Nothing Special   »   [go: up one dir, main page]

WO2019080118A1 - Tcm ointment for treating allergic dermatitis - Google Patents

Tcm ointment for treating allergic dermatitis

Info

Publication number
WO2019080118A1
WO2019080118A1 PCT/CN2017/108113 CN2017108113W WO2019080118A1 WO 2019080118 A1 WO2019080118 A1 WO 2019080118A1 CN 2017108113 W CN2017108113 W CN 2017108113W WO 2019080118 A1 WO2019080118 A1 WO 2019080118A1
Authority
WO
WIPO (PCT)
Prior art keywords
parts
extract
ointment
chinese medicine
traditional chinese
Prior art date
Application number
PCT/CN2017/108113
Other languages
French (fr)
Chinese (zh)
Inventor
吴克
Original Assignee
江苏奇力康皮肤药业有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江苏奇力康皮肤药业有限公司 filed Critical 江苏奇力康皮肤药业有限公司
Priority to PCT/CN2017/108113 priority Critical patent/WO2019080118A1/en
Priority to CN201780001813.4A priority patent/CN108235683A/en
Publication of WO2019080118A1 publication Critical patent/WO2019080118A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Definitions

  • the invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine ointment for treating allergic dermatitis.
  • atopic dermatitis is generally non-specific, and the form, extent and severity of dermatitis are also different due to differences in contact, exposure, and individual response.
  • mild cases there are local erythema, reddish to bright red, slightly edema, or dense papules.
  • severe cases erythema swelling is obvious.
  • papules and blisters When the inflammation is severe, bullae can occur. The blister ruptures with erosion, exudation and scarring. If it is a strong primary stimulus, it can cause necrosis of the epidermis, and even deep ulceration of the dermis.
  • dermatitis occurs in loose areas of the tissue, such as the eyelids, lips, etc.
  • the swelling is obvious, with limited edema without clear edges, the skin is bright, and the surface texture disappears.
  • the location and extent of dermatitis are consistent with the contact area of the contact, and the boundary is very clear.
  • the contact is gas or dust, the dermatitis is diffuse without a clear boundary, but it occurs mostly in the exposed part of the body. Most of the symptoms are itchy and burning or painful. In a few serious cases, there may be systemic reactions such as fever, chills, headache, and nausea.
  • the course of the disease is self-limiting. Generally, after the cause is removed, it can be cured properly and can be cured within 1 to 2 weeks. Repeated contact or improper treatment, can be converted to subacute or chronic dermatitis, reddish brown mossy or eczema-like changes.
  • Irritant contact dermatitis can manifest as erythema, blisters, and exudation in the clinical acute phase. Subacute, chronic can show erythema, roughness, scaling, and splitting. According to the nature of the contact irritant and the length of contact time, it can be clinically characterized as acute irritant dermatitis, delayed acute irritant dermatitis, irritating reaction, cumulative irritant dermatitis, pustular irritant dermatitis, mechanical stimuli-induced dermatitis. Wait.
  • the existing external drugs for allergic dermatitis are mainly hormonal drugs, but the drugs have certain toxic and side effects, and are not suitable for special groups such as pregnant women and infants.
  • the present invention provides a traditional Chinese medicine ointment for treating allergic dermatitis.
  • a traditional Chinese medicine ointment for treating allergic dermatitis comprising the following components by weight: 6-8 parts of Artemisia argyi extract; 4-6 parts of Sophora flavescens extract; 2-4 parts of flax extract; Polygonum multiflorum extract 2 4 parts; pearl powder 10-15 parts; ointment accessories 55-60 parts.
  • the traditional Chinese medicine ointment for treating allergic dermatitis wherein the ointment auxiliary comprises glyceryl monostearate, beeswax, ozokerite, liquid paraffin, white petrolatum, hydroxyethyl ester and distilled water .
  • the traditional Chinese medicine ointment for treating allergic dermatitis further comprises 2-4 parts of purple garlic extract.
  • the traditional Chinese medicine ointment for treating allergic dermatitis further comprises 2-4 parts of Cnidium extract.
  • the traditional Chinese medicine ointment for treating allergic dermatitis further comprises 3-5 parts of polyethylene glycol.
  • the traditional Chinese medicine ointment for treating allergic dermatitis wherein the polyethylene glycol has a number average molecular weight of 2500-3500 g/mol.
  • the traditional Chinese medicine ointment for treating allergic dermatitis comprises the following components by weight: 7 parts of Artemisia argyi extract; 5 parts of Sophora flavescens extract; 3 parts of flax extract; 3 parts of Polygonum multiflorum extract 12 parts of pearl powder; 58 parts of ointment accessories.
