WO2023038029A1

WO2023038029A1 - Brain wave measurement device

Info

Publication number: WO2023038029A1
Application number: PCT/JP2022/033451
Authority: WO
Inventors: 稔吉水; 康落合; 貞雄政吉
Original assignee: 住友ファーマ株式会社
Priority date: 2021-09-07
Filing date: 2022-09-06
Publication date: 2023-03-16
Also published as: CA3231722A1; CN117915837A; JP2024046663A; JP7429333B2; EP4400052A1; JPWO2023038029A1

Abstract

A problem of the present invention is to provide a wearable brain wave measurement device having a structure capable of both improving durability and improving fitting feeling to contribute to improvement of the quality of a measured brain wave signal. The present invention provides a brain wave measurement device wearable on the head of a living body, the device comprising: a housing unit at least including a central front-side member, a left front-side member, a right front-side member, and a back-side member, the housing unit having a curved shape to be disposed, when worn, along the head of the living body from the left-side head to the right-side head via the front head; at least one measurement electrode fixed on the back-side member to be in contact with the front head when worn; and a signal processing unit housed in the housing unit for processing an electric signal obtained via the measurement electrode, wherein the rigidities of the at least two members of the central front-side member, the left front-side member, the right front-side member, and the back-side member are different each other.

Description

Electroencephalogram measuring device

The present invention relates to an electroencephalogram measurement device, and more particularly to an electroencephalogram measurement device that can measure electroencephalograms while attached to the head of a living body.

As a wearable electroencephalogram measurement device (wearable electroencephalograph) for measuring electroencephalograms by wearing it on the head of a living body such as a human body, Patent Document 1 (Non-Patent Document 1), Non-Patent

Documents

2 and 3, device is known. The electroencephalogram measuring apparatus of Patent Document 1 (Non-Patent Document 1) has two electrodes on the frontal region side and has a double band structure consisting of an outer band and an inner band. Each is an integral part (FIG. 16 of Patent Document 1), and the device of Patent Document 1 (Non-Patent Document 1) has a problem with wearing comfort. The electroencephalogram measurement device of Non-Patent Document 2 is a hair band type device with two electrodes on the frontal side, but the device has a problem in durability because it is a hair band type using a soft material. In addition, the device of Non-Patent Document 2 is considered to have a high risk of failure such as disconnection. The electroencephalogram measurement device of Non-Patent Document 3 has a structure in which a large number of electrodes protrude from the main body. There is a risk that the electrodes on the forehead side may not be sufficiently fixed because the device is attached to the body, and in the device of Non-Patent Document 3, many wires from many electrodes protrude from the main body Therefore, the device of Non-Patent Document 3 also has a problem in durability.

Conventional wearable electroencephalographs, such as hairband-type electroencephalographs that use soft materials, are the mainstream, but they are inferior in durability and have a high frequency of breakdowns such as disconnection. On the other hand, if a wearable electroencephalograph with a housing structure made of hard materials is used to increase durability, it will be suitable for all people's heads because the shape of the head varies from person to person. It is difficult to produce an electroencephalograph that does so. There are problems such as unstable signal quality due to insufficient contact of the electrodes with the head, or effects on electroencephalograms due to pain felt by the subject.

U.S. Pat. No. 9,867,571

In view of the above, it is an object of the present invention to provide a wearable electroencephalogram measurement device having a structure capable of achieving both improved durability and improved fit in order to contribute to the improvement of the quality of electroencephalogram signals to be measured. and

In order to solve the above problems, the present invention is an electroencephalogram measurement device that can be worn on the head of a living body, and includes at least a central front side component, a left front side component, a right front side component, and a back side component, and has a left side when worn. A housing portion having a curved shape so as to be arranged along the living body head from the head to the forehead to the right side of the head, and at least one measurement electrode fixed to the back side part and in contact with the forehead when worn. and a signal processing unit accommodated in the accommodation unit for processing electrical signals obtained through the measurement electrodes, at least two of a central front component, a left front component, a right front component, and a back component. To provide an electroencephalogram measuring device in which two parts have different rigidity.

In the above electroencephalogram measurement device, the number of measurement electrodes may be at least two or more.

In the above electroencephalogram measurement device, the rigidity of the left front part and the right front part may be higher than the rigidity of the center front part.

In the above electroencephalogram measurement device, when the number of measurement electrodes is two or more, the centers of the surfaces of the measurement electrodes that come into contact with the forehead when worn are on the left and right sides of each other by 40 mm or more and 90 mm or less along the shape of the back side part. may be spaced apart.

