WO2012156473A3 - A set of micrornas as markers and targets in cancer and immune system related diseases, methods for their application and a kit - Google Patents
A set of micrornas as markers and targets in cancer and immune system related diseases, methods for their application and a kit Download PDFInfo
- Publication number
- WO2012156473A3 WO2012156473A3 PCT/EP2012/059186 EP2012059186W WO2012156473A3 WO 2012156473 A3 WO2012156473 A3 WO 2012156473A3 EP 2012059186 W EP2012059186 W EP 2012059186W WO 2012156473 A3 WO2012156473 A3 WO 2012156473A3
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- WO
- WIPO (PCT)
- Prior art keywords
- targets
- micrornas
- markers
- cancer
- immune system
- Prior art date
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D3/00—Cutting work characterised by the nature of the cut made; Apparatus therefor
- B26D3/18—Cutting work characterised by the nature of the cut made; Apparatus therefor to obtain cubes or the like
- B26D3/185—Grid like cutters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D5/00—Arrangements for operating and controlling machines or devices for cutting, cutting-out, stamping-out, punching, perforating, or severing by means other than cutting
- B26D5/08—Means for actuating the cutting member to effect the cut
- B26D5/10—Hand or foot actuated means
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D3/00—Cutting work characterised by the nature of the cut made; Apparatus therefor
- B26D3/18—Cutting work characterised by the nature of the cut made; Apparatus therefor to obtain cubes or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D5/00—Arrangements for operating and controlling machines or devices for cutting, cutting-out, stamping-out, punching, perforating, or severing by means other than cutting
- B26D5/08—Means for actuating the cutting member to effect the cut
- B26D5/18—Toggle-link means
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D7/00—Details of apparatus for cutting, cutting-out, stamping-out, punching, perforating, or severing by means other than cutting
- B26D7/06—Arrangements for feeding or delivering work of other than sheet, web, or filamentary form
- B26D7/0608—Arrangements for feeding or delivering work of other than sheet, web, or filamentary form by pushers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D7/00—Details of apparatus for cutting, cutting-out, stamping-out, punching, perforating, or severing by means other than cutting
- B26D7/18—Means for removing cut-out material or waste
- B26D7/1818—Means for removing cut-out material or waste by pushing out
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mechanical Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Forests & Forestry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention involves detection of differential expression of specific microRNAs (miRNAs) in certain biological/pathological conditions, and functional applications of miR-511, miR-193b,miR-99b and other listed miRNAs as markers and targets in cancer and immune system related diseases. The microRNAs are used as an expression modulation targets for influencing proliferative properties of a cell and/or immune functions of an organism.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EEP201100037A EE201100037A (en) | 2011-05-16 | 2011-05-16 | Use of microRNAs as biomarkers and targets for influencing cell proliferative properties and a method and kit for detecting their expression level |
EEP201100037 | 2011-05-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012156473A2 WO2012156473A2 (en) | 2012-11-22 |
WO2012156473A3 true WO2012156473A3 (en) | 2013-03-07 |
Family
ID=45937266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2012/059186 WO2012156473A2 (en) | 2011-05-16 | 2012-05-16 | A set of micrornas as markers and targets in cancer and immune system related diseases, methods for their application and a kit |
Country Status (2)
Country | Link |
---|---|
EE (1) | EE201100037A (en) |
WO (1) | WO2012156473A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106957894A (en) * | 2016-01-11 | 2017-07-18 | 中国医学科学院肿瘤医院 | MicroRNA molecule express spectra is used to predict the purposes that brain transplantation of non small cell Lung shifts risk |
CN107137701B (en) * | 2017-05-07 | 2020-07-14 | 山东兴瑞生物科技有限公司 | Gene target and inhibitor for improving anti-liver cancer effect of DC vaccine and DC tumor vaccine |
CN108125976B (en) * | 2017-12-29 | 2020-07-31 | 唐山市人民医院 | Molecular marker miR-4270 for predicting lung cancer brain metastasis and application thereof in medicines and diagnostic kits |
