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WO2014167454A1 - Oral cleaning appliance producing pulses of gas with mouthwash - Google Patents

Oral cleaning appliance producing pulses of gas with mouthwash Download PDF

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Publication number
WO2014167454A1
WO2014167454A1 PCT/IB2014/060309 IB2014060309W WO2014167454A1 WO 2014167454 A1 WO2014167454 A1 WO 2014167454A1 IB 2014060309 W IB2014060309 W IB 2014060309W WO 2014167454 A1 WO2014167454 A1 WO 2014167454A1
Authority
WO
WIPO (PCT)
Prior art keywords
gas
mouthwash
range
fluid
pulses
Prior art date
Application number
PCT/IB2014/060309
Other languages
French (fr)
Inventor
Yu-Wen Chang
Gregory Russ Goddard
Original Assignee
Koninklijke Philips N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips N.V. filed Critical Koninklijke Philips N.V.
Publication of WO2014167454A1 publication Critical patent/WO2014167454A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C17/00Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
    • A61C17/02Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication
    • A61C17/0202Hand-pieces
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C17/00Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
    • A61C17/02Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication
    • A61C17/028Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication with intermittent liquid flow

Definitions

  • This invention relates generally to apparatus for cleaning teeth using a combination of bursts of gas and bursts of fluid to produce a desired gas/fluid mix, and more particularly concerns a single assembly for producing both gas bursts and fluid bursts in coordination, as well as an assembly for producing a jet pattern of gas and fluid in another embodiment.
  • An oral care appliance comprises: a fluid pump assembly; a source of gas; a source of mouthwash, wherein the pump is in operative communication with the source of the mouthwash and gas to produce a series of gas-injected fluid pulses or a series of fluid slugs in a jet stream directed to a nozzle assembly (80) from which the resulting pulses are directed to the teeth, wherein the pulses or slugs produce a breakdown effect on the mouthwash to its active ingredients, making the mouthwash more effective against the biofilm, wherein the pulses have a pulse width within the range of 0.001-0.5 seconds, a pulse height from 0.1-10 Newtons, a rise/fall time range of 0.5-250 ms, a repetition rate in the range of 2H to 20Hz, and wherein the gas/liquid mixture range from 40-95% volume to volume gas to liquid, or wherein the fluid slugs in the jet flow have a volume in the range of 0.05-0.5 ml per orifice, a diameter in the range of 0.1-2 mm
  • Figure 2 is an elevational view of the opposing side of the apparatus of Figure 1.
  • Figure 3 is an exploded view of the apparatus of Figure 1.
  • Figure 4 is a partially cutaway elevational view of Figure 1.
  • Figure 5 is a perspective view of the apparatus showing the opposing side of the apparatus, similar to Figure 2.
  • Figure 6 is a perspective exterior view of an appliance incorporating the apparatus of Figures 1-5.
  • Figure 7 A is a front elevational view of the nozzle assembly portion of Figure 6.
  • Figure 7B is a cross-sectional view of the nozzle assembly of Figure 7A.
  • Figure 8 is another cross-sectional view of an exit portion of a nozzle assembly.
  • Figure 9 is a simplified view of an alternative arrangement to that of Figures 1-6.
  • Figure 10 is a simplified view of an appliance using the apparatus of Figures 1-6 or 9 with a power toothbrush.
  • Figures 1-5 show one embodiment of an apparatus, generally at 10, for producing successive bursts of gas and liquid, such as water, which mix to produce a stream of gas and liquid droplets used for cleaning teeth, especially the interproximal areas of the teeth, accomplishing a "flossing" function.
  • gas can include air or other gases or mixtures.
  • Apparatus 10 forms the major part of a complete teeth cleaning appliance, the exterior of which is shown in Figure 6 and described in more detail below.
  • apparatus 10 includes an gas cylinder 12, which in the embodiment shown is approximately 2.5 inches long with an internal diameter of 0.5-1.0 inches.
  • gas cylinder 12 At a distal end 14 of gas cylinder 12 is a nozzle 16 through which a mix of water or other liquid bursts and fluid, typically gas, exit, in the form of a stream of high velocity liquid droplets.
  • the liquid droplets are directed toward the teeth of a user, particularly the interproximal area, for cleaning.
  • the apparatus includes a motor 20 which in the embodiment shown is a DC motor, typically with high torque, e.g. 15 Newton meters, although this value is typically achieved after gear reduction.
  • the motor itself thus does not have to produce such a value of torque itself.
  • Such motors are widely commercially available.
  • Various motors are suitable. Motors made by Mitsumi are for instance examples of a suitable motor.
  • Motor 20 includes an output shaft 21 on which is mounted a motor drive gear 22 ( Figure 4). In the embodiment shown, there are 8 teeth on the motor drive gear. The number of teeth on gear 22, as with the number of teeth on the other gears, can be varied.
  • Motor 20 is positioned at 24 at the rear upper surface of gas cylinder 12.
  • Motor drive gear 22 engages a first (outer) gear part 26 of a first compound gear 28 located at a first side of the apparatus.
  • the first compound gear 28 in the embodiment shown is made of plastic as are the other gears, however it could be made of other material as well.
  • the first gear part 26 of gear 28 in the embodiment shown has 53 teeth.
  • the motor drive gear 22 in operation rotates it in a clockwise direction.
  • the first compound gear 28 also includes a gear shaft 30 and a second (inner) gear part 32 coincident with the distal end of shaft 30, as shown in Figure 3. In the embodiment shown, the second gear part of the first compound gear has 8 teeth.
  • the shaft 30 with the second gear part 32 of the first compound gear 28 extends through apparatus 10 and mates with a first (outer) gear part 34 of a second compound gear 36 positioned on an opposing side of the apparatus.
  • the first gear part 34 of the second compound gear has 48 teeth, although this can be varied, as noted above.
  • a second (inner) gear part 38 of second compound gear 36 is positioned adjacent the first gear part 34 on a center gear shaft 37.
  • the second gear part of the second compound gear has two parts, a first part comprising a partial set of 8 teeth referred to at 39 spaced around approximately one-half of the circumference of the second gear part and a second part 40 which has no teeth, i.e. the surface is smooth at the base of the teeth portion of the second gear part.
