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WO2022160151A1 - 接驳装置、样本架操纵设备及自动检测系统 - Google Patents

接驳装置、样本架操纵设备及自动检测系统 Download PDF

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Publication number
WO2022160151A1
WO2022160151A1 PCT/CN2021/074069 CN2021074069W WO2022160151A1 WO 2022160151 A1 WO2022160151 A1 WO 2022160151A1 CN 2021074069 W CN2021074069 W CN 2021074069W WO 2022160151 A1 WO2022160151 A1 WO 2022160151A1
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WO
WIPO (PCT)
Prior art keywords
sample
sample rack
identification code
docking device
mirror
Prior art date
Application number
PCT/CN2021/074069
Other languages
English (en)
French (fr)
Inventor
左立党
杨丹明
Original Assignee
贝克曼库尔特实验系统（苏州）有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 贝克曼库尔特实验系统（苏州）有限公司 filed Critical 贝克曼库尔特实验系统（苏州）有限公司
Priority to PCT/CN2021/074069 priority Critical patent/WO2022160151A1/zh
Priority to US18/274,774 priority patent/US20240094235A1/en
Priority to EP21921771.8A priority patent/EP4286858A4/en
Publication of WO2022160151A1 publication Critical patent/WO2022160151A1/zh

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00792—Type of components bearing the codes, other than sample carriers
    • G01N2035/00801—Holders for sample carriers, e.g. trays, caroussel, racks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0412—Block or rack elements with a single row of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0412—Block or rack elements with a single row of samples
    • G01N2035/0415—Block or rack elements with a single row of samples moving in two dimensions in a horizontal plane
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/046—General conveyor features
    • G01N2035/0465—Loading or unloading the conveyor

Definitions

  • the present application relates to the field of medical technology, and more particularly, to a docking device, a sample rack manipulation device including the docking device, and an automatic detection system including the sample rack manipulation device.
  • the analysis and detection instrument usually includes a sample rack manipulation part, a sampling part and a detection part.
  • the sample rack manipulation part is used to transport the sample container to the sampling part, and the sampling part transfers the sample in the sample container to the detection part for detection.
  • a sample rack is used to receive, support, align, hold and/or carry one or more sample containers to ensure that the sample containers are positioned and/or transported within the analytical detector.
  • the sample rack handling device (sample rack handling section) is configured for loading, transporting and/or unloading one or more sample racks. In order to distinguish the individual sample containers and the sample holders, identification codes are applied to the sample holders and the individual sample containers.
  • a sample rack handling device which includes two code readers fixed to the rack. One reader is used to read the identification code on the sample rack, and the other is used to read the identification code on the sample container. Therefore, the cost of the sample rack handling device is high. In addition, each time the sample rack needs to be transported to the barcode reader to read the identification code of the sample rack, thus increasing the time and space required for transporting the sample rack.
  • sample holder handling device which includes a barcode reader and a mirror that can be rotated. After the barcode reader reads the identification code of the sample holder, the mirror needs to be rotated to a specific position to read the identification code on the sample container. Likewise, after reading the identification code on the sample container, the mirror needs to be rotated back so that it can read the identification code of the next sample holder. Therefore, the sample holder handling apparatus adds components for driving the mirror to rotate during operation, thereby increasing the cost.
  • a docking device for a sample rack handling apparatus is provided.
  • the docking device is adapted to transport sample racks containing sample containers between the loading/unloading area, the sampling area and the buffer area of the sample rack handling apparatus.
  • An identification code reading device is provided on the docking device, and the identification code reading device is adapted to be able to read the sample rack when the sample rack is loaded onto the docking device from the loading/unloading area. The identification code and/or the identification code of the sample container on this sample rack.
  • the docking device is integrated with an identification code reading device.
  • the identification code reading device can sequentially read the identification codes of the sample racks and the identification codes of the sample containers on the sample racks. Therefore, it is possible to save time and space for transporting the sample racks to the barcode reader fixed on the rack of the automatic detection system to read the sample racks.
  • the identification code reading device is an optical reading device. Optical pickups allow for more flexibility and lower cost in the design of docking devices.
  • the optical reading device comprises at least one barcode reader and at least one mirror, the barcode reader being configured to detect, by means of the mirror, an identification code of a sample holder and/or an identification code of a sample container. Reflection to read the identification code of the sample holder and/or the identification code of the sample container.
  • both the identification code of the sample rack and the identification code of the sample container can be read by one code reader. Therefore, the docking device according to the present disclosure can significantly reduce costs.
  • the mirror is fixedly mounted on a fixed structure of the docking device.
  • the docking device according to the present disclosure there is no need to rotate the mirror when reading the identification code of the sample holder and the identification code of the sample container. Therefore, the docking device according to the present disclosure does not need to include parts for driving the mirror to rotate, whereby the structure can be simplified and the cost can be reduced.
  • the mirror is adjustably mounted on a fixed structure of the docking device via a mirror support.
  • the barcode reader is adjustably mounted on a fixed structure of the docking device via a barcode reader support.
  • Mirrors and/or code readers can be mounted in an adjustable manner and can be adapted to read identification codes on different sample holders or different sample containers.
