WO2015066869A1

WO2015066869A1 - Multifunctional herb particle structure for inhibiting blood glucose

Info

Publication number: WO2015066869A1
Application number: PCT/CN2013/086683
Authority: WO
Inventors: 郭曜豪; 廖家庆; 郑惠玲; 林明仁
Original assignee: 星科生物科技股份有限公司
Priority date: 2013-11-07
Filing date: 2013-11-07
Publication date: 2015-05-14

Abstract

The present invention is a multifunctional herb particle structure for inhibiting blood glucose, comprising: a core body containing Lycium barbarum, a Gynostemma pentaphyllum layer coated on the outer surface of the core body containing Lycium barbarum and an outer layer containing Momordica charantia vine coated on the outer surface of the Gynostemma pentaphyllum layer. The present invention can achieve the effect of effectively reducing postprandial blood glucose, oxidation resistance and inhibiting cancer cell growth.

Description

Multifunctional herbal particle structure for cotton blood sugar

The present invention provides a multifunctional particle structure, particularly a multifunctional herb particle structure capable of effectively inhibiting blood sugar. Background technique

In recent years, the dietary habits of Chinese people have become more and more refined, the three meals have been irregular, or the number of outside foods has increased. The ratio of the situation in all aspects of the body has increased year by year, and the age of physical warning has also become increasingly young. The most important factor is the long-term dietary westernization. The ingredients in the diet cause blood sugar to rise rapidly, which can damage blood vessels, raise cholesterol levels, increase the risk of heart disease, and even affect memory, and the chance of causing specific cancers to occur. increase.

Being able to have a healthy body is the goal that every modern person aspires to. How to have a healthy body is the life topic that people pay most attention to. As a result, a variety of natural nutritious health foods have emerged, including: health foods, nutritional supplements, organic foods, drinking water, etc., including the elderly to reduce blood sugar treatment and prevent diabetes, anti-cancer and enhance immunity. Foods; or groups of young people need foods that control blood sugar, enhance physical strength, resist oxidation, and inhibit obesity. However, many of the vitamins that are naturally extracted are only partially derived from nature. In the end, they still need to undergo a synthetic process to change the natural essence, but not to promote health. In addition, some natural nutritious health foods are expensive, how to choose effective nutritious health foods to protect the health of the body in a limited budget, and simply choose a nutrient containing multiple body supplements. The economical way of health food, and the function of guarding the health of the body is a difficult problem to overcome.

Accordingly, it is an object of the present invention to provide a multifunctional herbal particle structure for inhibiting blood sugar comprising: a ruthenium-containing core, a 7 o'clock layer coated on the outer surface of the ruthenium-containing core, and a coating The outer surface of the esculentum layer comprising an outer layer of bitter gourd; wherein the thickness ratio of the ruthenium-containing core, the esculent layer and the outer layer containing the bitter gourd is 1: 1: 1 to 1: 1: 6. Therefore, the present invention can effectively reduce the sugar, anti-oxidation, inhibit the growth of cancer cells, and inhibit the activity of α-glucosidase after meal. Sexual and sputum effects of macrophage inflammatory response.

In a preferred embodiment of the present invention, the blood glucose-suppressing multifunctional herbal microparticle structure is a health food or a pharmaceutical product; it is in the form of being filled into a capsule or as a lozenge; wherein the lozenge is a double-layer ingot, foaming Ingot or sustained release ingot; in addition, the present invention can also be dissolved in water to form a solution for drinking, or directly ingested through the oral cavity.

In a preferred embodiment of the invention, the blood glucose-suppressing multifunctional herbal particulate structure is in the form of a fillable packet or as a beverage.

The efficacy of the present invention has the effects of inhibiting blood sugar, anti-oxidation and inhibiting the growth of cancer cells,

0 inch has multiple effects of losing weight, calming the mind, lowering blood fat and blood pressure. The multifunctional herbal microparticle structure for suppressing blood sugar provided by the invention is a functional nutritious product which is beneficial to health and health, can effectively improve the difficulty in eating and preserving natural natural Chinese medicinal materials, and has the advantages of good stability and generality. The public can obtain the nutrients in bitter gourd, esculenta and medlar in a more direct and convenient way, and extend the shelf life of these ingredients. In addition, the multi-functionality of the blood-suppressing multifunctional herbal particle structure of the present invention is suitable for different ages of the consumer group, and includes a plurality of dosage forms, which can effectively enhance the consumer's double degree.

