WO2022191136A1 - Dispositif d'administration de liquide pharmaceutique - Google Patents
Dispositif d'administration de liquide pharmaceutique Download PDFInfo
- Publication number
- WO2022191136A1 WO2022191136A1 PCT/JP2022/009752 JP2022009752W WO2022191136A1 WO 2022191136 A1 WO2022191136 A1 WO 2022191136A1 JP 2022009752 W JP2022009752 W JP 2022009752W WO 2022191136 A1 WO2022191136 A1 WO 2022191136A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- drug
- administration device
- plunger
- plunger rod
- solution administration
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 10
- 238000003780 insertion Methods 0.000 claims abstract description 21
- 230000037431 insertion Effects 0.000 claims abstract description 21
- 239000000243 solution Substances 0.000 claims description 79
- 239000003814 drug Substances 0.000 claims description 23
- 229940079593 drug Drugs 0.000 claims description 18
- 239000008155 medical solution Substances 0.000 claims description 18
- 238000007789 sealing Methods 0.000 claims description 6
- 238000012377 drug delivery Methods 0.000 claims description 2
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 description 35
- POIUWJQBRNEFGX-XAMSXPGMSA-N cathelicidin Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C)C1=CC=CC=C1 POIUWJQBRNEFGX-XAMSXPGMSA-N 0.000 description 26
- 238000002347 injection Methods 0.000 description 12
- 239000007924 injection Substances 0.000 description 12
- 239000000126 substance Substances 0.000 description 11
- 230000001681 protective effect Effects 0.000 description 8
- 230000001149 cognitive effect Effects 0.000 description 5
- 210000000078 claw Anatomy 0.000 description 4
- 238000012790 confirmation Methods 0.000 description 4
- 230000004323 axial length Effects 0.000 description 3
- 239000013013 elastic material Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
Definitions
- such a drug delivery device includes a needle protection sleeve and a piston slidably provided in a casing, and a sleeve acting on the piston when discharging a drug solution. a shaped actuating member and a first spring acting on the actuating member.
- FIG. 19 is an overall cross-sectional view showing a state where the medicinal-solution administration device of FIG. 18 starts to pierce the skin; 22 is an enlarged cross-sectional view showing the vicinity of the proximal end of the drug-solution administration device of FIG. 21; FIG. FIG. 22 is an overall cross-sectional view showing a state in which puncturing of the skin by the drug-solution administration device of FIG. 21 is completed; 24 is an enlarged cross-sectional view showing the vicinity of the proximal end of the drug-solution administration device of FIG. 23; FIG. FIG. 24 is an overall cross-sectional view showing another cross-section of the drug-solution administration device after puncturing of FIG.
- the housing 12 is made of, for example, a resin material, and includes a cylindrical body 20 having a circular cross section and substantially constant outer diameter and inner diameter along the axial direction (directions of arrows A and B), and a base of the cylindrical body 20. It is composed of a sleeve body 22 accommodated on the end side (in the direction of arrow A) and an end cap 24 closing the proximal end of the cylindrical body 20 .
- the guide ribs 34 are, for example, provided at least three or more at equal intervals along the circumferential direction of the body main body 30, and have a substantially constant thickness along the inner periphery. They are formed in the same shape so that they linearly protrude radially inward from the surface and have the same protruding length in the radial direction from the inner peripheral surface.
- four guide ribs 34 are arranged at intervals of 90° with respect to the axial center of the main body 30, and a set of guide ribs 34 are arranged so as to face each other with the axial center of the main body 30 interposed therebetween. A case will be described.
- the rod body 84 has a circular cross-section, and a plurality of slide grooves 92 are formed on the outer peripheral surface thereof so as to be recessed radially inward and into which the guide ribs 34 of the sleeve body 22 are inserted.
- the slide grooves 92 are recessed, for example, in a rectangular cross-section with respect to the outer peripheral surface, and are provided at equal intervals in the circumferential direction corresponding to the number and arrangement of the guide ribs 34 .
- four slide grooves 92 corresponding to the guide ribs 34 will be described.
