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WO2020214716A1 - Inhibiteurs de la protéase du vih à base de 2-imino-5-oxo-imidazolidine - Google Patents

Inhibiteurs de la protéase du vih à base de 2-imino-5-oxo-imidazolidine Download PDF

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Publication number
WO2020214716A1
WO2020214716A1 PCT/US2020/028336 US2020028336W WO2020214716A1 WO 2020214716 A1 WO2020214716 A1 WO 2020214716A1 US 2020028336 W US2020028336 W US 2020028336W WO 2020214716 A1 WO2020214716 A1 WO 2020214716A1
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WIPO (PCT)
Prior art keywords
inhibitors
hiv
compound
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
PCT/US2020/028336
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English (en)
Inventor
Aesop Cho
John O. Link
Jie Xu
Original Assignee
Gilead Sciences, Inc.
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Publication date
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Priority to EP20724627.3A priority Critical patent/EP3955921A1/fr
Publication of WO2020214716A1 publication Critical patent/WO2020214716A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Definitions

  • the present disclosure relates to compounds for use in the treatment of Retroviridae viral infection including infections caused by the HIV virus.
  • the present disclosure also relates to compounds for use in the treatment of Coronaviridae virus infections, including infections caused by the SARS virus, the MERS virus, or the 2019-nCoV (COVID-19) virus.
  • the present disclosure also relates to preparation of the compounds provided herein and their intermediates, and pharmaceutical compositions comprising compounds provided herein.
  • HIV infection and related diseases are a major public health problem worldwide.
  • Human immunodeficiency virus type 1 (HIV-1) encodes three enzymes which are required for viral replication: reverse transcriptase, protease, and integrase.
  • PI protease inhibitors
  • PI inhibitors are presently approved for use in AIDS or HIV. Yet many PI inhibitors suffer from high rates of hepatic metabolism, which may require co administration of a booster or more frequent dosing.
  • viral resistance remains a problem. Accordingly, there is a need for new compounds that inhibit the replication of HIV.
  • the present disclosure provides compounds and methods for the treatment of an HIV infection.
  • the present disclosure also provides compounds and methods for the treatment of a coronavirus infection, including an infection caused by the SARS virus, the MERS virus, or the 2019-nCoV (COVID-19) virus.
  • a coronavirus infection including an infection caused by the SARS virus, the MERS virus, or the 2019-nCoV (COVID-19) virus.
  • compositions comprising a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
  • the pharmaceutical composition further comprises one or more additional therapeutic agents.
  • HIV human immunodeficiency virus
  • coronavirus infection is an infection caused by the SARS virus, the MERS virus, or the 2019-nCoV (COVID-19) virus.
  • a compound disclosed herein or“a compound of the present disclosure” refers to the compounds of Examples 1-9 (Compounds 1-9).
  • Certain of the compounds described herein contain one or more asymmetric centers and may thus give rise to enantiomers, diastereomers, and other stereoisomeric forms that may be defined, in terms of absolute stereochemistry, as (R)- or (S)-.
  • the present disclosure is meant to include all such possible isomers, including racemic and scalemic mixtures, optically pure forms and intermediate mixtures. Where chirality is not specified but is present, it is understood that the embodiment is directed to either the specific diastereomerically or enantiomerically enriched form; or a racemic or scalemic mixture of such compound(s).
  • “scalemic mixture” is a mixture of stereoisomers at a ratio other than 1 : 1.
  • IC 95 or“EC 95 ” refers to the inhibitory concentration required to achieve 95% of the maximum desired effect, which in many cases here is the inhibition of the HIV virus. This term is obtained using an in vitro assay evaluating the concentration-dependent inhibition of wild type HIV virus.
  • “Pharmaceutically acceptable excipient” includes without limitation any adjuvant, carrier, excipient, glidant, sweetening agent, diluent, preservative, dye/colorant, flavor enhancer, surfactant, wetting agent, dispersing agent, suspending agent, stabilizer, isotonic agent, solvent, or emulsifier which has been approved by the United States Food and Drug Administration as being acceptable for use in humans or domestic animals.
  • “Pharmaceutically acceptable salt” refers to a salt of a compound that is
  • salts include acid addition salts formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like; or formed with organic acids such as acetic acid, benzenesulfonic acid, benzoic acid, camphorsulfonic acid, citric acid, ethanesulfonic acid, fumaric acid, glucoheptonic acid, gluconic acid, lactic acid, maleic acid, malonic acid, mandelic acid, methanesulfonic acid, 2-napththalenesulfonic acid, oleic acid, palmitic acid, propionic acid, stearic acid, succinic acid, tartaric acid, p-toluenesulfonic acid, trimethylacetic acid, and the like, and salts formed when an acidic proton present in the parent
  • ammonium and substituted or quaternized ammonium salts are also included in this definition.
  • Representative non-limiting lists of pharmaceutically acceptable salts can be found in S.M. Berge et ah, J. Pharma Sci., 66(1), 1-19 (1977), and Remington: The Science and Practice of Pharmacy, R. Hendrickson, ed., 21st edition, Lippincott, Williams & Wilkins, Philadelphia, PA, (2005), at p. 732, Table 38-5, both of which are hereby incorporated by reference herein.
  • A“prodrug” is defined in the pharmaceutical field as a biologically inactive derivative of a drug that upon administration to the human body is converted to the biologically active parent drug according to some chemical or enzymatic pathway.
  • Subject and“subjects” refers to humans, domestic animals (e.g ., dogs and cats), farm animals (e.g., cattle, horses, sheep, goats and pigs), laboratory animals (e.g, mice, rats, hamsters, guinea pigs, pigs, pocket pets, rabbits, dogs, and monkeys), and the like.
  • beneficial or desired results include, but are not limited to, alleviation of a symptom and/or diminishment of the extent of a symptom and/or preventing a worsening of a symptom associated with a disease or condition.
  • “treatment” or“treating” includes one or more of the following: a) inhibiting the disease or condition (e.g, decreasing one or more symptoms resulting from the disease or condition, and/or diminishing the extent of the disease or condition); b) slowing or arresting the development of one or more symptoms associated with the disease or condition (e.g, stabilizing the disease or condition, delaying the worsening or progression of the disease or condition); and/or c) relieving the disease or condition, e.g, causing the regression of clinical symptoms, ameliorating the disease state, delaying the progression of the disease, increasing the quality of life, and/or prolonging survival.
  • “delaying” development of a disease or condition means to defer, hinder, slow, retard, stabilize and/or postpone development of the disease or condition. This delay can be of varying lengths of time, depending on the history of the disease and/or subject being treated. As is evident to one skilled in the art, a sufficient or significant delay can, in effect, encompass prevention, in that the subject does not develop the disease or condition.
  • a method that“delays” development of AIDS or of COVID-19 related symptoms is a method that reduces the probability of disease development in a given time frame and/or reduces extent of the disease in a given time frame, when compared to not using the method.
  • Such comparisons may be based on clinical studies, using a statistically significant number of subjects.
  • the development of AIDS can be detected using known methods, such as confirming a subject’s HIV + status and assessing the subject’s T-cell count or other indication of AIDS development, such as extreme fatigue, weight loss, persistent diarrhea, high fever, swollen lymph nodes in the neck, armpits or groin, or presence of an opportunistic condition that is known to be associated with AIDS (e.g, a condition that is generally not present in subjects with functioning immune systems but does occur in AIDS patients). Development may also refer to disease progression that may be initially undetectable and includes occurrence, recurrence and onset.
  • “prevention” or“preventing” refers to a regimen that protects against the onset of the disease or disorder such that the clinical symptoms of the disease do not develop.
  • “prevention” relates to administration of a therapy (e.g ., administration of a therapeutic substance) to a subject before signs of the disease are detectable in the subject (e.g., administration of a therapeutic substance to a subject in the absence of detectable infectious agent (e.g, virus) in the subject).
  • the subject may be an individual at risk of developing the disease or disorder, such as an individual who has one or more risk factors known to be associated with development or onset of the disease or disorder.
  • the term“preventing HIV infection” refers to administering to a subject who does not have a detectable HIV infection an anti -HIV therapeutic substance. It is understood that the subject for anti -HIV preventative therapy may be an individual at risk of contracting the HIV virus.
  • the term “preventing coronavirus infection” refers to administering to a subject who does not have a detectable coronavirus infection (e.g, a MERS, SARS, or COVID-19 infection) an anti- coronavirus therapeutic substance. Further, it is understood that prevention may not result in complete protection against onset of the disease or disorder. In some instances, prevention includes reducing the risk of developing the disease or disorder. The reduction of the risk may not result in complete elimination of the risk of developing the disease or disorder.
  • an“at risk” individual is an individual who is at risk of developing a condition to be treated.
  • An individual“at risk” may or may not have detectable disease or condition, and may or may not have displayed detectable disease prior to the treatment of methods described herein.
  • “At risk” denotes that an individual has one or more so-called risk factors, which are measurable parameters that correlate with development of a disease or condition and are known in the art. An individual having one or more of these risk factors has a higher probability of developing the disease or condition than an individual without these risk factor(s). For example, individuals at risk for AIDS are those having HIV.
  • the term "therapeutically effective amount” or“effective amount” refers to an amount that is effective to elicit the desired biological or medical response, including the amount of a compound that, when administered to a subject for treating a disease, is sufficient to effect such treatment for the disease or to an amount that is effective to protect against the contracting or onset of a disease.
  • the effective amount will vary depending on the compound, the disease, and its severity and the age, weight, etc., of the subject to be treated.
  • the effective amount can include a range of amounts.
  • an effective amount may be in one or more doses, i.e., a single dose or multiple doses may be required to achieve the desired treatment outcome.
  • An effective amount may be considered in the context of administering one or more therapeutic agents, and a single agent may be considered to be given in an effective amount if, in conjunction with one or more other agents, a desirable or beneficial result may be or is achieved.
  • Suitable doses of any co-administered compounds may optionally be lowered due to the combined action (e.g ., additive or synergistic effects) of the compounds.
  • the compounds described herein include solvates, hydrates, tautomers, stereoisomers and salt forms thereof.
  • n is the number of hydrogen atoms in the molecule.
  • the deuterium atom is a non radioactive isotope of the hydrogen atom.
  • Such compounds exhibit may increase resistance to metabolism, and thus may be useful for increasing the half-life of the compounds when administered to a mammal. See , e.g., Foster,“Deuterium Isotope Effects in Studies of Drug Metabolism,” Trends Pharmacol. Sci., 5(12):524-527 (1984).
  • Such compounds are synthesized by means well known in the art, for example by employing starting materials in which one or more hydrogen atoms have been replaced by deuterium.
  • Examples of isotopes that can be incorporated into the disclosed compounds also include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorus, fluorine, chlorine, and iodine, such as 2 H, 3 ⁇ 4, U C, 13 C, 14 C, 13 N, 15 N, 15 0, 17 0, 18 0, 31 P, 32 P, 35 S, 18 F, 36 C1, 123 I, and 125 I, respectively.
  • Substitution with positron emitting isotopes, such as U C, 18 F, 15 0 and 13 N can be useful in Positron Emission Topography (PET) studies for examining substrate receptor occupancy.
  • PET Positron Emission Topography
  • Isotopically-labeled compounds of provided herein can generally be prepared by conventional techniques known to those skilled in the art or by processes analogous to those described in the Examples as set out below using an appropriate isotopically-labeled reagent in place of the non-labeled reagent previously employed.
  • the compounds described herein may be covalently bound to a polyethylene glycol (PEG) substituent, i.e.“pegylated” in order to enhance pharmacokinetic and metabolic profiles.
  • PEG polyethylene glycol
  • darunavir is a HIV protease inhibitor having the structure:
  • Atazanavir is a HIV protease inhibitor having the structure:
  • the compound is selected from:
  • the compound is selected from:
  • the compound is selected from:
  • the compound is selected from:
  • the compound is Compound 1 having the structure:
  • the compound is Compound 2 having the structure:
  • the compound is Compound 3 having the structure:
  • the compound is Compound 4 having the structure:
  • the compound is Compound 5 having the structure:
  • the compound is Compound 6 having the structure:
  • the compound is Compound 7 having the structure:
  • the compound is Compound 8 having the structure:
  • the compound is Compound 9 having the structure:
  • compositions of compounds provided herein may be any pharmaceutical compositions of compounds provided herein.
  • the compounds described herein may be administered orally. Oral administration may be via, for example, capsule or enteric coated tablets.
  • Oral administration may be via, for example, capsule or enteric coated tablets.
  • the pharmaceutical compositions that include at least one compound disclosed herein, or a pharmaceutically acceptable salt is usually diluted by an excipient and/or enclosed within such a carrier that can be in the form of a capsule, sachet, paper or other container.
  • the excipient serves as a diluent, it can be in the form of a solid, semi-solid, or liquid material (as above), which acts as a vehicle, carrier or medium for the active ingredient.
  • compositions can be in the form of tablets, pills, powders, lozenges, sachets, cachets, elixirs, suspensions, emulsions, solutions, syrups, aerosols (as a solid or in a liquid medium), ointments containing, for example, up to 10% by weight of the active compound, soft and hard gelatin capsules, sterile injectable solutions, and sterile packaged powders.