The ίΦ blood glucose multifunctional herb particle structure provided by the invention has the functions of reducing postprandial blood glucose level, ex-glucosylase activity, anti-oxidation, ίΦ breast cancer cell and lung cancer cell growth, and W cell formation The multiple effects of inflammation. DRAWINGS

BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a schematic cross-sectional view showing the structure of a multi-functional herbal microparticle for suppressing blood sugar according to a preferred embodiment of the present invention.

Figure 2 is a perspective view of a blood glucose-suppressing multifunctional herbal particle structure filled in a capsule in accordance with a preferred embodiment of the present invention.

Figure 3 is a schematic illustration of a brew packet containing a multifunctional herbaceous particulate structure that inhibits glycoside in a preferred embodiment of the invention.

Fig. 4 is a graph showing the inhibition of blood glucose-suppressing multifunctional herb microparticle structure and bitter gourd vine, esculenta and scorpion scorpion (X-glucosidase activity).

Figure 5 is a multi-functional herb particle structure for inhibiting blood sugar of the present invention, and bitter gourd vine, scutellaria and scorpion Inhibition of sputum cold water and hot water sputum (X-glucosidase activity comparison.

Figure 6 is a graph showing the effect of the blood glucose-suppressing multifunctional herb particle structure of the present invention on postprandial blood glucose in normal mice.

Fig. 7 is a comparison of the effects of the glycemic-suppressing multi-functional herbal microparticle structure of the present invention on the postprandial blood glucose of normal mice with the effects of bitter/II vine, esculin, and sputum.

Fig. 8 is a comparison of the antioxidant capacity of the multi-functional herbicidal microparticle structure for inhibiting blood sugar of the present invention with bitter / II vine, esculenta and scorpion scorpion.

Fig. 9 is a comparison of the ability of the multi-functional herbal microparticle structure for inhibiting blood glucose and the lung cancer cells of Bitter / II vine, esculenta and scorpion scorpion in the present invention.

Fig. 10 is a comparison of the ability of the multi-functional herbal microparticle structure for inhibiting blood sugar of the present invention with the ίΦ breast cancer cell of bitter gourd, scutellaria and sputum.

Fig. II is a comparison of the inhibition rate of the multi-functional herbal microparticle structure of ίΦ blood glucose and the inflammatory reaction of bacterial endotoxin (LPS)-induced macrophage RAW264.7 cells with NO.

Description of the symbols

I Multifunctional herbal microparticle structure

10 outer layer containing bitter gourd

20 pm 'biliary layer

30 枸杞 containing core

40 capsules

50 capsule body

60 groove

70 brewing bag

80 bags

90 line body

The present invention provides a multi-functional herbal microparticle structure for blood glucose production, which fully and clearly discloses the technical content and the purpose of the present invention, as described in detail below, and with reference to FIG. In order to show a schematic cross-sectional view of one embodiment of the multifunctional herb particle structure of the present invention, this embodiment is selected as a sphere, but is not limited thereto. The blood glucose-suppressing multifunctional herb particle structure 1 of the present invention comprises an outer layer 10 containing bitter gourd vine, a esculent layer 20 and a scorpion-containing core 30, which can effectively reduce postprandial blood sugar, anti-oxidation and sputum cancer cells. The effect of growth.

The present invention provides a multifunctional herbicidal particle structure for inhibiting blood sugar, wherein the thickness ratio of the ruthenium-containing core, the esculentum layer and the outer layer containing bitter gourd is 1 : 1 : 1 to 1: 1:6.

Afww tfea charantia Linn, is the stem of the bitter gourd of the Cucurbitaceae plant. The Compendium of Materia Medica records its bitterness, coldness, and non-toxicity. It has the effects of removing evil heat, relieving fatigue, clearing the mind and clearing the eye, and strengthening the qi and strengthening the yang. The whole plant contains roots, stems and leaves. Recent studies have pointed out that the organic solvent extracts of bitter gourd fruits, vines and seeds can significantly increase the utilization rate of intracellular glucose, the effect is similar to that of insulin sensitizer (troglitazone), and bitter gourd is rich in vitamins and minerals; The creators have experimentally confirmed that bitter gourd has antioxidant activity and inhibits the growth of cancer cells, and the authors' research on the inhibition of cancer cell growth and blood glucose reduction by bitter melon is also published in the Joumai of Agricultural and Food Chemistry.