  • the invention has the beneficial effects that the traditional Chinese medicine ointment provided by the invention is applied to the affected part of the skin without irritating, hormone-free and antibiotic-free, and can effectively alleviate the symptoms such as erythema, swelling and papules on the affected part of the skin.
  • a traditional Chinese medicine ointment for treating allergic dermatitis comprising the following components by weight: 6 parts of Artemisia argyi extract; 4 parts of Sophora flavescens extract; 2 parts of flax extract; 2 parts of Polygonum multiflorum extract; 10 parts of pearl powder; Ointment accessories 55 parts.
  • a traditional Chinese medicine ointment for treating allergic dermatitis comprising the following components by weight: 8 parts of Artemisia argyi extract; 6 parts of Sophora flavescens extract; 4 parts of flax extract; 4 parts of Polygonum multiflorum extract; 15 parts of pearl powder; 60 parts of ointment accessories.
  • a traditional Chinese medicine ointment for treating allergic dermatitis comprising the following components by weight: 6 parts of Artemisia argyi extract; 4 parts of Sophora flavescens extract; 2 parts of flax extract; 2 parts of Polygonum multiflorum extract; 10 parts of pearl powder; 55 parts of ointment excipient; 2 parts of purple garlic extract.
  • a traditional Chinese medicine ointment for treating allergic dermatitis comprising the following components by weight: 8 parts of Artemisia argyi extract; 6 parts of Sophora flavescens extract; 4 parts of flax extract; 4 parts of Polygonum multiflorum extract; 15 parts of pearl powder; 60 parts of ointment excipient; 4 parts of purple garlic extract.
  • a traditional Chinese medicine ointment for treating allergic dermatitis comprising the following components by weight: 6 parts of Artemisia argyi extract; 4 parts of Sophora flavescens extract; 2 parts of flax extract; 2 parts of Polygonum multiflorum extract; 10 parts of pearl powder; 55 parts of ointment excipient; 2 parts of purple garlic extract; 2 parts of Cnidium extract.
  • a traditional Chinese medicine ointment for treating allergic dermatitis comprising the following components by weight: 8 parts of Artemisia argyi extract; 6 parts of Sophora flavescens extract; 4 parts of flax extract; 4 parts of Polygonum multiflorum extract; 15 parts of pearl powder; 60 parts of ointment excipient; 4 parts of purple garlic extract; 4 parts of Cnidium extract.
  • a traditional Chinese medicine ointment for treating allergic dermatitis comprising the following components by weight: 6 parts of Artemisia argyi extract; 4 parts of Sophora flavescens extract; 2 parts of flax extract; 2 parts of Polygonum multiflorum extract; 10 parts of pearl powder; 55 parts of ointment adjuvant; 2 parts of purple garlic extract; 2 parts of Cnidium extract; 3 parts of polyethylene glycol.
  • a traditional Chinese medicine ointment for treating allergic dermatitis comprising the following components by weight: 8 parts of Artemisia argyi extract; 6 parts of Sophora flavescens extract; 4 parts of flax extract; 4 parts of Polygonum multiflorum extract; 15 parts of pearl powder; 60 parts of ointment excipient; 4 parts of purple garlic extract; 4 parts of Cnidium extract; 5 parts of polyethylene glycol.
  • a traditional Chinese medicine ointment for treating allergic dermatitis comprising the following components by weight: 7 parts of Artemisia argyi extract; 5 parts of Sophora flavescens extract; 3 parts of flax extract; 3 parts of Polygonum multiflorum extract; 12 parts of pearl powder; ointment 58 parts of accessories.
  • the traditional Chinese medicine ointment provided by the invention is applied to the affected part of the skin without irritating, hormone-free and antibiotic-free, and can effectively alleviate erythema, swelling and papules on the affected part of the skin.
  • Test method 30 volunteers (aged 25-40 years old) were randomly divided into 6 groups according to the principle of parallel control. Each group consisted of 5 people. One group of volunteers used the existing hormonal ointment on the market as a comparative example. The remaining 5 groups of volunteers used the traditional Chinese medicine ointments of Examples 1, 3, 5, 7, and 9, respectively, and the test volunteers applied twice in the morning and evening for one week.
  • the erythema, swelling, and papule symptoms of the skin of the test volunteers using the traditional Chinese medicine ointment of Examples 1, 3, 5, 7, and 9 were significantly improved; the skin of the test volunteers using the hormone ointment in the comparative example was used.
  • the symptoms of erythema, swelling and papules in the affected area also improved, indicating that the traditional Chinese medicine ointment in this case is equivalent to the existing hormonal drugs.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

