WO2023136489A1

WO2023136489A1 - Subcutaneous injection chamber unit having drug storage and discharge function

Info

Publication number: WO2023136489A1
Application number: PCT/KR2022/020763
Authority: WO
Inventors: 김일환; 노태훈
Original assignee: 인제대학교 산학협력단
Priority date: 2022-01-13
Filing date: 2022-12-20
Publication date: 2023-07-20
Also published as: KR102600940B1; KR20230109262A

Abstract

The present invention relates to a subcutaneous injection chamber unit having an improved structure to have a drug storage and discharge function. The chamber unit is configured to store a necessary amount of drug in a pocket member for drug storage such that the drug is injected subcutaneously by bringing a magnet close to the skin at any time when a user needs the drug to be injected. Therefore, a drug can be injected without piercing by a syringe needle so as to enable a constant dose of drug to be administered without repeated injection for a long time with one drug charge.

Description

Subcutaneous injection chamber unit with drug storage and release function

The present invention relates to a subcutaneous injection chamber unit, and more particularly, to a hypodermic injection chamber unit whose structure is improved to have functions of storing and releasing drugs.

Among various methods of injecting drugs into the body, intravascular injection is injecting a drug solution into a blood vessel while a needle is inserted into a blood vessel. According to the medical law, only skilled professionals in hospitals are allowed to perform the injection. If you need to receive an intravenous injection, you have to accept the inconvenience and visit the hospital.

However, visiting the hospital every time you need to receive an intravenous injection is in itself very inconvenient. In particular, when accessibility to the hospital is poor, or when the patient has a walking disorder or cannot move at all, the hospital visit itself is very inconvenient. Because it is difficult, many people give up getting intravenous injections and take oral medications that replace intravenous injections. Oral medications have the advantage of being able to take the medication at home for a long period of time without frequent visits to the hospital. However, not all drugs can be made into oral dosage forms.

To solve this problem, subcutaneous injection is applied. Unlike intravenous injections, subcutaneous injections do not require expertise and proficiency in administration. This is because, unlike blood vessel injections, in which the needle is inserted into the blood vessel in the correct direction and depth to administer the correct dose, the drug solution can only be injected by piercing the abdomen, upper arm, buttocks, or thigh with a needle anywhere.

Compared to oral administration, drugs administered by subcutaneous injection have advantages such as rapid absorption in the body, no action of digestive juices, and no detoxification in the liver during absorption. For this reason, for example, insulin, thrombosis inhibitors, or growth hormones used for the treatment of childhood growth disorders are administered by subcutaneous injection.

As described above, since expertise is not required for subcutaneous injection, an individual is often prescribed a subcutaneous injection solution and directly administers the drug at home. Even though it is an injection, it is so convenient because you do not have to visit the hospital every day.

On the other hand, long-term administration of drugs using subcutaneous injection gives patients a psychological burden and physical pain that they have to be pricked with an injection needle every day. Although there is convenience in administering injections, the pain of piercing the skin with an injection needle more than once a day sometimes acts as a factor that reduces the patient's adherence to treatment.

As described above, in the case of drug administration by subcutaneous injection injection method according to the prior art, since there is no structure in which the drug is stored and the user can discharge and use the drug as needed, the syringe is injected at least once a day and up to 4 times. There was a problem in that the injection solution had to be filled and then repeatedly injected into the injection solution as much as the required capacity.

- Prior art literature

(Patent Document 1) Korean Patent Registration No. 10-1502157 (patch-type drug injector)

The present invention has been made to solve the above problems, and an object of the present invention is a subcutaneous drug storage and discharge function that allows a constant dose of drug to be administered without repeated injection stabbing for a long time with a single drug charge. It is intended to provide an injection chamber unit.

In order to achieve the above object, the subcutaneous injection chamber unit having the function of storing and discharging drugs according to the present invention is a part in which drugs are temporarily stored, and is disposed in a space in the human body such as the abdominal cavity, and is made of a material capable of expanding and contracting. Pocket member for drug storage consisting of; In a state connected to the pocket member, a portion is located in the subcutaneous layer and the remaining portion is located in the muscle layer, and has an accommodation space fluidly communicating with the pocket member, so that the drug is introduced into the subcutaneous layer via the accommodation space. A case in which a drug outlet for communicating the accommodation space and the subcutaneous layer is formed, and a pressurizing member installed in the case so as to be liftable to pressurize the drug accommodated in the accommodation space by an upward operation so that the drug is discharged to the subcutaneous layer through the drug outlet. A housing for dispensing the drug comprising; It is installed in the housing for drug injection to enable connection of a syringe for drug injection, and the injection unit located in the subcutaneous layer communicates with the injection unit and the internal space of the drug storage pocket member. a drug injection port member including a conduit connected to the pocket member for drug storage; and operating means for selectively opening and closing the drug outlet and selectively lifting the pressing member.