  • the mirror is located at one end of the docking device. In some embodiments, the one end of the docking device is adjacent to the loading/unloading zone. This is beneficial, the identification code reading device can start to read the identification code of the sample rack when the sample rack is just loaded on the docking device, and when the sample rack is loaded in place on the docking device, the identification code reading device Also just finished reading the identification code of the last sample container. In this way, the entire process of reading the identification code by the identification code reading device is optimized.
  • the docking device includes a sample rack loading part for carrying a sample rack and a code reading part for carrying the identification code reading device, the code reading part and the sample rack loading part are arranged horizontally adjacent to each other.
  • the sample rack loading portion has a longitudinal direction substantially coincident with the longitudinal direction of the sample rack loaded thereon, wherein the plurality of sample containers are arranged along the longitudinal direction of the sample rack.
  • the optical reading device comprises a first optical path from the identification code of the sample holder and/or the identification code of the sample container to the mirror and a second optical path from the mirror to the code reader , wherein the second optical path is substantially parallel to the longitudinal direction of the sample holder loading portion. In this way, the structure of the docking device can be made more compact.
  • the connection device includes two code reading parts located on opposite sides of the sample rack loading part, and the identification code reading device is installed on the two code reading parts. In this way, the reading accuracy can be judged and improved by comparing the reading results of the two identification code reading devices.
  • one identification code reading device can be used as a backup device, for example, which can be activated in the event of a failure of another identification code reading device.
  • the identification code reading device is adapted to sequentially read the identification code of the sample rack and the identification code of the sample container on the sample rack when the sample rack is loaded in a stepwise manner or in a continuous manner.
  • a sample rack handling apparatus comprising the above-mentioned docking device.
  • the sample rack handling device includes a sample rack for containing sample containers, the sample rack has a plurality of accommodating portions for accommodating a plurality of sample containers, and the plurality of accommodating portions are along the The longitudinal directions are arranged at equal intervals.
  • each of the receptacles has a notch for exposing the identification code of the sample container, and the notch faces the identification code reading device.
  • an automatic detection system including the above-mentioned sample rack manipulation device.
  • Fig. 1 is the schematic diagram of the main structure of automatic detection system
  • FIG. 2 is a schematic top view of a docking device according to an embodiment of the present disclosure, wherein a code reader on the docking device is reading an identification code on a first sample container;
  • connection device of FIG. 2 is a schematic perspective view of the connection device of FIG. 2;
  • Fig. 4 is another perspective schematic view of the connecting device of Fig. 2;
  • FIG. 5 is a perspective view of the code reader on the docking device of FIG. 2 when reading the identification code on the sample rack;
  • FIG. 6 is a perspective view of the code reader on the docking device of FIG. 2 when reading the identification code on the second sample container;
  • FIG. 7 is a schematic perspective view of the code reader on the docking device of FIG. 2 when reading the identification code on the last sample container;
  • FIG. 8 is a schematic diagram of a barcode reader support according to an embodiment of the present disclosure.
  • FIG. 9 is a schematic diagram of a mirror support according to an embodiment of the present disclosure.
  • Example embodiments are provided so that this disclosure will be thorough, and will fully convey the scope to those skilled in the art. Numerous specific details are set forth such as examples of specific components, devices, and methods in order to provide a thorough understanding of embodiments of the present disclosure. It will be apparent to those skilled in the art that specific details need not be employed, that example embodiments may be embodied in many different forms and should not be construed to limit the scope of the disclosure. In some example embodiments, well-known methods, well-known device structures, and well-known technologies are not described in detail.
  • FIG. 1 is a schematic diagram of the main structure of an automatic detection system 1 .
  • the automatic detection system 1 is configured to automatically perform detection analysis of a plurality of samples such as clinical chemistry, immunology or genetics.
  • the automatic detection system 1 mainly includes a sample rack manipulation device 10 , a sampler 11 , a reaction table 12 , a reagent distributor 13 , a reagent storage 14 , an optical analysis device 15 , a stirring device 16 and a cleaning device 17 .
  • a container (test tube) 20 containing the sample is placed on the sample rack 30 , and then the sample rack 30 is loaded into the sample rack manipulation device 10
  • the load/unload area TA The sample racks 30 are transported from the loading/unloading zone TA to the sampling zone TD or via the buffer zone TC to the sampling zone TD by the docking device 100 moving in the transfer zone TB.
  • the sample in the container 20 is collected into the reaction table 12 by the sampler 11 .
  • the reaction table 12 is rotated to deliver the sample to the reagent dispenser 13, which dispenses the corresponding reagent stored in the reagent storage 14 into the sample.
  • the stirring device 16 agitates the mixture of the sample and the reagent so that it is uniformly mixed for the reaction to occur.
  • the reaction table 12 is rotated to the detection position, whereby the reaction product is detected and analyzed by means of the optical analysis device 15 to obtain a detection and analysis result.
  • the reaction table 12 is cleaned by the cleaning device 17 for the next detection and analysis.
  • the sample rack handling device 10 transports the tested sample racks 30 to the loading/unloading area TA or finally to the loading/unloading area TA via the buffer area TC.
