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WO2018224506A3 - Auto immune diagnosis using t cell populations - Google Patents

Auto immune diagnosis using t cell populations Download PDF

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Publication number
WO2018224506A3
WO2018224506A3 PCT/EP2018/064789 EP2018064789W WO2018224506A3 WO 2018224506 A3 WO2018224506 A3 WO 2018224506A3 EP 2018064789 W EP2018064789 W EP 2018064789W WO 2018224506 A3 WO2018224506 A3 WO 2018224506A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell populations
auto immune
immune diagnosis
diagnosis
diagnosing
Prior art date
Application number
PCT/EP2018/064789
Other languages
French (fr)
Other versions
WO2018224506A2 (en
Inventor
Luis GRAÇA
Válter FONSECA
Vasco Madeira CRISPIM ROMÃO
João Eurico Cortez CABRAL DA FONSECA
Original Assignee
Instituto De Medicina Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto De Medicina Molecular filed Critical Instituto De Medicina Molecular
Publication of WO2018224506A2 publication Critical patent/WO2018224506A2/en
Publication of WO2018224506A3 publication Critical patent/WO2018224506A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to the diagnosis of autoimmune disorders, and pertains to methods, uses, products, biomarkers and kits for diagnosing, identifying or stratifying patients with an autoimmune disorder. In particular, the invention relates to a kit, product, biomarker, use or method for diagnosing or stratifying Sjögren Syndrome.
PCT/EP2018/064789 2017-06-06 2018-06-05 Auto immune diagnosis using t cell populations WO2018224506A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT110129 2017-06-06
PT11012917 2017-06-06

Publications (2)

Publication Number Publication Date
WO2018224506A2 WO2018224506A2 (en) 2018-12-13
WO2018224506A3 true WO2018224506A3 (en) 2019-01-17

Family

ID=62748905

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2018/064789 WO2018224506A2 (en) 2017-06-06 2018-06-05 Auto immune diagnosis using t cell populations

Country Status (1)

Country Link
WO (1) WO2018224506A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202009148D0 (en) * 2020-06-16 2020-07-29 Ucl Business Ltd Method
GB202109179D0 (en) * 2021-06-25 2021-08-11 Univ Ulster A cell based test to monitor DMARD drug response
CN113552347A (en) * 2021-07-16 2021-10-26 华中科技大学同济医学院附属同济医院 Application of reagent for detecting follicular regulatory T cells in preparation of diagnostic reagent for prognosis of immunotherapy of allergic rhinitis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170108514A1 (en) * 2014-03-23 2017-04-20 The Regents Of The University Of Colorado, A Body Corporate Diagnosis of multiple sclerosis in human and animal subjects

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170108514A1 (en) * 2014-03-23 2017-04-20 The Regents Of The University Of Colorado, A Body Corporate Diagnosis of multiple sclerosis in human and animal subjects

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
ANA RAQUEL MACEIRAS ET AL: "T follicular helper and T follicular regulatory cells have different TCR specificity", NATURE COMMUNICATIONS, vol. 8, 21 April 2017 (2017-04-21), pages 15067, XP055498035, DOI: 10.1038/ncomms15067 *
ANA RAQUEL MACEIRAS ET AL: "T follicular regulatory cells in mice and men", IMMUNOLOGY, vol. 152, no. 1, 27 July 2017 (2017-07-27), GB, pages 25 - 35, XP055498098, ISSN: 0019-2805, DOI: 10.1111/imm.12774 *
CINDY S MA ET AL: "Human T follicular helper (Tfh) cells and disease", IMMUNOLOGY AND CELL BIOLOGY, vol. 92, no. 1, 22 October 2013 (2013-10-22), AU, pages 64 - 71, XP055318710, ISSN: 0818-9641, DOI: 10.1038/icb.2013.55 *
DEEPAK A. RAO ET AL: "Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis", NATURE, vol. 542, no. 7639, 1 February 2017 (2017-02-01), GB, pages 110 - 114, XP055498123, ISSN: 0028-0836, DOI: 10.1038/nature20810 *
DIANA GOMEZ-MARTIN ET AL: "Follicular helper T cells poise immune responses to the development of autoimmune pathology", AUTOIMMUNITY REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 10, no. 6, 6 November 2010 (2010-11-06), pages 325 - 330, XP028159585, ISSN: 1568-9972, [retrieved on 20101215], DOI: 10.1016/J.AUTREV.2010.11.007 *
PETER T. SAGE ET AL: "T follicular regulatory cells in the regulation of B cell responses", TRENDS IN IMMUNOLOGY, vol. 36, no. 7, 1 July 2015 (2015-07-01), GB, pages 410 - 418, XP055386876, ISSN: 1471-4906, DOI: 10.1016/j.it.2015.05.005 *
SZABO KRISZTINA ET AL: "Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome", CLINICAL IMMUNOLOGY, ACADEMIC PRESS, US, vol. 147, no. 2, 15 March 2013 (2013-03-15), pages 95 - 104, XP028581844, ISSN: 1521-6616, DOI: 10.1016/J.CLIM.2013.02.024 *
TESSA DHAEZE ET AL: "Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis", THE JOURNAL OF IMMUNOLOGY, vol. 195, no. 3, 12 June 2015 (2015-06-12), US, pages 832 - 840, XP055498224, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1500759 *
UENO HIDEKI: "Human Circulating T Follicular Helper Cell Subsets in Health and Disease", JOURNAL OF CLINICAL IMMUNOLOGY, KLUWER ACADEMIC PUBLISHERS, NEW YORK, vol. 36, no. 1, 17 March 2016 (2016-03-17), pages 34 - 39, XP035916780, ISSN: 0271-9142, [retrieved on 20160317], DOI: 10.1007/S10875-016-0268-3 *
VALTER R. FONSECA ET AL: "The Ratio of Blood T Follicular Regulatory Cells to T Follicular Helper Cells Marks Ectopic Lymphoid Structure Formation While Activated Follicular Helper T Cells Indicate Disease Activity in Primary Sjögren's Syndrome", ARTHRITIS & RHEUMATOLOGY (HOBOKEN), vol. 70, no. 5, 25 March 2018 (2018-03-25), US, pages 774 - 784, XP055498089, ISSN: 2326-5191, DOI: 10.1002/art.40424 *
XIE XIAOLI ET AL: "ATRA alters humoral responses associated with amelioration of EAMG symptoms by balancing Tfh/Tfr helper cell profiles", CLINICAL IMMUNOLOGY, vol. 148, no. 2, 24 May 2013 (2013-05-24), pages 162 - 176, XP028674567, ISSN: 1521-6616, DOI: 10.1016/J.CLIM.2013.05.009 *
YANBIN WEN ET AL: "Imbalance of circulating CD4 + CXCR5 + FOXP3 + Tfr-like cells and CD4 + CXCR5 + FOXP3 - Tfh-like cells in myasthenia gravis", NEUROSCIENCE LETTERS, vol. 630, 1 September 2016 (2016-09-01), AMSTERDAM, NL, pages 176 - 182, XP055498226, ISSN: 0304-3940, DOI: 10.1016/j.neulet.2016.07.049 *
YOUNG UK KIM ET AL: "Regulation of Autoimmune Germinal Center Reactions in Lupus-Prone BXD2 Mice by Follicular Helper T Cells", PLOS ONE, vol. 10, no. 3, 13 March 2015 (2015-03-13), pages e0120294, XP055498737, DOI: 10.1371/journal.pone.0120294 *

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