The accommodation space includes an opening and closing room in which the drug outlet is formed and is partitioned from other spaces and communicates with the other spaces, and the operating means is installed in the opening and closing room to be movable and made of a magnetic material, an opening/closing member that opens the drug outlet by rising due to external magnetic force and closes the drug outlet by descending to an original position when the magnetic force is removed; It is preferable to include; and a magnet for generating the magnetic force.

Preferably, the pressing member is made of a material with magnetism and is configured to move up and down by the magnetism.

The present invention includes a connection pipe fluidly connecting the pocket member for storing the drug and the housing for discharging the drug to each other; It is preferable to include; and an on/off valve installed in the connection pipe to selectively move the drug.

The on-off valve is made of a magnetic material and is installed in the connection pipe to be able to move up and down, so that it rises by the magnet to close the passage inside the connection pipe and returns to its original position when the magnetic force by the magnet is removed. It is preferably configured to be restored to open the passage inside the connection pipe.

The present invention is to make it possible to adjust the amount of the drug to be accommodated in the accommodation space of the case, and is disposed opposite to the pressing member in the accommodation space to limit the size of the accommodation space together with the pressing member, and the opening and closing chamber is integrated. It is preferably made to include a position adjusting screw rotatably installed in the case and the amount control member provided with, and screwed with the amount control member.

The subcutaneous injection chamber unit having the function of storing and dispensing the drug according to the present invention having the configuration as described above stores the drug in the required amount in the pocket member for storing the drug, and allows the user to inject the drug at any time. Since the drug is configured to be injected subcutaneously by bringing the magnet close to the skin at the point of time, it is possible to inject the drug without being stabbed by a needle by a syringe, so that a constant dose of drug can be administered without repeated injection for a long time with one drug charge. derive an effect that enables

1 is a perspective view of a subcutaneous injection chamber unit having a drug storage and discharge function according to an embodiment of the present invention.

Figure 2 is a cross-sectional view of one embodiment of the present invention.

Figure 3 is an enlarged view of part Ⅲ of Figure 2;

4 is a view showing a state in which drugs are stored in a pocket member for storing drugs employed in one embodiment of the present invention.

5 is a view for explaining a process of discharging a drug to the subcutaneous layer using a magnet employed in one embodiment of the present invention.

6 is a view for explaining a process of injecting a drug through a port member for drug injection employed in one embodiment of the present invention.

Figure 7 is a view for explaining the configuration and operating principle for adjusting the size of the case receiving space employed in one embodiment of the present invention.

In order to clarify the understanding of the present invention in the following description, descriptions of known techniques for the features of the present invention will be omitted. The following examples are detailed descriptions to aid understanding of the present invention, and it will be natural that they do not limit the scope of the present invention. Therefore, equivalent inventions that perform the same functions as the present invention will also fall within the scope of the present invention.

And, in the following description, the same identification symbol means the same configuration, and unnecessary redundant descriptions and descriptions of known technologies will be omitted. In addition, the description of each embodiment of the present invention below, which overlaps with the description of the background technology of the present invention, will also be omitted.

Hereinafter, a subcutaneous injection chamber unit having a function of storing and discharging a drug according to an embodiment of the present invention will be described in detail with reference to the unit.

1 is a perspective view of a subcutaneous injection chamber unit having a function of storing and discharging drugs according to an embodiment of the present invention, FIG. 2 is a cross-sectional view of an embodiment of the present invention, and FIG. 3 is an enlarged view of part III of FIG. 2 4 is a view showing a state in which drugs are stored in the pocket member for drug storage employed in an embodiment of the present invention, and FIG. 6 is a view for explaining a process of injecting a drug through a port member for drug injection employed in one embodiment of the present invention, and FIG. 7 is a case receiving space employed in one embodiment of the present invention. It is a drawing for explaining the configuration and operation principle for adjusting the size of

As well shown in FIGS. 1, 2 and 5, the subcutaneous injection chamber unit having a function of storing and discharging a drug D according to an embodiment of the present invention includes a pocket member 1 for storing drugs and It comprises a housing for dispensing the drug (2), a port member (3) for drug injection, and an operating means (4).

