes ene ce von z..,-mm escrcmernve mzr eurac vonuunnaameeseennmvoreenenese as zuruna ,esasessn oenerrzne.mausees oeer. eerreerancuzneseemeunnereacaunscuace sn nc e were. We can also eat it uensasornscacenu annersrenunreceneeneeeeern.aun he also eernun ernneeensee. en ee es erm c ormscuss anerre meneurc enen nesenearsewnewecersenus runsvarane e ercmezun ea emaeras zwscen° un °.aurc auc after nereraerun e ° enroe es rosenewecseesmvaereraasrenneesrmemsusan un esann en emerauren nuzaremac werceenn.cuzeseen ere nunes nerweerenus runsvarane wr eormsa e eressoe .e un urc rzussveraren cc zeenauseenxeawneeerreemusrarunzsuvraruane,e er nerevereunsscc n ee s un ener were. ese wese racun enerac nercceenen aene rmee e from > m rumceereu u un soren ren ene ecm e es rn from unecm eneracer rme. as to eneressenerenusnuzun erm eenweercmssecmeaeersaunesseceerenernerereacun er am erra scener eseswes un. e ce evorzu ,mm. e,mm smm, er. nnernaze . esce rac veerns s,ce ccee anuecnmannecnnanne ereren aomer ernneorrn ewuenren enerac sen, soass se erm emene n ener weerenus runsvarane wrevrerenacruan sucmecene.n rmnenermmaun er eemene auera er us run sscc enerac.n ener weeren eemensvearsoananeewerracen,raassssceceseenvo asuenraoer ewese umeen.n ener weerenus r er werera scceen vonnne unsvarane ascace anerac.n enenr awn ean er us runsvarane werera sceceeren ean erascace anerac.n from auen to nerweaceurnenseunserumnsvaernsaonreennzwurr eernunseme un os on sowe m an essun vonemeraur see .. ee uaonssensoren ausesae nnera eneser ueeruensane ene sc essun eremerau mene.erensor re asenwecsemaerars wlaufenera es an wece ermr rac,evorzu aneran, anuaonsscuzveracun anrenz.er a sensor was anrenn ne between e en eemenen anerac un ee er som, or re-sereorac eounse r nnnerea eerneue weurrune.saeneesmmuner eesn nen-eercneonaonnee. e omnao nuecnsoreenrmsnce.ee eeuenrrnveurnasceumn,ez.er.aecnuenraeronnsecasccenoneera ener ese. e ee enen ermscencuz r ersez emeraurem n cee amene un sc he som e rcoeunnonerse zmumeraaureneen.reunemeeremrece vosneeerne acnenuoaseoncsnazcewersanserareenzaemrenee.ereesowe enen

Claims

aenansrce: e.neerrmacrvuenracrunarmazzeuursucnearzeunsse, umassen merereros me eneross oer wensens zewneeneesramrmrazeuscenrzeunsses and around veracun together from sn asc eene eemene, eewes en ,enwenrmeaseenc,ewromaeeraeunssn eneruns so e rmrveracun orman oe , an e nseason eass s un evorzu c , weers uemreasasenseene rcme,mmaunn eserane, un errmrveracu sscc , e aner aenwarmese n aewaneneees rmrveracuncerma,erevaorszu vaonesornne,s um un.e .e errmeacmumn nac nsruc ,aurc eennzecne,ass erunssounsscec, an ananeresuerena-oernnensee s. neen aneorne .eenn ezreacun after nsruc oer,aurc rmeecne,eass vone <,rmemmmun ausswcesc. ene .eennezreaccnuen,naacssnserucrme,mmuoner,aurc umass oer from sscc eneroe from <, eseme e un ene rmee e rmee m aeuwevosn<oe,renema auuuwmesso.aon m ener .eennezreaccnuen,naacsseneemernsrce s,aurc von-mm auwes. rmemmunsscc enece . eracun after enem aeuennzecne,asseunesrsnosrcee,ss,easurracen -soeu veons un– vorzuswe ² se from enemaera m enem ansre von,-mm aumwmese.se un vorzuswese ene .eennezreaccnuen,naacsseneemunesrsnsrce s,aurc eaunewnems.es enesezevero arenseer,ese zumenneserec .eueracun nacnsruc ,aurceennzecne,ass e annsesrouensee eeneevorezuezoenecae auwes, ae oeroe verscoss meness. wensens ener .assereacaune noacernosreuce a,usaeunrecmeecnnzecne, nsesonereerunm enaera, umnumve aera, we z.. ener auwes.runoe,ese un enece von,-mm e.ennezreaccnuen,naacsseneemwenersnesnsrzcwee see,maurc ren menaner together ene e menwrennannen zurus and annerroormsecauswseseenn. appointapproved e.ennezreaccnuen,naacsseneemweernsrce s ,aurc enemrreverse zersrnaresnensc zewreesseeemene m sn sne.weennomsmeennssznwe,woeeemeene e.ennezreaccnuen after enemernsrce sn,eamsserwaen ,aurc esmmun vo ursunensrenvorenessoerens z .ur e.ennezreaccnuen,naacsseennemaernsrce s ,aurc erre nuaonsscuzsensor an aneornnneeense.zwscenen wensen two eemenen e.ennezreaccnuen,naacsseneemereracnusnrce s ,aurc ase umee ene ermrveracun ,,,, augenerevereuns scc rmee e svoenemaera m ener auwes. N > m e.ennezreaccnuen,naacsseneemeernsrce s ,aurc aenwrmesecerm ceraaz es ,evorzu >aeras, em.erec s e.ennezreaccnuen,naacsseanemernsrce s ,aurc enem sowo oer- ass aucaeunnwerrmaeseecermaera n asenwecseenermeerramaurereasvaere r ormsa newrmess.ecermaeras e.ennezreaccnuen,naacsseneemremrrvnesrrce s ,aurc serveracun ,mue, acun as uoneor,ue,ose oerneeeons aaumsuee,e ssc.cen, _^