In the above electroencephalogram measurement device, the contour of the surface of the measurement electrode that contacts the forehead when worn may have a circular shape with a diameter of 10 mm to 25 mm.

In the above electroencephalogram measurement device, the signal processing section may be arranged between the left front side component and the back side component, or between the right front side component and the back side component.

By using the electroencephalogram measurement apparatus of the present invention, the risk of disconnection of the conductors connecting the electrodes and the signal processing unit is reduced, the durability is improved, and the user (test subject) wears the device comfortably. It can improve the quality of EEG signal.

1 is a schematic diagram of an electroencephalogram measurement apparatus according to an embodiment of the present invention (a diagram viewed obliquely from the front of a user wearing the device); FIG. 1 is a schematic diagram of an electroencephalogram measuring apparatus according to an embodiment of the present invention (viewed obliquely from behind the user wearing the device); FIG. FIG. 1 is a schematic diagram of an electroencephalogram measurement device that is an embodiment of the present invention (a top view of a user wearing the device). FIG. 1 is a schematic diagram of an electroencephalogram measurement device that is an embodiment of the present invention (viewed from below by a user wearing the device). FIG. 1 is a schematic diagram of an electroencephalogram measurement device that is an embodiment of the present invention (viewed from the right ear side of a user wearing the device). 1 is a schematic diagram of an electroencephalogram measurement device that is an embodiment of the present invention (viewed from the left ear side of a user wearing the device). FIG. 1 is a schematic diagram of an electroencephalogram measurement device that is an embodiment of the present invention (a form worn on a user's head). Schematic diagram of a wearing auxiliary band. FIG. 3 is an exploded view (perspective view) when the housing section is disassembled into components. FIG. 3 is an exploded view (perspective view) when the housing section is disassembled into components. FIG. 3 is an exploded view (perspective view) when the housing section is disassembled into components. FIG. 3 is an exploded view when the housing section is disassembled into each component (a top view of the user wearing the device); 1 is a block diagram showing the configuration of an electroencephalogram measurement apparatus that is an embodiment of the present invention; FIG. FIG. 2 is a block diagram showing the configuration of a data collection terminal device; 4 is a flow chart showing the operation of the electroencephalogram measuring device and the data collection terminal device according to one embodiment of the present invention.

An electroencephalogram measurement apparatus, which is an exemplary embodiment of the present invention, will be described below with reference to the drawings. However, it should be noted that the electroencephalogram measurement apparatus according to the present invention is not limited to the specific embodiments described below, and can be appropriately modified within the scope of the present invention. Individual functions, elements, and the like included in the embodiments described later can be appropriately deleted or changed within the scope of the present invention (for example, in FIG. The electroencephalogram measurement apparatus may be implemented without a communication unit by storing in a memory device), and arbitrary functions, elements, etc. not included in the embodiments may be added within the scope of the present invention. be. For example, in the following embodiments, it is assumed that the storage section is composed of four parts, namely, a central front part, a left front part, a right front part, and a back part. (For example, the central front side part may be disassembled into two parts). In addition, although it is preferable that the material of each component of the housing part is an insulator, at least a part of each component is made of metal or the like as long as short circuits between electrodes and circuit elements do not occur. It may be configured including a conductive material. Each component may be made of any material including silicon, rubber, plastic, resin, or may be made of any plurality of materials, and each component may be further divided into two or more parts. It may be decomposable. Unless otherwise specified, all components related to the electroencephalogram measuring device, not limited to the component parts of the housing section, can be made of any material and can be decomposed into any number of elements. In the following embodiments, the number of measurement electrodes is described as 2, but the number of measurement electrodes can be changed to any number of 1 or more, such as 1 or 3 or more. Also, the position of the measuring electrode is arbitrary. The number of reference electrodes and ground electrodes can also be changed arbitrarily (at least one of them need not be provided as long as the electroencephalogram measuring apparatus operates). As the attachment assisting band, any band can be used without being limited to the mode shown in the embodiment, and the electroencephalogram measurement apparatus 1 can be implemented without using the attachment assisting band. Various functional units that perform signal processing, etc., which will be described later, can be realized by any configuration such as an ASIC (application specific integrated circuit), an embedded system, a microcomputer, or the like. Digital information processing may be performed by providing a processing unit (central processing unit), a memory device, or the like. In addition, the user in the following embodiments may be any living creature including humans, and the size of the whole electroencephalogram measurement apparatus and the size of each component are also arbitrary.