  • the unloading area TA takes out the tested sample rack 30 .
  • the sample rack manipulation device 10 constitutes the sample rack manipulation unit of the automatic detection system 1
  • the components 11 to 17 shown in FIG. 1 constitute the sample detection unit of the automatic detection system 1
  • the automatic detection system 1 shown in FIG. 1 is for illustrative purposes only, and is not intended to limit the present invention.
  • the sample rack 30 is used to receive, support, align and hold one or more sample containers 20 containing samples, and the sample containers 20 are arranged in a row on the sample rack 30 .
  • the number of sample containers 20 that can be carried on one sample rack 30 is generally 6 to 10, and the figure is shown as 7, that is, the sample containers 201 to 207 .
  • the sample rack 30 has an elongated shape, and the sample containers 201 to 207 are arranged in a row along the longitudinal direction of the sample rack 30 .
  • the number of sample containers can be comprehensively considered based on factors such as the size of the equipment and the waiting time for the next sample rack to be injected. It will be understood that the present invention is not limited to this number. However, the number of sample containers 20 actually filled on the sample rack 30 may be determined according to actual conditions.
  • the sample holder 30 may be a sample holder common to common sample containers, such as cylindrical test tubes or cups, available from Beckman Coulter, Inc.
  • each sample rack 30 and each sample container 20 on the sample rack 30 carry their own unique identification codes, such as barcodes or RFID (Radio Frequency Identification, not shown) label.
  • the identification code on the sample rack 30 may contain sample rack identification information only related to the sample rack, and the identification code on the sample container 20 may contain sample identification information only related to the sample in the sample container.
  • the sample holder 30 includes a handle portion 32 for an operator to grasp, a front end portion 34 opposite to the handle portion 32 , and a main body portion 31 between the handle portion 32 and the front end portion 34 .
  • the handle portion 32 is near a door (not shown) of the sample rack handling apparatus 10
  • the front end portion 34 is near the transfer area TB of the sample rack handling apparatus 10 .
  • the identification code of the sample holder 30 may be attached to the front end portion 34 , for example, on the front end surface 34 a of the front end portion 34 .
  • the main body portion 31 is provided with seven accommodating portions 33 along the longitudinal direction of the sample rack 30 to accommodate the sample containers 201 to 207 (see FIG. 4 ), respectively. Shape of accommodating portion 33 and sample container 20
  • the accommodating portion 33 has a notch 332 extending along the height of the sample rack 30 to expose the identification code (not shown) on the sample container 20, thereby enabling the identification code reading device to The identification code on the sample container 20 is easily read.
  • the sample rack 30 is loaded onto the rail 130 of the docking device 100 along the direction D indicated by the arrow in the figure.
  • the identification code reading device is integrated on the docking device 100 for transporting the sample rack.
  • the identification code reading device sequentially reads the sample rack identification code on the front end face of the sample rack 30 and the respective sample identification codes of the sample containers 201 to 207 .
  • the docking device 100 includes a sample rack loading part 100a and a code reading part (fixed structure) 100b.
  • the sample rack loading portion 100a has a rail 130 for carrying the sample rack 30 (see FIG. 2 ).
  • the code reading portion 100b and the loading portion 100a are arranged side by side, that is, arranged horizontally adjacent to each other.
  • the code reading part 100b is located on one side of the sample rack 30 (see FIG. 7).
  • the docking device may include two code reading parts located on opposite sides of the sample rack loading part, and an identification code reading device may be installed on both of the two code reading parts. In this way, the two code reading parts can verify the accuracy of recognition by comparing their recognition results, or can be designed as a redundant design for failure.
  • the identification code reading device of the docking device 100 includes a code reader 110 and a mirror 120 .
  • the barcode reader 110 scans and reads the identification codes (eg, barcodes) of the sample racks and sample containers by reflection of the mirrors 120 on these identification codes.
  • the reflection of the identification code by the mirror 120 is indicated by reference numeral 122 in the figure.
  • the identification code reading device in the illustrated example is an optical reading device.
  • the identification code reading device may be any other device known to those skilled in the art capable of reading identification codes of sample racks and/or sample containers, for example, a device that reads the identification codes through electrical signal feedback. device.
  • the mirror 120 is close to one end of the docking device 100 where the sample rack 30 is loaded first, so that the identification code of the sample rack 30 and the identification codes of the sample containers 201 to 207 can be scanned and scanned one by one during the whole process of loading the sample rack 30. read.
  • the notch 332 of the accommodating portion 33 of the sample holder 30 is located on the side facing the mirror. In this way, it is beneficial for the mirror 120 to reflect the identification code on the sample container 20 to the code reader 110 via the notch.
  • the optical reading device includes a first optical path from the identification code of the sample holder and/or sample container to the mirror and a second optical path from the mirror to the code reader.
  • the second optical path is substantially parallel to the longitudinal direction of the sample holder loading portion.
  • the longitudinal direction of the sample rack loading portion substantially coincides with the longitudinal direction of the sample rack loaded thereon, wherein a plurality of sample containers are arranged along the longitudinal direction of the sample rack.