Hawthorn bile (G^ostewww^«3⁄43⁄4^y//«», which is rich in ginseng saponin-like chemical constituents, is also known as southern ginseng. The Compendium of Materia Medica records the effects of promoting metabolism, thirst, and reducing anger. Recent studies have indicated that esculenta has anti-inflammatory, anti-oxidant, anti-tumor, liver-protecting, hypolipidemic and other activities.

枸杞 (less 'cw Chinese), which is one of the traditional Chinese medicines commonly used by the general public. It contains glutinous polysaccharides, various amino acids, trace elements, vitamins, taurine, etc. It has the functions of nourishing liver and kidney, and benefiting the essence. . Recent studies have confirmed that sputum reduces blood lipids, lowers blood pressure, protects the liver, fights tumors, resists oxidation, enhances immunity, delays aging, and enhances physical activity. At the same time, lycium polysaccharide has an inhibitory effect on X-glucosidase, and can effectively prevent diabetes, and is used for the auxiliary treatment of diabetes.

In a preferred embodiment of the invention, the glyco-inhibiting multifunctional herbal particle structure can be filled into the form of capsule 40. As shown in FIG. 2, the pair of capsule bodies 50 are made of a gelatinous material of a grade, the pair of capsule bodies 50 are respectively concavely formed with grooves 60, and the pair of capsule bodies 50 may be recessed 60. The openings are covered with each other; the blood glucose-suppressing multifunctional herb particle structure 1 of the present invention is mountable in the capsule body 50.

In a preferred embodiment of the invention, the blood glucose-suppressing multifunctional herb particle structure 1 is soluble Drink a uniform dispersion solution in water at room temperature. Further, as shown in Fig. 3, the blood glucose-inhibiting multifunctional herb particle structure 1 of the present invention can also be made into a brewing bag 70 for enclosing a multifunctional herbal particle structure 1 for blood sugar suppression into a bag 80 such as a non-woven fabric, and then The wire body 90 is fixed to the bag 80 such as a non-woven fabric to facilitate consumption by the consumer immediately after brewing. In another preferred embodiment of the present invention, the blood glucose-suppressing multifunctional herbal particle structure 1 can also be made into a drink or concentrated as a concentrated essence and sold in a container.

In a preferred embodiment of the present invention, it can be in the form of a double-layer ingot, a foamed ingot, and a sustained-release tablet, which can be further added with lactose, starch or cellulose, citric acid or malic acid, and sodium hydrogencarbonate foaming. A tablet base such as a component or a sustained-release component is compressed into a tablet.

The experimental results confirmed that the multi-functional herbal microparticle structure of the present blood glucose control has the effects of reducing postprandial blood sugar value, anti-oxidation and free radical removal, and growth of cancer cells. A detailed description of the implementation is as follows:

Example 1 Inhibition of α-glucosidase activity analysis

L1 Comparison of W-type ex-glucosidase activity of the multi-functional herbal microparticles of blood glucose-inhibiting and bitter gourd, scutellaria and alfalfa

The multi-functional herbal microparticle structure for inhibiting blood sugar of the present invention is prepared by a specific ratio of bitter gourd vine, sapphire and medlar raw materials. The blood sugar-suppressing multifunctional herb particle structure of the present invention and the bitter gourd vine, the scutellaria and the sorghum seed material are respectively taken into 2 g of liquid which is brewed in 30 mL of hot water for 3 minutes to 5 minutes (hereinafter referred to as leeches) :.

At the same time, the commercially available Glucobay oral drug is used as a control group. The main component of the sugar stalk is Acarbose, which is a pseudotetrasaccharide extracted from microbial biomass. ), mainly in the intestinal tract, its mechanism of action is mainly responsible for the enzyme responsible for the decomposition of disaccharides, oligosaccharides and polysaccharides in the intestinal tract, namely α-glucosidase, and this mechanism of action can delay carbohydrates depending on the dose administered. break down. Most importantly, it can delay the decomposition of carbohydrates into glucose and enter the systemic circulation. Through the above mechanism of action, the sugar stalk can delay and reduce the blood sugar rise after a meal, thereby balancing the intestinal tract to glucose, while maintaining a stable blood glucose concentration within one day, and reducing the average blood sugar level. Therefore, this experiment used Oral Drugs as a control group.

