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WO2015170340A3 - Novel polymorphs of sitagliptin hydrochloride, processes for its preparation and pharmaceutical composition thereof - Google Patents

Novel polymorphs of sitagliptin hydrochloride, processes for its preparation and pharmaceutical composition thereof Download PDF

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Publication number
WO2015170340A3
WO2015170340A3 PCT/IN2015/000197 IN2015000197W WO2015170340A3 WO 2015170340 A3 WO2015170340 A3 WO 2015170340A3 IN 2015000197 W IN2015000197 W IN 2015000197W WO 2015170340 A3 WO2015170340 A3 WO 2015170340A3
Authority
WO
WIPO (PCT)
Prior art keywords
processes
preparation
pharmaceutical composition
sitagliptin hydrochloride
novel polymorphs
Prior art date
Application number
PCT/IN2015/000197
Other languages
French (fr)
Other versions
WO2015170340A2 (en
Inventor
Ravindra Babu Bollu
Venkata Sunil Kumar Indukuri
Vamsee Krishna Muppidi
Seeta Rama Anjaneyulu GORANTLA
Satyanarayana Chava
Original Assignee
Laurus Labs Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laurus Labs Private Limited filed Critical Laurus Labs Private Limited
Publication of WO2015170340A2 publication Critical patent/WO2015170340A2/en
Publication of WO2015170340A3 publication Critical patent/WO2015170340A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to novel polymorphic forms of sitagliptin hydrochloride, processes for its preparation and pharmaceutical compositions comprising the same.
PCT/IN2015/000197 2014-05-06 2015-05-06 Novel polymorphs of sitagliptin hydrochloride, processes for its preparation and pharmaceutical composition thereof WO2015170340A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2266CH2014 2014-05-06
IN2266/CHE/2014 2014-05-06

Publications (2)

Publication Number Publication Date
WO2015170340A2 WO2015170340A2 (en) 2015-11-12
WO2015170340A3 true WO2015170340A3 (en) 2016-03-31

Family

ID=54393113

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/000197 WO2015170340A2 (en) 2014-05-06 2015-05-06 Novel polymorphs of sitagliptin hydrochloride, processes for its preparation and pharmaceutical composition thereof

Country Status (1)

Country Link
WO (1) WO2015170340A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023139276A1 (en) 2022-01-24 2023-07-27 Zaklady Farmaceutyczne Polpharma S.A. Process for preparing crystalline sitagliptin hydrochloride monohydrate

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699871B2 (en) * 2001-07-06 2004-03-02 Merck & Co., Inc. Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2005072530A1 (en) * 2004-01-16 2005-08-11 Merck & Co., Inc. Novel crystalline salts of a dipeptidyl peptidase-iv inhibitor
US20100204470A1 (en) * 2006-06-27 2010-08-12 Sandoz Ag method for salt preparation
EP2318411A2 (en) * 2008-07-03 2011-05-11 Ratiopharm GmbH Crystalline salts of sitagliptin
WO2012025944A2 (en) * 2010-08-27 2012-03-01 Usv Limited Sitagliptin, salts and polymorphs thereof
WO2013084210A1 (en) * 2011-12-08 2013-06-13 Ranbaxy Laboratories Limited Amorphous form of sitagliptin salts

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699871B2 (en) * 2001-07-06 2004-03-02 Merck & Co., Inc. Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2005072530A1 (en) * 2004-01-16 2005-08-11 Merck & Co., Inc. Novel crystalline salts of a dipeptidyl peptidase-iv inhibitor
US20100204470A1 (en) * 2006-06-27 2010-08-12 Sandoz Ag method for salt preparation
EP2318411A2 (en) * 2008-07-03 2011-05-11 Ratiopharm GmbH Crystalline salts of sitagliptin
WO2012025944A2 (en) * 2010-08-27 2012-03-01 Usv Limited Sitagliptin, salts and polymorphs thereof
WO2013084210A1 (en) * 2011-12-08 2013-06-13 Ranbaxy Laboratories Limited Amorphous form of sitagliptin salts

Also Published As

Publication number Publication date
WO2015170340A2 (en) 2015-11-12

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