  • FIG. 5 shows a state in which the docking device 100 is reading the identification code of the sample rack 30 .
  • the identification code on the front end 34 of the sample rack 30 first enters the reading position of the identification code reading device.
  • the code reader 110 first reads the identification code of the sample holder 30 through the reflection of the mirror 120 .
  • the first sample container 201 reaches the reading position of the barcode reader 110 .
  • the code reader 110 reads the identification code of the first sample container 201 through the reflection of the mirror 120 .
  • FIG. 6 shows the code reader 110 reading the identification code on the second sample container 202 .
  • the second sample container 202 is in the reflecting position of the mirror 120 , ie, reaching the reading position of the code reader 110 .
  • FIG. 7 shows the code reader 110 reading the identification code on the last sample container 207 .
  • the last sample container 207 is in the reflecting position of the mirror 120 , ie, reaching the reading position of the code reader 110 .
  • the docking device 100 can load sample racks in a step-by-step manner in order to read the identification codes of the sample racks and the sample containers.
  • the docking device 100 may also continuously load sample racks depending on the scanning or reading frequency of the barcode reader 110, the size (eg, width) of the identification code, and the loading speed of the sample racks.
  • FIG. 8 shows a barcode reader support 130 for mounting and supporting barcode reader 110 .
  • the code reader 110 is fixedly installed on the code reader support 130
  • the code reader support 130 is fixedly installed on the code reading portion 100 b of the docking device 100 .
  • the code reader support 130 is provided with a mounting hole 132, and the code reader support 130 is fixedly connected to the code reading part 100b by inserting a fastener (not shown) into the mounting hole 132 .
  • the barcode reader support 130 is provided with mounting holes 134, and the barcode reader 110 is fixedly connected to the barcode reader support 130 by inserting fasteners (not shown) into the mounting holes 134.
  • the present disclosure is not limited to the connection manner of the illustrated mounting holes and fasteners, but may adopt any suitable connection manner known in the art.
  • the installation position of the code reader support 130 relative to the code reading portion 100b can be adjusted in at least one direction.
  • the mounting hole 132 may be an elongated hole so as to adjust the position of the code reader support 130 relative to the code reading portion 100b.