As shown in FIG. 4 and Table I, the blood glucose-suppressing multifunctional herb microparticle structure of the present invention inhibits the activity of α-glucosidase in vitro, and the inhibition rate thereof is 19.8 ± 0.4%, which shows the blood glucose inhibiting activity of the present invention. 钊 (X glucosidase activity. The activity of the three proglucosidases, the rate of sequestration is divided into L, Table 1, the multi-functional herb particle structure of the blood glucose control of the present invention and bitter melon vine, scutellaria and scorpion Effect on the activity of α-glucosidase

Acarbose - mouth The present invention 苦 bitter in vine

(0.5mg/mL.) Inhibition rate (%) 19.80 20.88 13.66 14.31 70.07 Standard deviation 0.39 1 ,70 0.46 0,64 0.57

1.2 The multi-functional herbal microparticle structure of the present invention for inhibiting blood sugar and the cold water and hot water of bitter gourd, esculenta and sorghum 10% concentrated aqueous sputum inhibition α-glucosidase activity comparison

After brewing the blood-suppressing multi-functional herb microparticle structure of the present invention with cold water and hot water, and the three raw materials of bitter gourd, esculenta and sorghum, the 10-fold concentrated aqueous sputum has \\- Ex-glucosidase activity

o

The role of sex (Figure 5 and Table 2). Although the positive control group acarbose inhibits the ex-glucose bosidase activity by 70%, the blood glucose-suppressing multifunctional herb particle structure and the concentrated water sputum inhibition rate of the sputum of the present invention are all above 50%. , showing a significant effect on the inhibition of a-glucosidase activity.

Table 2. The multi-functional herbal microparticle structure of ίΦ blood glucose preparation of the present invention and the ten-fold concentrated cold water and hot water mash of bitter gourd vine, esculenta and scorpion scorpion for inhibiting ex-glucosidase activity

Inhibition of α-glucosidase (%) cold water hot water The present invention 55,69 士 i. i6 50,29 士 0,84

掏祀 54.18 ± 0,89

Bitter / vine 28,66 0.25

Seven-leaf gallbladder 23.82 soil 2,40

Acarbose 70,07 ± 0.57 -

Therefore, the blood glucose-suppressing multifunctional herb microparticle structure of the present invention can effectively inhibit the action on α-glucosidase activity, and the inhibition rate is about 20%, and its IC ₅ value is 23,02 ± 0.73 mg/mL. Example 2 Postprandial Blood Glucose Inhibition Ability - Animal Experiment

2.1 The effect of the multi-functional herbal microparticle structure of the blood glucose control of the present invention on the postprandial blood glucose of mice. Normal ICR (Impriniing Control Region) mice are fed with the hydrating liquid of the multifunctional herbal microparticle structure of the present invention. Drinking water, after 2 hours of feeding starch solution (2.25 g / kg normal mice postprandial blood glucose effect, the results shown in Figure 6. In the drinking water group, blood glucose continued to rise significantly within 2 hours (blood sugar value by the fasting blood glucose value From 60 mg/dl to 100 mg/dl, which rises to about 200 mg/dl to 250 mg/dl), the highest value is reached in 75 minutes; the blood glucose-suppressing multifunctional herbal particle structure of the present invention has blood glucose within 75 minutes. Significantly lower than the drinking water group (blood sugar value from fasting blood glucose value of about 60 mg / dl to 100 mg / dl, about 200 mg / di to 250 mg / d), so the M sugar-inhibiting multifunctional herb of the present invention The microparticle structure significantly inhibited the increase in postprandial blood glucose levels in normal mice (*P < 0.05, ** Ρ < 0, 01).

22 Comparison of the multi-functional herbal microparticle structure of blood glucose-suppressing agent of the present invention and the postprandial sugar-inhibiting ability of bitter gourd, scutellaria and alfalfa

The medicinal granules obtained by injecting the medicinal granules of the succulent granules of the present invention and the three kinds of raw materials of the bitter gourd, the schisandra, and the sorghum are fed to the normal mice, and the postprandial blood glucose values are influences. As shown in Fig. 7, with the anti-glycable multifunctional herb particle structure of the present invention and the action of reducing the postprandial blood glucose level, the blood sugar-suppressing multifunctional herb particle structure of the present invention has a lower effect on reducing postprandial blood glucose in mice. It is superior to hydrazine, and as a result, it can be inferred that the gluten-free multi-functional herbal microparticle structure of the present invention has a far lower effect on postprandial blood glucose than any unilateral effect.