1 to 6 show an electroencephalogram measurement device according to an embodiment of the present invention from the front diagonally below (FIG. 1), the rear diagonally below (FIG. 2), the top (FIG. 3), and the bottom. 4, right ear side (FIG. 5), and left ear side (FIG. 6). FIG. It is the schematic which shows the aspect with which the user's head was mounted|worn. As shown in FIG. 7, the user wears the electroencephalogram measuring device 1 so that the electroencephalogram measuring device 1 is arranged along the user's head from the left temporal region to the frontal region and then to the right temporal region. A reference electrode 8 placed inside (assumed to be made of an insulating material) (a reference electrode 8 is placed on each of the parts on both sides of the clip-like member, a total of two reference electrodes 8 being placed). , collectively referred to as a reference electrode 8 in the following description)) is held in contact with the ear by a clip-like member. As described above, the size of the electroencephalogram measurement device 1 is arbitrary, but in one example, the height (length in the short side direction when the electroencephalogram measurement device 1 is viewed as shown in FIGS. 5 and 6) is 30 mm, and the width (Fig. 3. The length in the left-right direction when looking at the electroencephalogram measurement device 1 as shown in FIG. This is the length in the vertical direction when looking at 1, and the length in the front-rear direction of the user when wearing it) can be 150 mm (excluding protrusions and legs).
When the electroencephalogram measurement device 1 is worn on the head, the storage section extends in a belt shape along the head toward the left and right auricles, and the left and right ends of the storage section extend toward the left and right ears, respectively. It will be located near the top of the via. When the electroencephalogram measurement device 1 is viewed from above, the curvature near the ends is smaller than the curvature at the central portion, and the thickness in the normal direction is the smallest at the approximately central portion of the accommodating portion. , the width in the vertical direction is also minimum. The reference electrode 8 may be provided at one end in the longitudinal direction of the accommodating portion.

The electroencephalogram measurement device 1 includes a right front part 2, a central front part 3, a left front part 4, and a back part 5. When worn, the electroencephalogram measurement device 1 moves the user's head from the left head to the front head to the right head. and at least one measuring electrode 6, 7 (in this embodiment the measuring electrodes The number of measurement electrodes is set to 2, but as described above, the number of measurement electrodes may be any number of 1 or more. a signal processing unit (see a signal processing unit 25 in FIG. 13 described later) housed in the housing unit for processing. As will be explained in more detail below, the stiffness of at least two of the central front part 3, the left front part 4, the right front part 2 and the back part 5 are different from each other, in one example the stiffness of the right front part 2. and the left front part 4 are higher than the rigidity of the central front part 3 (more preferably, the rigidity of the right front part 2 and the left front part 4 are higher than the rigidity of the back part 5 material and shape of each part are selected. That is, the rigidity of the part can be appropriately set by selecting the material and cross-sectional shape of the part. 1 to 12 are schematic diagrams, and the dimensions and the like of each part in the electroencephalogram measurement device 1 are not limited to the examples of these drawings, but in one example, the circumferential length of the central front side part 3 is It may be about 30% to about 50% of the circumferential length of the electroencephalogram measurement device 1 (excluding protrusions and legs; the same shall apply hereinafter), and the circumferential length of the left front side component 4 is equal to the circumference of the electroencephalogram measurement device 1. The circumferential length of the right front component 2 may be about 25% to about 35% of the circumferential length of the electroencephalogram measurement device 1 . The circumferential length of the left front component 4 and the circumferential length of the right front component 2 may be equal to or different from each other.

The measurement electrode 6 is connected to the signal processing section 25 via a (covered) lead wire, and the measurement electrode 7 is also connected to the signal processing section 25 via a (covered) lead wire. The electroencephalogram measuring device 1 further comprises a reference electrode 8 which is connected to the signal processor 25 via a (coated) reference electrode lead wire (conductor) 9 . In addition, when a ground electrode (GND electrode) is provided in the electroencephalogram measurement apparatus 1 (GND electrode 24 in FIG. 13 described later). A reference potential in operation 1 can be applied, and this reference potential can be used as a reference for the potentials of the other electrodes.) The ground electrode is connected to the signal processor 25 via a (coated) conductor. is connected with Each of these electrodes is configured to be separately connected to the signal processing section 25 to input an electrical signal to the signal processing section 25 (a (coated) lead wire extends separately from each electrode to perform signal processing). It is connected to a separate terminal of the part 25. The risk of disconnection is reduced by wiring each (covered) lead wire so that the (covered) lead wire other than the reference electrode lead wire 9 passes only through the inside of the housing part. (There are cases where the ground electrode 24 is in contact with something other than the head, so wiring inside the housing is not essential.), and the electrodes are not short-circuited. Note Although the material of each electrode is arbitrary, in one example, stainless steel, silver-silver chloride (Ag/AgCl), or silver can be used as the electrode material.