  • the barcode reader support 130 may be adjustably mounted to the barcode reading portion 100b in any suitable manner known in the art.
  • the installation position of the code reader 110 relative to the code reader support 130 can be adjusted in at least one direction.
  • the mounting holes 134 may be elongated holes for adjusting the position of the code reader 110 relative to the code reader support 130 .
  • the barcode reader 110 may be adjustably mounted to the barcode reader support 130 in any suitable manner known in the art.
  • FIG. 9 shows mirror support 140 for mounting and supporting mirror 120 .
  • the mirror 120 is fixedly mounted on the mirror support 140
  • the mirror support 140 is fixedly mounted on the code reading part 100 b of the docking device 100 .
  • the mirror support 140 is provided with a mounting hole 142
  • the mirror support 140 is fixedly connected to the code reading part 100 b by inserting a fastener (not shown) into the mounting hole 142 .
  • a fastener not shown
  • the installation position of the mirror support 140 relative to the code reading portion 100b can be adjusted in at least one direction.
  • the mounting hole 142 may be an elongated hole so as to adjust the position of the mirror support 140 relative to the code reading portion 100b.
  • the mirror support 140 may be adjustably mounted to the code reading portion 100b in any suitable manner known in the art.
  • the mounting position of mirror 120 relative to mirror support 140 may be adjusted in at least one direction in any suitable manner known in the art.

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  • Life Sciences & Earth Sciences (AREA)
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Abstract

一种用于样本架操纵设备（10）的接驳装置（100），接驳装置（100）适于在样本架操纵设备（10）的加载/卸载区（TA）、采样区（TD）和缓冲区（TC）之间运送盛装有样本容器（20）的样本架（30）；接驳装置（100）上设置有标识码读取装置，标识码读取装置适于在从加载/卸载区（TA）将样本架（30）加载至接驳装置（100）上时能够读取样本架（30）的标识码和样本架（30）上的样本容器（20）的标识码；还涉及一种包括接驳装置（100）的样本架操纵设备（10）以及包括样本架操纵设备（10）的自动检测系统（1）。

Description

接驳装置、样本架操纵设备及自动检测系统 技术领域
本申请涉及医学技术领域，更具体地，涉及接驳装置、包括该接驳装置的样本架操纵设备以及包括该样本架操纵设备的自动检测系统。
背景技术
本部分的内容仅提供了与本公开相关的背景信息，其可能不必构成现有技术。
自动检测系统(也可称为分析检测仪)通常为了各种目的用于对样本容器中的内容物进行分析。分析检测仪通常包括样本架操纵部、采样部和检测部。样本架操纵部用于将样本容器输送至采样部，采样部将样本容器中的样本转移至检测部以对其进行检测。
样本架用于接收、支持、对齐、保持和/或运载一个或多个样本容器，以确保样本容器在分析检测仪内被安置和/或运送。样本架操纵设备(样本架操纵部)构造成用于加载、运送和/或卸载一个或多个样本架。为了区分各个样本容器以及样本架，在样本架和各个样本容器上贴敷有标识码。
已知一种样本架操纵设备，其包括固定至机架上的两个读码器。一个读码器用于读取样本架的标识码，另一个读码器用于读取样本容器上的标识码。因此，该样本架操纵设备的成本较高。此外，每次需要将样本架运送至该读码器处以读取样本架的标识码，因此，增加了运输样本架所需的时间和空间。
已知另一种现有样本架操纵设备，其包括一个读码器和一个能够旋转的镜子。在该读码器读取样本架的标识码之后，需要使镜子旋转至特定位置， 才能读取样本容器上的标识码。同样地，在读取完样本容器上的标识码之后，还需要将镜子旋转回去使其能够读取下一个样本架的标识码。因此，该样本架操纵设备增加了在操作期间驱动镜子旋转的零部件，由此增加了成本。