Disclosed is a TCM ointment for treating allergic dermatitis, consisting of 6-8 parts of Artemisia argyi extract, 4-6 parts of radix Sophora flavescens extract, 2-4 parts of sesame extract, 2-4 parts of Tuber fleeceflower extract, 10-15 parts of pearl powder, and 55-60 parts of ointment excipient. Said ointment can relieve affected skin area, such as erythema, swelling, papule, and the like.

Description

一种用于治疗过敏性皮炎的中药软膏Traditional Chinese medicine ointment for treating allergic dermatitis 技术领域Technical field
本发明属于中药领域，特别涉及一种用于治疗过敏性皮炎的中药软膏。The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine ointment for treating allergic dermatitis.
背景技术Background technique
过敏性皮炎表现一般无特异性，由于接触物、接触方式及个体反应不同，发生皮炎的形态、范围及严重程度也不相同。轻症时局部呈红斑，淡红至鲜红色，稍有水肿，或有针尖大丘疹密集，重症时红斑肿胀明显，在此基础上有多数丘疹、水疱，炎症剧烈时可以发生大疱。水疱破裂则有糜烂、渗液和结痂。如为烈性的原发刺激，可使表皮坏死脱落，甚至深及真皮发生溃疡。当皮炎发生于组织疏松部位，如眼睑、口唇等处则肿胀明显，呈局限性水肿而无明确的边缘，皮肤发亮，表面纹理消失。皮炎的部位及范围与接触物接触部位一致，境界非常鲜明，但如接触物为气体、粉尘，则皮炎呈弥漫性而无一定的鲜明界限，但多发生在身体暴露部位。自觉症状大多有痒和烧灼感或胀痛感，少数严重病例可有全身反应，如发热、畏寒、头痛、恶心等。病程有自限性，一般去除病因后，处理得当，1～2周可痊愈。反复接触或处理不当，可以转为亚急性或慢性皮炎，呈红褐色苔藓样变或湿疹样改变。The expression of atopic dermatitis is generally non-specific, and the form, extent and severity of dermatitis are also different due to differences in contact, exposure, and individual response. In mild cases, there are local erythema, reddish to bright red, slightly edema, or dense papules. In severe cases, erythema swelling is obvious. On this basis, there are many papules and blisters. When the inflammation is severe, bullae can occur. The blister ruptures with erosion, exudation and scarring. If it is a strong primary stimulus, it can cause necrosis of the epidermis, and even deep ulceration of the dermis. When dermatitis occurs in loose areas of the tissue, such as the eyelids, lips, etc., the swelling is obvious, with limited edema without clear edges, the skin is bright, and the surface texture disappears. The location and extent of dermatitis are consistent with the contact area of the contact, and the boundary is very clear. However, if the contact is gas or dust, the dermatitis is diffuse without a clear boundary, but it occurs mostly in the exposed part of the body. Most of the symptoms are itchy and burning or painful. In a few serious cases, there may be systemic reactions such as fever, chills, headache, and nausea. The course of the disease is self-limiting. Generally, after the cause is removed, it can be cured properly and can be cured within 1 to 2 weeks. Repeated contact or improper treatment, can be converted to subacute or chronic dermatitis, reddish brown mossy or eczema-like changes.
刺激性接触性皮炎在临床上急性期可表现为红斑、水疱、渗出。亚急性、慢性可表现红斑、粗糙、脱屑、皲裂。根据接触刺激物的性质和接触时间长短，临床上可表现为急性刺激性皮炎、延迟性急性刺激性皮炎、刺激性反应、累积性刺激性皮炎、脓疱性刺激性皮炎、机械性刺激诱发皮炎等。Irritant contact dermatitis can manifest as erythema, blisters, and exudation in the clinical acute phase. Subacute, chronic can show erythema, roughness, scaling, and splitting. According to the nature of the contact irritant and the length of contact time, it can be clinically characterized as acute irritant dermatitis, delayed acute irritant dermatitis, irritating reaction, cumulative irritant dermatitis, pustular irritant dermatitis, mechanical stimuli-induced dermatitis. Wait.