The shape of the measuring electrode 6 and the measuring electrode 7 is arbitrary, but in one example, the contour of the surface that contacts the user's forehead when worn (see FIG. 2) has a circular shape with a diameter of 10 mm to 25 mm. (This also applies to the case where three or more measurement electrodes are provided. Alternatively, appropriate adjustments may be made, such as providing a concave portion in a part of the circular shape.). The shape of the surface that contacts the forehead (forehead) of the user when the

measurement electrodes

6 and 7 are worn is also arbitrary. For example, as shown in FIGS. The surface that contacts the forehead may be at least partially recessed from the user's point of view) or a convex surface (the surface that contacts the forehead is at least partially protruding from the user's point of view when wearing it). However, in order to give the user a good wearing feeling, it is preferable to use a shape other than a convex surface (the same applies to the case where three or more measurement electrodes are provided). By shaping the

measurement electrodes

6 and 7 so as to conform to the user's forehead, the area of contact is increased and the accuracy of electroencephalogram measurement can be improved. The shape and size of the reference electrode 8 and the ground electrode 24 may also be the same and are arbitrary. Also, the centers of the surfaces (see FIG. 2) of the

measurement electrodes

6 and 7 that come into contact with the forehead when worn are aligned along the shape of the back side part 5 (from the directions of FIGS. It is preferable to arrange the measuring

electrodes

6 and 7 so that they are separated from each other by 40 mm or more and 90 mm or less to the left and right (along the curve drawn by the back side part 5 when viewed from above) (even if three or more measuring electrodes are provided, each measuring electrode may be spaced similarly). The distance between the

measurement electrodes

6 and 7 is preferably about 20% of the front temporal head circumference (the length of the head circumference on the front side of the center of both ears). The user should wear the electroencephalogram measurement device 1 so that the midpoint between the center points of the surfaces that contact the head is positioned at the center of the forehead, that is, on (extended line of) the user's nasal bridge. is preferable), and as a result of measuring the frontal temporal circumference of a plurality of people, it is considered that the length of 20% of the frontal temporal circumference is generally within the range of 40 mm to 90 mm. For example, as an example of the positions of the measuring

electrodes

6 and 7, the positions Fp1 and Fp2 of the International 10-20 method may be used.

A power button 10 is provided as an operation unit on the right front component 2, and when the user presses the power button 10, the operation of the electroencephalogram measurement device 1 is switched between on (operating state) and off (stopped state). In addition, a display LED (light emitting diode) 11 is provided on the right front side component 2, and the lighting, extinguishing, blinking, and emission color are switched according to the operating state and charging state. The right component 2 is also provided with a charging port (charging port) 12. By opening the charging port cover 13 and connecting the charging cable to the charging port 12, the lithium ion battery of the power supply unit 32 (see FIG. 13) can be charged. can be charged. A (right) non-slip sheet 14 and a (left) anti-slip sheet 15 are provided at a position corresponding to the right front side part 2 and the left front side part 4, respectively, in the back side part 5. To prevent an electroencephalogram measurement device 1 from being deviated from the head in a state of being worn on the head of a person. Although any material can be used for the

non-slip sheets

14 and 15, urethane, silicone, or the like can be used as the material for the

non-slip sheets

14 and 15 in one example. A (right) auxiliary band mounting hole 16 is provided at the end of the back side component 5 on the right front side component 2 side, and a (left) auxiliary band mounting hole 17 is provided at the end of the back side component 5 on the left front side component 4 side. One end and the other end of an auxiliary mounting band (belt) 19 shown in FIG. 8, the ring-shaped member 20 in the shape of a rectangular ring attached to one end of the hook-and-loop fastener hook portion 21A side is turned sideways (the hook-and-loop fastener hook portions 21A and the hook-and-loop fastener loop portions 21B on both ends are The ring-shaped member 20 is passed through the auxiliary band mounting hole 16, and the ring-shaped member 20 on the side of the hook-and-loop fastener hook portion 21A at the other end is turned sideways, and the ring-shaped member 20 is inserted into the auxiliary band mounting hole. 17, and the respective hook-and-loop fastener hook portions 21A are folded back and attached to the hook-and-loop fastener loop portions 21B).