  • the two parts are each one-half of the second gear part.
  • the second compound central gear shaft 37 extends back through the apparatus to the first side of the apparatus and engages a peristaltic fluid pump assembly 46, which includes a pump 48.
  • Peristaltic pump assembly 46 includes a first tube section 48 which extends to a fluid reservoir 50.
  • the fluid in reservoir 50 is water, although other fluids can be used as well.
  • these include various formulations which assist in cleaning teeth, such as chlorhexidine, hydrogen peroxide-based rinses, mixtures of water, baking soda, essential oils or mouthwash, for example.
  • the peristaltic pump assembly 46 also includes a second tube 52 which extends from the pump and above the body of the apparatus, in a U-shaped mounting element 54, and then along the outer surface of the gas cylinder to a mixing chamber 58 on the distal end of the gas cylinder.
  • the second gear part 38 of the second compound gear 36 mates with a linear rack member 62 which is positioned at a proximal end 61 of gas cylinder 12.
  • rack member 62 is approximately 2 inches long and includes a set of 8 spaced teeth on the upper surface thereof.
  • the distal end of rack member 62 includes a seal member 64 which mates in a fluid tight relationship with the interior surface of gas cylinder 12. Extending from the distal end of rack 62 at seal 64 and encircling the rack along most of the length thereon is a compression spring 66.
  • the proximal end 68 of spring 66 is positioned against a stop element 70 in body portion 20, as shown in Figure 4.
  • Figure 5 is similar to Figure 2, showing motor 20, and the second compound gear 36, specifically, the second gear part 38 thereof.
  • Figure 5 also shows a microprocessor controller 80, in the form of a printed circuit board, for the apparatus, which controls all of the operations thereof and is mounted on an internal frame portion of the apparatus.
  • Figure 5 also shows an on/off power button 82 for the appliance which enables the operation of the appliance by connecting battery 84, which in the embodiment shown is a lithium-polymer battery, to motor 20. When the on/off button 82 is on, a power light comes on.
  • the appliance also includes an actuation button 86 which, when operated by a user, produces a single shot (burst) of the liquid/gas mixture out the nozzle end 16 of the appliance.
  • spring 66 operates to move the rack quickly forwardly, moving the sealed end of the rack forwardly in the gas cylinder, forcing a burst of gas into the mixing chamber, along with a liquid (water) burst, produced concurrently by action of the pump 68 or somewhat prior, driven by shaft 37 of the second compound gear.
  • there is one shot of gas per revolution of the motor shaft every 400-900 milliseconds (or faster); further, there is approximately .15 ml of fluid provided to the mixing chamber per revolution of the motor shaft.
  • activation button 84 is pressed by the user.
  • rack member 62 and the seal 64 are fully forward, with the partial set of teeth 39 of the second gear part of the second compound gear just engaging the rear end of the rack member 62.
  • Motor 20, as indicated above initiates action of the entire gear train, resulting in the rack member 62 moving rearwardly and seal 64 retracting in the gas cylinder. This results in compression of spring 66, and the pulling of gas into the gas cylinder.
  • peristaltic pump assembly 46 operates, causing pump 48 to move fluid, such as water, into the mixing chamber of the apparatus.
  • the outer gear part 34 of second compound gear 36 includes a magnet 88 ( Figure 5) on an outer surface thereof.
  • a Hall Effect sensor 90 positioned on the internal frame portion of the appliance detects the magnet as it moves past the sensor, and in response starts a software implemented delay time present in controller 80, which turns off motor 20 at the end of the time.
  • the timing of the software delay is established such that motor 20 is not shut off until after the start of the exhaust portion of the operating cycle.
  • the Hall Effect sensor software delay times out and the motor is shut off.
  • the momentum in the gear train allows the second gear part 38 of the second compound gear 36 to continue to rotate until the partial set of teeth 39 initially engages with the first tooth or so of the rack 62. This small amount of rotation results in some water being moved into the mixing chamber by the continued action of the peristaltic pump.
  • the total volume of water provided for each shot is the amount of water provided by a full 360° rotation of the peristaltic pump 48.
  • the apparatus is now in a condition to begin the next shot/burst.
  • the gear train at the end of each operating sequence stops in the same position after each burst, in accordance with the software timer action operating the motor.
  • the delay timer also acts to prevent the user from operating the unit too rapidly and overheating the motor. It prevents the start of another operating sequence, even though the activation button 84 is pressed. At the end of the delay time, pressing the activation button will initiate action of the apparatus, producing a successive burst of liquid/gas mixture.
  • Figure 6 shows the exterior of such an appliance 70. It includes a handle/receiver portion 72 and an extending nozzle portion 74. Located in the handle/receiver portion 74 is a liquid/gas mixture burst-generating system and a power source therefor, as shown in Figures 1-5 above. Nozzle portion 74 extends away from the handle and is relatively slim, in order to conveniently fit into the mouth of a user, for reaching all of the interproximal and gingival areas of the teeth. The nozzle portion terminates in a nozzle exit member 81 having a small opening 83 in a forwardly extending portion, through which the successive bursts of liquid/gas mixture are directed to the teeth.
  • the opening in the embodiment shown is approximately 1 mm in diameter, although this can be varied.
  • exit member 81 has a surface configuration to facilitate proper contact and placement of the exit member in the interproximal areas of the teeth.
  • the handle/receiver includes an on/off switch 82 and a control member 86 which when operated by the user produces the bursts of liquid/gas mixture. While the liquid will frequently will be water, it should be understood that other liquids, such as mouthwash and medications, can also be utilized.
  • an elongated nozzle portion which terminates in a nozzle exit member 80 is shown in more detail, including a base portion 91 and a tip portion 92. At the center of tip portion 92 is an exit opening 94 through which high velocity droplets are delivered to the teeth of the user for cleaning when the appliance is positioned properly by the user in the mouth.
  • the nozzle exit member is generally configured to provide a guidance function for the interproximal areas.
  • the tip portion 92 extends above a surrounding intermediate portion 96 by approximately 1-3 mm. In some cases, the exit nozzle member can be slightly tapered, with an exterior diameter of approximately 2 mm.
  • the intermediate trough portion 96 tapers slightly away from exit member 24.