The pocket member 1 for storing the drug (hereinafter referred to as the 'pocket member') is for temporarily storing the drug D so that the user can use the stored drug D as needed. It is placed in a space in the human body such as the abdominal cavity (A) and is made of an expandable and contractible material such as silicone, so that it expands and has elasticity when the drug (D) is introduced as shown in FIG. 4, and as shown in FIG. When the pressing member is raised by the actuating means), it is contracted to its original shape by the elastic force retained during its expansion, enabling smooth release of the drug (D).

The housing 2 for dispensing the drug is connected to the pocket member 1, and a portion is located in the subcutaneous layer C and the remaining portion is located in the muscle layer B, so that the drug D accommodated in the pocket member 1 is released. It is intended to be able to discharge to the subcutaneous layer (C), and includes a case 21 and a pressing member 22.

As well shown in FIGS. 3 and 4 , the case 21 has an accommodation space 211 communicating fluidly with the pocket member 1, and the drug D is stored in the accommodation space. A drug outlet 211a is formed to communicate the accommodation space 211 and the subcutaneous layer C so as to flow into the subcutaneous layer C via the 211.

The pressing member 22 is installed in the case 21 so as to be able to move up and down, and pressurizes the drug D accommodated in the accommodation space 211 by an upward operation as shown in FIG. (C).

The drug injection port member 3 is installed in the drug discharge housing 2 to enable connection of a syringe for drug D injection, as shown in FIG. 6, and to the subcutaneous layer C. Connected to the injection part 31 and the drug storage pocket member 1 so that the injection part 31 and the internal space of the injection part 31 and the drug storage pocket member 1 can be communicated. It consists of a conduit portion (32).

As shown in FIGS. 4 and 5, the operating means 4 is for selectively opening and closing the drug outlet 211a and selectively lifting the pressing member 22, and may be implemented in various configurations, but the present embodiment In the example, a structure that is easy to carry and convenient and enables the user to inject the drug (D) without being pierced with a needle is adopted instead of the method of injecting the drug (D) by the user being pierced with a needle by a syringe.

That is, the operating means 4 includes an opening and closing member 41 made of a magnetic material and installed in the opening and closing chamber 212 so as to be able to move up and down, and a magnetic 42 generating magnetic force to the opening and closing member 41. So, as shown in FIG. 5, the opening and closing member 41 is lifted by the magnetic 42 that generates magnetic force in a skin contact method from the outside to open the drug outlet 211a, and when the magnetic force is removed as shown in FIG. 4 In this case, the opening/closing member 41 descends to its original position by its own weight and the elastic force of the spring 43 to close the drug outlet 211a.

In the hypodermic injection chamber unit having the function of storing and discharging the drug D according to one embodiment of the present invention having such a configuration, the drug D is stored in the required amount in the pocket member 1 for drug storage, , The drug (D) is injected subcutaneously by bringing the magnetic 42 close to the skin at any point in time when the user is required to inject the drug (D), thereby injecting the drug (D) without being pierced with a needle by a syringe It has the advantage of being able to receive a constant dose of the drug (D) without repetitive injection stabbing for a long time with one charge of the drug (D).

The drug outlet 211a is sufficient to provide a passage through which the drug D can be injected into the subcutaneous layer C in the accommodation space 211 of the case 21, but in this embodiment, it is separated from other spaces. It is preferable to be provided in a separate opening and closing room 212 communicating with the other space.

The pressing member 22 employed in this embodiment is made of a magnetic material similarly to the opening and closing member 41, so that the opening and closing member 41 can be moved up and down without a separate configuration for operating the pressing member 22. As it is configured to perform the lifting operation by the magnet 42, it is possible to simplify the configuration.

In this embodiment, a connection pipe 5 connecting the pocket member 1 for storing the drug and the housing 2 for discharging the drug to be fluidly connected to each other, and installed in the connection pipe 5, It is made including an on-off valve 51 for selectively moving.

In this embodiment having such a configuration, as shown in FIG. 5, when the magnet 42 approaches the skin by the user's manipulation at the time when medication is required, the on-off valve 51 closes the connection pipe 5. Since the pressure member 22 placed on the case 21 pressurizes the drug D contained in the accommodation space 211 in the state in which it is administered, only the amount present in the accommodation space 211 can be accurately administered. Conversely, in the state shown in FIG. 4 where the storage state of the drug (D) is maintained because there is no need for administration, the pocket member 1 for storing the drug Allows the drug (D) stored in to flow into the receiving space 211 of the case 21.