  • excipients include lactose, dextrose, sucrose, sorbitol, mannitol, starches, gum acacia, calcium phosphate, alginates, tragacanth, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, sterile water, syrup, and methyl cellulose.
  • the formulations can additionally include: lubricating agents such as talc, magnesium stearate, and mineral oil; wetting agents; emulsifying and suspending agents;
  • preserving agents such as methyl and propylhydroxy-benzoates; sweetening agents; and flavoring agents.
  • compositions that include at least one compound provided herein, or a pharmaceutically acceptable salt can be formulated so as to provide quick, sustained or delayed release of the active ingredient after administration to the subject by employing procedures known in the art.
  • Controlled-release drug delivery systems for oral administration include osmotic pump systems and dissolutional systems containing polymer-coated reservoirs or drug- polymer matrix formulations. Examples of controlled release systems are given in U.S. Patent Nos. 3,845,770; 4,326,525; 4,902,514; and 5,616,345.
  • Another formulation for use in the methods of the present disclosure employs transdermal delivery devices (“patches”). Such transdermal patches may be used to provide continuous or discontinuous infusion of the compounds of the present disclosure in controlled amounts.
  • transdermal patches for the delivery of pharmaceutical agents is well known in the art. See , e.g., U.S. Patent Nos. 5,023,252, 4,992,445 and 5,001,139. Such patches may be constructed for continuous, pulsatile, or on demand delivery of pharmaceutical agents.
  • compositions may, in some embodiments, be formulated in a unit dosage form.
  • unit dosage forms refers to physically discrete units suitable as unitary dosages for human subjects and other mammals, each unit containing a predetermined quantity of active material calculated to produce the desired therapeutic effect, in association with a suitable pharmaceutical excipient (e.g, a tablet, capsule, ampule).
  • a suitable pharmaceutical excipient e.g, a tablet, capsule, ampule.
  • the compounds are generally administered in a pharmaceutically effective amount.
  • each dosage unit contains from about 10 mg to about 1000 mg of a compound described herein, for example from about 50 mg to about 500 mg, for example about 50 mg, about 75 mg, about 100 mg, about 150 mg, about 200 mg, about 225 mg, about 250 mg, about 275 mg, about 300 mg, about 325 mg, about 350 mg, about 375 mg, about 400 mg, about 425 mg, about 450 mg, about 475 mg , or about 500 mg.
  • each dosage unit contains from 0.1 to 700 mg of a compound a compound described herein. It will be understood, however, that the amount of the compound actually administered usually will be determined by a physician, in the light of the relevant
  • dosage levels may be from 0.1 mg to 100 mg per kilogram of body weight per day, for example from about 1 mg to about 50 mg per kilogram, for example from about 5 mg to about 30 mg per kilogram. Such dosage levels may, in certain instances, be useful in the treatment of the above-indicated conditions. In other embodiments, dosage levels may be from about 10 mg to about 2000 mg per subject per day.
  • the amount of active ingredient that may be combined with the vehicle to produce a single dosage form will vary depending upon the host treated and the particular mode of administration. Dosage unit forms may contain from 1 mg to 1000 mg of an active ingredient.
  • the compounds disclosed herein, or a pharmaceutically acceptable salt thereof may be administered to a subject in accordance with an effective dosing regimen for a desired period of time or duration, such as at least about one day, at least about one week, at least about one month, at least about 2 months, at least about 3 months, at least about 4 months, at least about 6 months, or at least about 12 months or longer.
  • the compound is administered on a daily or intermittent schedule.
  • the compound is administered on a monthly schedule.
  • the compound is administered every two months.
  • the compound is administered every three months.
  • the compound is administered every four months.
  • the compound is administered every five months.
  • the compound is administered every 6 months.
  • the pharmaceutically acceptable salt thereof may be adjusted over the course of the treatment, based on the judgment of the administering physician.
  • the compound may be administered to a subject (e.g ., a human) in an effective amount. In certain embodiments, the compound is administered once daily.
  • the principal active ingredient may be mixed with a pharmaceutical excipient to form a solid preformulation composition containing a homogeneous mixture of a compound of provided herein, or a pharmaceutically acceptable salt, thereof.
  • a pharmaceutical excipient When referring to these preformulation compositions as homogeneous, the active ingredient may be dispersed evenly throughout the composition so that the composition may be readily subdivided into equally effective unit dosage forms such as tablets, pills and capsules.
  • the tablets or pills of the compounds described herein may be coated or otherwise compounded to provide a dosage form affording the advantage of prolonged action, or to protect from the acid conditions of the stomach.
  • the tablet or pill can comprise an inner dosage and an outer dosage component, the latter being in the form of an envelope over the former.
  • the two components can be separated by an enteric layer that serves to resist disintegration in the stomach and permit the inner component to pass intact into the duodenum or to be delayed in release.
  • enteric layers or coatings such materials including a number of polymeric acids and mixtures of polymeric acids with such materials as shell, acetyl alcohol, and cellulose acetate.
  • formulations suitable for parenteral administration e.g ., intramuscular (IM) and subcutaneous (SC) administration
  • IM intramuscular
  • SC subcutaneous
  • formulations suitable for parenteral administration will include one or more excipients.
  • Excipients should be compatible with the other ingredients of the formulation and
  • excipients physiologically innocuous to the recipient thereof.
  • suitable excipients are well known to the person skilled in the art of parenteral formulation and may be found, e.g., in Handbook of Pharmaceutical Excipients (eds. Rowe, Sheskey & Quinn), 6th edition 2009.
  • immunodeficiency virus (HIV) infection comprising administering a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, to a subject in need thereof.
  • a method of treating a human immunodeficiency virus (HIV) infection comprising administering a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, to a subject in need thereof, is provided.
  • the method comprises
  • the subject is at risk of contracting the HIV virus, such as a subject who has one or more risk factors known to be associated with contracting the HIV virus.
  • the subject may have not previously received antiviral treatment (treatment naive).
  • the subject may have previously received antiviral treatment (treatment experienced).
  • the subject may have previously received antiviral treatment and developed resistance to the previously received antiviral treatment.
  • a method of treating or preventing a coronavirus infection comprising administering a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, to a subject in need thereof.
  • a method of treating a coronavirus infection comprising administering a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, to a subject in need thereof.
  • the method comprises administering a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with one or more (e.g, one, two, three, one or two, or one to three) additional therapeutic agents.
  • the subject is at risk of contracting the coronavirus.
  • immunodeficiency virus (HIV) infection or coronavirus infection comprising administering a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, to a subject in need thereof, in combination with a therapeutically effective amount of one or more (e.g ., one, two, three, or four; or one or two; or one to three; or one to four) additional therapeutic agents selected from the group consisting of combination drugs for HIV, other drugs for treating HIV, HIV protease inhibitors, HIV non-nucleoside or non-nucleotide inhibitors of reverse transcriptase, HIV nucleoside or nucleotide inhibitors of reverse transcriptase, HIV integrase inhibitors, HIV non-catalytic site (or allosteric) integrase inhibitors, HIV entry inhibitors, HIV maturation inhibitors, immunomodulators,
  • HIV protease inhibitors HIV non-nucleoside or non-nucleotide inhibitors of reverse transcriptase
  • immunotherapeutic agents antibody-drug conjugates, gene modifiers, gene editors (such as CRISPR/Cas9, zinc finger nucleases, homing nucleases, synthetic nucleases, TALENs), cell therapies (such as chimeric antigen receptor T-cell, CAR-T, and engineered T cell receptors, TCR-T, autologous T cell therapies), latency reversing agents, compounds that target the HIV capsid, immune-based therapies, phosphatidylinositol 3-kinase (PI3K) inhibitors, HIV antibodies, bispecific antibodies and“antibody-like” therapeutic proteins, HIV pl7 matrix protein inhibitors, IL-13 antagonists, peptidyl-prolyl cis-trans isomerase A modulators, protein disulfide isomerase inhibitors, complement C5a receptor antagonists, DNA methyltransferase inhibitor, HIV vif gene modulators, Vif dimerization antagonists, HIV-1 viral infectivity factor inhibitors, TAT protein inhibitors, HIV-1
  • the one or more (e.g., one, two, three, or four; or one or two; or one to three; or one to four) additional therapeutic agents are selected from the group consisting of combination drugs for HIV, other drugs for treating HIV, HIV nucleoside reverse transcriptase translocation inhibitors, HIV protease inhibitors, HIV reverse transcriptase inhibitors, HIV integrase inhibitors, HIV non-catalytic site (or allosteric) integrase inhibitors, HIV entry (fusion) inhibitors, HIV maturation inhibitors, latency reversing agents, capsid inhibitors, immune-based therapies, PI3K inhibitors, HIV antibodies, and bispecific antibodies, and“antibody-like” therapeutic proteins, and combinations thereof.
  • combination drugs for HIV other drugs for treating HIV, HIV nucleoside reverse transcriptase translocation inhibitors, HIV protease inhibitors, HIV reverse transcriptase inhibitors, HIV integrase inhibitors, HIV non-catalytic site (or allosteric) integrase inhibitor
  • the one or more (e.g, one, two, three, or four; or one or two; or one to three; or one to four) additional therapeutic agents are selected from immunomodulators, immunotherapeutic agents, antibody-drug conjugates, gene modifiers, gene editors (such as CRISPR/Cas9, zinc finger nucleases, homing nucleases, synthetic nucleases, TALENs), and cell therapies such as chimeric antigen receptor T-cell, CAR-T (e.g., YESCARTA® (axicabtagene ciloleucel)), engineered T cell receptors, TCR-T, and combinations thereof.
  • immunomodulators e.g., one, two, three, or four; or one or two; or one to three; or one to four
  • additional therapeutic agents are selected from immunomodulators, immunotherapeutic agents, antibody-drug conjugates, gene modifiers, gene editors (such as CRISPR/Cas9, zinc finger nucleases, homing nucleases, synthetic nucle
  • the one or more (e.g, one, two, three, or four; or one or two; or one to three; or one to four) additional therapeutic agents are selected from the group consisting of an antiviral agent, a 5-substituted 2’-deoxyuridine analogue, a nucleoside analogue, a pyrophosphate analogue, a nucleoside reverse transcriptase inhibitor, a non nucleoside reverse transcriptase inhibitor, a protease inhibitor, an integrase inhibitor, an entry inhibitor, an acyclic guanosine analogue, an acyclic nucleoside phosphonate analogue, a HCV NS5A/NS5B inhibitor, an influenza virus inhibitor, an interferon, an immunostimulatory agent, an agent for treatment of RSV, an agent for treatment of picomavirus, an agent for treatment of malaria, an agent for treatment of coronavirus, an agent for treatment of ebola virus, an
  • a method for inhibiting the replication of the HIV virus, treating AIDS or delaying the onset of AIDS in a subject comprising administering a compound disclosed herein, or a pharmaceutically acceptable salt thereof, to the subject is disclosed.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof, for use in medical therapy of an HIV infection (e.g, HIV-1) or the replication of the HIV virus (e.g, HIV-1) or AIDS or delaying the onset of AIDS in a subject (e.g, a human) is disclosed.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof, for use in medical therapy of a coronavirus infection, or the replication of a coronavirus, or COVID-19, or delaying the onset of COVID-19 in a subject e.g., a human
  • the coronavirus is a SARS virus, a MERS virus, or a 2019-nCoV (COVID-19) virus.
  • the coronavirus is a SARS virus.
  • the coronavirus is a MERS virus.
  • the coronavirus is a 2019-nCoV (COVID-19) virus.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof, for use in the manufacture of a medicament for treating an HIV infection or the replication of the HIV virus or AIDS or delaying the onset of AIDS in a subject is disclosed.
  • a subject e.g, a human
  • One embodiment relates to a compound disclosed herein, or a
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof, for use in the manufacture of a medicament for treating a coronavirus infection, or the replication of a coronavirus, or COVID-19, or delaying the onset of COVID-19 related symptoms in a subject e.g, a human
  • a subject e.g, a human
  • the coronavirus is a SARS virus, a MERS virus, or a 2019-nCoV (COVID-19) virus.
  • the coronavirus is a SARS virus.
  • the coronavirus is a MERS virus.
  • the coronavirus is a 2019-nCoV (COVID-19) virus.
  • a pharmaceutically acceptable salt thereof for the manufacture of a medicament for an HIV infection in a subject (e.g, a human) is disclosed.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof, for use in the prophylactic or therapeutic treatment of an HIV infection is disclosed.
  • the coronavirus infection is an infection caused by the SARS virus, the MERS virus, or the 2019- nCoV (COVID-19) virus.
  • the coronavirus infection is an infection caused by the SARS virus.
  • the coronavirus infection is an infection caused by the MERS virus.
  • the coronavirus infection is an infection caused by the 2019-nCoV (COVID-19) virus.
  • the administration is to a subject (e.g ., a human) in need of the treatment. In certain embodiments, in the methods of use, the administration is to a subject (e.g., a human) who is at risk of developing AIDS.
  • the administration is to a subject (e.g, a human) in need of the treatment. In certain embodiments, in the methods of use, the administration is to a subject (e.g, a human) who is at risk of developing symptoms related to a coronavirus infection.