  • the intermediate portion 96 terminates in a boundary portion 98 which has a curved upper surface which defines a lip for the tip portion 92. Additional details and advantages of such a structure are set forth U.S. Application 61/289,589, which is owned by the assignee of the present invention, the contents of which application are hereby incorporated by reference.
  • a tip portion 98 of the nozzle assembly 80 is separable from a base portion 94 thereof which extends from body 12. This is shown in Figure 8.
  • the tip portion is replaceable.
  • the replaceable tip portion of the nozzle has a number of advantages. These include the ability to replace the tip of the nozzle due to wear. It also permits nozzle variations depending on a desired hardness, (or softness) of the material. Further, the diameter of the exit orifice of the tip portion can be changed to alter the characteristic of the liquid droplet spray.
  • Figure 9 shows a fluid-based cleaning appliance, generally at 120.
  • Figure 9 shows a more generalized system, capable of providing a spray output, a pulse output or a jet output producing bursts of gas at selective frequencies, under control of a microprocessor.
  • the fluid is water, although it could be other liquids, including medications or mouthwash.
  • the appliance 12 includes an appliance body 122, which includes a fluid delivery system for producing discrete bursts of gas/fluid mixtures, including sprays, bursts and jets, and an outlet for the fluid bursts which proceed through a fluid delivery path 123 in an outlet member 124, at the end of which is a nozzle assembly 126, as described above, which could include a single nozzle or a plurality of nozzles.
  • the discrete fluid bursts from nozzle 126 are sufficient to effectively manage biofilm through mechanical removal thereof, with a resulting reduction in the virulence of microorganisms in the mouth.
  • the discrete fluid bursts provide a cleansing benefit greater than toothbrush bristles alone, because the fluid bursts are able to reach between the teeth and along the gum line where bristles cannot reach.
  • the use of discrete i.e. separate, bursts of fluid, as opposed to a continuous or pulsed jet of fluid, does result in substantially less total liquid volume per brushing event, which may be an advantage as it enhances user comfort and compliance, while maintaining effectiveness.
  • the cleaning event is typically two minutes.
  • the delivery system includes a displacement pump 130, which is programmed in combination with a regulator 132, to provide discrete bursts of liquid, typically water, as indicated above, from a tank 134.
  • the liquid could be various medications or mouthwashes.
  • the regulator 132 maintains the pressure in the water tank 134 at a specified level. Typically, the pressure is in the range of 40-120 psi, with a preferred range of 70-112 psi.
  • the water tank holds a cleansing event amount of liquid, slightly less than 0.2 ml. It has been discovered that a user can readily tolerate this amount of liquid in a normal cleansing event of two minutes.
  • the appliance also includes a battery 136, which operates pump 130, and a conventional charger coil 138, which is used with a charging member (not shown). Controlling the release of liquid from the water tank is a valve 140, which is for instance a solenoid valve, and a timer 141.
  • the appliance also includes a power button 144 and a firing button 146, although those two functions can be combined in a single element.
  • a microcontroller 148 controls the operation of the appliance, including an automatic mode of operation for the appliance.
  • the microcontroller can control various fluid dynamics parameters, as discussed in more detail below. This is an alternative to the pump/controller system of Figure 1.
  • the discrete fluid bursts are predefined in terms of time duration and firing rate.
  • the bursts are generated by operating firing button 146.
  • Timer 141 controls the duration of the fluid bursts.
  • the burst time duration range is 0.02-2 seconds, with a preferred time duration of 0.05-0.2 seconds.
  • the firing rate in a manual mode is controlled by the user, which is typically significantly longer than the burst duration.
  • the time duration of the liquid burst will be the same as in the manual mode.
  • the automatic mode may be initiated by a programmed sequence of operating the on-off switch or by a separate switch member/button for the user to operate.
  • the firing rate can be automatically controlled or pre-programmed, typically, 0.1-2 seconds, with a preferred range of firing rate of 0.5-1.5 seconds.
  • the time duration of the burst and the firing rate may be adjusted by the user by a predefined sequence of operating the on-off switch. In other cases, the firing rate is permanently set during manufacture.
  • the advantage of the present system is that the discrete fluid bursts produced by the system of Figure 9 provides effective cleaning for the teeth and effective treatment of the gum tissue, but with the total volume of liquid being comfortable for the user with a typical cleansing event time of two minutes, which is an encouragement for regular use.
  • Figure 10 shows a variation of the embodiment of Figure 9, with the appliance having a similar fluid delivery arrangement thereto, or to the specific system of Figures 1-6 but with the addition of outlet member 150 being driven in a desired physical movement, such as a back-and-forth oscillatory action, with a set of bristles 152 being positioned at the end of the outlet member.
  • Nozzle 154 or nozzles will typically be positioned within the set of bristles 152, but hollow bristles could provide the nozzle function as well.
  • the appliance will include a drive train assembly 160, with a drive shaft 162 extending therefrom to drive outlet member.
  • the drive train assemblyl60 could comprise various arrangements, including a motor.
  • the drive train is controlled by microcontroller 164.
  • the drive arrangement could be a resonant toothbrush action at a frequency in the range of 230-260 Hz for instance.
  • biofilm plaque has the following mechanical and viscoelastic properties which must be overcome: Young's modulus between 1 Pa and 50 kPa; shear modulus between 1.1 and 50 Pa; cohesive shear strengths between 2 and 50 Pa; adhesive strengths of 5-75 Pa or 0.05-1 J/m 2 ; tensile strengths between 0.1 Pa and 6 kPa; adhesion shear stresses of 0.1 to 0.65 J/m 2 ; storage moduli of 1-10 kPa; loss modulus between 0.1-3 nJ/ ⁇ 3 ; and failure strains of 150-320%.
  • Young's modulus between 1 Pa and 50 kPa shear modulus between 1.1 and 50 Pa; cohesive shear strengths between 2 and 50 Pa; adhesive strengths of 5-75 Pa or 0.05-1 J/m 2 ; tensile strengths between 0.1 Pa and 6 kPa; adhesion shear stresses of 0.1 to 0.65 J/m 2 ; storage moduli of 1-10 kPa; loss modulus between 0.1-3 nJ/ ⁇ 3 ; and failure
  • Fluid delivery, gas delivery, fluid/gas mixing and the nozzles described above can all be varied as follows:
  • Fluid pumps can include peristaltic, diaphragm, rotary, impeller, electroosmotic, gear, microannular, cyclone or via a pressurized gas/pneumatic cylinder/container, either positively or negatively pressure driven. Fluid can be passively pulled in through a venturi or via the Bernoulli effect into a nozzle.
