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WO2012097084A3 - Tenomodulin (tnmd) isoforms and uses thereof - Google Patents

Tenomodulin (tnmd) isoforms and uses thereof Download PDF

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Publication number
WO2012097084A3
WO2012097084A3 PCT/US2012/020969 US2012020969W WO2012097084A3 WO 2012097084 A3 WO2012097084 A3 WO 2012097084A3 US 2012020969 W US2012020969 W US 2012020969W WO 2012097084 A3 WO2012097084 A3 WO 2012097084A3
Authority
WO
WIPO (PCT)
Prior art keywords
tenomodulin
tnmd
isoforms
polypeptide
methods
Prior art date
Application number
PCT/US2012/020969
Other languages
French (fr)
Other versions
WO2012097084A2 (en
Inventor
Albert Banes
Jie Qi
Mari TSUZAKI
Donald K. BYNUM
Ashley BANES
Jacob DMOCHOWSKI
Megan PATTERSON
Original Assignee
The University Of North Carolina At Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Of North Carolina At Chapel Hill filed Critical The University Of North Carolina At Chapel Hill
Publication of WO2012097084A2 publication Critical patent/WO2012097084A2/en
Publication of WO2012097084A3 publication Critical patent/WO2012097084A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The presently disclosed subject matter relates to tenomodulin (TNMD) and its isoforms. Also described are diagnostic and therapeutic uses of tenomodulin (TNMD) and its isoforms, such as in connective tissues such as tendon. More particularly, provided herein are methods of detecting a tenomodulin polypeptide, methods of detecting a nucleic acid molecule that encodes a tenomodulin polypeptide, and methods of modulating the biological activity of a tenomodulin polypeptide.
PCT/US2012/020969 2011-01-11 2012-01-11 Tenomodulin (tnmd) isoforms and uses thereof WO2012097084A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161431576P 2011-01-11 2011-01-11
US61/431,576 2011-01-11

Publications (2)

Publication Number Publication Date
WO2012097084A2 WO2012097084A2 (en) 2012-07-19
WO2012097084A3 true WO2012097084A3 (en) 2012-11-15

Family

ID=46507652

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/020969 WO2012097084A2 (en) 2011-01-11 2012-01-11 Tenomodulin (tnmd) isoforms and uses thereof

Country Status (1)

Country Link
WO (1) WO2012097084A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2269267B1 (en) 2008-04-28 2017-12-13 Wispry, Inc. Tunable duplexing antenna and methods
CN103503314B (en) 2010-12-10 2016-01-27 维斯普瑞公司 MEMS tunable notch filter frequency automatic control loop system and method

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE NCBI 18 December 2006 (2006-12-18), "Tenomodulin, isoform CRA_c [Homo sapiens]", accession no. AX02808 *
DATABASE NCBI 27 December 2010 (2010-12-27), "Homo sapiens tenomodulin (TNMD), mRNA", accession no. M_022144 *
DATABASE NCBI 27 December 2010 (2010-12-27), "Tenomodulin [Homo sapiens]", accession no. P_071427 *
DATABASE NCBI 27 October 2008 (2008-10-27), "Homo sapiens tenomodulin, mRNA (cDNA clone IMAGE:4294374), with apparent retained intron", accession no. C034030 *
SHUKUNAMI, C. ET AL.: "Molecular cloning of tenomodulin, a novel chondromodulin-I related gene", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 280, no. 5, 9 February 2001 (2001-02-09), pages 1323 - 1327 *

Also Published As

Publication number Publication date
WO2012097084A2 (en) 2012-07-19

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