为此，本领域中期望提供一种能够节省占用空间和运行时间和/或能够降低成本的样本架操纵设备。
发明内容
本部分提供本公开的总体概述，而不是本公开的全部范围或其所有特征的全面公开。
根据本发明的一个方面，提供了一种用于样本架操纵设备的接驳装置。所述接驳装置适于在所述样本架操纵设备的加载/卸载区、采样区和缓冲区之间运送盛装有样本容器的样本架。所述接驳装置上设置有标识码读取装置，所述标识码读取装置适于在从所述加载/卸载区将样本架加载至所述接驳装置上时能够读取该样本架的标识码和/或该样本架上的样本容器的标识码。
根据本公开的接驳装置集成有标识码读取装置。这样，随着从加载/卸载区将样本架加载至接驳装置上，标识码读取装置可以依次读取样本架的标识码以及样本架上的样本容器的标识码。因此，可以节省将样本架运送至固定于自动检测系统的机架上的读码器处以读取样本架的运送时间和空间。
在一些实施方式中，所述标识码读取装置是光学读取装置。光学读取装置使得接驳装置的设计更加灵活且成本较低。
在一些实施方式中，所述光学读取装置包括至少一个读码器和至少一个镜子，所述读码器构造成借助于所述镜子对样本架的标识码和/或样本容器的标识码的反射来读取该样本架的标识码和/或该样本容器的标识码。在根据本 公开的接驳装置中，可以通过一个读码器既能够读取样本架的标识码，还能够读取样本容器的标识码。因此，根据本公开的接驳装置可以显著降低成本。
在一些实施方式中，所述镜子固定地安装在所述接驳装置的固定结构上。在根据本公开的接驳装置中，读取样本架的标识码和样本容器的标识码时无需旋转镜子。因此，根据本公开的接驳装置无需包括用于驱动镜子旋转的零部件，由此可以简化结构并能够降低成本。
在一些实施方式中，所述镜子经由镜子支承件以可调节的方式安装在所述接驳装置的固定结构上。在一些实施方式中，所述读码器经由读码器支承件以可调节的方式安装在所述接驳装置的固定结构上。以可调节的方式安装镜子和/或读码器，可以适于读取不同样本架或不同样本容器上的标识码。
在一些实施方式中，所述镜子位于所述接驳装置的一个端部处。在一些实施方式中，所述接驳装置的所述一个端部邻近所述加载/卸载区。这有利于，在样本架刚刚加载到接驳装置上时，标识码读取装置就可以开始读取样本架的标识码，而当样本架在接驳装置上加载到位时，标识码读取装置也刚刚读取完最后一个样本容器的标识码。这样，优化了标识码读取装置读取标识码的整个过程。
在一些实施方式中，所述接驳装置包括用于承载样本架的样本架加载部和用于承载所述标识码读取装置的读码部，所述读码部与所述样本架加载部以水平地彼此邻接的方式布置。
在一些实施方式中，所述样本架加载部具有与加载在其上的样本架的纵向方向基本一致的纵向方向，其中，多个样本容器沿着该样本架的纵向方向布置。所述光学读取装置包括从所述样本架的标识码和/或所述样本容器的标 识码到所述镜子的第一光学路径以及从所述镜子到所述读码器的第二光学路径，其中，所述第二光学路径基本平行于所述样本架加载部的纵向方向。这样，可以使得接驳装置的结构更加紧凑。
在一些实施方式中，所述接驳装置包括位于所述样本架加载部的相对两侧的两个读码部，所述两个读码部上均安装有所述标识码读取装置。这样，可以通过比较两个标识码读取装置的读取结果来判断和提高读取准确性。或者，可以将一个标识码读取装置作为备用装置，例如，该标识码读取装置可以在另一个标识码读取装置出现故障时启用。
在一些实施方式中，所述标识码读取装置适于在以步进的方式或连续的方式加载样本架时依次读取该样本架的标识码和该样本架上的样本容器的标识码。
根据本公开的另一方面，提供一种样本架操纵设备，所述样本架操纵设备包括上述接驳装置。
在一些实施方式中，所述样本架操纵装置包括用于盛装样本容器的样本架，所述样本架具有用于容置多个样本容器的多个容置部，所述多个容置部沿纵向方向等间隔地布置。
在一些实施方式中，所述容置部中的每个容置部具有用于露出样本容器的标识码的凹口，并且所述凹口面向所述标识码读取装置。
根据本公开的又一方面，提供一种自动检测系统，包括上述样本架操纵设备。
通过下文中给出的详细描述和仅以说明的方式给出并且因此并不认为是限制本公开的附图，将更充分地理解本公开的上述及其他目的、特征和优 点。
附图说明
本文中描述的附图仅出于说明选定实施方式而非所有可能的实施方案的目的，而不意在限制本公开的范围。
图1是自动检测系统的主要结构的示意图；
图2是根据本公开实施方式的接驳装置的俯视示意图，其中，接驳装置上的读码器在读取第一个样本容器上的标识码；
图3是图2的接驳装置的立体示意图；
图4是图2的接驳装置的另一立体示意图；
图5是图2的接驳装置上的读码器在读取样本架上的标识码时的立体示意图；
图6是图2的接驳装置上的读码器在读取第二个样本容器上的标识码时的立体示意图；
图7是图2的接驳装置上的读码器在读取最后一个样本容器上的标识码时的立体示意图；
图8是根据本公开实施方式的读码器支承件的示意图；以及
图9是根据本公开实施方式的镜子支承件的示意图。
贯穿附图中的若干视图，对应的附图标记指示对应的部件。
具体实施方式
现在将参照附图更充分地描述根据本公开的示例性实施方式。
提供了示例性实施方式以使得本公开将是透彻的并且将向本领域技术人员充分地传达范围。阐述了许多具体细节例如特定部件、装置和方法的示 例，以提供对本公开的实施方式的透彻理解。对于本领域技术人员而言将明显的是，不需要采用具体细节，示例性实施方式可以以许多不同的形式来实施并且不应被解释为限制本公开的范围。在一些示例性实施方式中，对公知的方法、公知的装置结构和公知的技术不再进行详细描述。
自动检测系统的概述
下面参照图l来描述自动检测系统1的主要结构和工作原理。图1是自动检测系统1的主要结构的示意图。为清楚起见，图1中省去了自动检测系统1的一些部件，特别地，省去盖、支撑结构、控制装置等。自动检测系统1构造成用于自动地执行多个样本的例如临床化学、免疫学或遗传学的检测分析。如图所示，自动检测系统1主要包括样本架操纵设备10、采样器11、反应台12、试剂分配器13、试剂存储器14、光学分析装置15、搅拌装置16以及清洗装置17。