FIGS. 9 to 12 are exploded views of the accommodation section when it is disassembled into components (FIGS. 9 to 11 are perspective views, and FIG. 12 is a top view of the user wearing the device). By dividing the front side part in this way, the user's wearing comfort is improved. In one example, the signal processing unit 25 and the communication unit 29 shown in FIG. The circuit board is placed in the circuit board accommodation position 22 (the position of the circuit board is arbitrary, preferably between the left front component 4 and the back component 5 or between the right front component 2 and the back component 5). In a mode in which the rigidity of the left front component 4 and the rigidity of the right front component 2 are higher than the rigidity of the central front component 3 and higher than the rigidity of the back component 5, such a circuit board arrangement The circuit board is protected from impact by removing the The right front part 2, the central front part 3, the left front part 4, and the back part 5 are manufactured by selecting materials, shapes, etc., so that at least two of them have different rigidity. 2 and the left front part 4 are preferably made higher than the central front part 3 and the back part 5 respectively. A reinforcing member can be used for screwing the central front part 3 and the back part 5 .

The term "rigidity" in this embodiment is defined by the Young's modulus (longitudinal elastic modulus) of the material and the geometrical moment of inertia due to the cross-sectional shape in the case of a member of a certain length. That is, under the premise that the length of the parts is the same, in the case of parts with the same cross-sectional shape, if the Young's modulus of the material of one part is higher than that of another part, or if the Young's modulus of the same Young's modulus In the case of material parts, if the area moment of inertia of one part is greater than the area moment of inertia of another part, then "the rigidity of one part is higher than the rigidity of another part". However, in this embodiment, the contribution of the Young's modulus due to the material to the rigidity of the part is greater than the geometrical moment of inertia due to the cross-sectional shape. That is, it is primarily through proper selection of materials for each part that a more suitable stiffness for each part is achieved. As a method for measuring the Young's modulus, for example, the right front part 2 is punched, the width in the plane direction (the direction of the plane that is approximately parallel to the back side part 5 when the housing part is formed) is about 1.8 mm, and the width in the plane direction (strictly A sample with a thickness of about 0.1 mm in the direction perpendicular to the curved surface but approximately flat) is prepared and used as a test sample. Using Shimadzu precision universal testing machine Autograph AG-IS MS type manufactured by Shimadzu Corporation, a tensile test was performed in physiological saline at 20 ° C. Young's modulus (MPa) was calculated as the tensile elastic modulus from the stress-elongation curve. The Young's modulus of the right front side component 2 can be measured by calculation (pulling speed is 100 mm/min). The Young's modulus of other parts such as the central front part 3, the left front part 4, the back part 5, etc. can be similarly measured (the "plane direction" in the sample of the back part 5 is, for example, the direction of the sample of the right front part 2). It may be the direction of a plane that is approximately parallel to the “plane direction”). The materials of the right front part 2, the central front part 3, the left front part 4, and the back part 5 are arbitrary, and the Young's modulus values of these parts may be arbitrary values, but in one example,
The Young's modulus (tensile modulus) of the central front side part 3 is 49.5 MPa (megapascal) (manufactured by DuPont Toray Co., Ltd. Material: Thermoplastic polyester elastomer Hytrel (registered trademark) Grade: 4047N. The test method is JIS K7113-1995. compliant),
The Young's modulus (tensile modulus) of both the right front part 2 and the left front part 4 is 2550 MPa (megapascal) (Mitsubishi Engineering Co., Ltd. Material: PBT resin (polybutylene terephthalate resin) NOVADURAN (registered trademark) grade : 5010R5.The test method conforms to ISO 527-1, 527-2),
The Young's modulus (tensile modulus) of the back side part is 1350 MPa (megapascal) (manufactured by Japan Polypropylene Corporation, material: PP (polypropylene) Novatec (registered trademark), grade: BC4BSW. The test method conforms to JIS K7161 7162:1994).
Each part can be manufactured as follows (the physical properties of each material are the specification values published by the manufacturer, so the test methods are different, but the size relationship of Young's modulus remains unchanged even if the test method is unified).
The moment of inertia of area can be determined from the cross-sectional shape by a known formula. By reducing the thickness in the normal direction of the central front side part 3 positioned substantially at the center of the housing portion, the cross-sectional shape of the central front side part 3 has a smaller geometrical moment of inertia, and the rigidity is further reduced. can be done.

FIG. 13 is a block diagram showing the configuration of an electroencephalogram measurement device that is an embodiment of the present invention, and FIG. 14 is a block diagram showing the configuration of a data collection terminal device. In this embodiment, electroencephalogram data obtained by measurement by the electroencephalogram measurement device 1 is transmitted from the electroencephalogram measurement device 1 to the data collection terminal device 33, and analysis processing of the electroencephalogram data, etc. are performed in the data collection terminal device 33. and

The electroencephalogram measuring apparatus 1 shown in FIG. 13 includes N (N is a natural number of 1 or more) measuring electrodes 6 to 23 (if there is only one measuring electrode, the measuring electrode 23 is unnecessary), and REF It has an electrode (reference electrode) 8 , a GND electrode (ground electrode) 24 , a signal processing section 25 , a communication section 29 , an operation section 10 , a display LED 11 and a power supply section 32 . As already described, each electrode is separately connected to the signal processing section 25 , and an electric signal from each electrode is input to the amplifier circuit 26 of the signal processing section 25 .