  • Gas pumps can include peristaltic, diaphragm, rotary, impeller, electroosmotic, gear, microannular, cyclone or gas can be moved directly from a pressurized gas "tank", either positively or negatively driven. Gas can be passively pulled in through a venturi or via the Bernoulli effect over an orifice.
  • the gas and fluid mixing can be achieved through a tortuous path channel, array or orifices, a string of periodic/aperiodic orifices, dynamic elements or through direct phase control driving of the pumps (fluid or gas).
  • Various nozzles can be used, including any of the elements to create pulsation or gas/fluid mixing through tortuous paths, with the inner and outer dimensions of the part and direction changes within the fluid/gas/aerosol path.
  • One category of fluid dynamics involves a pulse-type fluid flow operation.
  • the pulse operation utilizes the mechanics of Figures 1-5 and 9, which are capable of delivering a variety of pulsing liquid flows, producing gas pulses and fluid having various characteristics, which can include sputtering and spray.
  • the particular fluid flow characteristics produced in this embodiment are produced by programming the microcontroller, but also by various mechanical characteristics of the nozzle assembly and the nozzle exit member. These include the characteristics of the exit orifices, the configuration of the fluid channel or variable surface characteristics of the fluid channel which interact with the flow. It can also include flexible membrane or various elastic elements within the flow.
  • the pulse pattern can include 1-10 pulses per pulse burst.
  • the flow parameters of the individual pulses include pulse width, pulse height, rise/fall time, the number of sub-pulses, i.e. pulses within a larger pulse, and the repetition rate of the pulse.
  • the pulse width ranges from 0.001 to 0.5 seconds.
  • the pulse height ranges from 0.1 to 10 Newtons.
  • Rise/fall time range from 0.5 to 250 ms, while the sub-pulses per pulse range from 1 to 5.
  • Repetition rate ranges from 2 Hz to 20 Hz, while the gas-liquid mixture ranges from 40-95% by volume between gas and liquid.
  • This embodiment can be used with incident angles from 0-90°, with 0 being parallel to the tooth surface. Also, a nozzle fan angle is 5-150°, with flow rates of 0.15 ml per shot, or within a range of 0.05-0.07. Delivery durations are 0.001-0.5 seconds, while the flow is described by Reynold's numbers between 100-10,000.
  • the slug would have the following parameters:
  • the volume of the slugs range from 0.05 to 0.5 ml per orifice, with slug diameters of 0.1-2 mm. Repetition rates vary between 2Hz
  • a jet/slug fluid flow is produced, which is a more laminar-type of flow.
  • the slugs, boundaried pockets of liquid in a jet stream are produced by control of the liquid and gas sources by programming the microcontroller and by adapting the physical characteristics of the fluid flow channel, as well as use of flexible membrane of elastic members affecting the flow.
  • the parameter of the resulting slugs in the jet flow include diameter, volume, slug-to-slug delay, repetition rate and velocity.
  • the volume of the slugs range from 0.05 to 0.5 ml per orifice, with slug diameters of 0.1-2 mm.
  • Repetition rates vary between 2Hz to 20Hz, while the gas/liquid mixture varies between 40-95% by volume, gas to liquid.
  • the fluid flow is in the form of separate slugs.
  • This embodiment can also be used with incident angle from 0-90°, with 0° being parallel to the tooth surface. Further, a nozzle fan angle with a range between 0-10° is possible.
  • the fluid dynamics set forth above When mouthwash is used for the fluid, the fluid dynamics set forth above, either in the form of a pulsed fluid flow or a jet flow with fluid slugs, have a positive effect on the mouthwash, enhancing its ordinary effect. Typically, this will result in the active ingredients becoming more effective, due to a breaking down of the mouthwash.
  • gas nucleation or de-gassing of the mouthwash fluid can be accomplished by using heat or pressure drop or other means, such as ultrasonic, optical and electrical means, in order to break down or degrade the mouthwash. This results in an increased effect of the mouthwash and a more direct impact on the biofilm.

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  • Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Brushes (AREA)

Abstract

An oral care appliance comprises: a fluid pump assembly (46); a source of gas (12); and a source of mouthwash (50), wherein the pump is in operative communication with the source of the mouthwash and gas to produce a series of gas-injected fluid pulses or a series of fluid slugs in a jet stream directed to a nozzle assembly (80) from which the resulting pulses are directed to the teeth, wherein the pulses or slugs produce a breakdown effect on the mouthwash to its active ingredients, making the mouthwash more effective against the biofilm. The pulses have a pulse width within the range of 0.001-0.5 seconds, a pulse height from 0.1-10 Newtons, a rise/fall time range of 0.5-250 ms, a repetition rate in the range of 2H to 20Hz, and wherein the gas/liquid mixture range from 40-95% volume to volume gas to liquid. The fluid slugs in the jet flow have a volume in the range of 0.05-0.5 ml per orifice, a diameter in the range of 0.1-2 mm and a repetition rate within the range of 2Hz to 20Hz.

Description

ORAL CLEANING APPLIANCE PRODUCING PULSES OF GAS WITH MOUTHWASH
Technical Field
This invention relates generally to apparatus for cleaning teeth using a combination of bursts of gas and bursts of fluid to produce a desired gas/fluid mix, and more particularly concerns a single assembly for producing both gas bursts and fluid bursts in coordination, as well as an assembly for producing a jet pattern of gas and fluid in another embodiment.
Background of the Invention
In systems which produce teeth cleaning with a combination of bursts of gas and fluid, such as water, it is important that the gas and fluid are mixed in a way to deliver the greatest efficacy of cleaning. In addition it is important to coordinate the timing of these two functions while still being relatively simple in structure and operation, and sufficiently small to fit within a specific device footprint. Use of separate liquid and gas delivery systems typically have some problems with timing, as well as space constraints and the need for dual power sources.