现有的针对过敏性皮炎的外用药主要以激素类药物为主，但这种药物具有一定的毒副作用，不太适用于孕妇、婴幼儿等特殊群体。The existing external drugs for allergic dermatitis are mainly hormonal drugs, but the drugs have certain toxic and side effects, and are not suitable for special groups such as pregnant women and infants.
发明内容Summary of the invention
针对现有技术中的不足之处，本发明提供了一种用于治疗过敏性皮炎的中药软膏。 In view of the deficiencies in the prior art, the present invention provides a traditional Chinese medicine ointment for treating allergic dermatitis.
本发明的技术方案概述如下：The technical solution of the present invention is summarized as follows:
一种用于治疗过敏性皮炎的中药软膏，其包括以下重量份的成分：艾叶提取物6-8份；苦参提取物4-6份；胡麻提取物2-4份；何首乌提取物2-4份；珍珠粉10-15份；软膏辅料55-60份。A traditional Chinese medicine ointment for treating allergic dermatitis, comprising the following components by weight: 6-8 parts of Artemisia argyi extract; 4-6 parts of Sophora flavescens extract; 2-4 parts of flax extract; Polygonum multiflorum extract 2 4 parts; pearl powder 10-15 parts; ointment accessories 55-60 parts.
优选的是，所述的用于治疗过敏性皮炎的中药软膏，其中，所述软膏辅料包括有单硬脂酸甘油脂、蜂腊、地蜡、液体石蜡、白凡士林、羟苯乙酯和蒸馏水。Preferably, the traditional Chinese medicine ointment for treating allergic dermatitis, wherein the ointment auxiliary comprises glyceryl monostearate, beeswax, ozokerite, liquid paraffin, white petrolatum, hydroxyethyl ester and distilled water .
优选的是，所述的用于治疗过敏性皮炎的中药软膏，其中，还包括有2-4份的紫皮蒜提取物。Preferably, the traditional Chinese medicine ointment for treating allergic dermatitis further comprises 2-4 parts of purple garlic extract.
优选的是，所述的用于治疗过敏性皮炎的中药软膏，其中，还包括有2-4份的蛇床子提取物。Preferably, the traditional Chinese medicine ointment for treating allergic dermatitis further comprises 2-4 parts of Cnidium extract.
优选的是，所述的用于治疗过敏性皮炎的中药软膏，其中，还包括有3-5份的聚乙二醇。Preferably, the traditional Chinese medicine ointment for treating allergic dermatitis further comprises 3-5 parts of polyethylene glycol.
优选的是，所述的用于治疗过敏性皮炎的中药软膏，其中，所述聚乙二醇的数均分子量为2500-3500g/mol。Preferably, the traditional Chinese medicine ointment for treating allergic dermatitis, wherein the polyethylene glycol has a number average molecular weight of 2500-3500 g/mol.
优选的是，所述的用于治疗过敏性皮炎的中药软膏，其中，包括以下重量份的成分：艾叶提取物7份；苦参提取物5份；胡麻提取物3份；何首乌提取物3份；珍珠粉12份；软膏辅料58份。Preferably, the traditional Chinese medicine ointment for treating allergic dermatitis comprises the following components by weight: 7 parts of Artemisia argyi extract; 5 parts of Sophora flavescens extract; 3 parts of flax extract; 3 parts of Polygonum multiflorum extract 12 parts of pearl powder; 58 parts of ointment accessories.
本发明的有益效果是：本发明提供的中药软膏涂于皮肤患处，无刺激性、不含激素、无抗生素，能有效缓解皮肤患处的红斑、肿胀、丘疹等症状。The invention has the beneficial effects that the traditional Chinese medicine ointment provided by the invention is applied to the affected part of the skin without irritating, hormone-free and antibiotic-free, and can effectively alleviate the symptoms such as erythema, swelling and papules on the affected part of the skin.
具体实施方式Detailed ways
下面结合实施例对本发明做进一步的详细说明，以令本领域技术人员参照说明书文字能够据以实施。The present invention will be further described in detail below with reference to the embodiments, so that those skilled in the art can refer to the description.