  • the coronavirus infection is an infection caused by the SARS virus, the MERS virus, or the 2019-nCoV (COVID-19) virus. In certain embodiments, the coronavirus infection is an infection caused by the SARS virus. In certain embodiments, the coronavirus infection is an infection caused by the MERS virus. In certain embodiments, the coronavirus infection is an infection caused by the 2019-nCoV (COVID-19) virus.
  • a pharmaceutically acceptable salt thereof is for use in a method of treating an HIV infection or the replication of the HIV virus or AIDS or delaying the onset of AIDS in a subject (e.g, a human).
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is for use in a method of treating a coronavirus infection, or the replication of a coronavirus, or coronavirus related symptoms, or delaying the onset of coronavirus related symptoms in a subject (e.g, a human).
  • the coronavirus is a SARS virus, a MERS virus, or a 2019-nCoV (COVID-19) virus.
  • the coronavirus is a SARS virus.
  • the coronavirus is a MERS virus. In certain embodiments, the coronavirus is a 2019-nCoV (COVID-19) virus.
  • the compounds disclosed herein, or a pharmaceutically acceptable salt thereof, for use in a method of treating or preventing HIV infection in a subject in need thereof are provided. In certain embodiments, a compound disclosed herein, or a pharmaceutically acceptable salt thereof, for use in a method of treating HIV infection in a subject in need thereof is provided.
  • the subject in need thereof is a human who has been infected with HIV. In certain embodiments, the subject in need thereof is a human who has been infected with HIV but who has not developed AIDS. In certain embodiments, the subject in need thereof is a subject at risk for developing AIDS. In certain embodiments, the subject in need thereof is a human who has been infected with HIV and who has developed AIDS.
  • the compounds disclosed herein, or a pharmaceutically acceptable salt thereof, for use in a method of treating or preventing a coronavirus infection in a subject in need thereof are provided.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof, for use in a method of treating a coronavirus infection in a subject in need thereof is provided.
  • the subject in need thereof is a human who has been infected with a coronavirus.
  • the subject in need thereof is a human who has been infected with a coronavirus but who has not developed a coronavirus infection related symptom.
  • the subject in need thereof is a subject at risk for developing a coronavirus infection related symptom.
  • the subject in need thereof is a human who has been infected with a coronavirus and who has developed a coronavirus infection related symptom.
  • the coronavirus is a SARS virus, a MERS virus, or a 2019-nCoV (COVID-19) virus.
  • the coronavirus is a SARS virus.
  • the coronavirus is a MERS virus.
  • the coronavirus is a 2019-nCoV (COVID-19) virus.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with one or more (e.g ., one, two, three, or four; or one or two; or one to three; or one to four) additional therapeutic agents as described herein for use in a method of treating or preventing HIV infection in a subject in need thereof is provided.
  • said additional therapeutic agents are selected from the group consisting of combination drugs for HIV, other drugs for treating HIV, HIV protease inhibitors, HIV non-nucleoside or non nucleotide inhibitors of reverse transcriptase, HIV nucleoside or nucleotide inhibitors of reverse transcriptase, HIV integrase inhibitors, HIV non-catalytic site (or allosteric) integrase inhibitors, HIV entry inhibitors, HIV maturation inhibitors, immunomodulators, immunotherapeutic agents, antibody-drug conjugates, gene modifiers, gene editors (such as CRISPR/Cas9, zinc finger nucleases, homing nucleases, synthetic nucleases, TALENs), cell therapies (such as chimeric antigen receptor T-cell, CAR-T, and engineered T cell receptors, TCR-T, autologous T cell therapies), latency reversing agents, compounds that target the HIV capsid, immune-based therapies, phosphatidylinositol 3-
  • said additional therapeutic agents are selected from the group consisting of HIV protease inhibiting compounds, HIV non-nucleoside inhibitors of reverse transcriptase, HIV non-nucleotide inhibitors of reverse transcriptase, HIV nucleoside inhibitors of reverse transcriptase, HIV nucleotide inhibitors of reverse transcriptase, HIV integrase inhibitors, gp41 inhibitors, CXCR4 inhibitors, gpl20 inhibitors, CCR5 inhibitors, capsid polymerization inhibitors, pharmacokinetic enhancers, and other drugs for treating HIV, and any combinations thereof.
  • said additional therapeutic agents are selected from the group consisting of combination drugs for HIV, other drugs for treating HIV, HIV nucleoside reverse transcriptase translocation inhibitors, HIV protease inhibitors, HIV reverse transcriptase inhibitors, HIV integrase inhibitors, HIV non-catalytic site (or allosteric) integrase inhibitors, HIV entry (fusion) inhibitors, HIV maturation inhibitors, latency reversing agents, capsid inhibitors, immune-based therapies, PI3K inhibitors, HIV antibodies, and bispecific antibodies, and“antibody-like” therapeutic proteins, and combinations thereof.
  • said additional therapeutic agents are selected from the group consisting of immunomodulators, immunotherapeutic agents, antibody- drug conjugates, gene modifiers, gene editors (such as CRISPR/Cas9, zinc finger nucleases, homing nucleases, synthetic nucleases, TALENs), and cell therapies such as chimeric antigen receptor T-cell, CAR-T (e.g ., YESCARTA® (axicabtagene ciloleucel)), engineered T cell receptors, TCR-T, and combinations thereof.
  • immunomodulators such as CRISPR/Cas9, zinc finger nucleases, homing nucleases, synthetic nucleases, TALENs
  • cell therapies such as chimeric antigen receptor T-cell, CAR-T (e.g ., YESCARTA® (axicabtagene ciloleucel)), engineered T cell receptors, TCR-T, and combinations thereof.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with a first additional therapeutic agent selected from the group consisting of tenofovir alafenamide fumarate, tenofovir alafenamide, and tenofovir alafenamide hemifumarate, and a second additional therapeutic agent, wherein the second additional therapeutic agent is emtricitabine, is provided for use in a method of treating or preventing HIV infection in a subject in need thereof.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with a first additional therapeutic agent selected from the group consisting of tenofovir disoproxil fumarate, tenofovir disoproxil, and tenofovir disoproxil hemifumarate, and a second additional therapeutic agent, wherein the second additional therapeutic agent is emtricitabine, is provided for use in a method of treating or preventing HIV infection in a subject in need thereof.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with one or more (e.g., one, two, three, or four; or one or two; or one to three; or one to four) additional therapeutic agents as described herein for use in a method of treating or preventing a coronavirus infection in a subject in need thereof is provided.
  • said additional therapeutic agents are selected from the group consisting of an antiviral agent, a 5-substituted 2’-deoxyuridine analogue, a nucleoside analogue, a
  • pyrophosphate analogue a nucleoside reverse transcriptase inhibitor, a non-nucleoside reverse transcriptase inhibitor, a protease inhibitor, an integrase inhibitor, an entry inhibitor, an acyclic guanosine analogue, an acyclic nucleoside phosphonate analogue, a HCV NS5A/NS5B inhibitor, an influenza virus inhibitor, an interferon, an immunostimulatory agent, an agent for treatment of RSV, an agent for treatment of picomavirus, an agent for treatment of malaria, an agent for treatment of coronavirus, an agent for treatment of ebola virus, an agent for treatment of HCV, a NS5A inhibitor, an anti-HBV agent, an agent for treatment of HIV, a KRAS inhibitor, a proteasome inhibitor, a vaccine, an antibody, and a polymerase inhibitor.
  • a compound disclosed herein or a pharmaceutically acceptable salt thereof are provided for use to prevent HIV infection from taking hold if the individual is exposed to the virus and/or to keep the virus from establishing a permanent infection and/or to prevent the appearance of symptoms of the disease and/or to prevent the virus from reaching detectable levels in the blood, for example for pre-exposure prophylaxis (PrEP) or post-exposure prophylaxis (PEP).
  • methods for reducing the risk of acquiring HIV e.g ., HIV-1 and/or HIV-2
  • methods for reducing the risk of acquiring HIV comprise administration of a compound disclosed herein, or a pharmaceutically acceptable salt thereof.
  • methods for reducing the risk of acquiring HIV comprise administration of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with one or more additional therapeutic agents.
  • methods for reducing the risk of acquiring HIV comprise
  • composition comprising a therapeutically effective amount of the compound disclosed herein, or pharmaceutically acceptable salt thereof, and a
  • methods for reducing the risk of acquiring HIV comprise administration of a compound of disclosed herein, or a
  • methods for reducing the risk of acquiring HIV comprise administration to an individual at risk of acquiring HIV.
  • individuals at high risk for acquiring HIV include, without limitation, an individual who is at risk of sexual transmission of HIV.
  • the reduction in risk of acquiring HIV is at least about 40%, 50%, 60%, 70%, 80%, 90%, or 95%. In certain embodiments, the reduction in risk of acquiring HIV is at least about 75%. In certain embodiments, the reduction in risk of acquiring HIV is about 80%, 85%, or 90%.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof are provided for use to prevent a coronavirus infection from taking hold if the individual is exposed to the virus and/or to keep the virus from establishing a permanent infection and/or to prevent the appearance of symptoms of the disease and/or to prevent the virus from reaching detectable levels in the blood, for example for pre-exposure prophylaxis (PrEP) or post-exposure prophylaxis (PEP).
  • PrEP pre-exposure prophylaxis
  • PEP post-exposure prophylaxis
  • methods for reducing the risk of acquiring a coronavirus e.g ., MERS, SARS, or COVID-19.
  • methods for reducing the risk of acquiring a coronavirus comprise administration of a compound disclosed herein, or a pharmaceutically acceptable salt thereof.
  • methods for reducing the risk of acquiring a coronavirus comprise administration of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with one or more additional therapeutic agents.
  • methods for reducing the risk of acquiring a coronavirus comprise administration of a pharmaceutical composition comprising a therapeutically effective amount of the compound disclosed herein, or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
  • the reduction in risk of acquiring a coronavirus is at least about 40%, 50%, 60%, 70%, 80%, 90%, or 95%. In certain embodiments, the reduction in risk of acquiring a coronavirus is at least about 75%. In certain embodiments, the reduction in risk of acquiring a coronavirus is about 80%, 85%, or 90%.
  • the coronavirus is a SARS virus, a MERS virus, or a 2019-nCoV (COVID-19) virus. In certain embodiments, the coronavirus is a SARS virus. In certain embodiments, the coronavirus is a MERS virus. In certain embodiments, the coronavirus is a 2019-nCoV (COVID-19) virus.
  • the compounds of the present invention can be administered at any time to a human who may come into contact with humans suffering from a coronavirus infection or is already suffering from a coronavirus infection.
  • the compounds of the present invention can be administered prophylactically to humans coming into contact with humans suffering from a coronavirus infection or at risk of coming into contact with humans suffering from a coronavirus infection, e.g. , healthcare providers.
  • administration of the compounds of the present invention can be to humans testing positive for a coronavirus infection but not yet showing symptoms of the coronavirus infection.
  • administration of the compounds of the present invention can be to humans upon
  • the coronavirus infection is an infection caused by the SARS virus, the MERS virus, or the 2019- nCoV (COVID-19) virus.
  • the coronavirus infection is an infection caused by the SARS virus.
  • the coronavirus infection is an infection caused by the MERS virus.
  • the coronavirus infection is an infection caused by the 2019-nCoV (COVID-19) virus.
  • the methods disclosed herein comprise event driven administration of a compound provided herein, or a pharmaceutically acceptable salt thereof, to the subject.
  • the terms“event driven” or“event driven administration” refer to administration of a compound provided herein, or a pharmaceutically acceptable salt thereof, (1) prior to an event (e.g., 2 hours, 1 day, 2 days, 5 day, or 7 or more days prior to the event) that would expose the individual to a coronavirus (or that would otherwise increase the individual’s risk of acquiring a coronavirus); and/or (2) during an event (or more than one recurring event) that would expose the individual to a coronavirus (or that would otherwise increase the individual’s risk of acquiring a coronavirus); and/or (3) after an event (or after the final event in a series of recurring events) that would expose the individual to a coronavirus (or that would otherwise increase the individual’s risk of acquiring a coronavirus).
  • an event e.g., 2 hours, 1 day, 2 days, 5 day, or 7 or more days prior to the event
  • an event e.g., 2 hours, 1 day, 2 days,
  • the event driven administration is performed pre-exposure of the subject to the coronavirus. In some embodiments, the event driven administration is performed post-exposure of the subject to the coronavirus. In some embodiments, the event driven administration is performed pre exposure of the subject to the coronavirus and post-exposure of the subject to the coronavirus.
  • the coronavirus is a SARS virus, a MERS virus, or a 2019-nCoV (COVID-19) virus. In certain embodiments, the coronavirus is a SARS virus. In certain embodiments, the coronavirus is a MERS vims. In certain embodiments, the coronavirus is a 2019-nCoV (COVID-19) vims.
  • the methods disclosed herein involve administration prior to and/or after an event that would expose the individual to a coronavims or that would otherwise increase the individual’s risk of acquiring a coronavims, e.g ., as pre-exposure prophylaxis (PrEP) and/or as post-exposure prophylaxis (PEP).
  • the methods disclosed herein comprise pre-exposure prophylaxis (PrEP).