Summary of the Invention
An oral care appliance comprises: a fluid pump assembly; a source of gas; a source of mouthwash, wherein the pump is in operative communication with the source of the mouthwash and gas to produce a series of gas-injected fluid pulses or a series of fluid slugs in a jet stream directed to a nozzle assembly (80) from which the resulting pulses are directed to the teeth, wherein the pulses or slugs produce a breakdown effect on the mouthwash to its active ingredients, making the mouthwash more effective against the biofilm, wherein the pulses have a pulse width within the range of 0.001-0.5 seconds, a pulse height from 0.1-10 Newtons, a rise/fall time range of 0.5-250 ms, a repetition rate in the range of 2H to 20Hz, and wherein the gas/liquid mixture range from 40-95% volume to volume gas to liquid, or wherein the fluid slugs in the jet flow have a volume in the range of 0.05-0.5 ml per orifice, a diameter in the range of 0.1-2 mm and a repetition rate within the range of 2Hz to 20Hz. Brief Description of the Drawings Figure 1 is a perspective view showing the apparatus.
Figure 2 is an elevational view of the opposing side of the apparatus of Figure 1.
Figure 3 is an exploded view of the apparatus of Figure 1.
Figure 4 is a partially cutaway elevational view of Figure 1.
Figure 5 is a perspective view of the apparatus showing the opposing side of the apparatus, similar to Figure 2.
Figure 6 is a perspective exterior view of an appliance incorporating the apparatus of Figures 1-5.
Figure 7 A is a front elevational view of the nozzle assembly portion of Figure 6.
Figure 7B is a cross-sectional view of the nozzle assembly of Figure 7A.
Figure 8 is another cross-sectional view of an exit portion of a nozzle assembly.
Figure 9 is a simplified view of an alternative arrangement to that of Figures 1-6.
Figure 10 is a simplified view of an appliance using the apparatus of Figures 1-6 or 9 with a power toothbrush.
Detailed Description
Figures 1-5 show one embodiment of an apparatus, generally at 10, for producing successive bursts of gas and liquid, such as water, which mix to produce a stream of gas and liquid droplets used for cleaning teeth, especially the interproximal areas of the teeth, accomplishing a "flossing" function. The term gas can include air or other gases or mixtures. Apparatus 10 forms the major part of a complete teeth cleaning appliance, the exterior of which is shown in Figure 6 and described in more detail below.
Referring now specifically to Figures 1 and 2, apparatus 10 includes an gas cylinder 12, which in the embodiment shown is approximately 2.5 inches long with an internal diameter of 0.5-1.0 inches. At a distal end 14 of gas cylinder 12 is a nozzle 16 through which a mix of water or other liquid bursts and fluid, typically gas, exit, in the form of a stream of high velocity liquid droplets. The liquid droplets are directed toward the teeth of a user, particularly the interproximal area, for cleaning.
The apparatus includes a motor 20 which in the embodiment shown is a DC motor, typically with high torque, e.g. 15 Newton meters, although this value is typically achieved after gear reduction. The motor itself thus does not have to produce such a value of torque itself. Such motors are widely commercially available. Various motors are suitable. Motors made by Mitsumi are for instance examples of a suitable motor. Motor 20 includes an output shaft 21 on which is mounted a motor drive gear 22 (Figure 4). In the embodiment shown, there are 8 teeth on the motor drive gear. The number of teeth on gear 22, as with the number of teeth on the other gears, can be varied. Motor 20 is positioned at 24 at the rear upper surface of gas cylinder 12. Motor drive gear 22 engages a first (outer) gear part 26 of a first compound gear 28 located at a first side of the apparatus. The first compound gear 28 in the embodiment shown is made of plastic as are the other gears, however it could be made of other material as well. The first gear part 26 of gear 28 in the embodiment shown has 53 teeth. The motor drive gear 22 in operation rotates it in a clockwise direction. The first compound gear 28 also includes a gear shaft 30 and a second (inner) gear part 32 coincident with the distal end of shaft 30, as shown in Figure 3. In the embodiment shown, the second gear part of the first compound gear has 8 teeth.
The shaft 30 with the second gear part 32 of the first compound gear 28 extends through apparatus 10 and mates with a first (outer) gear part 34 of a second compound gear 36 positioned on an opposing side of the apparatus.. In the embodiment shown, the first gear part 34 of the second compound gear has 48 teeth, although this can be varied, as noted above. A second (inner) gear part 38 of second compound gear 36 is positioned adjacent the first gear part 34 on a center gear shaft 37. The second gear part of the second compound gear has two parts, a first part comprising a partial set of 8 teeth referred to at 39 spaced around approximately one-half of the circumference of the second gear part and a second part 40 which has no teeth, i.e. the surface is smooth at the base of the teeth portion of the second gear part. Typically, but not necessarily, the two parts are each one-half of the second gear part.
The second compound central gear shaft 37 extends back through the apparatus to the first side of the apparatus and engages a peristaltic fluid pump assembly 46, which includes a pump 48. Peristaltic pump assembly 46 includes a first tube section 48 which extends to a fluid reservoir 50. In the embodiment shown, the fluid in reservoir 50 is water, although other fluids can be used as well. These include various formulations which assist in cleaning teeth, such as chlorhexidine, hydrogen peroxide-based rinses, mixtures of water, baking soda, essential oils or mouthwash, for example. The peristaltic pump assembly 46 also includes a second tube 52 which extends from the pump and above the body of the apparatus, in a U-shaped mounting element 54, and then along the outer surface of the gas cylinder to a mixing chamber 58 on the distal end of the gas cylinder.
The second gear part 38 of the second compound gear 36 mates with a linear rack member 62 which is positioned at a proximal end 61 of gas cylinder 12. In the embodiment shown, rack member 62 is approximately 2 inches long and includes a set of 8 spaced teeth on the upper surface thereof. The distal end of rack member 62 includes a seal member 64 which mates in a fluid tight relationship with the interior surface of gas cylinder 12. Extending from the distal end of rack 62 at seal 64 and encircling the rack along most of the length thereon is a compression spring 66. The proximal end 68 of spring 66 is positioned against a stop element 70 in body portion 20, as shown in Figure 4.