The signal processing unit 25 includes an amplifier circuit 26, an A/D converter (Analog-to-Digital Converter) 27, and a digital signal processing unit 28. The amplifier circuit 26 is a circuit that amplifies biopotentials input as electrical signals from various electrodes, measures the potential difference between the measurement electrode 6 and the reference electrode 8, amplifies this potential difference, and converts it into an A/D signal. Output to the converter 27, measure the potential difference between the measurement electrode 7 and the reference electrode 8, amplify the potential difference, and output to the A/D converter 27 (the number of measurement electrodes is 3 or more). The A/D converter 27 is a conversion circuit that converts an analog signal into a digital signal. Output. In one example, the digital signal processing unit 28 is composed of memory devices such as a CPU, RAM (Random Access Memory), ROM (Read Only Memory), etc., as described above, and the A/D converter 27 By processing the digital signal input from, for example, a digital signal indicating the potential difference between the measuring electrode 6 and the reference electrode 8 as a numerical value, or the potential difference between the measuring electrode 7 and the reference electrode 8 as a numerical value (similarly when the number of measurement electrodes is 3 or more), and outputs these digital signals to the communication circuit 31 of the communication unit 29 . In addition, the digital signal processing unit 28 executes FFT (Fast Fourier Transformation) on the digital signal input from the A/D converter 27 by the CPU executing the program stored in the memory device. A digital signal indicating the obtained result may be output to the communication circuit 31 of the communication unit 29 by performing such processing.

The communication unit 29 includes an antenna 30 and a communication circuit 31. The communication circuit 31 transmits the digital signal input from the digital signal processing unit 28 to the data collection terminal device 33 via the antenna 30 . In one example, the communication unit 29 wirelessly communicates with the communication unit 42 of the data collection terminal device 33 using a BLE (Bluetooth Low Energy) system.

As already described, the operation unit 10 is the power button 10, and when the user presses the power button 10, the operation of the electroencephalogram measurement device 1 is switched between on (operating state) and off (stopped state). The display LED 11 is switched between lighting, extinguishing, blinking, and emission color according to the operating state and charging state. The power supply unit 32 includes a lithium ion battery, a circuit for supplying electric power to each part of the electroencephalogram measurement apparatus 1, and the like, and is arranged in the housing unit.

　The data collection terminal device 33 shown in FIG.

The control unit 34 includes a CPU 35 and a RAM 36 as temporary memory. By executing the measurement program 38 recorded in the storage unit 37 by the CPU 35, the CPU 35 processes the electroencephalogram measurement data received from the electroencephalogram measurement device 1 and performs various measurement processes (the above-described FFT is performed by the data collection terminal device). When the measurement is performed on the 33 side, a program for executing the FFT is stored in the storage section 37 as the measurement program 38). The CPU 35 also executes and controls various operations of the data collection terminal device 33 by executing various programs 39 such as an OS (Operating System) and various applications stored in the storage unit 37 .

The storage unit 37 is a recording device equipped with a hard disk drive, SSD (Solid State Drive), etc., and stores the measurement program 38 and various programs 39 described above. The storage unit 37 also stores measurement data 40 (analysis result data obtained by executing FFT processing, etc.) and various data 41 .

The communication unit 42 includes an antenna 43 and a communication circuit 44. The communication circuit 44 performs data transmission/reception such as reception of electroencephalogram measurement data from the electroencephalogram measurement device 1 via the antenna 43 . In one example, the communication unit 42 wirelessly communicates with the communication unit 31 of the electroencephalogram measurement device 1 using the BLE method.

The input/output unit 45 includes a keyboard 46 and a mouse 47 for the operator of the data collection terminal device 33 (person who analyzes electroencephalogram measurement data) to input commands and data to the data collection terminal device 33, and various displays. A display device 48 (liquid crystal display device, organic electroluminescence (EL: organic electroluminescence) display device, etc.) is provided. In addition, the input/output unit 45 may include an output device such as a speaker.

The power supply unit 49 includes a circuit or the like for receiving power from an external power supply to supply power to each unit of the data collection terminal device 33, and may include a battery such as a lithium ion battery.