  • methods disclosed herein comprise post-exposure prophylaxis (PEP).
  • the coronavims is a SARS vims, a MERS vims, or a 2019-nCoV (COVID-19) vims.
  • the coronavims is a SARS vims. In certain embodiments, the coronavims is a MERS vims. In certain embodiments, the coronavims is a 2019-nCoV (COVID-19) vims.
  • a compound provided herein, or a pharmaceutically acceptable salt thereof is administered before exposure of the subject to a coronavims (e.g, a MERS, SARS, or COVID-19 vims).
  • a coronavims e.g, a MERS, SARS, or COVID-19 vims.
  • a compound provided herein, or a pharmaceutically acceptable salt thereof is administered before and after exposure of the subject to a coronavims (e.g, a MERS, SARS, or COVID-19 vims).
  • a coronavims e.g, a MERS, SARS, or COVID-19 vims.
  • a compound provided herein, or a pharmaceutically acceptable salt thereof is administered after exposure of the subject to a coronavims (e.g, a MERS, SARS, or COVID-19 vims).
  • a coronavims e.g, a MERS, SARS, or COVID-19 vims.
  • the effective dose of a compound of the present invention for treating a coronavims infection can depend on whether the dose is to be used prophylactically or to treat a human already suffering from 2019-nCoV infection. Moreover, the dose can depend on whether the human suffering from 2019-nCoV infection does not yet show symptoms or is already showing symptoms of 2019-nCoV infection. Larger doses may be necessary for treating humans testing positive for 2019-nCoV infection and for humans showing symptoms of 2019-nCoV infection as compared to humans receiving prophylactic treatment.
  • the coronavims infection is an infection caused by the SARS vims, the MERS vims, or the 2019-nCoV
  • the coronavims infection is an infection caused by the SARS vims. In certain embodiments, the coronavims infection is an infection caused by the MERS vims. In certain embodiments, the coronavirus infection is an infection caused by the 2019-nCoV (COVID-19) vims.
  • administration can be for from 1 day to 100 days, including 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 40, 50, 60, 70, 80, or 90 days.
  • the administration can also be for from 1 week to 15 weeks, including 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14 weeks. Longer periods of administration are also contemplated.
  • the time for administration can depend on whether the compound is being administered prophylactically or to treat a human suffering from a coronavims infection.
  • a prophylactic administration can be for a period of time while the human is in regular contact with other humans suffering from a coronavims infection, and for a suitable period of time following the last contact with a human suffering from a coronavims infection.
  • the period of administration can be for any length of time necessary to treat the patient and a suitable period of time following a negative test for a coronavims infection to ensure the coronavims infection does not return.
  • the coronavims infection is an infection caused by the SARS vims, the MERS vims, or the 2019-nCoV (COVID-19) vims.
  • the coronavims infection is an infection caused by the SARS vims. In certain embodiments, the coronavims infection is an infection caused by the MERS vims. In certain embodiments, the coronavims infection is an infection caused by the 2019-nCoV (COVID-19) vims.
  • Also disclosed herein is a compound disclosed herein, or a pharmaceutically acceptable salt thereof, for use in the therapeutic treatment or delaying the onset of AIDS.
  • Also disclosed herein is a compound disclosed herein, or a pharmaceutically acceptable salt thereof, for use in the prophylactic or therapeutic treatment of an HIV infection.
  • the coronavims infection is an infection caused by a SARS vims, a MERS virus, or a 2019-nCoV (COVID-19) virus.
  • the coronavirus infection is an infection caused by a SARS virus.
  • the coronavirus infection is an infection caused by a MERS virus.
  • the coronavirus infection is an infection caused by a 2019-nCoV (COVID-19) virus.
  • the coronavirus infection is an infection caused by a SARS virus, a MERS virus, or a 2019-nCoV (COVID-19) virus.
  • the coronavirus infection is an infection caused by a SARS virus.
  • the coronavirus infection is an infection caused by a MERS virus.
  • the coronavirus infection is an infection caused by a 2019-nCoV (COVID- 19) virus.
  • the coronavirus infection is an infection caused by a SARS virus, a MERS virus, or a 2019-nCoV (COVID-19) virus.
  • the coronavirus infection is an infection caused by a SARS virus.
  • the coronavirus infection is an infection caused by a MERS virus.
  • the coronavirus infection is an infection caused by a 2019-nCoV (COVID-19) virus.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof can be used as a research tool (e.g ., to study the inhibition of HIV reverse transcriptase in a subject or in vitro).
  • Kits that include a compound provided herein, or a pharmaceutically acceptable salt, thereof, and suitable packaging are provided.
  • a kit further includes instructions for use.
  • a kit includes a compound provided herein, or a
  • a method for treating or preventing an HIV infection in a human having or at risk of having the infection comprising administering to the human a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with a therapeutically effective amount of one or more e.g ., one, two, three, one or two, or one to three) additional therapeutic agents.
  • a method for treating an HIV infection in a human having or at risk of having the infection comprising administering to the human a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with a therapeutically effective amount of one or more (e.g., one, two, three, one or two, or one to three) additional therapeutic agents.
  • a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof in combination with a therapeutically effective amount of one or more (e.g., one, two, three, one or two, or one to three) additional therapeutic agents.
  • a method for treating or preventing a coronavirus infection in a human having or at risk of having the infection comprising administering to the human a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with a therapeutically effective amount of one or more (e.g, one, two, three, one or two, or one to three) additional therapeutic agents.
  • a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof in combination with a therapeutically effective amount of one or more (e.g, one, two, three, one or two, or one to three) additional therapeutic agents.
  • a method for treating a coronavirus infection in a human having or at risk of having the infection comprising administering to the human a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with a therapeutically effective amount of one or more (e.g., one, two, three, one or two, or one to three) additional therapeutic agents.
  • the coronavirus infection is an infection caused by a SARS virus, a MERS virus, or a 2019-nCoV (COVID-19) virus.
  • the coronavirus infection is an infection caused by a SARS virus.
  • the coronavirus infection is an infection caused by a MERS virus.
  • the coronavirus infection is an infection caused by a 2019-nCoV (COVID- 19) virus.
  • compositions comprising a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with one or more (e.g, one, two, three, one or two, or one to three) additional acceptable carrier, diluent, or excipient are provided.
  • the present disclosure provides a method for treating an HIV infection, comprising administering to a patient in need thereof a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with a therapeutically effective amount of one or more additional therapeutic agents which are suitable for treating an HIV infection.
  • the present disclosure provides a method for treating a coronavirus infection, comprising administering to a patient in need thereof a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with a therapeutically effective amount of one or more additional therapeutic agents which are suitable for treating a coronavirus infection.
  • the coronavirus infection is an infection caused by a SARS virus, a MERS virus, or a 2019-nCoV (COVID-19) virus.
  • the coronavirus infection is an infection caused by a SARS virus.
  • the coronavirus infection is an infection caused by a MERS virus.
  • the coronavirus infection is an infection caused by a 2019-nCoV (COVID-19) virus.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with one, two, three, four, or more additional therapeutic agents.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with two additional therapeutic agents.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with three additional therapeutic agents.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with four additional therapeutic agents.
  • the one, two, three, four, or more additional therapeutic agents can be different therapeutic agents selected from the same class of therapeutic agents, and/or they can be selected from different classes of therapeutic agents.
  • a compound disclosed herein is administered with one or more additional therapeutic agents.
  • Co-administration of a compound disclosed herein with one or more additional therapeutic agents generally refers to simultaneous or sequential administration of a compound disclosed herein and one or more additional therapeutic agents, such that therapeutically effective amounts of the compound disclosed herein and the one or more additional therapeutic agents are both present in the body of the patient.
  • the combination may be administered in two or more administrations.
  • Co-administration includes administration of unit dosages of the compounds disclosed herein before or after administration of unit dosages of one or more additional therapeutic agents.
  • the compound disclosed herein may be administered within seconds, minutes, or hours of the administration of the one or more additional therapeutic agents.
  • a unit dose of a compound disclosed herein is administered first, followed within seconds or minutes by administration of a unit dose of one or more additional therapeutic agents.
  • a unit dose of one or more additional therapeutic agents is administered first, followed by administration of a unit dose of a compound disclosed herein within seconds or minutes.
  • a unit dose of a compound disclosed herein is administered first, followed, after a period of hours (e.g ., 1-12 hours), by administration of a unit dose of one or more additional therapeutic agents.
  • a unit dose of one or more additional therapeutic agents is administered first, followed, after a period of hours (e.g., 1-12 hours), by administration of a unit dose of a compound disclosed herein.
  • a compound disclosed herein is combined with one or more additional therapeutic agents in a unitary dosage form for simultaneous administration to a patient, for example as a solid dosage form for oral administration.
  • a compound of provided herein is formulated as a tablet, which may optionally contain one or more other compounds useful for treating HIV.
  • the tablet can contain another active ingredient for treating HIV, such as HIV protease inhibitors, HIV non-nucleoside or non-nucleotide inhibitors of reverse transcriptase, HIV nucleoside or nucleotide inhibitors of reverse transcriptase, HIV integrase inhibitors, HIV non-catalytic site (or allosteric) integrase inhibitors, pharmacokinetic enhancers, and
  • kits comprising a compound disclosed herein, or a pharmaceutically acceptable salt thereof, in combination with one or more (e.g ., one, two, three, one or two, or one to three) additional therapeutic agents are provided.
  • such tablets are suitable for once daily dosing.
  • the additional therapeutic agent may be an anti -HIV agent.
  • HIV protease inhibitors HIV non-nucleoside or non-nucleotide inhibitors of reverse transcriptase, HIV nucleoside or nucleotide inhibitors of reverse transcriptase, HIV integrase inhibitors, HIV non-catalytic site (or allosteric) integrase inhibitors, HIV entry inhibitors, HIV maturation inhibitors, immunomodulators, immunotherapeutic agents, antibody-drug conjugates, gene modifiers, gene editors (such as CRISPR/Cas9, zinc finger nucleases, homing nucleases, synthetic nucleases, TALENs), cell therapies (such as chimeric antigen receptor T-cell, CAR-T, and engineered T cell receptors, TCR-T, autologous T cell therapies), latency reversing agents, compounds that target the HIV capsid, immune-based therapies, phosphatidylinositol 3-kinase, HIV integra
  • the additional therapeutic agent is selected from the group consisting of combination drugs for HIV, other drugs for treating HIV, HIV protease inhibitors, HIV reverse transcriptase inhibitors, HIV integrase inhibitors, HIV non-catalytic site (or allosteric) integrase inhibitors, HIV entry (fusion) inhibitors, HIV maturation inhibitors, latency reversing agents, capsid inhibitors, immune-based therapies, PI3K inhibitors, HIV antibodies, and bi specific antibodies, and“antibody-like” therapeutic proteins, and combinations thereof.
  • combination drugs include ATRIPLA ® (efavirenz, tenofovir disoproxil fumarate, and emtricitabine); BIKTARVY ® (bictegravir, emtricitabine, and tenofovir alafenamide); COMPLERA ® (EVIPLERA ® ; rilpivirine, tenofovir disoproxil fumarate, and emtricitabine); STRIBILD ® (elvitegravir, cobicistat, tenofovir disoproxil fumarate, and emtricitabine); TRUVADA K (tenofovir disoproxil fumarate and emtricitabine; TDF+FTC); DESCOVY® (tenofovir alafenamide and emtricitabine); ODEFSEY® (tenofovir alafenamide, emtricitabine, and rilpivirine); GENVOYA® (efavirenz,
  • CIMDUTM (lamivudine and tenofovir disoproxil fumarate); tenofovir and lamivudine; tenofovir alafenamide and emtricitabine; tenofovir alafenamide hemifumarate and emtricitabine; tenofovir alafenamide hemifumarate, emtricitabine, and rilpivirine; tenofovir alafenamide hemifumarate, emtricitabine, cobicistat, and elvitegravir; COMBIVIR ® (zidovudine and lamivudine;
  • EPZICOM ® (LIVEXA ® ; abacavir sulfate and lamivudine; ABC+3TC);
  • KALETRA ® ALUVIA K ; lopinavir and ritonavir
  • TRIUMEQ ® diolutegravir, abacavir, and lamivudine
  • TRIZIVIR ® abacavir sulfate, zidovudine, and lamivudine
  • ABC+AZT+3TC atazanavir and cobicistat; atazanavir sulfate and cobicistat; atazanavir sulfate and ritonavir
  • darunavir and cobicistat dolutegravir and rilpivirine; dolutegravir and rilpivirine hydrochloride
  • raltegravir and lamivudine doravirine, lamivudine, and
  • doravirine, lamivudine, and tenofovir disoproxil dapivirine + levonorgestrel, dolutegravir + lamivudine, dolutegravir + emtricitabine + tenofovir alafenamide, elsulfavirine + emtricitabine + tenofovir disoproxil, lamivudine + abacavir + zidovudine, lamivudine + abacavir, lamivudine + tenofovir disoproxil fumarate, lamivudine + zidovudine + nevirapine, lopinavir + ritonavir, lopinavir + ritonavir + abacavir + lamivudine, lopinavir + ritonavir + zidovudine + lamivudine, tenofovir + lamivudine,
  • Examples of other drugs for treating HIV include acemannan, alisporivir, astodrimer, BanLec, CC-11050, deferiprone, Gamimune, griffithsin, metenkefalin, naltrexone, Prolastin, REP 9, RPI-MN, Vorapaxar, VSSP, Hlviral, SB-728-T, 1,5-dicaffeoylquinic acid, rHIV7-shl- TAR-CCR5RZ, MazF gene therapy, MK-8527, BlockAide, PSC-RANTES, ABX-464, AG- 1105, APH-0812, BIT-225, CYT-107, HGTV-43, HPH-116, HS-10234, IMO-3100, IND-02, MK-1376, MK-2048, MK-4250, MK-8507, MK-8591, NOV-205, PA-1050040 (PA-040), PGN- 007
  • HIV protease inhibitors include amprenavir, atazanavir, brecanavir, darunavir, fosamprenavir, fosamprenavir calcium, indinavir, indinavir sulfate, lopinavir, nelfmavir, nelfmavir mesylate, ritonavir, saquinavir, saquinavir mesylate, tipranavir, DG-17, TMB-657 (PPL- 100), T-169, BL-008, MK-8122, TMB-607, and TMC-310911.