Therefore, the ίΦ blood glucose multifunctional herb microparticle structure of the present invention can reduce the postprandial blood glucose of a normal mouse animal experiment, and the blood glucose level can be lowered by about 35 mg/dl to 45 mg/dl at 60 minutes compared with the starch group. , can reduce about 20% postprandial blood glucose.

Example 3 Analysis of antioxidant capacity

3,1 The anti-oxidation ability of the multi-functional herbal microparticle structure of ίΦ blood glucose and the bitter gourd, scutellaria and alfalfa of the present invention

The multi-functional herbal microparticle structure for inhibiting blood sugar of the present invention is prepared from a bitter gourd vine, a scutellaria, and a sorghum seed material in a specific ratio. The multi-functional herbal microparticle structure for inhibiting blood sugar of the present invention is extracted with cold water (room temperature: hot water (about 95 Ό) and 95% alcohol, respectively, and the extract is removed by 1,1,1 respectively. Diphenyl-2- 2-nitrophenyl hydrazine (!, 1-diphenyl- 2-picryihydrazyl, DPPH) Analysis of the antioxidant capacity of free radicals.

As shown in FIGS. 8A and B, the blood glucose-reducing multifunctional herb microparticle structure of the present invention has an ability to scavenge DPPH radicals by about 76% to 78% of the extract obtained by brewing cold water, hot water and 95% alcohol. . The removal ability of the three kinds of raw materials of bitter gourd, scutellaria and sorghum is better with water extract, and the scavenging ability is about 63% to 93%. The clearing water extract of sorghum and esculenta is significantly higher than that. For hot water extracts, only the hot water extract of Momordica charantia has a higher removal ability than the cold water extract. The removal rate of the 95% alcohol extract of the three raw materials is lower than that of the water extract, which is only 10% to 20%. The extraction rate of the multi-functional herbal microparticle structure for inhibiting blood glucose according to the present invention was 36%, and the IC ₅₀ value for purifying DPPH radicals was 0.83 ± 0.14 mg/mL.

Therefore, the multi-functional herb microparticle structure of the blood glucose control of the invention has excellent anti-oxidation effect, and has the ability to scavenge 1,1 - diphenyl- 2-trinitrophenylhydrazine (DPPH) free radicals, and scavenges DPPH free radicals. The IC ₅₀ value was 0,83 ± 0.14 mg/mL.

Example 4 Analysis of ability to inhibit cancer cells

4, 1 Comparison of the ability of the multi-functional herbal microparticles of blood glucose suppression of the present invention with W cancer cells of bitter gourd, scutellaria and alfalfa

The multi-functional herbal microparticle structure for inhibiting blood sugar of the present invention is prepared by a specific ratio of bitter gourd vine, sapphire and medlar raw materials. The water-suppressing multi-functional herb microparticle structure of the present invention and the water mash of the sputum seed material are each obtained by injecting 2 g each with 30 mL of hot water for 3-5 minutes and then filtering. As shown in Table 3, the inhibitory effect of the aqueous sputum on A549 lung cancer cells (Fig. 9) and MCF-7 breast cancer cells (Fig. 10), the hydrating solution of the saccharide-inhibiting multifunctional herbic particulate structure of the present invention The inhibition rate of the two cancer cell lines was 8.24% and 77,40 ± 1,04%. The experimental results show that the leeches of the multi-functional herbal microparticle structure of the blood glucose of the present invention are optimal for the ίΦ549 lung cancer cells and the MCF-7 breast cancer cells, and are superior to the water of the bitter gourd, the sclerotium and the scorpion. Sputum.

Table 3. Inhibitory effects of the multi-functional herbicidal microparticle structure and three raw materials of the present invention on Α549 lung cancer cells and MCF-7 breast cancer cells

Ή-FI mouth The present invention 枸杞苦藤七胆对 Α Α 549 lung cancer cells

42,36 soil 9,04 15.84 ± 6,21 33.66 ± 1 L38 36.73 ± 3.70 growth inhibition rate (%)

For MCF-7 breast cancer cells

77,40士1.04 18.44土0,32 11.10 ± 6.60 49.92士8.08 Growth inhibition rate (%) Therefore, the multifunctional herbal microparticle structure of the blood glucose control of the present invention has an effect of inhibiting the growth of cancer cells, and the rejection rate against MCF 7 breast cancer cells is about 77%; the inhibition rate against A549 lung cancer cells is about 42%.