- the outer diameter D1 of the collar portion 96 of the flexible portion 86 is slightly larger than the inner diameter D2 of the main body 30 of the sleeve body 22 (D1>D2).
- a syringe holder 130 for holding the syringe 16 is formed with a pair of protrusions 142 protruding radially outward from the outer peripheral surface. 130 is held movably along the axial direction (directions of arrows A and B) inside the cover sleeve 14 together with the syringe 16 .
- the axial length L1 of this engaging hole 120 is formed to be greater than the axial length L2 of the outer hook 150 (L1>L2). That is, the outer hook 150 is engaged with the engagement hole 120 so as to be movable in the axial direction (directions of arrows A and B).
- the end cap 24 that constitutes the housing 12 has the shaft portion 78 that extends axially toward the distal end side (the direction of the arrow B).
- a plunger rod 82 accommodated in the interior of the plunger 12 so as to be movable in the axial direction (directions of arrows A and B) has a second rod hole 100 through which the shaft portion 78 is inserted.
- the shaft portion 78 is provided with a plurality of guide walls 78a projecting radially outward and extending in the axial direction. , and a second wall portion 79b provided in the vicinity of the tip of the shaft portion 78 with a width dimension W2 widened in the width direction with respect to the first wall portion 79a.
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Dispositif d'administration de liquide pharmaceutique (10) comprenant un bouchon d'extrémité (24) ayant une tige (78) pourvue d'une pluralité de parois de guidage (78a). La pluralité des parois de guidage (78a) comprend : de premières portions de paroi (79a) qui s'étendent dans le sens axial ; et de secondes portions de paroi (79b) qui sont plus larges dans un sens de la largeur par rapport aux premières portions de paroi (79a) et qui sont disposées à proximité d'une extrémité de pointe de la tige (78). Une extrémité de pointe d'une tige de piston (82) ayant de seconds trous de tige (100) à travers lesquels les parois de guidage (78a) respectives de la tige (78) sont insérées. Lorsque la tige (78) est insérée dans des rainures d'insertion (101) des seconds trous de tige (100), les premières portions de paroi (79a) sont libres de contact, tandis que les secondes portions de paroi (79b) se trouvent en contact avec les parois de rétention (102a, 102b) pour réduire la vitesse de mouvement de la tige de piston (82).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023505548A JPWO2022191136A1 (fr) | 2021-03-12 | 2022-03-07 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021040764 | 2021-03-12 | ||
| JP2021-040764 | 2021-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2022191136A1 true WO2022191136A1 (fr) | 2022-09-15 |
Family
ID=83226718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2022/009752 WO2022191136A1 (fr) | 2021-03-12 | 2022-03-07 | Dispositif d'administration de liquide pharmaceutique |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPWO2022191136A1 (fr) |
| WO (1) | WO2022191136A1 (fr) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017518791A (ja) * | 2014-05-07 | 2017-07-13 | アムジエン・インコーポレーテツド | 衝撃低減要素を有する自動注入器 |
| WO2019202128A1 (fr) * | 2018-04-19 | 2019-10-24 | Sanofi | Réduction de force dans des dispositifs d'injection |
| JP2020524529A (ja) * | 2017-06-22 | 2020-08-20 | アムジエン・インコーポレーテツド | デバイス起動による衝突／衝撃の低減 |
-
2022
- 2022-03-07 WO PCT/JP2022/009752 patent/WO2022191136A1/fr active Application Filing
- 2022-03-07 JP JP2023505548A patent/JPWO2022191136A1/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017518791A (ja) * | 2014-05-07 | 2017-07-13 | アムジエン・インコーポレーテツド | 衝撃低減要素を有する自動注入器 |
| JP2020524529A (ja) * | 2017-06-22 | 2020-08-20 | アムジエン・インコーポレーテツド | デバイス起動による衝突／衝撃の低減 |
| WO2019202128A1 (fr) * | 2018-04-19 | 2019-10-24 | Sanofi | Réduction de force dans des dispositifs d'injection |
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2022191136A1 (fr) | 2022-09-15 |
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