  • transcriptase include dapivirine, delavirdine, delavirdine mesylate, doravirine, efavirenz, etravirine, lentinan, MK-8583, nevirapine, rilpivirine, TMC-278LA, ACC-007, AIC-292, KM- 023, PC-1005, and elsulfavirine (VM-1500). Further examples of non-nucleoside reverse transcriptase inhibitors are disclosed in U.S. Patent Publication No. US2016/0250215.
  • HIV nucleoside or nucleotide inhibitors of reverse transcriptase include adefovir, adefovir dipivoxil, azvudine, emtricitabine, tenofovir, tenofovir alafenamide, tenofovir alafenamide fumarate, tenofovir alafenamide hemifumarate, tenofovir disoproxil, tenofovir disoproxil fumarate, tenofovir disoproxil hemifumarate, VIDEX ® and VIDEX EC ® (didanosine, ddl), abacavir, abacavir sulfate, alovudine, apricitabine, censavudine, didanosine, elvucitabine, festinavir, fosalvudine tidoxil, CMX-157, dapivirine, doravi
  • HIV integrase inhibitors include elvitegravir, curcumin, derivatives of curcumin, chicoric acid, derivatives of chicoric acid, 3,5-dicaffeoylquinic acid, derivatives of 3,5-dicaffeoylquinic acid, aurintricarboxylic acid, derivatives of aurintricarboxylic acid, caffeic acid phenethyl ester, derivatives of caffeic acid phenethyl ester, tyrphostin, derivatives of tyrphostin, quercetin, derivatives of quercetin, raltegravir, dolutegravir, JTK-351, bictegravir, AVX-15567, BMS-986197, cabotegravir (long-acting injectable), diketo quinolin-4-1 derivatives, integrase-LEDGF inhibitor, ledgins, M-522, M-532, NSC-310217, NSC-371056, NSC
  • NICKI HIV non-catalytic site, or allosteric, integrase inhibitors
  • HIV entry (fusion) inhibitors examples include cenicriviroc, CCR5 inhibitors, gp41 inhibitors, CD4 attachment inhibitors, DS-003 (BMS-599793), gpl20 inhibitors, and CXCR4 inhibitors.
  • CCR5 inhibitors include aplaviroc, vicriviroc, maraviroc, cenicriviroc, leronlimab (PRO-140), adaptavir (RAP-101), nifeviroc (TD-0232), anti-GP120/CD4 or CCR5 bispecific antibodies, B-07, MB-66, polypeptide C25P, TD-0680, and vMIP (Haimipu).
  • gp41 inhibitors include albuvirtide, enfuvirtide, BMS-986197, enfuvirtide biobetter, enfuvirtide biosimilar, HIV-1 fusion inhibitors (P26-Bapc), ITV-1, ITV-2, ITV-3, ITV-4, PIE-12 trimer and sifuvirtide.
  • CD4 attachment inhibitors include ibalizumab and CADA analogs.
  • gpl20 inhibitors examples include Radha-108 (receptol) 3B3-PE38, BanLec, bentonite-based nanomedicine, fostemsavir tromethamine, IQP-0831, and BMS-663068.
  • CXCR4 inhibitors include plerixafor, ALT-1188, N15 peptide, and vMIP (Haimipu).
  • HIV maturation inhibitors include BMS-955176, BMS-986197, GSK- 3640254 and GSK-2838232.
  • latency reversing agents examples include histone deacetylase (HD AC) inhibitors, proteasome inhibitors such as velcade, and ixazomib citrate, protein kinase C (PKC) activators, Smyd2 inhibitors, BET-bromodomain 4 (BRD4) inhibitors, ionomycin, PMA, SAHA
  • PKC activators include indolactam, prostratin, ingenol B, and DAG- lactones.
  • immune-based therapies include toll-like receptors modulators such as TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13; programmed cell death protein 1 (PD-1) modulators; programmed death-ligand 1 (PD- Ll) modulators; IL-15 modulators; DermaVir; interleukin-7; plaquenil (hydroxychloroquine); proleukin (aldesleukin, IL-2); interferon alfa; interferon alfa-2b; interferon alfa-n3; pegylated interferon alfa; interferon gamma; hydroxyurea; mycophenolate mofetil (MPA) and its ester derivative mycophenolate mofetil (MMF); ribavirin; polymer polyethyleneimine (PEI); gepon; IL-12; WF-10; VGV-1; MOR-22; BMS-936559
  • PD-1
  • TLR agonists examples include vesatolimod (GS-9620), GS-986, IR-103, lefitolimod, tilsotolimod, rintatolimod, DSP-0509, AL-034, G-100, cobitolimod, AST-008, motolimod, GSK-1795091, GSK-2245035, VTX-1463, GS-9688, LHC-165, BDB-001, RG- 7854, telratolimod, and RO-7020531.
  • PI3K inhibitors include idelalisib, alpelisib, buparlisib, CAI orotate, copanlisib, duvelisib, gedatolisib, neratinib, panulisib, perifosine, pictilisib, pilaralisib, puquitinib mesylate, rigosertib, rigosertib sodium, sonolisib, taselisib, AMG-319, AZD-8186, BAY-1082439, CLR-1401, CLR-457, CUDC-907, DS-7423, EN-3342, GSK-2126458, GSK- 2269577, GSK-2636771, INCB-040093, LY-3023414, MLN-1117, PQR-309, RG-7666, RP- 6530, RV-1729, SAR-245409, SAR-260
  • integrin alpha-4/beta-7 antagonists examples include PTG-100, TRK-170, abrilumab, etrolizumab, carotegrast methyl, and vedolizumab.
  • Examples of those targeting HIV in such a manner include bavituximab, UB-421, C2F5, 2G12, C4E10, C2F5+C2G12+C4E10, 8ANC195, 3BNC117, 3BNC117-LS, 3BNC60, D1D2, 10-1074, 10-1074-LS, GS-9722, DH411-2, BG18, PGT145, PGT121, PGT122, PGT- 151, PGT-133, PGT-135, PGT-128, MDX010 (ipilimumab), DH511, DH511-2, N6, N6LS, N49P6, N49P7, N49P7.1, N49P9, N49P11, N60P1.1, N60P25.1, N60P2.1, N60P31.1, N60P22, NIH 45-46, PG9, PG16, 8ANC195, 2Dm2m, 4Dm2m, 6Dm2m, VRC-01
  • Examples of pharmacokinetic enhancers include cobicistat and ritonavir.
  • HIV vaccines include peptide vaccines, recombinant subunit protein vaccines, live vector vaccines using viral vectors such as arenavirus, lymphocytic
  • Examples of cell therapy include dendritic cell therapy or T-cell therapy (e.g ., CD4- positive T-cells or CD8-positive T-cells).
  • dendritic cell therapy e.g ., CD4- positive T-cells or CD8-positive T-cells.
  • Examples of a T-cell therapy include a TCR-T cell therapy.
  • Examples of dendritic cell therapy include AGS-004, C34-CCR5/C34-CXCR4 expressing CD4-positive T cell, and AGT- 103 -transduced autologous T cell therapy.
  • Genome editing systems include a CRISPR/Cas9 system, a zinc finger nuclease system, a TALEN system, a homing endonucleases system, and a meganuclease system.
  • HIV targeting CRISPR/Cas9 systems examples include EBT-101.
  • a CAR-T cell therapy can involve a population of immune effector cells engineered to express a chimeric antigen receptor (CAR), wherein the CAR comprises an HIV antigen binding domain.
  • the HIV antigen can include an HIV envelope protein or a portion thereof, gpl20 or a portion thereof, a CD4 binding site on gpl20, the CD4-induced binding site on gpl20, N-glycan on gpl20, the V2 of gpl20, the membrane proximal region on gp41.
  • the immune effector cell can be a T-cell or an NK cell.
  • the T-cell is a CD4- positive T-cell, a CD8-positive T-cell, or a combination thereof.
  • CAR-T cells can be autologous or allogeneic.
  • HIV CAR-T examples include VC-CAR-T, anti-CD4 CART cell therapy, autologous hematopoietic stem cells genetically engineered to express a CD4 CAR and the C46 peptide.
  • TCR-T cell therapy examples include VC-CAR-T, anti-CD4 CART cell therapy, autologous hematopoietic stem cells genetically engineered to express a CD4 CAR and the C46 peptide.
  • TCR-T cells can be engineered to target HIV-derived peptides present on the surface of virus-infected cells.
  • Examples of drugs in development as long acting regimens include cabotegravir LA, rilpivirine LA, cabotegravir LA + rilpivirine LA, any integrase LA, VM-1500A-LAI, maraviroc (LAI), tenofovir implant, MK-8591 implant, long-acting dolutegravir, long acting raltegravir + lamivudine.
  • Therapeutic agents used for birth control include cyproterone acetate, desogestrel, dienogest, drospirenone, estradiol valerate, ethinyl Estradiol, ethynodiol, etonogestrel, levomefolate, levonorgestrel, lynestrenol, medroxyprogesterone acetate, mestranol, mifepristone , misoprostol, nomegestrol acetate, norelgestromin, norethindrone, noretynodrel, norgestimate, ormeloxifene, segestersone acetate, ulipristal acetate, and any combinations thereof.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with one, two, three, four or more additional therapeutic agents selected from ATRIPLA ® (efavirenz, tenofovir disoproxil fumarate, and emtricitabine); BIKTARVY ® (bictegravir, emtricitabine, and tenofovir alafenamide); COMPLERA ®
  • EVIPLERA ® rilpivirine, tenofovir disoproxil fumarate, and emtricitabine
  • STRIBILD ® elvitegravir, cobicistat, tenofovir disoproxil fumarate, and emtricitabine
  • TRIUMEQ ® (dolutegravir, abacavir, and lamivudine); dolutegravir, abacavir sulfate, and lamivudine; raltegravir; raltegravir and lamivudine; maraviroc; enfuvirtide; ALUVIA K (KALETRA ® ; lopinavir and ritonavir); COMBIVIR ® (zidovudine and lamivudine; AZT+3TC); EPZICOM ® (LIVEXA ® ; abacavir sulfate and lamivudine; ABC+3TC); TRIZIVIR ® (abacavir sulfate,
  • indinavir indinavir sulfate; tenofovir and lamivudine; zidovudine; nevirapine; saquinavir;
  • saquinavir mesylate aldesleukin; zalcitabine; tipranavir; amprenavir; delavirdine; delavirdine mesylate; Radha-108 (receptol); lamivudine and tenofovir disoproxil fumarate; efavirenz, lamivudine, and tenofovir disoproxil fumarate; phosphazid; lamivudine, nevirapine, and zidovudine; abacavir; and abacavir sulfate.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with an HIV nucleoside or nucleotide inhibitor of reverse transcriptase and an HIV non-nucleoside inhibitor of reverse transcriptase.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with an HIV nucleoside or nucleotide inhibitor of reverse transcriptase, and an HIV protease inhibiting compound.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with an HIV nucleoside or nucleotide inhibitor of reverse transcriptase, an HIV non-nucleoside inhibitor of reverse transcriptase, and a pharmacokinetic enhancer.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with at least one HIV nucleoside inhibitor of reverse transcriptase, an integrase inhibitor, and a pharmacokinetic enhancer.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with two HIV nucleoside or nucleotide inhibitors of reverse transcriptase.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with abacavir sulfate, tenofovir, tenofovir disoproxil, tenofovir disoproxil fumarate, tenofovir disoproxil hemifumarate, tenofovir alafenamide, or tenofovir alafenamide hemifumarate.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with tenofovir, tenofovir disoproxil, tenofovir disoproxil fumarate, tenofovir alafenamide, or tenofovir alafenamide hemifumarate.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with a first additional therapeutic agent selected from the group consisting of abacavir sulfate, tenofovir, tenofovir disoproxil, tenofovir disoproxil fumarate, tenofovir alafenamide, and tenofovir alafenamide hemifumarate, and a second additional therapeutic agent selected from the group consisting of emtricitabine and lamivudine.