FIG. 15 is a flow chart showing the operation of the electroencephalogram measurement device and the data collection terminal device according to one embodiment of the present invention. First, the user (examination subject) of the electroencephalogram measurement apparatus 1 activates the electroencephalogram measurement apparatus 1 by continuously pressing the power button 10 for about 1 to 2 seconds (step S101). It is assumed that the data collection terminal device 33 has already started. When the electroencephalogram measurement device 1 is activated, on the condition that the BLE connection is enabled on the data collection terminal device 33 side, communication between the communication unit 29 of the electroencephalogram measurement device 1 and the communication unit 42 of the data collection terminal device 33 A BLE connection is established (step S102). A user of the electroencephalogram measurement device 1 wears the electroencephalogram measurement device 1 on his or her head as shown in FIG. They are brought into symmetrical contact with each other from the center line of the ear, and the reference electrode 8 is brought into contact with their ear. When the electroencephalogram measurement apparatus 1 is provided with the ground electrode 24, the ground electrode 24 is brought into contact with the subject's head or body at an arbitrary position.

In this state, the potential difference between the potential of the measuring electrode 6 and the potential of the reference electrode 8 is amplified by the amplifier circuit 26, and the amplified analog signal is converted to a digital signal by the A/D converter 27, and the A/D The digital signal generated by the conversion by the converter 27 is processed by the digital signal processing unit 28 (step S103), and the time change of the potential difference between the potential of the measurement electrode 6 and the potential of the reference electrode 8 generated thereby. is transmitted from the communication unit 29 of the electroencephalogram measurement device 1 to the communication unit 42 of the data collection terminal device 33 (step S104). Similarly, the potential difference between the potential of the measuring electrode 7 and the potential of the reference electrode 8 is amplified by the amplifier circuit 26, and the amplified analog signal is converted to a digital signal by the A/D converter 27, and the A/D converter The digital signal generated by the conversion by 27 is processed by the digital signal processing unit 28 (step S103), and the time change of the potential difference generated thereby between the potential of the measurement electrode 7 and the potential of the reference electrode 8 is obtained. The indicated digital signal is transmitted from the communication unit 29 of the electroencephalogram measurement device 1 to the communication unit 42 of the data collection terminal device 33 (step S104). Similarly, when there are three or more measurement electrodes, a digital signal indicating the temporal change in potential difference between the potential of each measurement electrode and the potential of the reference electrode 8 is generated and sent from the communication unit 29 of the electroencephalogram measurement apparatus 1 to the data collection terminal. It is transmitted to the communication unit 42 of the device 33 . These processes on the side of the electroencephalogram measurement device 1 are performed at predetermined time intervals unless the electroencephalogram measurement device 1 is turned off by pressing the power button 10 of the electroencephalogram measurement device 1 again for about 1 to 2 seconds. It continues to be repeatedly performed (NO in the determination process of step S105). When the CPU 35 of the data collection terminal device 33 starts executing the measurement application (assumed to be included in the measurement program 38) in response to an input by the operator of the data collection terminal device 33, the CPU 35 executing the measurement program 38 Based on the digital signal received from the electroencephalogram measurement device 1, each channel (in one example, the potential difference between the potential of the measuring electrode 7 and the potential of the reference electrode 8 is the potential difference of the channel 1, and the potential of the measuring electrode 6 and the reference The potential difference between the electrode 8 and the potential difference of the channel 2) continues to be stored in the storage unit 37 as the measurement data 40. According to the input of the operator of the data collection terminal device 33 (the tap of the measurement end button on the display device 48), the storage of the electroencephalogram data in the storage unit 37 is terminated, and the operator of the data collection terminal device 33 inputs The BLE connection between the electroencephalogram measurement device 1 and the data collection terminal device 33 is released (disconnected) in response to (disconnection of the communication connection with the electroencephalogram measurement device 1). When the power button 10 of the electroencephalogram measurement device 1 is pressed again for about 1 to 2 seconds to turn off the power of the electroencephalogram measurement device 1 (YES in the determination process of step S105), the operation of the electroencephalogram measurement device 1 is stopped. (Step S106)