Figure 5 is similar to Figure 2, showing motor 20, and the second compound gear 36, specifically, the second gear part 38 thereof. Figure 5 also shows a microprocessor controller 80, in the form of a printed circuit board, for the apparatus, which controls all of the operations thereof and is mounted on an internal frame portion of the apparatus. Figure 5 also shows an on/off power button 82 for the appliance which enables the operation of the appliance by connecting battery 84, which in the embodiment shown is a lithium-polymer battery, to motor 20. When the on/off button 82 is on, a power light comes on. The appliance also includes an actuation button 86 which, when operated by a user, produces a single shot (burst) of the liquid/gas mixture out the nozzle end 16 of the appliance.
In operation, in general, as the motor drive gear 22 turns, rack 62 moves rearwardly by action of the partial set of teeth 39 of the second gear part of the second compound gear 36, the rack moving relatively away from the proximal end 61 of the gas cylinder, compressing spring 66 against stop 70. Gas enters the gas cylinder through an opening at distal end 14 thereof. In the embodiment shown, spring 66 undergoes 30 mm of compression. Spring 66 in typical operation is compressed successively every 400 to 900 milliseconds, depending on the precise rpm of the motor and the action of the control assembly. It is possible to operate faster than every 400 ms, even down to 100 ms.
When the second compound gear 36 rotates so that the no-tooth gear portion 40 of the second gear part of compound gear 36 comes adjacent the rack, such that there is no longer a gear contact between the second gear part and the rack, and hence no gear holding the rack in position, spring 66 operates to move the rack quickly forwardly, moving the sealed end of the rack forwardly in the gas cylinder, forcing a burst of gas into the mixing chamber, along with a liquid (water) burst, produced concurrently by action of the pump 68 or somewhat prior, driven by shaft 37 of the second compound gear. Typically, there is one shot of gas per revolution of the motor shaft, every 400-900 milliseconds (or faster); further, there is approximately .15 ml of fluid provided to the mixing chamber per revolution of the motor shaft.
More particularly, in the start sequence of operation, with the power button 82 in an on condition, activation button 84 is pressed by the user. This begins the intake stroke of the apparatus. In the starting position, rack member 62 and the seal 64 are fully forward, with the partial set of teeth 39 of the second gear part of the second compound gear just engaging the rear end of the rack member 62. Motor 20, as indicated above, initiates action of the entire gear train, resulting in the rack member 62 moving rearwardly and seal 64 retracting in the gas cylinder. This results in compression of spring 66, and the pulling of gas into the gas cylinder. As the motor and the gear train operates, peristaltic pump assembly 46 operates, causing pump 48 to move fluid, such as water, into the mixing chamber of the apparatus. The outer gear part 34 of second compound gear 36 includes a magnet 88 (Figure 5) on an outer surface thereof. As gear 34 rotates, a Hall Effect sensor 90 positioned on the internal frame portion of the appliance detects the magnet as it moves past the sensor, and in response starts a software implemented delay time present in controller 80, which turns off motor 20 at the end of the time. The timing of the software delay is established such that motor 20 is not shut off until after the start of the exhaust portion of the operating cycle.
In the exhaust portion of the cycle, when rack 62 and seal 64 are pulled to their rearmost position, with spring 66 fully compressed against stop 70 by the action of the partial set of teeth 39, further rotation of the second compound gear by action of the motor results in the non tooth portion 40 of the second gear part 38 coming adjacent the rack so that there is a disengagement between the second gear part 38 and the rack. Rack 62 and seal 64 move quickly forward, driven by the release action of spring 66. The gas in the gas cylinder is forced rapidly out of the cylinder into the mixing chamber where it mixes with the liquid present therein. The resulting liquid/gas mix, in the form of a single burst, is then forced out of the nozzle.
The Hall Effect sensor software delay times out and the motor is shut off. The momentum in the gear train allows the second gear part 38 of the second compound gear 36 to continue to rotate until the partial set of teeth 39 initially engages with the first tooth or so of the rack 62. This small amount of rotation results in some water being moved into the mixing chamber by the continued action of the peristaltic pump. The total volume of water provided for each shot is the amount of water provided by a full 360° rotation of the peristaltic pump 48.
At this point, the apparatus is now in a condition to begin the next shot/burst. The gear train at the end of each operating sequence stops in the same position after each burst, in accordance with the software timer action operating the motor. The delay timer also acts to prevent the user from operating the unit too rapidly and overheating the motor. It prevents the start of another operating sequence, even though the activation button 84 is pressed. At the end of the delay time, pressing the activation button will initiate action of the apparatus, producing a successive burst of liquid/gas mixture.
The successive bursts of gas and liquid are brought together in the mixing chamber 58, with proper, consistent timing, from which the resulting mixture exits through port 16, directed through the nozzle assembly toward the teeth of the user for cleaning thereof.
Figure 6 shows the exterior of such an appliance 70. It includes a handle/receiver portion 72 and an extending nozzle portion 74. Located in the handle/receiver portion 74 is a liquid/gas mixture burst-generating system and a power source therefor, as shown in Figures 1-5 above. Nozzle portion 74 extends away from the handle and is relatively slim, in order to conveniently fit into the mouth of a user, for reaching all of the interproximal and gingival areas of the teeth. The nozzle portion terminates in a nozzle exit member 81 having a small opening 83 in a forwardly extending portion, through which the successive bursts of liquid/gas mixture are directed to the teeth. The opening in the embodiment shown is approximately 1 mm in diameter, although this can be varied. Further, exit member 81 has a surface configuration to facilitate proper contact and placement of the exit member in the interproximal areas of the teeth. The handle/receiver includes an on/off switch 82 and a control member 86 which when operated by the user produces the bursts of liquid/gas mixture. While the liquid will frequently will be water, it should be understood that other liquids, such as mouthwash and medications, can also be utilized.
In Figures 7-8, an elongated nozzle portion which terminates in a nozzle exit member 80 is shown in more detail, including a base portion 91 and a tip portion 92. At the center of tip portion 92 is an exit opening 94 through which high velocity droplets are delivered to the teeth of the user for cleaning when the appliance is positioned properly by the user in the mouth. The nozzle exit member is generally configured to provide a guidance function for the interproximal areas. The tip portion 92 extends above a surrounding intermediate portion 96 by approximately 1-3 mm. In some cases, the exit nozzle member can be slightly tapered, with an exterior diameter of approximately 2 mm. The intermediate trough portion 96 tapers slightly away from exit member 24. The intermediate portion 96 terminates in a boundary portion 98 which has a curved upper surface which defines a lip for the tip portion 92. Additional details and advantages of such a structure are set forth U.S. Application 61/289,589, which is owned by the assignee of the present invention, the contents of which application are hereby incorporated by reference.