  • a first additional therapeutic agent selected from the group consisting of abacavir sulfate, tenofovir, tenofovir disoproxil, tenofovir disoproxil fumarate, tenofovir alafenamide, and tenofovir alafenamide hemifumarate
  • a second additional therapeutic agent selected from the group consisting of emtricitabine and lamivudine.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with a first additional therapeutic agent selected from the group consisting of tenofovir, tenofovir disoproxil, tenofovir disoproxil fumarate, tenofovir alafenamide, and tenofovir alafenamide hemifumarate, and a second additional therapeutic agent, wherein the second additional therapeutic agent is emtricitabine.
  • a compound as disclosed herein may be combined with one or more additional therapeutic agents in any dosage amount of the compound provided herein (e.g ., from 1 mg to 500 mg of compound).
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with 5-30 mg tenofovir alafenamide fumarate, tenofovir alafenamide hemifumarate, or tenofovir alafenamide, and 200 mg emtricitabine.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with 5-10, 5-15, 5-20, 5-25, 25-30, 20-30, 15-30, or 10-30 mg tenofovir alafenamide fumarate, tenofovir alafenamide hemifumarate, or tenofovir alafenamide, and 200 mg emtricitabine.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with 10 mg tenofovir alafenamide fumarate, tenofovir alafenamide hemifumarate, or tenofovir alafenamide, and 200 mg emtricitabine. In certain embodiments, a compound disclosed herein, or a pharmaceutically acceptable salt thereof, is combined with 25 mg tenofovir alafenamide fumarate, tenofovir alafenamide hemifumarate, or tenofovir alafenamide, and 200 mg emtricitabine.
  • a compound as disclosed herein may be combined with the agents provided herein in any dosage amount of the compound ( e.g. , from 1 mg to 500 mg of compound) the same as if each combination of dosages were specifically and individually listed.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with 200-400 mg tenofovir disoproxil fumarate, tenofovir disoproxil hemifumarate, or tenofovir disoproxil, and 200 mg emtricitabine.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with 200-250, 200-300, 200-350, 250-350, 250-400, 350-400, 300-400, or 250-400 mg tenofovir disoproxil fumarate, tenofovir disoproxil hemifumarate, or tenofovir disoproxil, and 200 mg emtricitabine.
  • a compound disclosed herein, or a pharmaceutically acceptable salt thereof is combined with 300 mg tenofovir disoproxil fumarate, tenofovir disoproxil hemifumarate, or tenofovir disoproxil, and 200 mg emtricitabine.
  • a compound as disclosed herein may be combined with the agents provided herein in any dosage amount of the compound (e.g., from 1 mg to 500 mg of compound) the same as if each combination of dosages were specifically and individually listed.
  • kits comprising a compound disclosed herein, or a
  • pharmaceutically acceptable salt thereof in combination with one or more (e.g, one, two, three, one or two, or one to three) additional therapeutic agents are provided.
  • the coronavirus infection is an infection caused by a SARS virus, a MERS virus, or a 2019-nCoV (COVID-19) virus.
  • the coronavirus infection is an infection caused by a SARS virus.
  • the coronavirus infection is an infection caused by a MERS virus.
  • the coronavirus infection is an infection caused by a 2019-nCoV (COVID-19) virus.
  • the additional therapeutic agent is an antiviral agent.
  • Any suitable antiviral agent can be used in the methods described herein.
  • the antiviral agent is selected from the group consisting of 5-substituted 2’-deoxyuridine analogues, nucleoside analogues, pyrophosphate analogues, nucleoside reverse transcriptase inhibitors, non nucleoside reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, entry inhibitors, acyclic guanosine analogues, acyclic nucleoside phosphonate analogues, HCV NS5A/NS5B inhibitors, influenza virus inhibitors, interferons, immunostimulators,
  • oligonucleotides oligonucleotides, antimitotic inhibitors, and combinations thereof.
  • the additional therapeutic agent is a 5-substituted T - deoxyuridine analogue.
  • the additional therapeutic agent is selected from the group consisting of idoxuridine, trifluridine, brivudine [BVDU], or a combination thereof.
  • the additional therapeutic agent is a nucleoside analogue.
  • the additional therapeutic agent is selected from the group consisting of vidarabine, entecavir (ETV), telbivudine, lamivudine, adefovir dipivoxil, tenofovir disoproxil fumarate (TDF) and combinations thereof.
  • the additional therapeutic agent is favipiravir, ribavirin, galidesivir, or a combination thereof.
  • the additional therapeutic agent is a pyrophosphate analogue.
  • the additional therapeutic agent is foscarnet or
  • the additional therapeutic agent is foscarnet.
  • the additional therapeutic agent is a nucleoside reverse transcriptase inhibitor.
  • the antiviral agent is zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir, emtricitabine, or a combination thereof.
  • the additional therapeutic agent is a non-nucleoside reverse transcriptase inhibitor.
  • the antiviral agent is selected from the group consisting of nevirapine, delavirdine, efavirenz, etravirine, rilpivirine, and combinations thereof.
  • the additional therapeutic agent is a protease inhibitor.
  • the protease inhibitor is a HIV protease inhibitor.
  • the antiviral agent is selected from the group consisting of saquinavir, ritonavir, indinavir, nelfmavir, amprenavir, lopinavir, atazanavir, fosamprenavir, darunavir, tipranavir, cobicistat, and combinations thereof.
  • the antiviral agent is selected from the group consisting of saquinavir, ritonavir, indinavir, nelfmavir, amprenavir, lopinavir, atazanavir, fosamprenavir, darunavir, tipranavir, and combinations thereof.
  • the protease inhibitor is a HCV NS3/4A protease inhibitor.
  • the additional therapeutic agent is selected from the group consisting of asunaprevir, boceprevir, paritaprevir, simeprevir, telaprevir, vaniprevir, grazoprevir, ribavirin, danoprevir, faldaprevir, vedroprevir, sovaprevir, deldeprevir, narlaprevir and combinations thereof.
  • the additional therapeutic agent is selected from the group consisting of asunaprevir, boceprevir, paritaprevir, simeprevir, telaprevir, vaniprevir, grazoprevir, and combinations thereof. Integrase Inhibitor
  • the additional therapeutic agent is an integrase inhibitor.
  • the additional therapeutic agent is selected from the group consisting of raltegravir, dolutegravir, elvitegravir, abacavir, lamivudine, and combinations thereof.
  • the additional therapeutic agent is selected from the group consisting of raltegravir, dolutegravir, elvitegravir, and combinations thereof.
  • the additional therapeutic agent is an entry inhibitor.
  • the additional therapeutic agent is selected from the group consisting of docosanol, enfuvirtide, maraviroc, palivizumab, respiratory syncytial virus immune globulin, intravenous [RSV-IGIV], varicella-zoster immunoglobulin [VariZIG], varicella-zoster immune globulin [VZIG], and combinations thereof.
  • the additional therapeutic agent is an acyclic guanosine analogue.
  • the additional therapeutic agent is selected from the group consisting of acyclovir, ganciclovir, valacyclovir (also known as valaciclovir), valganciclovir, penciclovir, famciclovir, and combinations thereof.
  • the additional therapeutic agent is an acyclic nucleoside phosphonate analogue.
  • the additional therapeutic agent is selected from a group consisting of cidofovir, adefovir, adefovir dipivoxil, tenofovir, TDF, emtricitabine, efavirenz, rilpivirine, elvitegravir, and combinations thereof.
  • the additional therapeutic agent is selected from the group consisting of cidofovir, adefovir, adefovir dipivoxil, tenofovir, TDF, and combinations thereof. In some embodiment, the additional therapeutic agent is selected from the group consisting of cidofovir, adefovir dipivoxil, TDF, and combinations thereof.
  • the additional therapeutic agent is a HCV NS5A/NS5B inhibitor. In some embodiments, the additional therapeutic agent is a NS3/4A protease inhibitor. In some embodiments, the additional therapeutic agent is a NS5A protein inhibitor. In some embodiments, the additional therapeutic agent is a NS5B polymerase inhibitor of the
  • the additional therapeutic agent is a NS5B polymerase inhibitor of the nonnucleoside type.
  • the additional therapeutic agent is selected from the group consisting of daclatasvir, ledipasvir, ombitasvir, elbasvir, sofosbuvir, dasabuvir, ribavirin, asunaprevir, simeprevir, paritaprevir, ritonavir, elbasvir, grazoprevir, and combinations thereof.
  • the additional therapeutic agent is selected from the group consisting of daclatasvir, ledipasvir, ombitasvir, elbasvir, sofosbuvir, dasabuvir, and combinations thereof.
  • the additional therapeutic agent is an influenza virus inhibitor.
  • the additional therapeutic agents is a matrix 2 inhibitor.
  • the additional therapeutic agent is selected from the group consisting of amantadine, rimantadine, and combinations thereof.
  • the additional therapeutic agent is a neuraminidase inhibitor.
  • the additional therapeutic agent is selected from the group consisting of zanamivir, oseltamivir, peramivir, laninamivir octanoate, and combinations thereof.
  • the additional therapeutic agent is a polymerase inhibitor.
  • the additional therapeutic agent is selected from the group consisting of ribavirin, favipiravir, and combinations thereof.
  • the additional therapeutic agent is selected from the group consisting of amantadine, rimantadine, arbidol (umifenovir), baloxavir marboxil, oseltamivir, peramivir, ingavirin, laninamivir octanoate, zanamivir, favipiravir, ribavirin, and combinations thereof.
  • the additional therapeutic agent is selected from the group consisting of amantadine, rimantadine, zanamivir, oseltamivir, peramivir, laninamivir octanoate, ribavirin, favipiravir, and combinations thereof.
  • the additional therapeutic agent is an interferon.
  • the additional therapeutic agent is selected from the group consisting of interferon alfacon 1, interferon alfa lb, interferon alfa 2a, interferon alfa 2b, pegylated interferon alfacon 1, pegylated interferon alfa lb, pegylated interferon alfa 2a (PegIFNa-2a), and PegIFNa-2b.
  • the additional therapeutic agent is selected from the group consisting of interferon alfacon 1, interferon alfa lb, interferon alfa 2a, interferon alfa 2b, pegylated interferon alfa 2a (PegIFNa-2a), and PegIFNa-2b.
  • the additional therapeutic agent is selected from the group consisting of interferon alfacon 1, pegylated interferon alfa 2a (PegIFNa-2a), PegIFNa-2b, and ribavirin.
  • the additional therapeutic agent is pegylated interferon alfa-2a, pegylated interferon alfa-2b, or a combination thereof.
  • the additional therapeutic agent is an immunostimulatory agent.
  • the additional therapeutic agent is an oligonucleotide.
  • the additional therapeutic agent is an antimitotic inhibitor.
  • the additional therapeutic agent is selected from the group consisting of fomivirsen, podofilox, imiquimod, sinecatechins, and combinations thereof.
  • the additional therapeutic agent is selected from the group consisting of besifovir, nitazoxanide, REGN2222, doravirine, sofosbuvir, velpatasvir, daclatasvir, asunaprevir, beclabuvir, FV100, and letermovir, and combinations thereof.
  • Anti-RSV Agents are selected from the group consisting of besifovir, nitazoxanide, REGN2222, doravirine, sofosbuvir, velpatasvir, daclatasvir, asunaprevir, beclabuvir, FV100, and letermovir, and combinations thereof.
  • the additional therapeutic agent is an agent for treatment of RSV.
  • the antiviral agent is ribavirin, ALS-8112 or presatovir.
  • the antiviral agent is ALS-8112 or presatovir.
  • the additional therapeutic agent is an agent for treatment of picornavirus.
  • the additional therapeutic agent is selected from the group consisting of hydantoin, guanidine hydrochloride, L-buthionine sulfoximine, Py-11, and combinations thereof.
  • the additional therapeutic agent is a picornavirus polymerase inhibitor.
  • the additional therapeutic agent is rupintrivir.
  • the additional therapeutic agent is an agent for treatment of malaria.
  • the additional therapeutic agent is selected from the group consisting of hydroxychloroquine, chloroquine, artemether, lumefantrine, atovaquone, proguanil, tafenoquine, pyronaridine, artesunate, artenimol, piperaquine, artesunate,
  • the additional therapeutic agent is an agent for treatment of coronavirus.
  • the additional therapeutic agent is selected from a group consisting of IFX-1, FM-201, CYNK-001, DPP4-Fc, ranpimase, nafamostat, LB-2, AM-1, anti- viroporins, and combinations thereof.
  • Anti-Ebola Virus Agents are selected from a group consisting of IFX-1, FM-201, CYNK-001, DPP4-Fc, ranpimase, nafamostat, LB-2, AM-1, anti- viroporins, and combinations thereof.
  • the additional therapeutic agent is an agent for treatment of ebola virus.
  • the additional therapeutic agent is selected from the group consisting of ribavirin, palivizumab, motavizumab, RSV-IGIV (RespiGam ® ), MEDI-557, A-60444, MDT-637, BMS-433771, amiodarone, dronedarone, verapamil, Ebola Convalescent Plasma (ECP), TKM-100201, BCX4430 ((2S,3S,4R,5R)-2-(4-amino-5H- pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol), favipiravir (also known as T-705 or Avigan),T-705 monophosphate, T-705 diphosphate, T-705 triphosphate, FGI-106 (l-N,7-N-bis[3-(dimethyla)
  • the additional therapeutic agent is an agent for treatment of HCV.