实施例1Example 1
一种用于治疗过敏性皮炎的中药软膏，其包括以下重量份的成分：艾叶提取物6份；苦参提取物4份；胡麻提取物2份；何首乌提取物2份；珍珠粉10份；软膏辅料55份。A traditional Chinese medicine ointment for treating allergic dermatitis, comprising the following components by weight: 6 parts of Artemisia argyi extract; 4 parts of Sophora flavescens extract; 2 parts of flax extract; 2 parts of Polygonum multiflorum extract; 10 parts of pearl powder; Ointment accessories 55 parts.
实施例2 Example 2
一种用于治疗过敏性皮炎的中药软膏，其包括以下重量份的成分：艾叶提取物8份；苦参提取物6份；胡麻提取物4份；何首乌提取物4份；珍珠粉15份；软膏辅料60份。A traditional Chinese medicine ointment for treating allergic dermatitis, comprising the following components by weight: 8 parts of Artemisia argyi extract; 6 parts of Sophora flavescens extract; 4 parts of flax extract; 4 parts of Polygonum multiflorum extract; 15 parts of pearl powder; 60 parts of ointment accessories.
实施例3Example 3
一种用于治疗过敏性皮炎的中药软膏，其包括以下重量份的成分：艾叶提取物6份；苦参提取物4份；胡麻提取物2份；何首乌提取物2份；珍珠粉10份；软膏辅料55份；紫皮蒜提取物2份。A traditional Chinese medicine ointment for treating allergic dermatitis, comprising the following components by weight: 6 parts of Artemisia argyi extract; 4 parts of Sophora flavescens extract; 2 parts of flax extract; 2 parts of Polygonum multiflorum extract; 10 parts of pearl powder; 55 parts of ointment excipient; 2 parts of purple garlic extract.
实施例4Example 4
一种用于治疗过敏性皮炎的中药软膏，其包括以下重量份的成分：艾叶提取物8份；苦参提取物6份；胡麻提取物4份；何首乌提取物4份；珍珠粉15份；软膏辅料60份；紫皮蒜提取物4份。A traditional Chinese medicine ointment for treating allergic dermatitis, comprising the following components by weight: 8 parts of Artemisia argyi extract; 6 parts of Sophora flavescens extract; 4 parts of flax extract; 4 parts of Polygonum multiflorum extract; 15 parts of pearl powder; 60 parts of ointment excipient; 4 parts of purple garlic extract.
实施例5Example 5
一种用于治疗过敏性皮炎的中药软膏，其包括以下重量份的成分：艾叶提取物6份；苦参提取物4份；胡麻提取物2份；何首乌提取物2份；珍珠粉10份；软膏辅料55份；紫皮蒜提取物2份；蛇床子提取物2份。A traditional Chinese medicine ointment for treating allergic dermatitis, comprising the following components by weight: 6 parts of Artemisia argyi extract; 4 parts of Sophora flavescens extract; 2 parts of flax extract; 2 parts of Polygonum multiflorum extract; 10 parts of pearl powder; 55 parts of ointment excipient; 2 parts of purple garlic extract; 2 parts of Cnidium extract.
实施例6Example 6
一种用于治疗过敏性皮炎的中药软膏，其包括以下重量份的成分：艾叶提取物8份；苦参提取物6份；胡麻提取物4份；何首乌提取物4份；珍珠粉15份；软膏辅料60份；紫皮蒜提取物4份；蛇床子提取物4份。A traditional Chinese medicine ointment for treating allergic dermatitis, comprising the following components by weight: 8 parts of Artemisia argyi extract; 6 parts of Sophora flavescens extract; 4 parts of flax extract; 4 parts of Polygonum multiflorum extract; 15 parts of pearl powder; 60 parts of ointment excipient; 4 parts of purple garlic extract; 4 parts of Cnidium extract.
实施例7Example 7
一种用于治疗过敏性皮炎的中药软膏，其包括以下重量份的成分：艾叶提取物6份；苦参提取物4份；胡麻提取物2份；何首乌提取物2份；珍珠粉10份；软膏辅料55份；紫皮蒜提取物2份；蛇床子提取物2份；聚乙二醇3份。A traditional Chinese medicine ointment for treating allergic dermatitis, comprising the following components by weight: 6 parts of Artemisia argyi extract; 4 parts of Sophora flavescens extract; 2 parts of flax extract; 2 parts of Polygonum multiflorum extract; 10 parts of pearl powder; 55 parts of ointment adjuvant; 2 parts of purple garlic extract; 2 parts of Cnidium extract; 3 parts of polyethylene glycol.