In one embodiment, a tip portion 98 of the nozzle assembly 80 is separable from a base portion 94 thereof which extends from body 12. This is shown in Figure 8. The tip portion is replaceable. The replaceable tip portion of the nozzle has a number of advantages. These include the ability to replace the tip of the nozzle due to wear. It also permits nozzle variations depending on a desired hardness, (or softness) of the material. Further, the diameter of the exit orifice of the tip portion can be changed to alter the characteristic of the liquid droplet spray.
Figure 9 shows a fluid-based cleaning appliance, generally at 120. Figure 9 shows a more generalized system, capable of providing a spray output, a pulse output or a jet output producing bursts of gas at selective frequencies, under control of a microprocessor. Typically the fluid is water, although it could be other liquids, including medications or mouthwash. The appliance 12 includes an appliance body 122, which includes a fluid delivery system for producing discrete bursts of gas/fluid mixtures, including sprays, bursts and jets, and an outlet for the fluid bursts which proceed through a fluid delivery path 123 in an outlet member 124, at the end of which is a nozzle assembly 126, as described above, which could include a single nozzle or a plurality of nozzles. The discrete fluid bursts from nozzle 126 are sufficient to effectively manage biofilm through mechanical removal thereof, with a resulting reduction in the virulence of microorganisms in the mouth. The discrete fluid bursts provide a cleansing benefit greater than toothbrush bristles alone, because the fluid bursts are able to reach between the teeth and along the gum line where bristles cannot reach. The use of discrete i.e. separate, bursts of fluid, as opposed to a continuous or pulsed jet of fluid, does result in substantially less total liquid volume per brushing event, which may be an advantage as it enhances user comfort and compliance, while maintaining effectiveness. The cleaning event is typically two minutes.
The delivery system includes a displacement pump 130, which is programmed in combination with a regulator 132, to provide discrete bursts of liquid, typically water, as indicated above, from a tank 134. The liquid could be various medications or mouthwashes. The regulator 132 maintains the pressure in the water tank 134 at a specified level. Typically, the pressure is in the range of 40-120 psi, with a preferred range of 70-112 psi. The water tank holds a cleansing event amount of liquid, slightly less than 0.2 ml. It has been discovered that a user can readily tolerate this amount of liquid in a normal cleansing event of two minutes. The appliance also includes a battery 136, which operates pump 130, and a conventional charger coil 138, which is used with a charging member (not shown). Controlling the release of liquid from the water tank is a valve 140, which is for instance a solenoid valve, and a timer 141. The appliance also includes a power button 144 and a firing button 146, although those two functions can be combined in a single element. A microcontroller 148 controls the operation of the appliance, including an automatic mode of operation for the appliance. The microcontroller can control various fluid dynamics parameters, as discussed in more detail below. This is an alternative to the pump/controller system of Figure 1.
The discrete fluid bursts are predefined in terms of time duration and firing rate. In a manual mode, the bursts are generated by operating firing button 146. Timer 141 controls the duration of the fluid bursts. In one embodiment, the burst time duration range is 0.02-2 seconds, with a preferred time duration of 0.05-0.2 seconds. The firing rate in a manual mode is controlled by the user, which is typically significantly longer than the burst duration.
In automatic mode, which is controlled by microcontroller 148, the time duration of the liquid burst will be the same as in the manual mode. The automatic mode may be initiated by a programmed sequence of operating the on-off switch or by a separate switch member/button for the user to operate. The firing rate can be automatically controlled or pre-programmed, typically, 0.1-2 seconds, with a preferred range of firing rate of 0.5-1.5 seconds. In some cases, the time duration of the burst and the firing rate may be adjusted by the user by a predefined sequence of operating the on-off switch. In other cases, the firing rate is permanently set during manufacture.
The advantage of the present system is that the discrete fluid bursts produced by the system of Figure 9 provides effective cleaning for the teeth and effective treatment of the gum tissue, but with the total volume of liquid being comfortable for the user with a typical cleansing event time of two minutes, which is an encouragement for regular use.
Figure 10 shows a variation of the embodiment of Figure 9, with the appliance having a similar fluid delivery arrangement thereto, or to the specific system of Figures 1-6 but with the addition of outlet member 150 being driven in a desired physical movement, such as a back-and-forth oscillatory action, with a set of bristles 152 being positioned at the end of the outlet member. Nozzle 154 or nozzles will typically be positioned within the set of bristles 152, but hollow bristles could provide the nozzle function as well. The appliance will include a drive train assembly 160, with a drive shaft 162 extending therefrom to drive outlet member. The drive train assemblyl60 could comprise various arrangements, including a motor. The drive train is controlled by microcontroller 164. The drive arrangement could be a resonant toothbrush action at a frequency in the range of 230-260 Hz for instance.
For optimal plaque removal and for corresponding oral health benefits, the shear stress provided on the biofilm must exceed the elastic and plastic deformation points of plaque and in addition overcome the adhesive action within the biofilm itself and/or the adhesive forces holding the biofilm to the dental surfaces. Accordingly, biofilm plaque has the following mechanical and viscoelastic properties which must be overcome: Young's modulus between 1 Pa and 50 kPa; shear modulus between 1.1 and 50 Pa; cohesive shear strengths between 2 and 50 Pa; adhesive strengths of 5-75 Pa or 0.05-1 J/m2; tensile strengths between 0.1 Pa and 6 kPa; adhesion shear stresses of 0.1 to 0.65 J/m2; storage moduli of 1-10 kPa; loss modulus between 0.1-3 nJ/μιη3; and failure strains of 150-320%. The above ranges depend on the type of the bacterial colony and age of the plaque and the other mechanical, chemical and physiochemical properties of the plaque on which it is positioned.