当需要对样本(例如，生物液体)进行检测分析时，如图1所示，将盛装有样本的容器(试管)20放置于样本架30上，然后将样本架30加载到样本架操纵设备10的加载/卸载区TA。通过在转运区TB中移动的接驳装置100将样本架30从加载/卸载区TA运送至采样区TD或者经由缓冲区TC运送至采样区TD。通过采样器11将容器20中的样本采集到反应台12中。反应台12旋转以将样本运送至试剂分配器13处，试剂分配器13将存储在试剂存储器14中的相应试剂分配至样本中。搅拌装置16对样本和试剂的混合物进行搅拌，使其均匀地混合以便发生反应。反应台12旋转至检测位置，由此借助于光学分析装置15对反应产物进行检测和分析以得出检测分析结果。在对样本架30上的所有样本检测分析完成后，通过清洗装置17对反应台12进行清洗 以便下一次检测分析。在对样本检测分析完成后，样本架操纵设备10将已检测过的样本架30运送至加载/卸载区TA或经由缓冲区TC最终运送至加载/卸载区TA，然后，操作者可以从加载/卸载区TA将已检测的样本架30取出。
通过上面的描述可知，样本架操纵设备10构成了自动检测系统1的样本架操纵单元，而图1所示的部件11至17则构成了自动检测系统1的样本检测单元。然而，应理解的是，图1中所示的自动检测系统1仅用于说明性的目的，而不是限制本发明。
样本架
参见图1至图4，样本架30用于接收、支承、对齐和保持一个或多个盛装样本的样本容器20，样本容器20在样本架30上布置成一列。一个样本架30上可以承载的样本容器20的数量一般为6个到10个，图中示出为7个，即，样本容器201至207。在图示的示例中，样本架30呈纵长形，并且样本容器201至207沿着样本架30的纵向方向布置成一列。样本容器的数量可以根据设备的大小、下一样本架的等待进样时间等因素综合考虑。可以理解，本发明对该数量没有限制。但是，样本架30上实际填充的样本容器20的数量可以根据实际情况而定。
样本架30可以是对于诸如圆筒形试管或杯等常用的样本容器通用的样本架，该通用样本架30可以由贝克曼库尔特公司(Beckman Coulter,Inc)购得。
如上所述，承载样本容器20的样本架30在样本架操纵设备10的各个区域TA、TB、TC和TD中穿行以进行各种操作。为了区别各个样本容器20中的样本和样本架30，每个样本架30和样本架30上的每个样本容器20上 都携带各自独有的标识码，例如，条形码或RFID(Radio Frequency Identification，图中未示出)标签。样本架30上的标识码可以包含仅与该样本架相关的样本架识别信息，样本容器20上的标识码可以包含仅与该样本容器中的样本相关的样本识别信息。
如图2至图4所示，样本架30包括供操作者抓握的把手部32、与把手部32相反的前端部34、以及在把手部32和前端部34之间的主体部31。把手部32靠近样本架操纵设备10的门(未示出)，而前端部34靠近样本架操纵设备10的转运区TB。样本架30的标识码可以贴敷在前端部34上，例如，前端部34的前端面34a上。
主体部31沿着样本架30的纵向方向设置有7个容置部33以分别容置样本容器201至207(参见图4)。容置部33的形状与样本容器20容置部33具有沿样本架30的高度延伸的凹口332以便露出样本容器20上的标识码(未示出)，由此使得标识码读取装置能够容易地读取到样本容器20上的标识码。
如图2所示，当接驳装置100从加载/卸载区TA加载样本架30时，沿图中的箭头所示的方向D将样本架30加载到接驳装置100的轨道130上。
根据本公开的标识码读取装置集成在用于运送样本架的接驳装置100上。当样本架30沿方向D被加载至接驳装置100上时，标识码读取装置依次读取样本架30的前端面上的样本架标识码和样本容器201至207的各自的样本标识码。
接驳装置
如图1所示，接驳装置100包括样本架加载部100a和读码部(固定结构)100b。样本架加载部100a具有用于承载样本架30的轨道130(参见图2)。 读码部100b与加载部100a并排地设置，即，以水平地彼此邻接的方式布置。当接驳装置100上加载有样本架30时，读码部100b位于样本架30的一侧(参见图7)。然而，应理解的是，本发明不局限于图示的具体示例。例如，接驳装置可以包括位于样本架加载部的相对两侧的两个读码部，所述两个读码部上均可以安装有标识码读取装置。这样，两个读码部可以通过比较其识别结果来验证识别的准确性，或者可以作为故障的冗余设计。
在图示的示例中，接驳装置100的标识码读取装置包括一个读码器110和一个镜子120。读码器110通过镜子120对样本架和样本容器的标识码(例如，条形码)的反射来扫描和读取这些标识码。图中用附图标记122来表示镜子120对标识码的反射。图示的示例中的标识码读取装置为光学读取装置。然而，应理解的是，标识码读取装置可以是本领域技术人员已知的能够读取样本架和/或样本容器的标识码的任何其他装置，例如，通过电信号反馈读取标识码的装置。
镜子120靠近接驳装置100的先加载样本架30的一个端部，这样有利于在样本架30加载的整个过程中逐个对样本架30的标识码以及样本容器201至207的标识码进行扫描和读取。
样本架30的容置部33的凹口332位于面向镜子的一侧。这样，有利于镜子120经由凹口将样本容器20上的标识码反射给读码器110。光学读取装置包括从样本架和/或样本容器的标识码到镜子的第一光学路径以及从镜子到读码器的第二光学路径。该第二光学路径基本平行于样本架加载部的纵向方向。样本架加载部的纵向方向与加载在其上的样本架的纵向方向基本一致，其中，多个样本容器沿着该样本架的纵向方向布置。
图5示出了接驳装置100的正读取样本架30的标识码的状态。如图5所示，在将样本架30加载至接驳装置100上时，位于样本架30的前端部34上的标识码首先进入标识码读取装置的读取位置。此时，读码器110通过镜子120的反射先读取样本架30的标识码。
随着样本架30继续加载至接驳装置100上，如图2至图4所示，第一个样本容器201到达读码器110的读取位置。此时，读码器110通过镜子120的反射读取第一个样本容器201的标识码。
图6示出了读码器110正读取第二个样本容器202上的标识码。在图6的示例中，第二个样本容器202正处于镜子120的反射位置，即，到达读码器110的读取位置。
图7示出了读码器110正读取最后一个样本容器207上的标识码。在图7的示例中，最后一个样本容器207正处于镜子120的反射位置，即，到达读码器110的读取位置。