实施例8Example 8
一种用于治疗过敏性皮炎的中药软膏，其包括以下重量份的成分：艾叶提取物8份；苦参提取物6份；胡麻提取物4份；何首乌提取物4份；珍珠粉15份；软膏辅料60份；紫皮蒜提取物4份；蛇床子提取物4份；聚乙二醇5份。 A traditional Chinese medicine ointment for treating allergic dermatitis, comprising the following components by weight: 8 parts of Artemisia argyi extract; 6 parts of Sophora flavescens extract; 4 parts of flax extract; 4 parts of Polygonum multiflorum extract; 15 parts of pearl powder; 60 parts of ointment excipient; 4 parts of purple garlic extract; 4 parts of Cnidium extract; 5 parts of polyethylene glycol.
实施例9Example 9
一种用于治疗过敏性皮炎的中药软膏，包括以下重量份的成分：艾叶提取物7份；苦参提取物5份；胡麻提取物3份；何首乌提取物3份；珍珠粉12份；软膏辅料58份。A traditional Chinese medicine ointment for treating allergic dermatitis, comprising the following components by weight: 7 parts of Artemisia argyi extract; 5 parts of Sophora flavescens extract; 3 parts of flax extract; 3 parts of Polygonum multiflorum extract; 12 parts of pearl powder; ointment 58 parts of accessories.
本发明提供的中药软膏涂于皮肤患处，无刺激性、不含激素、无抗生素，能有效缓解皮肤患处的红斑、肿胀、丘疹等症状。The traditional Chinese medicine ointment provided by the invention is applied to the affected part of the skin without irritating, hormone-free and antibiotic-free, and can effectively alleviate erythema, swelling and papules on the affected part of the skin.
试验方法：志愿者30人(年龄25-40岁)，按平行对照的原则随即分为6组，每组5人，其中1组的志愿者使用市场上现有的激素类软膏作为比较例，剩余的5组志愿者分别使用实施例1、3、5、7、9的中药软膏，试验志愿者早晚涂抹2次，连续一周。Test method: 30 volunteers (aged 25-40 years old) were randomly divided into 6 groups according to the principle of parallel control. Each group consisted of 5 people. One group of volunteers used the existing hormonal ointment on the market as a comparative example. The remaining 5 groups of volunteers used the traditional Chinese medicine ointments of Examples 1, 3, 5, 7, and 9, respectively, and the test volunteers applied twice in the morning and evening for one week.
使用一周后：使用实施例1、3、5、7、9中药软膏的试验志愿者的皮肤患处的红斑、肿胀、丘疹症状均有明显改善；使用比较例中激素类软膏的试验志愿者的皮肤患处的红斑、肿胀、丘疹症状也有改善，说明本案的中药软膏和现有的激素类药物等效。After one week of use: the erythema, swelling, and papule symptoms of the skin of the test volunteers using the traditional Chinese medicine ointment of Examples 1, 3, 5, 7, and 9 were significantly improved; the skin of the test volunteers using the hormone ointment in the comparative example was used. The symptoms of erythema, swelling and papules in the affected area also improved, indicating that the traditional Chinese medicine ointment in this case is equivalent to the existing hormonal drugs.
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节。 Although the embodiments of the present invention have been disclosed as above, they are not limited to the applications listed in the specification and the embodiments, and are fully applicable to various fields suitable for the present invention, and are easily accessible to those skilled in the art. The invention is not limited to the specific details, and the invention is not limited by the general concept defined by the appended claims.