As an example of the electroencephalogram measurement apparatus of the present invention, an electroencephalogram measurement apparatus having the following configuration was manufactured and performance tests were conducted.
(Electroencephalogram measurement device of the embodiment)
・Shape: the shape shown in FIGS. 9 to 12 ・Number of measurement electrodes (forehead electrodes): 2 (CH1, CH2)
・ Spacing between forehead electrodes (between the centers of the contact surfaces): 60 mm
・Shape of forehead electrode: Flat type, outline of contact surface is circular with a diameter of 15 mm ・Shape of reference electrode (ear electrode): Concave shape, outline of contact surface is circular with a diameter of 15 mm ・Materials of each component of the housing (Central front part 3) Thermoplastic polyester elastomer Hytrel (registered trademark) manufactured by Toray DuPont, grade: 4047N. Young's modulus 49.5 MPa (test method conforms to JIS K7113-1995)
(Right front part 2 and left front part 4) Mitsubishi Engineering PBT resin (polybutylene terephthalate resin) NOVADURAN (registered trademark) grade: 5010R5. Young's modulus 2550 MPa (test method conforms to ISO 527-1, 527-2)
(Back side part) Made by Japan Polypro Co., Ltd. Material: PP (polypropylene) Novatec (registered trademark) Grade: BC4BSW. Young's modulus 1350 MPa (test method conforms to JIS K7161 7162: 1994)

When the test subject wore the electroencephalogram measurement device with the above configuration on his head and confirmed the fit, the contact with the forehead electrode was compared with the prototype of the convex curved electrode (15 mm in diameter) and the concave curved electrode (20 mm in diameter). The pinching strength of the ear electrode was improved compared to the prototype with a flat diameter of 11 mm, and the feeling of tightness around the temple was reduced and the pain was eliminated by selecting the above material.

Furthermore, an electroencephalogram measurement test was performed on a subject using the electroencephalogram measurement apparatus configured in the above embodiment, and the result was compared with an electroencephalogram measurement test performed using an existing measurement apparatus, Polymate (registered trademark) (Miyuki Giken Co., Ltd.). We verified the consistency of The correlation coefficients of both test results are shown in Tables 1-4 below.

As described above, the electroencephalogram measurement device of the example gave good results in terms of both the subject's wearing comfort and the consistency of the measurement results with the existing electroencephalogram measurement device.

The present invention can be used for electroencephalogram measurement in any industry, including medical equipment and research equipment.

1 electroencephalogram measurement device 2 right front part 3 central front part 4 left front part 5 back part 6 (right) measurement electrode (forehead electrode)
7 (left side) measurement electrode (forehead electrode)
8 reference electrode (REF electrode, ear electrode)
9 (coated) reference electrode lead wire 10 power button (operator)
11 display LEDs
12 Charging port 13 Charging port lid 14 (Right side) Non-slip sheet 15 (Left side) Non-slip sheet 16 (Right side) Auxiliary band mounting hole 17 (Left side) Auxiliary band mounting hole 18 Human head 19 Attachment auxiliary band 20 Ring-shaped member 21A Velcro (hook)
21B hook-and-loop fastener (loop)
22 Circuit board accommodation position 23 Nth measurement electrode (N is 2 or more)
24 ground electrode (GND electrode)
25 signal processing unit 26 amplifier circuit 27 A/D (analog/digital) converter 28 digital signal processing unit 29 communication unit 30 antenna 31 communication circuit 32 power supply unit (lithium ion battery, etc.)
33 data collection terminal device 34 control unit 35 CPU
36 RAMs
37 storage unit 38 measurement program 39 various programs 40 measurement data 41 various data 42 communication unit 43 antenna 44 communication circuit 45 input/output unit 46 keyboard 47 mouse 48 display device 49 power supply unit

Claims

An electroencephalogram measurement device that can be attached to the head of a living body,
It includes at least a central front part, a left front part, a right front part, and a back part, and is curved to be arranged along the living body head from the left temporal region to the frontal region to the right temporal region when worn. a container having a shape;
at least one measurement electrode fixed to the back part and in contact with the forehead when worn;
a signal processing unit accommodated in the accommodation unit for processing an electrical signal obtained through the measurement electrode;
At least two of the central front side part, the left front side part, the right front side part, and the back side part have different rigidity,
Electroencephalogram measurement device.
The electroencephalogram measurement device according to claim 1, wherein the number of said measurement electrodes is at least two.
The electroencephalogram measurement device according to claim 1 or 2, wherein the rigidity of the left front part and the right front part is higher than the rigidity of the central front part.
4. Any one of claims 2 and 3, wherein the respective centers of the surfaces of the measurement electrodes that come into contact with the forehead when worn are laterally separated from each other by 40 mm or more and 90 mm or less along the shape of the back side part. The electroencephalogram measurement device according to item 1.
The electroencephalogram measurement device according to any one of claims 1 to 4, wherein the contour of the surface of the measurement electrode that contacts the forehead when worn has a circular shape with a diameter of 10 mm to 25 mm.
The electroencephalogram measurement according to any one of claims 1 to 5, wherein the signal processing unit is arranged between the left front component and the back component or between the right front component and the back component. Device.