  • the additional therapeutic agent is a HCV polymerase inhibitor.
  • the additional therapeutic agent is selected from the group consisting of sofosbuvir, GS-6620, PSI-938, ribavirin, tegobuvir, radalbuvir, MK-0608, and combinations thereof.
  • the additional therapeutic agent is a HCV protease inhibitor.
  • the additional therapeutic agent is selected from the group consisting of such as GS-9256, vedroprevir, voxilaprevir, and combinations thereof.
  • the additional therapeutic agent is a NS5A inhibitor.
  • the additional therapeutic agent is selected from the group consisting of ledipasvir, velpatasvir, and combinations thereof.
  • Anti-HBV Agents are selected from the group consisting of ledipasvir, velpatasvir, and combinations thereof.
  • the additional therapeutic agent is an anti-HBV agent.
  • the additional therapeutic agent is tenofovir disoproxil fumarate and emtricitabine, or a combination thereof.
  • additional anti HBV agents include but are not limited to alpha-hydroxytropolones, amdoxovir, antroquinonol, beta-hydroxycytosine nucleosides, ARB-199, CCC-0975, ccc-R08, elvucitabine, ezetimibe, cyclosporin A,
  • gentiopicrin gentiopicroside
  • HH-003, hepalatide FN1J-56136379
  • nitazoxanide birinapant
  • NJK14047 moleukin-205
  • NOV-205 moleukin-205
  • oligotide mivotilate, feron, GST-HG-131, levamisole, Ka Shu Ning, alloferon, WS-007, Y-101 (Ti Fen Tai), rSIFN-co, PEG-IIFNm, KW- 3, BP-Inter-014, oleanolic acid, HepB-nRNA, cTP-5 (rTP-5), HSK-II-2, HEISCO-106-1, HEISCO-106, Hepbarna, IBPB-006IA, Hepuyinfen, DasKloster 0014-01, ISA-204, Jiangantai (Ganxikang), MIV-210, OB-
  • the additional therapeutic agent is a HBV polymerase inhibitor.
  • HBV DNA polymerase inhibitors include, but are not limited to, adefovir (HEPSERA®), emtricitabine (EMTRIVA®), tenofovir disoproxil fumarate (VIREAD®), tenofovir alafenamide, tenofovir, tenofovir disoproxil, tenofovir alafenamide fumarate, tenofovir alafenamide hemifumarate, tenofovir dipivoxil , tenofovir dipivoxil fumarate, tenofovir octadecyloxy ethyl ester, CMX-157, tenofovir exalidex, besifovir, entecavir (BARACLUDE®), entecavir maleate, telbivudine (TYZEKA®), filocilo
  • the additional therapeutic agent is an agent for treatment of HIV.
  • the additional therapeutic agent is selected from the group consisting of HIV protease inhibitors, HIV integrase inhibitors, entry inhibitors, HIV nucleoside reverse transcriptase inhibitors, HIV nonnucleoside reverse transcriptase inhibitors, acyclic nucleoside phosphonate analogues, and combinations thereof.
  • the additional therapeutic agent is selected from the group consisting of combination drugs for HIV, other drugs for treating HIV, HIV protease inhibitors, HIV reverse transcriptase inhibitors, HIV integrase inhibitors, HIV non-catalytic site
  • the additional therapeutic agent is a HIV combination drug.
  • HIV combination drugs examples include, but are not limited to
  • ATRIPLA ® efavirenz, tenofovir disoproxil fumarate, and emtricitabine
  • BIKTARVY ® (bictegravir, emtricitabine, and tenofovir alafenamide); COMPLERA ®
  • EVIPLERA ® rilpivirine, tenofovir disoproxil fumarate, and emtricitabine
  • STRIBILD ® elvitegravir, cobicistat, tenofovir disoproxil fumarate, and emtricitabine
  • TRUV DA ® tenofovir disoproxil fumarate and emtricitabine
  • DESCOVY® tenofovir alafenamide and emtricitabine
  • ODEFSEY® tenofovir alafenamide, emtricitabine
  • GENVOYA® tenofovir alafenamide, emtricitabine, cobicistat, and elvitegravir
  • SYMTUZA darunavir, tenofovir alafenamide hemifumarate, emtricitabine, and cobicistat
  • SYMFITM efavirenz, lamivudine, and tenofovir disoproxil
  • CIMDUTM lamivudine and tenofovir disoproxil fumarate
  • tenofovir and lamivudine tenofovir alafenamide and emtricitabine
  • EPZICOM ® (LIVEXA ® ; abacavir sulfate and lamivudine; ABC+3TC); KALETRA ®
  • ALUVIA K lopinavir and ritonavir
  • TRIUMEQ ® diolutegravir, abacavir, and lamivudine
  • TRIZIVIR ® abacavir sulfate, zidovudine, and lamivudine
  • ABC+AZT+3TC ABC+AZT+3TC
  • Atazanavir and cobicistat atazanavir and cobicistat; atazanavir sulfate and cobicistat; atazanavir sulfate and ritonavir; darunavir and cobicistat; dolutegravir and rilpivirine; dolutegravir and rilpivirine
  • the additional therapeutic agent is a HIV protease inhibitor.
  • the additional therapeutic agent is selected from the group consisting of saquinavir, ritonavir, indinavir, nelfmavir, amprenavir, lopinavir, atazanavir, fosamprenavir, darunavir, tipranavir, cobicistat, ASC-09, AEBL-2, MK-8718, GS-9500, GS- 1156, and combinations thereof.
  • the additional therapeutic agent is selected from the group consisting of saquinavir, ritonavir, indinavir, nelfmavir, amprenavir, lopinavir, atazanavir, fosamprenavir, darunavir, tipranavir, cobicistat.
  • the additional therapeutic agent is selected from the group consisting of amprenavir, atazanavir, brecanavir, darunavir, fosamprenavir, fosamprenavir calcium, indinavir, indinavir sulfate, lopinavir, nelfmavir, nelfmavir mesylate, ritonavir, saquinavir, saquinavir mesylate, tipranavir, DG-17, TMB-657 (PPL-100), T-169, BL-008, MK-8122, TMB-607, TMC-310911, and combinations thereof.
  • the additional therapeutic agent is a HIV integrase inhibitor.
  • the additional therapeutic agent is selected from the group consisting of raltegravir, elvitegravir, dolutegravir, abacavir, lamivudine, bictegravir and combinations thereof.
  • the additional therapeutic agent is bictegravir.
  • the additional therapeutic agent is selected from a group consisting of bictegravir, elvitegravir, curcumin, derivatives of curcumin, chicoric acid, derivatives of chicoric acid, 3,5-dicaffeoylquinic acid, derivatives of 3,5-dicaffeoylquinic acid, aurintricarboxylic acid, derivatives of aurintricarboxylic acid, caffeic acid phenethyl ester, derivatives of caffeic acid phenethyl ester, tyrphostin, derivatives of tyrphostin, quercetin, derivatives of quercetin, raltegravir, dolutegravir, JTK-351, bictegravir, AVX-15567, BMS-986197, cabotegravir (long- acting injectable), diketo quinolin-4-1 derivatives, integrase-LEDGF inhibitor, ledgins, M-522, M-532, NSC-310217,
  • the additional therapeutic agent is a HIV entry inhibitor.
  • the additional therapeutic agent is selected from the group consisting of enfuvirtide, maraviroc, and combinations thereof.
  • the additional therapeutic agent is a HIV nucleoside reverse transcriptase inhibitor. In some embodiments, the additional therapeutic agent is a HIV nonnucleoside reverse transcriptase inhibitor. In some embodiments, the additional therapeutic agent is an acyclic nucleoside phosphonate analogue. In some embodiments, the additional therapeutic agent is a HIV capsid inhibitor.
  • the additional therapeutic agent is a HIV nucleoside or nucleotide inhibitor of reverse transcriptase.
  • the additional therapeutic agent is selected from the group consisting of adefovir, adefovir dipivoxil, azvudine, emtricitabine, tenofovir, tenofovir alafenamide, tenofovir alafenamide fumarate, tenofovir alafenamide hemifumarate, tenofovir disoproxil, tenofovir disoproxil fumarate, tenofovir disoproxil hemifumarate, VIDEX® and VIDEX EC® (didanosine, ddl), abacavir, abacavir sulfate, alovudine, apricitabine, censavudine, didanosine, elvucitabine, festinavir, fosalvudin
  • the additional therapeutic agent is a HIV non-nucleoside or non nucleotide inhibitor of reverse transcriptase.
  • the additional agent is selected from the group consisting of dapivirine, delavirdine, delavirdine mesylate, doravirine, efavirenz, etravirine, lentinan, MK-8583, nevirapine, rilpivirine, TMC-278LA, ACC-007, AIC-292, KM- 023, PC-1005, elsulfavirine rilp(VM-1500), and combinations thereof.
  • the additional therapeutic agents are selected from:
  • ATRIPLA ® efavirenz, tenofovir disoproxil fumarate, and emtricitabine
  • COMPLERA ® EVIPLERA ® ; rilpivirine, tenofovir disoproxil fumarate, and emtricitabine
  • STRIBILD ® elvitegravir, cobicistat, tenofovir disoproxil fumarate, and emtricitabine
  • TRUVADA ® tenofovir disoproxil fumarate and emtricitabine; TDF +FTC
  • DESCOVY® tenofovir alafenamide and emtricitabine
  • ODEFSEY® tenofovir alafenamide, emtricitabine, and rilpivirine
  • GENVOYA® tenofovir alafenamide, emtricitabine, cobicistat
  • elvitegravir adefovir; adefovir dipivoxil; cobicistat; emtricitabine; tenofovir; tenofovir disoproxil; tenofovir disoproxil fumarate; tenofovir alafenamide; tenofovir
  • TRIUMEQ ® dolutegravir, abacavir, and lamivudine
  • maraviroc enfuvirtide
  • ALUVIA ® KALETRA ® ; lopinavir and ritonavir
  • COMBIVIR ® zidovudine and lamivudine
  • AZT+3TC lopinavir and ritonavir
  • COMBIVIR ® zidovudine and lamivudine
  • AZT+3TC lopinavir and ritonavir
  • EPZICOM ® LIVEXA ® ; abacavir sulfate and lamivudine; ABC+3TC
  • TRIZIVIR ® abacavir sulfate, zidovudine, and lamivudine
  • Atazanavir and cobicistat darunavir and cobicistat; atazanavir; atazanavir sulfate; dolutegravir; elvitegravir; ritonavir; atazanavir sulfate and ritonavir; darunavir;
  • nelfmavir nelfmavir mesylate; interferon; didanosine; stavudine; indinavir; indinavir sulfate; tenofovir and lamivudine; zidovudine; nevirapine; saquinavir; saquinavir mesylate; aldesleukin; zalcitabine; tipranavir; amprenavir; delavirdine; delavirdine mesylate; Radha-108 (receptol); lamivudine and tenofovir disoproxil fumarate; efavirenz, lamivudine, and tenofovir disoproxil fumarate; phosphazid; lamivudine, nevirapine, and zidovudine; abacavir; and abacavir sulfate.
  • the additional therapeutic agent is selected from the group consisting of colistin, valrubicin, icatibant, bepotastine, epirubicin, epoprosetnol, vapreotide, aprepitant, caspofungin, perphenazine, atazanavir, efavirenz, ritonavir, acyclovir, ganciclovir, penciclovir, prulifloxacin, bictegravir, nelfmavir, tegobuvi, nelfmavir, praziquantel, pitavastatin, perampanel, eszopiclone, and zopiclone.
  • the additional therapeutic agent is an inhibitor of Bruton tyrosine kinase (BTK, AGMX1, AT, ATK, BPK, IGHD3, IMD1, PSCTK1, XLA; NCBI Gene ID: 695).
  • BTK Bruton tyrosine kinase
  • the additional therapeutic agent is selected from the group consisting of (S)-6-amino-9-(l-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)- 7H-purin-8(9H)-one, acalabrutinib (ACP-196), BGB-3111, CB988, HM71224, ibrutinib (Imbruvica), M-2951 (evobrutinib), M7583, tirabrutinib (ONO-4059), PRN-1008, spebrutinib (CC-292), TAK-020, vecabrutinib, ARQ-531, SHR-1459, DTRMWXHS-12, TAS-5315, AZD6738, calquence, danvatirsen, and combinations thereof.
  • the additional therapeutic agent is selected from a group consisting of tirabrutinib, ibrutinib, acalabrutinib, and combinations thereof. In some embodiments, the additional therapeutic agent is selected from a group consisting of tirabrutinib, ibrutinib, and combinations thereof.
  • the additional therapeutic agent is a KRAS inhibitor.
  • the additional therapeutic agent is selected from the group consisting of AMG-510, COTI-219, MRTX-1257, ARS-3248, ARS-853, WDB-178, BI-3406, BI- 1701963, ARS-1620 (G12C), SML-8-73-1 (G12C), Compound 3144 (G12D),
  • KRas GTP Kobe0065/2602 (Ras GTP), RT11, MRTX-849 (G12C) and K-Ras(G12D)-selective inhibitory peptides, including KRpep-2 (Ac-RRCPLYISYDPVCRR-NH2), KRpep-2d (Ac- RRRRCPLYISYDPVCRRRR-NH2), and combinations thereof.