Claims (7)

  1. 一种用于治疗过敏性皮炎的中药软膏，其特征在于，包括以下重量份的成分：艾叶提取物6-8份；苦参提取物4-6份；胡麻提取物2-4份；何首乌提取物2-4份；珍珠粉10-15份；软膏辅料55-60份。A traditional Chinese medicine ointment for treating allergic dermatitis, comprising the following components by weight: 6-8 parts of Artemisia argyi extract; 4-6 parts of Sophora flavescens extract; 2-4 parts of flax extract; Polygonum multiflorum extract 2-4 parts; pearl powder 10-15 parts; ointment accessories 55-60 parts.
  2. 如权利要求1所述的用于治疗过敏性皮炎的中药软膏，其特征在于，所述软膏辅料包括有单硬脂酸甘油脂、蜂腊、地蜡、液体石蜡、白凡士林、羟苯乙酯和蒸馏水。The traditional Chinese medicine ointment for treating allergic dermatitis according to claim 1, wherein the ointment auxiliary comprises glyceryl monostearate, beeswax, ozokerite, liquid paraffin, white petrolatum, hydroxyphenylethyl ester And distilled water.
  3. 如权利要求1所述的用于治疗过敏性皮炎的中药软膏，其特征在于，还包括有2-4份的紫皮蒜提取物。The traditional Chinese medicine ointment for treating allergic dermatitis according to claim 1, which further comprises 2-4 parts of extract of purple garlic.
  4. 如权利要求1所述的用于治疗过敏性皮炎的中药软膏，其特征在于，还包括有2-4份的蛇床子提取物。The traditional Chinese medicine ointment for treating atopic dermatitis according to claim 1, which further comprises 2-4 parts of a Cnidium extract.
  5. 如权利要求1所述的用于治疗过敏性皮炎的中药软膏，其特征在于，还包括有3-5份的聚乙二醇。The traditional Chinese medicine ointment for treating allergic dermatitis according to claim 1, which further comprises 3-5 parts of polyethylene glycol.
  6. 如权利要求5所述的用于治疗过敏性皮炎的中药软膏，其特征在于，所述聚乙二醇的数均分子量为2500-3500g/mol。The traditional Chinese medicine ointment for treating atopic dermatitis according to claim 5, wherein the polyethylene glycol has a number average molecular weight of 2,500 to 3,500 g/mol.
  7. 如权利要求1所述的用于治疗过敏性皮炎的中药软膏，其特征在于，包括以下重量份的成分：艾叶提取物7份；苦参提取物5份；胡麻提取物3份；何首乌提取物3份；珍珠粉12份；软膏辅料58份。 The traditional Chinese medicine ointment for treating allergic dermatitis according to claim 1, comprising the following components by weight: 7 parts of Artemisia argyi extract; 5 parts of Sophora flavescens extract; 3 parts of flax extract; Polygonum multiflorum extract 3 parts; 12 parts of pearl powder; 58 parts of ointment accessories.
PCT/CN2017/108113 2017-10-27 2017-10-27 Tcm ointment for treating allergic dermatitis WO2019080118A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/CN2017/108113 WO2019080118A1 (en) 2017-10-27 2017-10-27 Tcm ointment for treating allergic dermatitis
CN201780001813.4A CN108235683A (en) 2017-10-27 2017-10-27 A kind of traditional Chinese herb medicine for being used to treat allergic dermatitis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2017/108113 WO2019080118A1 (en) 2017-10-27 2017-10-27 Tcm ointment for treating allergic dermatitis