Fluid delivery, gas delivery, fluid/gas mixing and the nozzles described above can all be varied as follows:
Fluid pumps can include peristaltic, diaphragm, rotary, impeller, electroosmotic, gear, microannular, cyclone or via a pressurized gas/pneumatic cylinder/container, either positively or negatively pressure driven. Fluid can be passively pulled in through a venturi or via the Bernoulli effect into a nozzle.
Gas pumps can include peristaltic, diaphragm, rotary, impeller, electroosmotic, gear, microannular, cyclone or gas can be moved directly from a pressurized gas "tank", either positively or negatively driven. Gas can be passively pulled in through a venturi or via the Bernoulli effect over an orifice.
The gas and fluid mixing can be achieved through a tortuous path channel, array or orifices, a string of periodic/aperiodic orifices, dynamic elements or through direct phase control driving of the pumps (fluid or gas).
Various nozzles can be used, including any of the elements to create pulsation or gas/fluid mixing through tortuous paths, with the inner and outer dimensions of the part and direction changes within the fluid/gas/aerosol path.
There are various fluid dynamic actions produced by the above appliances which are effective against biofilm on the teeth. One category of fluid dynamics involves a pulse-type fluid flow operation. The pulse operation utilizes the mechanics of Figures 1-5 and 9, which are capable of delivering a variety of pulsing liquid flows, producing gas pulses and fluid having various characteristics, which can include sputtering and spray. The particular fluid flow characteristics produced in this embodiment are produced by programming the microcontroller, but also by various mechanical characteristics of the nozzle assembly and the nozzle exit member. These include the characteristics of the exit orifices, the configuration of the fluid channel or variable surface characteristics of the fluid channel which interact with the flow. It can also include flexible membrane or various elastic elements within the flow.
In the pulse arrangement, the pulse pattern can include 1-10 pulses per pulse burst. The flow parameters of the individual pulses include pulse width, pulse height, rise/fall time, the number of sub-pulses, i.e. pulses within a larger pulse, and the repetition rate of the pulse. The pulse width ranges from 0.001 to 0.5 seconds. The pulse height ranges from 0.1 to 10 Newtons. Rise/fall time range from 0.5 to 250 ms, while the sub-pulses per pulse range from 1 to 5. Repetition rate ranges from 2 Hz to 20 Hz, while the gas-liquid mixture ranges from 40-95% by volume between gas and liquid.
This embodiment can be used with incident angles from 0-90°, with 0 being parallel to the tooth surface. Also, a nozzle fan angle is 5-150°, with flow rates of 0.15 ml per shot, or within a range of 0.05-0.07. Delivery durations are 0.001-0.5 seconds, while the flow is described by Reynold's numbers between 100-10,000.
Another category of fluid dynamics operates so as to produce a slug or a jet-type fluid output, the slug would have the following parameters: The volume of the slugs range from 0.05 to 0.5 ml per orifice, with slug diameters of 0.1-2 mm. Repetition rates vary between 2Hz In this embodiment, using the appliance of Figures 1-6 and/or Figure 9, a jet/slug fluid flow is produced, which is a more laminar-type of flow. The slugs, boundaried pockets of liquid in a jet stream, are produced by control of the liquid and gas sources by programming the microcontroller and by adapting the physical characteristics of the fluid flow channel, as well as use of flexible membrane of elastic members affecting the flow. The parameter of the resulting slugs in the jet flow include diameter, volume, slug-to-slug delay, repetition rate and velocity. The volume of the slugs range from 0.05 to 0.5 ml per orifice, with slug diameters of 0.1-2 mm. Repetition rates vary between 2Hz to 20Hz, while the gas/liquid mixture varies between 40-95% by volume, gas to liquid. As indicated above, in this embodiment, the fluid flow is in the form of separate slugs. This embodiment can also be used with incident angle from 0-90°, with 0° being parallel to the tooth surface. Further, a nozzle fan angle with a range between 0-10° is possible.
When mouthwash is used for the fluid, the fluid dynamics set forth above, either in the form of a pulsed fluid flow or a jet flow with fluid slugs, have a positive effect on the mouthwash, enhancing its ordinary effect. Typically, this will result in the active ingredients becoming more effective, due to a breaking down of the mouthwash. In addition to the effect of the fluid dynamics, gas nucleation or de-gassing of the mouthwash fluid can be accomplished by using heat or pressure drop or other means, such as ultrasonic, optical and electrical means, in order to break down or degrade the mouthwash. This results in an increased effect of the mouthwash and a more direct impact on the biofilm.
Although a preferred embodiment of the invention has been disclosed for purposes of illustration, it should be understood that various changes, modifications and substitutions may be incorporated in the embodiment without departing from the spirit of the invention, which is defined by the claims which follow.
What is claimed is:

Claims

Claims
1. An oral care appliance, comprising:
a fluid pump assembly (46);
a source of gas (12);
a source of mouthwash (50), wherein the pump is in operative communication with the source of the mouthwash and gas to produce a series of gas-injected fluid pulses or a series of fluid slugs in a jet stream directed to a nozzle assembly (80) from which the resulting pulses are directed to the teeth, wherein the pulses or slugs produce a breakdown effect on the mouthwash to its active ingredients, making the mouthwash more effective against the biofilm, wherein the pulses have a pulse width within the range of 0.001-0.5 seconds, a pulse height from 0.1-10 Newtons, a rise/fall time range of 0.5-250 ms, a repetition rate in the range of 2H to 20Hz, and wherein the gas/liquid mixture range from 40-95% volume to volume gas to liquid, or wherein the fluid slugs in the jet flow have a volume in the range of 0.05-0.5 ml per orifice, a diameter in the range of 0.1-2 mm and a repetition rate within the range of 2Hz to 20Hz.
2. The appliance of claim 1, including a system producing a gas nucleation of the mouthwash.
3. The appliance of claim 1, including a heating element for increasing the breaking down of the mouthwash.
4. The appliance of claim 1, wherein the nozzle portion of the appliance is configured to produce a pressure drop on the fluid flow therethrough, which results in a gas nucleation of the mouthwash.
PCT/IB2014/060309 2013-04-09 2014-03-31 Oral cleaning appliance producing pulses of gas with mouthwash WO2014167454A1 (en)

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US61/791,450 2013-04-09

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