Example 5 Inhibition of Macrophage Inflammation Analysis Response Analysis

5.1 Comparison of the inflammatory response analysis of the multi-functional herb microparticle structure of the present invention for inhibiting blood sugar and macrophages of bitter gourd, scutellaria and scorpion

The blood glucose-suppressing multifunctional herb microparticle structure of the present invention and the three raw materials of Momordica charantia, scutellaria and scorpion venom on the bacterial endotoxin (LPS)-induced inflammatory response of mouse macrophage RAW264.7 cells are all nitric oxide (NO) production It has an inhibitory effect, as shown in Table 4 and Figure 11, with the lowest 枸杞, which inhibits the NO production rate by only 54%, followed by bitter melon vine, which is 87%. The blood sugar-suppressing multifunctional herb particle structure and the highest schisandrae of the present invention are the highest. About 97%, the novel blood glucose-suppressing multi-functional herb microparticle structure and seed material have an inhibitory effect on the growth of RAW264.7 cells, showing the multi-functional herb particle structure, bitter gourd vine, cockroach and shamrock of the present invention. The gallbladder has the effect of inflaming cells of the W system.

The extraction rate of the blood-suppressing multi-functional herb microparticle structure according to the present invention is 3.6% and the above-mentioned tanning rate is 97%, which can be converted into an IC ₎ value, and the anti-sugar-inhibiting multifunctional herb particle structure of the present invention induces bacterial endotoxin AW264.7 cellular inflammatory response inhibiting NO production IC _5. The value is 0.59 ± 0.08

Table 4, the ίΦ blood glucose multi-functional herb microparticle structure of the present invention and the three raw materials on the bacterial endotoxin (LPS) induced RAW264.7 cell inflammatory reaction to produce NO ίΦ rate

+3⁄4 mouth

m The present invention 枸杞 bitter gourd vine

97.2 soil 0,5 53,6 ± 13.5 87.4 soil 3,7 96.8 ± 0. 6 generation rate (%)

Therefore, the multi-functional herbal microparticle structure of the blood glucose of the present invention has an inflammatory effect of cells.

NO production was optimal, with an inhibition rate of approximately 97% and an IC ₅₀ value of 0.59 ± 0. 08 mg/mL.

In summary, the blood glucose-suppressing multifunctional herb microparticle structure of the present invention can effectively reduce the efficacy of postprandial blood glucose, and can also inhibit the activity of α-glucosidase x-gkicoskiase, thereby being useful for preventing or treating diabetes. In addition, the blood glucose-suppressing multifunctional herb microparticle structure of the present invention has an antioxidant effect, can prevent cell damage and fight aging; and has the effects of inhibiting the growth of lung cancer cells and breast cancer cells and inhibiting the inflammatory reaction of macrophages; Various dosage forms of the invention can be increased Adding convenience and selectivity to the consumer group is a functional supplement for good health.

Claims

L. A multi-functional herbaceous particulate structure of blood glucose, comprising: a crucible containing body, a esculent layer coated on an outer surface of the crucible containing the crucible, and a layer covering the esculent layer Outer surface

2. The blood glucose-suppressing multifunctional herbal particle structure according to claim 1, wherein a thickness ratio of the ruthenium-containing core, the esculentum layer, and the outer layer of the bitter gourd is 1: 1: 1 to 1 : 1 : 6.

3. The blood glucose-suppressing multifunctional herb particle structure according to claim 1, wherein the blood glucose-suppressing multifunctional herb particle structure is effective for reducing postprandial blood glucose, anti-oxidation, inhibiting cancer cell growth, and inhibiting α-glucosidase ( The activity of orglucos idase) and the inflammatory response of tanning macrophages.

The blood sugar-suppressing multifunctional herbal particle structure according to claim 1, which is used as a health food or a pharmaceutical.

The blood sugar-suppressing multifunctional herbal particle structure according to claim 1, which is in the form of being filled into a capsule.

6. The blood glucose inhibiting multifunctional herbal particle structure of claim 1 which is filled into a brew packet.

7. The blood glucose-suppressing multifunctional herbal particle structure according to claim 1, which is in the form of a drink.

8. The blood glucose-suppressing multifunctional herbal particle structure according to claim 1, which is in the form of a tablet.

The blood sugar-suppressing multifunctional herbal particle structure according to claim 8, which is a double-layered tablet, a foamed ingot or a sustained-release ingot.

10. The multi-functional herbal microparticle structure for tanning blood sugar according to claim 1, which is soluble in water to form a solution for drinking ffi, or directly ingested through the oral cavity.