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WO2016112875A3 - 二联苯衍生物及其应用 - Google Patents

二联苯衍生物及其应用 Download PDF

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Publication number
WO2016112875A3
WO2016112875A3 PCT/CN2016/076124 CN2016076124W WO2016112875A3 WO 2016112875 A3 WO2016112875 A3 WO 2016112875A3 CN 2016076124 W CN2016076124 W CN 2016076124W WO 2016112875 A3 WO2016112875 A3 WO 2016112875A3
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WO
WIPO (PCT)
Prior art keywords
diphenyl derivative
diphenyl
derivative
solvates
pharmaceutical salts
Prior art date
Application number
PCT/CN2016/076124
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English (en)
French (fr)
Other versions
WO2016112875A2 (zh
Inventor
王汝涛
陈涛
安龙
赵熠
王惟娇
郭树攀
肖飒
庞箐华
胡慧静
Original Assignee
西安力邦制药有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 西安力邦制药有限公司 filed Critical 西安力邦制药有限公司
Priority to AU2016207118A priority Critical patent/AU2016207118B2/en
Priority to JP2017536947A priority patent/JP2018503637A/ja
Priority to US15/543,454 priority patent/US10329243B2/en
Priority to EP16737100.4A priority patent/EP3246304A4/en
Publication of WO2016112875A2 publication Critical patent/WO2016112875A2/zh
Publication of WO2016112875A3 publication Critical patent/WO2016112875A3/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/18—Polycyclic aromatic halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/367—Halogenated derivatives polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/04—Formic acid esters
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    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/40—Succinic acid esters
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    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

本发明涉及二联苯衍生物及其应用，所述二联苯衍生物具有如说明书所定义的式(I)所示的结构。所述应用是指所述二联苯衍生物或其药用盐、溶剂化物，或包含所述二联苯衍生物或其药用盐、溶剂化物的药物组合物在制备治疗和/或预防缺血性脑卒中的药物中的应用。
PCT/CN2016/076124 2015-01-13 2016-03-11 二联苯衍生物及其应用 WO2016112875A2 (zh)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2016207118A AU2016207118B2 (en) 2015-01-13 2016-03-11 Diphenyl derivative and uses thereof
JP2017536947A JP2018503637A (ja) 2015-01-13 2016-03-11 ビフェニル誘導体及びその使用
US15/543,454 US10329243B2 (en) 2015-01-13 2016-03-11 Biphenyl derivative and uses thereof
EP16737100.4A EP3246304A4 (en) 2015-01-13 2016-03-11 DIPHENY DERIVATIVE AND USES THEREOF

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510016733.9 2015-01-13
CN201510016733.9A CN104557532B (zh) 2015-01-13 2015-01-13 二联苯衍生物及其应用

Publications (2)

Publication Number Publication Date
WO2016112875A2 WO2016112875A2 (zh) 2016-07-21
WO2016112875A3 true WO2016112875A3 (zh) 2016-09-09

Family

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Application Number Title Priority Date Filing Date
PCT/CN2016/076124 WO2016112875A2 (zh) 2015-01-13 2016-03-11 二联苯衍生物及其应用

Country Status (6)

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US (1) US10329243B2 (zh)
EP (1) EP3246304A4 (zh)
JP (1) JP2018503637A (zh)
CN (1) CN104557532B (zh)
AU (1) AU2016207118B2 (zh)
WO (1) WO2016112875A2 (zh)

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CN104557532B (zh) 2015-01-13 2017-03-01 西安力邦制药有限公司 二联苯衍生物及其应用
CN104546809B (zh) * 2015-01-13 2018-08-24 西安力邦制药有限公司 3,3’,5,5’-四异丙基-4,4’-二联苯酚在预防及治疗缺血性脑卒中中的应用
CN107556191A (zh) * 2016-06-30 2018-01-09 陕西合成药业股份有限公司 一种二联苯衍生物及其制备方法和在医学上的应用
CN110870856B (zh) 2018-08-31 2023-03-28 西安力邦肇新生物科技有限公司 一种gabaa受体变构增强剂在医药上的应用
CN110872213A (zh) * 2018-08-31 2020-03-10 西安力邦肇新生物科技有限公司 Gabaa受体变构增强化合物及其制备和用途
CN113845424B (zh) * 2021-10-14 2023-09-12 南京医科大学 右崁醇酯类化合物及其药物用途

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Also Published As

Publication number Publication date
US20180141895A1 (en) 2018-05-24
CN104557532B (zh) 2017-03-01
WO2016112875A2 (zh) 2016-07-21
EP3246304A4 (en) 2019-04-03
AU2016207118B2 (en) 2019-02-28
JP2018503637A (ja) 2018-02-08
US10329243B2 (en) 2019-06-25
CN104557532A (zh) 2015-04-29
EP3246304A2 (en) 2017-11-22
AU2016207118A1 (en) 2017-08-31

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