CN111053789A (en) * | 2019-11-26 | 2020-04-24 | 湖南营养树生物科技有限公司 | Methods and compositions for modulating the immune system |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006028967A2 (en) * | 2004-09-02 | 2006-03-16 | Yale University | Regulation of oncogenes by micrornas |
WO2006137941A2 (en) * | 2004-11-12 | 2006-12-28 | Ambion, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
WO2010056737A2 (en) * | 2008-11-11 | 2010-05-20 | Mirna Therapeutics, Inc. | Methods and compositions involving mirnas in cancer stem cells |
WO2010129919A1 (en) * | 2009-05-08 | 2010-11-11 | Research Development Foundation | Mirna expression in allergic disease |
WO2011025919A1 (en) * | 2009-08-28 | 2011-03-03 | Asuragen, Inc. | Mirna biomarkers of lung disease |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004032196A1 (en) | 2004-07-02 | 2006-02-02 | Strasser, Wolfgang, Dr.med. | Test kit and pressure-sensitive adhesive tape for a cytological examination of the skin surface |
US9394538B2 (en) | 2008-05-07 | 2016-07-19 | Shi-Lung Lin | Development of universal cancer drugs and vaccines |
EP2295598A4 (en) | 2008-05-07 | 2013-06-12 | Univ Sapporo Medical | Method and kit for detection of cancer, and therapeutic agent for cancer |
ITMI20091538A1 (en) | 2009-09-07 | 2011-03-08 | Istituto Naz Di Genetica Mole Colare Ingm | PROFILES OF EXPRESSION OF MICRO-RNA IN THE PERIPHERAL BLOOD OF PATIENTS WITH HEPATOCARCINOMA OR HEPATIC CIRROSIS AND THEIR USES |
-
2011
- 2011-05-16 EE EEP201100037A patent/EE201100037A/en unknown
-
2012
- 2012-05-16 WO PCT/EP2012/059186 patent/WO2012156473A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006028967A2 (en) * | 2004-09-02 | 2006-03-16 | Yale University | Regulation of oncogenes by micrornas |
WO2006137941A2 (en) * | 2004-11-12 | 2006-12-28 | Ambion, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
WO2010056737A2 (en) * | 2008-11-11 | 2010-05-20 | Mirna Therapeutics, Inc. | Methods and compositions involving mirnas in cancer stem cells |
WO2010129919A1 (en) * | 2009-05-08 | 2010-11-11 | Research Development Foundation | Mirna expression in allergic disease |
WO2011025919A1 (en) * | 2009-08-28 | 2011-03-03 | Asuragen, Inc. | Mirna biomarkers of lung disease |
Non-Patent Citations (9)
Title |
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CEPPI M ET AL.: "MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA, vol. 106, 24 February 2009 (2009-02-24), pages 2735 - 2740, XP002681809 * |
FULCI V ET AL.: "Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia", BLOOD, vol. 109, 1 June 2007 (2007-06-01), pages 4944 - 4951, XP002681810 * |
KIM T H ET AL.: "Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours", HISTOPATHOLOGY, vol. 57, 2010, pages 734 - 743, XP002681808 * |
LODISH H F ET AL.: "Micromanagement of the immune system by microRNAs", NATURE REVIEWS IN IMMUNOLOGY, vol. 8, 2008, pages 120 - 130, XP002681811 * |
MATTES JOERG ET AL: "Regulation of microRNA by antagomirs: a new class of pharmacological antagonists for the specific regulation of gene function?", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, AMERICAN LUNG ASSOCIATION, NEW YORK, NY, US, vol. 36, no. 1, 1 January 2007 (2007-01-01), pages 8 - 12, XP009086371, ISSN: 1044-1549, DOI: 10.1165/RCMB.2006-0227TR * |
SHAO W ET AL: "Combined Application of Blocking Antibodies and MicroRNA Interference in Inhibiting CD44 Expression", TRANSPLANTATION PROCEEDINGS, ELSEVIER INC, ORLANDO, FL; US, vol. 42, no. 7, 1 September 2010 (2010-09-01), pages 2777 - 2781, XP027272931, ISSN: 0041-1345, [retrieved on 20100909] * |
SHEEDY F J ET AL: "Adding fuel to fire: microRNAs as a new class of mediators of inflammation", ANNALS OF THE RHEUMATIC DISEASES, BRITISH MEDICAL ASSOCIATION, LONDON, GB, vol. 67, no. Suppl 3, 1 December 2008 (2008-12-01), pages 11150 - 11155, XP009122257, ISSN: 0003-4967, DOI: 10.1136/ARD.2008.100289 * |
TAGANOV KONSTANTIN D ET AL: "NF-.kappa.B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 103, no. 33, 15 August 2006 (2006-08-15), pages 12481 - 12486, XP002544549, ISSN: 0027-8424, DOI: 10.1073/PNAS.0605298103 * |
TSEREL L ET AL.: "MicroRNA expression profiles of human blood monocyte-derived dendritic cells and macrophages reveal miR-511 as putative positive regulator of Toll-like receptor 4", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 30, 29 July 2011 (2011-07-29), pages 26487 - 26495, XP002681812 * |
Also Published As
Publication number | Publication date |
---|---|
WO2012156473A2 (en) | 2012-11-22 |
EE201100037A (en) | 2012-12-17 |
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