根据本公开的接驳装置100可以以步进的方式加载样本架，以便读取样本架和样本容器的标识码。然而，应理解的是，根据读码器110的扫描或读码频率、标识码的尺寸(例如，宽度)以及样本架的加载速度，接驳装置100也可以连续地加载样本架。
图8示出了用于安装和支撑读码器110的读码器支承件130。读码器110固定地安装在读码器支承件130上，而读码器支承件130固定地安装在接驳装置100的读码部100b上。如图8所示，读码器支承件130上设置有安装孔132，通过将紧固件(未示出)插入安装孔132中而将读码器支承件130固定地连接至读码部100b。类似地，读码器支承件130上设置有安装孔134，通 过将紧固件(未示出)插入安装孔134中而将读码器110固定地连接至读码器支承件130。应理解的是，本公开不局限于图示的安装孔和紧固件的连接方式，而是可以采取本领域已知的任何合适的连接方式。
有利的是，可以沿至少一个方向调节读码器支承件130相对于读码部100b的安装位置。如图8所示，安装孔132可以是长形孔，以便调节读码器支承件130相对于读码部100b的位置。应理解的是，可以以本领域已知的任何合适的方式将读码器支承件130可调节地安装至读码部100b。
此外，可以沿至少一个方向调节读码器110相对于读码器支承件130的安装位置。如图8所示，安装孔134可以是长形孔，以便调节读码器110相对于读码器支承件130的位置。应理解的是，可以以本领域已知的任何合适的方式将读码器110可调节地安装至读码器支承件130。
图9示出了用于安装和支撑镜子120的镜子支承件140。镜子120固定地安装在镜子支承件140上，而镜子支承件140固定地安装在接驳装置100的读码部100b上。如图9所示，镜子支承件140上设置有安装孔142，通过将紧固件(未示出)插入安装孔142中而将镜子支承件140固定地连接至读码部100b。应理解的是，本公开不局限于图示的安装孔和紧固件的连接方式，而是可以采取本领域已知的任何合适的连接方式。
有利的是，可以沿至少一个方向调节镜子支承件140相对于读码部100b的安装位置。如图9所示，安装孔142可以是长形孔，以便调节镜子支承件140相对于读码部100b的位置。应理解的是，可以以本领域已知的任何合适的方式将镜子支承件140可调节地安装至读码部100b。
此外，可以沿至少一个方向以本领域已知的任何合适的方式调节镜子 120相对于镜子支承件140的安装位置。
上文已经具体描述了本发明的各种实施方式和变型，但是本领域技术人员应该理解，本发明并不局限于上述具体的实施方式和变型而是可以包括其他各种可能的组合和结合。在不偏离本发明的实质和范围的情况下可由本领域的技术人员实现其他的变型和变体。所有这些变型和变体都落入本发明的范围内。而且，所有在此描述的构件都可以由其他技术性上等同的构件来代替。

Claims (16)

  1. 一种用于样本架操纵设备的接驳装置,其中，所述接驳装置适于在所述样本架操纵设备的加载/卸载区、采样区和缓冲区之间运送盛装有样本容器的样本架，
    所述接驳装置上设置有标识码读取装置，所述标识码读取装置适于在从所述加载/卸载区将样本架加载至所述接驳装置上时能够读取该样本架的标识码和/或该样本架上的样本容器的标识码。
  2. 根据权利要求1所述的接驳装置，其中，所述标识码读取装置是光学读取装置。
  3. 根据权利要求2所述的接驳装置，其中，所述光学读取装置包括至少一个读码器和至少一个镜子，所述读码器构造成借助于所述镜子对样本架的标识码和/或样本容器的标识码的反射来读取该样本架的标识码和/或该样本容器的标识码。
  4. 根据权利要求3所述的接驳装置，其中，所述镜子固定地安装在所述接驳装置的固定结构上。
  5. 根据权利要求3所述的接驳装置，其中，所述镜子经由镜子支承件以可调节的方式安装在所述接驳装置的固定结构上。
  6. 根据权利要求3所述的接驳装置，其中，所述读码器经由读码器支承件以可调节的方式安装在所述接驳装置的固定结构上。
  7. 根据权利要求1至6中任一项所述的接驳装置，其中，所述镜子位于所述接驳装置的一个端部处。
  8. 根据权利要求7所述的接驳装置，其中，所述接驳装置的所述一个端部邻近所述加载/卸载区。
  9. 根据权利要求3至6中任一项所述的接驳装置，其中，所述接驳装置包括用于承载样本架的样本架加载部和用于承载所述标识码读取装置的读码部，所述读码部与所述样本架加载部以水平地彼此邻接的方式布置。
  10. 根据权利要求9所述的接驳装置，其中，所述样本架加载部具有与加载在其上的样本架的纵向方向基本一致的纵向方向，其中，多个样本容器沿着该样本架的纵向方向布置，
    所述光学读取装置包括从所述样本架的标识码和/或所述样本容器的标识码到所述镜子的第一光学路径以及从所述镜子到所述读码器的第二光学路径，其中，所述第二光学路径基本平行于所述样本架加载部的纵向方向。
  11. 根据权利要求9所述的接驳装置，其中，所述接驳装置包括位于所述样本架加载部的相对两侧的两个读码部，所述两个读码部上均安装有所述 标识码读取装置。
  12. 根据权利要求1至6中任一项所述的接驳装置，其中，所述标识码读取装置适于在以步进的方式或连续的方式加载样本架时依次读取该样本架的标识码和该样本架上的样本容器的标识码。
  13. 一种样本架操纵设备，所述样本架操纵设备包括如权利要求1至12中任一项所述的接驳装置。
  14. 根据权利要求13所述的样本架操纵设备，其中，所述样本架操纵装置包括用于盛装样本容器的样本架，所述样本架具有用于容置多个样本容器的多个容置部，所述多个容置部沿纵向方向等间隔地布置。
  15. 根据权利要求13所述的样本架操纵设备，其中，所述容置部中的每个容置部具有用于露出样本容器的标识码的凹口，并且所述凹口面向所述标识码读取装置。
  16. 一种自动检测系统，包括根据权利要求13至15中任一项所述的样本架操纵设备。
PCT/CN2021/074069 2021-01-28 2021-01-28 接驳装置、样本架操纵设备及自动检测系统 WO2022160151A1 (zh)

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