The on-off valve 51 may be implemented in various configurations, but in the present embodiment, it is made of a magnetic material and is installed in the connection pipe 5 so as to be able to move up and down, so that it rises by the magnetic 42 and When the passage inside the connection pipe 5 is closed and the magnetic force by the magnet 42 is removed, it is restored to its original position and the passage inside the connection pipe 5 is opened.

In this embodiment having such a configuration, the opening/closing member 41 for opening and closing the drug outlet 211a, the pressing member 22 for pressing the drug D to move toward the drug outlet 211a, and the opening/closing valve ( 51) can be simultaneously operated by the magnet 42 as one unit, thereby simplifying product configuration and slimming standards.

On the other hand, as well shown in FIGS. 1 and 7, this embodiment is intended to adjust the amount of the drug (D) to be accommodated in the accommodation space 211 of the case 21, the accommodation space ( 211) is disposed opposite to the pressing member 22 within the pressure member 22 to limit the size of the accommodation space 211 and the opening and closing chamber 212 is integrally provided with the amount control member 210 and the above It is rotatably installed in the case 21 and includes a position adjusting screw 6 screwed with the amount adjusting member 210, and the amount adjusting member 210 and the amount adjusting member 210 according to the rotation of the position adjusting screw 6 The size of the space between the pressing members 22 can be adjusted so that the amount of the drug D to be accommodated in the space can be smoothly adjusted.

In the drawing, reference numeral 61 is a screw portion enabling screw coupling between the position fixing screw and the amount adjusting member.

Although various embodiments of the present invention have been described above, this embodiment and the accompanying drawings only clearly show some of the technical ideas included in the present invention, and are included in the specification and drawings of the present invention. It will be apparent that all modified examples and specific embodiments that can be easily inferred by those skilled in the art within the scope of the technical idea are included in the scope of the present invention.

Claims

a pocket member for storing drugs, which is a part in which drugs are temporarily stored, and is disposed in a space in the human body such as the abdominal cavity and is made of a material capable of expansion and contraction;

In a state connected to the pocket member, a portion is located in the subcutaneous layer and the remaining portion is located in the muscle layer, and has an accommodation space fluidly communicating with the pocket member, so that the drug is introduced into the subcutaneous layer via the accommodation space. A case in which a drug outlet for communicating the accommodation space and the subcutaneous layer is formed, and a pressurizing member installed in the case so as to be liftable to pressurize the drug accommodated in the accommodation space by an upward operation so that the drug is discharged to the subcutaneous layer through the drug outlet. A housing for dispensing the drug comprising;

It is installed in the housing for drug injection to enable connection of a syringe for drug injection, and the injection unit located in the subcutaneous layer communicates with the injection unit and the internal space of the drug storage pocket member. a drug injection port member including a conduit connected to the pocket member for drug storage; and

A chamber unit for hypodermic injection having a function of storing and discharging a drug, comprising: an operating means for selectively opening and closing the drug outlet and selectively lifting the pressing member.
According to claim 1,

The accommodation space includes an opening and closing room in which the drug outlet is formed and is partitioned from other spaces and communicates with the other spaces,

The operating means is

An opening and closing that is installed in the opening and closing room to be movable and made of a magnetic material, rises by the magnetic force acting from the outside to open the drug outlet, and descends to the original position when the magnetic force is removed to close the drug outlet absence; And a magnet for generating the magnetic force; hypodermic injection chamber unit having a storage and discharge function of the drug comprising a.
According to claim 2,

The pressing member is made of a magnetic material, and the subcutaneous injection chamber unit having a storage and discharge function of the drug, characterized in that configured to be elevated by the magnet.
According to claim 2,

a connection pipe connecting the pocket member for storing the drug and the housing for discharging the drug to be fluidly connected to each other; and

A subcutaneous injection chamber unit having a storage and discharge function of a drug, characterized in that it comprises a; opening and closing valve installed in the connection pipe to selectively move the drug.
According to claim 4,

The on-off valve is made of a magnetic material and is installed in the connection pipe to be able to move up and down, so that it rises by the magnet to close the passage inside the connection pipe and returns to its original position when the magnetic force by the magnet is removed. A subcutaneous injection chamber unit having a function of storing and discharging drugs, characterized in that restored to open the passage inside the connecting tube.
According to claim 1,

In order to be able to adjust the amount of the drug to be accommodated in the accommodation space of the case, it is disposed opposite to the pressing member in the accommodation space to limit the size of the accommodation space together with the pressing member, and the opening and closing chamber is integrally provided A subcutaneous injection chamber unit having a function of storing and discharging a drug, characterized in that it comprises an amount control member and a position adjusting screw rotatably installed in the case and screwed with the amount control member.