  • the additional therapeutic agent is a proteasome inhibitor.
  • the additional therapeutic agent is selected from a group consisting of ixazomib, carfilzomib, marizomib, bortezomib, and combinations thereof.
  • the additional therapeutic agent is carfilzomib.
  • the additional therapeutic agent is a vaccine.
  • the additional therapeutic agent is a DNA vaccine, RNA vaccine, live- attenuated vaccine, protein-based vaccine, or a combination thereof.
  • the additional therapeutic agent is mRNA-1273.
  • the additional therapeutic agent is INO-4800 or INO-4700.
  • the additional therapeutic agent is live- attenuated RSV vaccine MEDI-559, human monoclonal antibody REGN2222 against RSV, palivizumab, respiratory syncytial virus immune globulin, intravenous [RSV-IGIV], and combinations thereof.
  • the additional therapeutic agent is a HBV vaccine, for example pediarix, engerix-B, and recombivax HB.
  • the additional therapeutic agent is a VZV vaccine, for example zostavax and varivax.
  • the additional therapeutic agent is a HPV vaccine, for example cervarix, gardasil 9, and gardasil.
  • the additional therapeutic agent is an influenza virus vaccine.
  • a (i) monovalent vaccine for influenza A e.g ., influenza A [H5N1] virus monovalent vaccine and influenza A [H1N1] 2009 virus monovalent vaccines
  • (ii) trivalent vaccine for influenza A and B viruses e.g., Afluria, Agriflu, Fluad, Fluarix, Flublok, Flucelvax, FluLaval, Fluvirin, and Fluzone
  • (iii) quadrivalent vaccine for influenza A and B viruses (FluMist, Fluarix, Fluzone, and FluLaval).
  • the additional therapeutic agent is a human adenovirus vaccine (e.g, Adenovirus Type 4 and Type 7 Vaccine, Live, Oral).
  • the additional therapeutic agent is a rotavirus vaccine (e.g, Rotarix for rotavirus serotype Gl, G3, G4, or G9 and RotaTeq for rotavirus serotype Gl, G2, G3, or G4).
  • the additional therapeutic agent is a hepatitis A virus vaccine (e.g, Havrix and Vaqta).
  • the additional therapeutic agent is poliovirus vaccines (e.g, Kinrix, Quadracel, and Ipol).
  • the additional therapeutic agent is a yellow fever virus vaccine (e.g ., YF-Vax).
  • the additional therapeutic agent is a Japanese encephalitis virus vaccines (e.g., Ixiaro and JE-Vax).
  • the additional therapeutic agent is a measles vaccine (e.g, M-M-R II and ProQuad).
  • the additional therapeutic agent is a mumps vaccine (e.g., M-M-R II and
  • the additional therapeutic agent is a rubella vaccine (e.g, M- M-R II and ProQuad). In some embodiments, the additional therapeutic agent is a varicella vaccine (e.g, ProQuad). In some embodiments, the additional therapeutic agent is a rabies vaccine (e.g, Imovax and Rab Avert). In some embodiments, the additional therapeutic agent is a variola virus (smallpox) vaccine (ACAM2000). In some embodiments, the additional therapeutic agent is a and hepatitis E virus (HEV) vaccine (e.g, HEV239).
  • rubella vaccine e.g, M- M-R II and ProQuad
  • the additional therapeutic agent is a varicella vaccine (e.g, ProQuad).
  • the additional therapeutic agent is a rabies vaccine (e.g, Imovax and Rab Avert).
  • the additional therapeutic agent is a variola virus (smallpox) vaccine (ACAM2000).
  • the additional therapeutic agent is a and hepatit
  • the additional therapeutic agent is an antibody, for example a monoclonal antibody. In some embodiments, the additional therapeutic agent is an antibody that binds to a coronavirus, for example an antibody that binds to SARS or MERS.
  • the additional therapeutic agent is recombinant cytokine gene- derived protein injection.
  • the additional therapeutic agent is a polymerase inhibitor.
  • the additional therapeutic agent is a DNA polymerase inhibitor.
  • the additional therapeutic agent is cidofovir.
  • the additional therapeutic agent is a RNA polymerase inhibitor.
  • the additional therapeutic agent is selected from the group consisting of ribavirin, favipiravir, lamivudine, pimodivir and combination thereof.
  • the additional therapeutic agent is selected from the group consisting of lopinavir, ritonavir, interferon-alpha-2b, ritonavir, arbidol, hydroxychloroquine, darunavir and cobicistat, abidol hydrochloride, oseltamivir, litonavir, emtricitabine, tenofovir alafenamide fumarate, baloxavir marboxil, ruxolitinib, and combinations thereof.
  • the additional therapeutic agent is selected from the group consisting of 6’-fluorinated aristeromycin analogues, acyclovir fleximer analogues, disulfiram, thiopurine analogues, ASC09F, GC376, GC813, phenylisoserine derivatives, neuroiminidase inhibitor analogues, pyrithiobac derivatives, bananins and 5-hydroxychromone derivatives, SSYAIO-OOI, griffithsin, HR2P-M1, HR2P-M2, P21S10, Dihydrotanshinone E-64-C and E-64- D, OC43-HR2P, MERS-5HB, 229E-HR1P, 229E-HR2P, resveratrol, l-thia-4-azaspiro[4.5] decan-3 -one derivatives, gemcitabine hydrochloride, loperamide, recombinant interferon
  • compositions disclosed herein are also used in combination with other active ingredients.
  • the other active therapeutic agent is active against coronavirus infections, for example COVID-19 virus infections.
  • the compounds and compositions provided herein are also intended for use with general care provided patients with COVID-19 viral infections, including parenteral fluids (including dextrose saline and Ringer’s lactate) and nutrition, antibiotic (including
  • metronidazole and cephalosporin antibiotics such as ceftriaxone and cefuroxime
  • antifungal prophylaxis fever and pain medication
  • antiemetic such as metoclopramide
  • antidiarrheal agents vitamin and mineral supplements (including Vitamin K and zinc sulfate)
  • anti-inflammatory agents such as ibuprofen or steroids
  • immonumodulatory medications e.g, interferon
  • other small molecule or biologies antiviral agents targeting COVID-19 such as but not limited to lopinavir/ritonavir, EIDD-1931, favipiravir, ribavirine, neutralizing antibodies, etc
  • vaccines pain medications, and medications for other common diseases in the patient population
  • anti-malarial agents including artemether and artesunate-lumefantrine combination therapy
  • typhoid including quinolone antibiotics, such as ciprofloxacin, macrolide antibiotics
  • the additional therapeutic agent is remdesivir.
  • Section 1 provides exemplary synthetic schemes for assembling compounds, preparation of intermediates as used herein, example syntheses and compounds.
  • Section 2 shows biological activity.
  • the reaction mixture was cooled to room temperature and this magnesium reagent was ready for use.
  • the magnesium reagent was added dropwise to a solution of isopropyl (S)-2-((tert-butylsulfmyl)imino)-2-(4-bromophenyl)acetate (4.0 g, 10.6 mmol) in dichloromethane (300 mL) at -78 °C and the resulting reaction mixture was stirred at -78 °C for 11 hr.
  • the reaction was quenched with saturated aq NH 4 CI solution (100 mL), and the mixture was extracted with dichloromethane (200 mL x 2). The organic extracts were combined and concentrated.
  • the reaction was then quenched by addition of saturated aqueous sodium bicarbonate (300 mL).
  • the resulting mixture was extracted with ethyl acetate (200 mL x 3).
  • the organic extracts were combined, washed with brine (300 mL), dried over anhydrous sodium sulfate, and concentrated.
  • the residue was triturated with hexanes (100 mL). The resulting solid was collected by filtration to afford the product.
  • Compound 2 was prepared in a similar manner to prepare Compound 1, except that (3-methylsulfonylphenyl)boronic acid was used instead of (4-methylsulfonylphenyl)boronic acid.
  • Compound 3 was prepared in a similar manner to prepare Compound 1, except that (3-fluoro-4-methylsulfonylphenyl)boronic acid was used instead of (4- methylsulfonylphenyl)boronic acid.
  • Compound 5 was prepared in a similar manner to prepare Compound 1, except that (4-fluorophenyl)boronic acid was used instead of (4-methylsulfonylphenyl)boronic acid.
  • Compound 5 was prepared in a similar manner to prepare Compound 1, except that (3-fluorophenyl)boronic acid was used instead of (4-methylsulfonylphenyl)boronic acid.
  • Compounds were tested in a high-throughput 384-well assay format for their ability to inhibit the replication of HIV-1 (IIIB) in MT-4 cells.
  • Compounds were serially diluted (1 :3) in DMSO on 384-well polypropylene plates and further diluted 200-fold into complete RPMI media (10% FBS, 1% P/S) using the Biotek Micro Flow and Agilent ECHO acoustic dispenser. Each plate contained up to 8 test compounds, with negative (No Drug Control) and 5 uM AZT positive controls.
  • MT-4 cells were pre-infected with 10 uL of either RPMI (mock-infected) or a fresh 1 :250 dilution of an HIV-1 (IIIB) concentrated virus stock.
  • Infected and uninfected MT-4 cells were further diluted in complete RPMI media and added to each plate using a Micro Flow dispenser. After 5 days incubation in a humidified and temperature controlled incubator (37 °C), Cell Titer Glo (Promega) was added to the assay plates to quantify the amount of luciferase.
  • EC50 and CC50 values were defined as the compound concentration that causes a 50% decrease in luminescence signal, and were calculated using a sigmoidal dose-response model to generate curve fits. Data for certain compounds are reported in Table 1 below.
  • Test compounds and one control compound were tested in 3 different species in duplicate sets.
  • Test compound concentration 1 mM
  • Protein concentration 0.5 mg/mL (for dog, rat, and human liver microsomes);
  • Cofactor NADPH-Regenerating system (NRS) solution.
  • Time- points 2, 12, 25, 45, and 65 minutes.
  • Reaction composition (in each incubation well) contains:
  • reaction mixture 25 pL was removed and added to a plate with 225 pL quenching solution (50 % MeOH, 25 % ACN, 25 % H2O, and 200 nM labetalol as internal standard). After plates were vortexed, they were centrifuged for 30 minutes to remove proteins. About 100pL supernatant was removed to a new plate and diluted with 150pL water. About 20 pL of the mixture was injected into LC/MS/MS system to monitor the compound’s response. In vitro measured ti/2 was used to calculate Cl mt values.
  • Inhibitor potency against HIV protease can be measured using an enzymatic assay with a fluorogenic readout.
  • a reaction buffer containing 100 mM ammonium acetate at pH 5.3 100 mM NaCl, 1 mM EDTA, 1 mM DTT, 0.25 mg/mL BSA and 1% DMSO are added 10 nM of recombinant HIV protease (concentration based on protein monomer) and test compound at one of various concentrations.
  • the enzymatic reaction is initiated by the addition of the fluorogenic substrate (2-aminobenzoyl)Thr-Ile-Nle-(p-nitro)Phe- Gln-Arg (Bachem; Product No. H-2992) (SEQ ID NO: 1) to a final concentration of 40 mM.
  • the total volume of the assay solution is 100 pL.
  • the reaction is measured over 10 minutes on a Tecan Infinite M1000 plate reader using an excitation wavelength of 320 nm and a detection wavelength of 420 nm.
  • the slopes of the progress curves are the measure of reaction rates.
  • Reaction rates are plotted as a function of inhibitor concentration, and the data are fit with a four-parameter logistic fit using Graphpad PRISM software to yield IC50 values.

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Abstract

La présente invention concerne des composés ou un sel de qualité pharmaceutique de ceux-ci, tels que décrits dans la description, utilisables pour traiter la prolifération du virus VIH, pour traiter le SIDA ou pour retarder l'apparition des symptômes du SIDA chez un patient. L'invention concerne également des compositions pharmaceutiques comprenant ces composés, des procédés pour les préparer et des méthodes thérapeutiques pour traiter la prolifération du virus VIH, pour traiter le SIDA ou pour retarder l'apparition des symptômes du SIDA chez un patient en utilisant ces composés. La présente invention concerne également des composés ou un sel de qualité pharmaceutique de ceux-ci, tels que décrits dans la description, utilisables pour traiter la prolifération d'un coronavirus, pour traiter les symptômes d'une infection à coronavirus ou pour retarder l'apparition des symptômes d'une infection à coronavirus chez le patient. L'invention concerne également des compositions pharmaceutiques comprenant ces composés, des procédés pour les préparer et des méthodes thérapeutiques pour traiter la prolifération d'un coronavirus, pour traiter les symptômes d'une infection à coronavirus ou pour retarder l'apparition des symptômes d'une infection à coronavirus chez le patient qui utilise ces composés.
PCT/US2020/028336 2019-04-17 2020-04-15 Inhibiteurs de la protéase du vih à base de 2-imino-5-oxo-imidazolidine WO2020214716A1 (fr)

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