Publications (1)

Publication Number Publication Date
WO2019080118A1 true WO2019080118A1 (en) 2019-05-02

Family

ID=62645480

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2017/108113 WO2019080118A1 (en) 2017-10-27 2017-10-27 Tcm ointment for treating allergic dermatitis

Country Status (2)

Country Link
CN (1) CN108235683A (en)
WO (1) WO2019080118A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101628061A (en) * 2009-08-20 2010-01-20 李书林 Medicine for treating urticaria
CN103550604A (en) * 2013-10-09 2014-02-05 李云丽 Traditional Chinese medicine for treating neurodermatitis
CN105125780A (en) * 2015-09-29 2015-12-09 成都倍加特生物科技有限公司 Medicine for oral taking and capable of treating chronic urticaria and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101628061A (en) * 2009-08-20 2010-01-20 李书林 Medicine for treating urticaria
CN103550604A (en) * 2013-10-09 2014-02-05 李云丽 Traditional Chinese medicine for treating neurodermatitis
CN105125780A (en) * 2015-09-29 2015-12-09 成都倍加特生物科技有限公司 Medicine for oral taking and capable of treating chronic urticaria and preparation method thereof

Also Published As

Publication number Publication date
CN108235683A (en) 2018-06-29

Similar Documents

Publication Publication Date Title
Walters Dermatological and transdermal formulations
GT200600096A (en) PHARMACEUTICAL COMPOSITION FOR CANCER TREATMENT
AR090349A1 (en) COMBINATION THERAPY FOR PROLIFERATIVE DISORDERS, KIT AND USE
AR070561A1 (en) INTOLVAGINAL MONOLITIC RINGS THAT INCLUDE PROGESTERONE AND METHODS FOR ITS MANUFACTURE AND USE
RU2638815C2 (en) Topical application compositions containing dapson and dapsone/adapalen, and methods for their application
CN114072162A (en) Compositions and methods for improving bruising and rejuvenating skin
JP2002520281A (en) Vitamin E and its esters for use in the topical treatment of mucosal diseases
Mittal et al. Molecular mechanisms and epigenetic regulation in diabetic cardiomyopathy
BR112022010435A2 (en) SOLUBLE SUPPORT LAYER FOR ORAL THIN FILM (OTF)
WO2019080118A1 (en) Tcm ointment for treating allergic dermatitis
ES2880437T3 (en) New topical compositions comprising usnic acid and its therapeutic use
WO2023201998A1 (en) Application of hydroxybetulinic acid compound in preparation of drugs for skin diseases
WO2022048213A1 (en) Use of scm-198 in preparation of drug for treating psoriasis
CO2022014853A2 (en) Novel compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate 4-methyl-2h-chromen-2-on-7-yl sulfate and use thereof
CN107072979B (en) Use of flavonoid compounds for preparing wound healing compositions
US20170360903A1 (en) Systems for treating dermal inflammatory conditions
Khera et al. Concurrent punctate keratosis of the palmar creases and focal acral hyperkeratosis
WO2019080117A1 (en) Chinese medicinal herbal skin cream for treating rhagades of hands and feet
JP6850406B2 (en) Suppression of itching by fucoxanthin
Yu et al. Role of atractylenolide I in cerebral ischemia reperfusion injury
JP2012519671A5 (en)
CN104490963A (en) Grinding method for panax notoginseng
ES2444299B1 (en) Use of a casein hydrolyzate as an antiherpetic agent
KR20200037121A (en) Medical device for treatment of HPV skin infection
RU2531045C1 (en) Toilet paper with therapeutic properties

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17930048

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 17930048

Country of ref document: EP

Kind code of ref document: A1